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Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade

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BIOCELL 2021年第1期45卷 89-101页

作者： ATTALLA EL-KOTT EMAN ELBEALY FAHMY ELSAID HAITHAM EL-MEKKAWY ABD-EL-KARIM ABD-LATEIF ABDULALI TAWEEL HEBA KHALIFA ahmad kandeel KAREEM MORSY ESSAM IBRAHIM MASHAEL MOHAMMED BIN-MEFERIJ Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceMansoura UniversityMansoura35511Egypt Zoology Department College of ScienceFayoum UniversityFayoum63511Egypt Zoology Department Faculty of ScienceAl-Zawia UniversityAl-ZawiaLibya Biology Department Faculty of ScienceCairo UniversityCairo12611Egypt Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha61413Saudi Arabia Blood Products Quality Control and Research Department National Organization for Research and Control of BiologicalsCairo12611Egypt Biology Department College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

This study investigates if the anti-tumor effect of Pterostilbene in the SKOV3 ovarian cancer(OC)cell line involves inhibition of cell metabolism and tested in this effect involves modulating AMPK and Akt-induced regulation of ***,SKOV3 cells were cultured in the humidified conditions in DMEM media for 24 h with or without increasing concentration of ***,the cells were incubated with Pterostilbene(IC_(50)=50μM)under similar conditions with or without pre-incubation with Dorsomorphin,an AMPK *** a dose-dependent manner,Pterostilbene inhibited SKOV3 cell survival and increased their lysate levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA).When SKOV3 cells were treated with 50μM Pterostilbene,Pterostilbene significantly suppressed cell migration and invasion,reduced lysate levels of lactic acid and the optical density of Oil Red O staining,and increased lysate glucose *** also increased levels of malondialdehyde(MDA),reactive oxygen species(ROS),and induced intrinsic cell apoptosis by upregulating protein levels of Bax and cleaved caspase-3 and reducing protein levels of ***,Pterostilbene reduced mRNA levels of sterol regulatory element-binding protein 1(SREBP-1),fatty acid synthase(FAS),acetyl CoA carboxylase-1(ACC-1),and AMP-activated protein kinase(AMPK).Furthermore,Pterostilbene increased the protein levels of p-AMPK,p-p53,p-raptor,p-TSC-2,but significantly decreased protein levels of p-Akt,p-TSC-2,p-mTOR,p-S6K1,and *** with Dorsomorphin(CC)abolished all the anti-tumorigenesis effects afforded by Pterostilbene and prevented Pterostilbene-induced phosphorylation of Akt,p53,and *** conclusion,the tumorsuppressive effect of Pterostilbene in SKOV3 cells involves the induction of ROS and inhibition of dysregulation cell metabolism mainly due to AMPK-induced Akt-dependent or independent suppression of mTOR.

关键词： Pterostilbene Ovarian cancer Lipogenesis Apoptosis AMPK

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Prevelance of Bovine Cysticercosis in Egypt and the Cysticidal Effect of Two Extracts Obtained from Balanites aegyptiaca and Moringa oleifera on Mice Model Affected with T. saginata Cysticerci

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Open Journal of Animal Sciences 2024年第2期14卷 39-55页

作者： Omnia M. Kandil Noha M. F. Hassan Doaa Sedky Hatem A. Shalaby Heba M. Ashry Nadia M. T. Abu El Ezz Sahar M. kandeel Mohamed S. Abdelfattah L. Ying Ebtesam M. Al-Olayan Parasitology and Animal Diseases Department Veterinary Research Institute National Research Centre Dokki Cairo Egypt Chemistry of Natural Compounds Department Pharmaceutical and Drugs Industries Research Institute National Research Centre Dokki Cairo Egypt Chemistry Department Faculty of Science Helwan University Cairo Egypt State Key Laboratory of Plateau Ecology and Agriculture Qinghai University Xining China College of Agriculture and Animal Husbandry Qinghai University Xining China Department of Zoology Collage of Science King Saud University Riyadh Saudi Arabia

