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Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report

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世界临床病例杂志 2023年第26期11卷 6262-6267页

作者： Mari Mori Satoru Takeshita Nami Nakamura Yuki Mizuno Akiko Tomita Mineyoshi Aoyama hiroki Kakita Yasumasa Yamada Department of Perinatal and Neonatal Medicine Aichi Medical UniversityNagakute 480-1195Japan Department of Pathobiology Nagoya City University Graduate School of Pharmaceutical SciencesNagoya 467-8603Japan Department of Pediatrics Aichi Medical UniversityNagakute 480-1195Japan Department of Pharmacy Aichi Medical UniversityNagakute 480-1195Japan

BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the *** HPE with diabetes insipidus due to associated pituitary dysfunction has been reported,HPE with the syndrome of inappropriate antidiuretic hormone secretion(SIADH)is very ***,a vasopressin V2 receptor antagonist,is effective in adults with ***,there is no report of its efficacy in infants with *** purpose of this report is to demonstrate that tolvaptan is effective for SIADH in infants and that administration of tolvaptan eliminates the need for restriction of water intake and sodium *** SUMMARY A 2414-g female infant was born at 38 wk by normal vaginal *** anomalies and head magnetic resonance imaging indicated semilobar *** birth,she had hyponatremia due to SIADH and was treated using water and sodium ***,she developed an exaggerated response to the fluid restrictions,resulting in large fluctuations in serum sodium *** administration of tolvaptan improved the fluctuations in serum sodium levels without the need for adjustment of water or sodium *** sodium was maintained within the normal range after discontinuation of tolvaptan at 80 d of *** were no side effects,such as hypernatremia or liver dysfunction,during the administration of *** This is the first report on the safety and efficacy of tolvaptan in an infant with SIADH associated with HPE.

关键词： Tolvaptan Holoprosencephaly Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Case report

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两例具有大磁滞的氰根桥联{Fe^(Ⅲ)_(2)Ni^(Ⅱ)}单链磁体

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无机化学学报 2023年第9期39卷 1775-1781页

作者：管雅慧赵亮姚念涛 hiroki Oshio 刘涛大连理工大学精细化工国家重点实验室大连116024

我们利用具有不同对称性的同分异构体,通过改变分子间氢键网络,操控单链磁体行为,成功合成了2例化合物:[Ni^(Ⅱ)(L1)][Fe^(Ⅲ)(Tp)(CN)_(3)]_(2)·3.5H_(2)O(1)和[Ni^(Ⅱ)(L2)][Fe^(Ⅲ)(Tp)(CN)_(3)]_(2)·3H_(2)O(2),其中Tp=hydrotris(pyrazolyl)borate,L1=3,4-bis(1H-imidazol-1-yl)thiophen,L2=1,2-bis(1H-imidazol-1-yl)thiophen)。磁性研究表明,1和2表现为具有不同矫顽场的单链磁体行为。1的矫顽场为8.41 kOe,而2的矫顽场为3.84 kOe。

关键词：单链磁体氰基桥联氢键矫顽场

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Preoperative microcoil embolization of the common hepatic artery for pancreatic body cancer

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World Journal of Gastroenterology 2012年第16期18卷 1940-1945页

作者： Isao Takasaka Nobuyuki Kawai Morio Sato Hirohiko Tanihata Tetsuo Sonomura hiroki Minamiguchi Motoki Nakai Akira Ikoma Kouhei Nakata hiroki Sanda Department of Radiology Wakayama Medical University811-1 KimiideraWakayama-shiWakayama 641-8510Japan