The aim of the present study was to determine the prevalence of bovine cysticercosis in both cattle and buffloas, in Egypt and to assess the cysticidal efficacy of Balanites aegyptiaca fruits (B. aegyptiaca) and Moringa oleifera seeds (M. oleifera) extracts in experimentally infected mice. The study detected the level of tumor necrosis factor (TNF-α) to monitor the immune and inflammatory responses of experimentally infected mice. Through meat inspection, a total number of 2125 male bovine, 2 to 5 years old, (1125 cattle and 1000 buffloes) were examined under the authority of Albsatine and Alwaraq official abattoirs in Cairo Governorate, Egypt covering the period extended from March 2022 to April 2023. The overall prevalence of the disease among bovine was 7.8% (6.31% of cattle and 9.5% of buffloes). Besides, B. aegyptiaca and M. oleifera extracts showed cysticidal activity in experimentally infected mice. A decrease in the numbers of cysticerci was found in all treated mice groups, and up to 88% reduction was achieved in the B. aegyptiaca-treated group;higher than that was recorded in both M. oleifera (72.23%) and albendazole-treated ones (80.56%). Postmortem findings proved that M. oleifera and B. aegyptiaca reduced cysticerci numbers comparable to a commercial anthelmintic. The study showed a significant decrease (P 0.001) in TNF-α levels after treatment with Balanites and Moringa extracts, compared with the untreated control and the albendazole-treated groups.

关键词： Prevalence Balanites aegyptiaca Moringa oleifera Mice T. saginata Cysticerci

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A computational model of the human glucose-insulin regulatory system

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The Journal of Biomedical Research 2010年第5期24卷 347-364页

作者： Keh-Dong Shiang Fouad kandeel Division of Biostatistics Department of Information SciencesCity of Hope National Medical Center Division of Hematopoietic Stem Cell and Leukemia Research City of Hope National Medical Center Division of Diabetes Endocrinology and MetabolismCity of Hope National Medical Center

Objective：A computational model of insulin secretion and glucose metabolism for assisting the diagnosis of diabetes mellitus in clinical research is *** proposed method for the estimation of parameters for a system of ordinary differential equations（ODEs）that represent the time course of plasma glucose and insulin concentrations during glucose tolerance test（GTT）in physiological studies is *** aim of this study was to explore how to interpret those laboratory glucose and insulin data as well as enhance the Ackerman mathematical ***：Parameters estimation for a system of ODEs was performed by minimizing the sum of squared residuals（SSR）function,which quantifies the difference between theoretical model predictions and GTT＇s experimental *** proposed perturbation search and multiple-shooting methods were applied during the estimating ***：Based on the Ackerman＇s published data,we estimated the key parameters by applying R-based iterative computer *** a result,the theoretically simulated curves perfectly matched the experimental data *** model showed that the estimated parameters,computed frequency and period values,were proven a good indicator of ***：The present paper introduces a computational algorithm to biomedical problems,particularly to endocrinology and metabolism fields,which involves two coupled differential equations with four parameters describing the glucose-insulin regulatory system that Ackerman proposed *** enhanced approach may provide clinicians in endocrinology and metabolism field insight into the transition nature of human metabolic mechanism from normal to impaired glucose tolerance.

关键词： Coupled ordinary differential equations glucose tolerance test parameters estimation sum of squared residuals cost function multiple shooting method

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Anthropometric assessment of a Middle Eastern group of autistic children

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World Journal of Pediatrics 2014年第4期10卷 318-323页

作者： Nagwa A Meguid Wafaa A kandeel Khaled E Wakeel Aly A El-Nofely Department of Research on Children with Special Needs National Research Centre(NRC)CairoEgypt Department of Biological Anthropology NRCCairoEgypt

Background:Growth abnormalities are uniquely associated with autism spectrum disorders(ASD);however,the extent to which growth abnormalities are present has hardly been *** current study aims to compare the differences in anthropometric parameters in a group of autistic Egyptian children and the healthy normal ***:We recruited 100 children with ASD from the Outpatient Clinic for"Autistic Children"at the Medical Research Hospital of Excellence,National Research Centre in Cairo,*** were diagnosed by DSM-IV criteria of the American Psychiatric Association,Autism Diagnostic Interview-Revised,and Childhood Autism Rating *** these children at age of 3-10 years,71 were males and 29 *** anthropometric parameters were assessed in view of data of the healthy Egyptians of pertinent sex and ***:Weight and body mass index increased because of a signifi cant increase in subcutaneous fat *** tendency with a probable decrease in muscle mass was more evident in male or in older children,likely resulting from sedentary life style and food ***:The Z head circumference score and its variance signifi cantly increased especially in males or older children,suggesting the relative overgrowth of the brain in a substantial percentage of Egyptian children with *** concluded that increased fat composition in Egyptian autistic children with decreased muscle mass necessitates tailoring a specially designed food supplementation program to ameliorate the severity of autism symptoms.