AIM:To evaluate safety and feasibility of microcoil embolization of the common hepatic artery under proper or distal balloon inflation in preoperative preparation for en bloc celiac axis resection for pancreatic body ***:Fifteen patients(11 males,4 females;median age,67 years) with pancreatic body cancer involving the nerve plexus surrounding the celiac artery underwent microcoil *** alter the total hepatic blood flow from superior mesenteric artery(SMA),microcoil embolization of the common hepatic artery(CHA) was conducted in 2 cases under balloon inflation at the proximal end of the CHA and in 13 cases under distal microballoon inflation at the distal end of the ***:Of the first two cases of microcoil embolization with proximal balloon inflation,the first was successful,but there was microcoil migration to the proper hepatic artery in the *** migrated microcoil was withdrawn to the CHA by an inflated microballoon *** embolization was successful in the other 13 cases with distal microballoon inflation,with no microcoil *** microcoil embolization under distal microballoon inflation created sufficient resistance against the vascular wall to prevent *** balloon inflation achieved the requisite 1 cm patency at the CHA end for vascular *** patients underwent en bloc celiac axis resection without arterial reconstruction or liver ***:To impede microcoil migration to the proper hepatic artery during CHA microcoil embolization,distal microballoon inflation is preferable to proximal balloon inflation.

关键词： Embolization Microcoil Balloon inflation En bloc celiac axis resection Pancreas body cancer

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“猫の额”——没有门的房间

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缤纷 2011年第2期 60-65页

作者： ninkipenl 黄梦斯 hiroki KAWATA

普通日本家庭的独立住宅面积大多非常狭小,并且受拥挤而产生的各种地形也着实为完美的小住宅造成大障碍。可是,相对于高楼大厦中的现代生活。

关键词：小住宅房间日本人设计师独立住宅拥挤子空间现代生活狭小日本家庭

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Erythropoietin gene transfer into rat testes by in vivo electropo-ration may reduce the risk of germ cell loss caused by cryptorchidism

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Asian Journal of Andrology 2005年第4期7卷 369-373,页

作者： Masaki Dobashi Kazumasa Goda hiroki Maruyama Masato Fujisawa Division of Urology Department of Organs Therapeutics Faculty of Medicine Kobe University Graduate School of Medicine Kobe 650-0017 Japan Division of Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences Niigata 951-8120 Japan

Aim： To investigate the effects of rat Erythropoietin （Epo） on spermatogenesis by transferring rat Epo gene into cryptorchid testes by means of in vivo electroporation. Methods： Sprague-Dawley rats with surgically-induced unilateral cryptorchidism were divided into three groups： the first group was given intratesticular injections of pCAGGS-Epo （pCAGGS-Epo group）, the second group was given intratesticular injections of pCAGGS （pCAGGS group）, and the third group were given intratesticular injections of phosphate-buffered saline （PBS group）. At the same time, square electric pulses of 30 V were applied six times with a time constant of 100 ms. One or two weeks after injection, each testis was weighed and the ratio of the total number of germ cells to that of Sertoli cells （G/S ratio） was calculated to evaluate the impairment of spermatogenesis. Ten testes taken from each of the three groups were examined at each time point. Results： The testicular weight after the injection of pCAGGS-Epo or pCAGGS control plasmid was （0.85 ± 0.08） g and （0.83 ± 0.03） g, respectively, at week 1 （P = 0.788） and （0.62 ± 0.06） g and （0.52 ± 0.02） g, respectively, at week 2 （P = 0.047）. At week 1, spermatids and sperm were more abundant in testes with pCAGGS-Epo than those in the control testes. At week 2, spermatids and sperm were hardly detected in either group. The G/S ratio was 23.27 ± 6.80 vs. 18.63 ± 5.30 at week 1 （P = 0.0078） and 7.16 ± 3.06 vs. 6.05 ± 1.58 at week 2 （P = 0.1471）, respectively. Conclusion： The transfer of Epo to rat testes by in vivo electroporation may reduce the risk of the germ cell loss caused by cryptorchidism.

关键词： electroporation gene transfer techniques erythropoietin spermatogenesis Epo

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Metastatic hormone-sensitive prostate cancer:How should it be treated?