关键词： anthropometry autism spectrum disorders Egypt growth

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男性性功能障碍病理生理与治疗学

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2009年

作者： fouadR.kandeel

这是一本由fouad ***等60多位男科/泌尿外科专家共同撰写完成的关于男性性功能障碍的病理生理和治疗的原著。全书详尽的介绍了男性性功能障碍的生理和病理改变，从男性的阴茎的历史、男性的生殖器解剖、男性勃起的神经内分泌调控、性激... 详细信息

ISBN: (纸本)9787509130339

这是一本由fouad ***等60多位男科/泌尿外科专家共同撰写完成的关于男性性功能障碍的病理生理和治疗的原著。全书详尽的介绍了男性性功能障碍的生理和病理改变，从男性的阴茎的历史、男性的生殖器解剖、男性勃起的神经内分泌调控、性激素和男性性行为、心理和社会对男性性功能的影响，以及引起男性性功能障碍疾病的病理生理变化与引起男性性功能障碍的常见疾病等方面进行阐述，以改善和提高男性性功能和性能力。

关键词：病理生理学功能性疾病

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Imaging pancreatic islet cells by positron emission tomography

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World Journal of Radiology 2016年第9期8卷 764-774页

作者： Junfeng Li Johann Karunananthan Bradley Pelham Fouad kandeel Department of Diabetes Endocrinology and Metabolism Beckman Research Institute of the City of Hope

It was estimated that every year more than 30000 persons in the United States- approximately 80 people per day- are diagnosed with type 1 diabetes(T1D). T1 D is caused by autoimmune destruction of the pancreatic islet(β cells) cells. Islet transplantation has become a promising therapy option for T1 D patients, while the lack of suitable tools is difficult to directly evaluate of the viability of the grafted islet over time. Positron emission tomography(PET) as an important non-invasive methodology providing high sensitivity and good resolution, is able to accurate detection of the disturbed biochemical processes and physiological abnormality in living organism. The successful PET imaging of islets would be able to localize the specific site where transplanted islets engraft in the liver, and to quantify the level of islets remain alive and functional over time. This information would be vital to establishing and evaluating the efficiency of pancreatic islet transplantation. Many novel imaging agents have been developed to improve the sensitivity and specificity of PET islet imaging. In this article, we summarize the latest developments in carbon-11, fluorine-18, copper-64, and gallium-68 labeled radioligands for the PET imaging of pancreatic islet cells.

关键词： Diabetes Pancreatic islet cells Positron emission tomography Imaging tracers

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Zinc Chloride Catalyzed Regioselective Nitration of Aromatic Hydrocarbons Using Tetrachlorosilane-Sodium Nitrate Homogeneous System

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International Journal of Organic Chemistry 2015年第2期5卷 49-56页

作者： Saad S. Elmorsy Saad Shaaban Fathy Eldesoky Ezzat kandeel Department of Chemistry Faculty of Science Mansoura University Mansoura Egypt

The development of a new silane reagent derived from tetrachlorosilane (TCS) was applied in the present work. TCS-sodium nitrate (NaNO3) binary reagent and zinc chloride (ZnCl2) were reported here as a homogeneous nitrating system. The later was used for the efficient mono nitration, in most cases, with high para-regioselectivity. The nitration proceeded smoothly under mild condition, fairly clean and in good yields. This readily available and inexpensive system is superior to other methods by avoidance of the use of corrosive nitrating reagents and therefore considered to be convenient in terms of risk reduction, economic advantages and environment protection. The present protocol was convenient and applicable to a variety of aromatic hydrocarbons and could be amenable to high throughput synthesis of combinatorial libraries for potential drug development, which needs to be studied as part of future investigations.

关键词： Nitration Regioselectivity Sodium Nitrate Tetrachlorosilane

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Liver Dysfunction in Sternness Burn Injury in Association to Age Estimate: A Conceivable Role of Antioxidant Biomarker and Tumor Necrosis Factor Alpha

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Journal of Biosciences and Medicines 2022年第2期10卷 111-123页

作者： Eman A. A. Abdallah Nermien A. Ibrahim Nadra A. kandeel Forensic Medicine and Clinical Toxicology Faculty of Medicine Zagazig University Egypt

Background: Burn injuries represent one of the greatest public health problems that induce significant patient morbidity and mortality. Scalds are the most common cause of burn injuries which is known to have long term grave consequences on general health. Aim: The current study was performed to identify the age of scald burn from histopathological changes and TNF-α immunoexpression. As well, study the probable relation between the scald age and the hepatic function impairment. Materials and Methods: A total number of 40 adult male albino rats were used in the study. Eight kept as control group I. Thirty-two rats were exposed to scald injury involving 20% of total body surface area (TBSA). Histopathological examination for the scald area, liver, and skin TNF-α immunohistochemistry was performed. Liver function tests and liver tissue malondialdehyde (MDA) were also determined. The study was carried out after 2, 7 days, 1 and 3 months of scald incidence. Results: Progressive histopathological changes and elevated liver enzymes were observed in the early scald ages while manifestations of healing and improvement in liver parameters, started to occur after 1 and 3 months of scald infliction in comparison with the other periods. There was a highly significant (P Conclusion: Overall, the results showed the ability to identify the age of scald injury using routine histopathological examination. Also, scald injury involving 20% of TBSA may cause long term impairment of hepatic function. Moreover, the proinflammatory results revealed that TNF-α may consider as mediators in the post-burn pathophysiological process. Furthermore, our results declare a significant correlation between MDA levels and the degree of burn complications, including shock and remote organ damage.

关键词： Scald TNF-α Histopathology Hepatic Function MDA

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温度对精子发生的调节作用与加热作为避孕方法的使用

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国际生殖健康/计划生育杂志 1988年第4期 227-229页

作者： kandeel FR Swerdloff RS 翁梨驹

本文回顾了温度升高对精子发生的影响,包括单纯加热、电磁能与超声波。从加热引起睾丸损伤的细胞学变化,可见到睾丸的不同细胞成份对热损伤有不同的敏感性,最初受损的为初级精母细胞,其次为精子。超声波与微波对睾丸的损伤还存在非热效... 详细信息

本文回顾了温度升高对精子发生的影响,包括单纯加热、电磁能与超声波。从加热引起睾丸损伤的细胞学变化,可见到睾丸的不同细胞成份对热损伤有不同的敏感性,最初受损的为初级精母细胞,其次为精子。超声波与微波对睾丸的损伤还存在非热效应。加热还可能改变睾丸的内分泌功能。现有知识提示在人类中采用睾丸加热作为可逆的男性避孕方法有潜在可行性,但在应用前应解决下列问题:维持可靠不育状态的最底有效量,睾丸功能变化的可逆性,对性腺的致突变可能等。

关键词：精子发生温度升高超声电磁能人类电磁波精细胞输精小管男性避孕

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Role of Urokinase-Type Plasminogen Activator Receptors as an Early Detector for Treatment Outcome in Adult Acute Myeloid Leukemia in Egyptian Patients

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Journal of Cancer Therapy 2015年第11期6卷 963-970页

作者： Hanan R. Nassar Eman Z. kandeel Laila A. E. Hegazy Amany M. Helal Tarek Darwish Soad A. Eltokhy Medical Oncology NCI Cairo Egypt Clinical Pathology NCI Cairo Egypt Clinical Pathology Faculty of Medicine Cairo University Cairo Egypt

Background: The urokinase-type plasminogen activator system which consists of a proteinase (the urokinase-type plasminogen activator, uPA), a receptor (the urokinase-type plasminogen activator receptor uPAR or CD87) and inhibitors (PAI1) is enriched in several types of tumors and involved in proteolysis, cell migration and invasion. High expression of uPA and uPAR is associated with an increased relapse rate and shorter survival in breast cancer and colorectal carcinomas. Aims: This study shed light on the expression of uPAR in adult acute myeloid leukemia (AML) and its prognostic relevance. Methods: Peripheral blood and bone marrow samples are obtained from 54 newly diagnosed AML adult patients, 20 healthy controls stained with anti CD87 and estimated on flow cytometry. Results: CD87 expression was heterogeneous in different FAB subtypes of AML with high expression in monocytic leukemia (M4/M5) (P value 0.001). High expression of CD87 was associated with shorter survival and poor response to therapy (P = 0.028, 0.002 respectively). The most discriminating cut off value of CD87 expression was 20%, patients with less than 20% expression had 4.6 times better treatment outcome than those with more than or equal to 20%. On the multivariate analysis, CD87 was the most significant single variable that affect treatment outcome compared to total leucocytic count, hemoglobin level, platelets count, cytogenetic and FLT expression. Summary/Conclusion: High CD87 expression is an independent prognostic parameter associated with poor response and shorter overall survival in adult AML patients.

关键词： AML Plasminogen Survival uPAR CD87

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