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World Journal of Clinical Oncology 2021年第2期12卷 43-49页

作者： Fernando López-Campos Carmen González-San Segundo Antonio JoséConde-Moreno Felipe Couñago Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology HGU Gregorio MarañonComplutense UniversityMadrid 28007Spain Department of Radiation Oncology Hospital Universitario y Politécnico La Fe.CEU Cardenal Herrera UniversityValencia 46026Spain Department of Radiation Oncology Hospital Universitario Quirón Salud MadridHospital La LuzUniversidad Europea de Madrid(UEM)Madrid 28223Spain

The number of treatment options for metastatic hormone-sensitive prostate cancer has increased substantially in recent *** classic treatment approach for these patients—androgen-deprivation therapy alone—is now considered *** randomized phase III clinical trials have demonstrated significant clinical benefits—including significantly better overall survival and quality of life—for treatments that combine androgen-deprivation therapy with docetaxel,abiraterone acetate,enzalutamide,apalutamide,and/or radiotherapy to the primary *** a result,these approaches are now included in treatment guidelines and considered standard of ***,the different treatment strategies have not been directly compared,and thus treatment selection remains at the discretion of the individual physician or,ideally,a multidisciplinary *** the range of available treatment approaches with varying toxicity profiles,treatment selection should be individualized based on the patient’s clinical characteristics and preferences,which implies active patient participation in the decision-making *** the present document,we discuss the changing landscape of the management of patients with metastatic hormonesensitive prostate cancer in the context of several recently-published landmark randomized *** addition,we discuss several unresolved issues,including the optimal sequencing of systemic treatments and the incorporation of local treatment of the primary tumour and metastases.

关键词： Metastatic hormone-sensitive prostate cancer Androgen-receptor signaling inhibitors Abiraterone acetate Enzalutamide Apalutamide Docetaxel

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Chemical Dynamics and Molecular Functions

Chemical Dynamics and Molecular Functions

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第九届全国化学动力学会议

作者： hiroki Nakamura Institute for Molecular Science National Institutes of Natural Sciences MyodaijiOkazaki 444-8585 Japan

＜正＞Needless to say, non-adiabatic transition and tunneling are the important quantum mechanical effects in order to properly comprehend chemical dynamics. Especially, non-adiabatic transitions can be usefully utilized to manifest and develop new molecular functions, and also to make chemical processes to occur more efficiently than those

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Three benefits of microcatheters for retrograde transvenous obliteration of gastric varices

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World Journal of Gastroenterology 2012年第12期18卷 1373-1378页

作者： Tetsuo Sonomura Wataru Ono Morio Sato Shinya Sahara Kouhei Nakata hiroki Sanda Nobuyuki Kawai hiroki Minamiguchi Motoki Nakai Kazushi Kishi Department of Radiology Wakayama Medical University Department of Gastroenterology Kishiwada Tokushukai Hospital

AIM： To evaluate the usefulness of the microcatheter techniques in balloon-occluded retrograde transvenous obliteration （BRTO） of gastric varices.METHODS： Fifty-six patients with gastric varices underwent BRTOs using microcatheters. A balloon catheter was inserted into gastrorenal or gastrocaval shunts. A microcatheter was navigated close to the varices, and sclerosant was injected into the varices through the microcatheter during balloon occlusion. The next morning, thrombosis of the varices was evaluated by contrast enhanced computed tomography （CE-CT）. In patients with incomplete thrombosis of the varices, a second BRTO was performed the following day. Patients were followed up with CE-CT and endoscopy.RESULTS： In all 56 patients, sclerosant was selectively injected through the microcatheter close to the varices. In 9 patients, microcoil embolization of collateral veinswas performed using a microcatheter. In 12 patients with incomplete thrombosis of the varices, additional injection of sclerosant was performed through the microcatheter that remained inserted overnight. Complete thrombosis of the varices was achieved in 51 of 56 patients, and the remaining 5 patients showed incomplete thrombosis of the varices. No recurrence of the varices was found in the successful 51 patients after a median follow up time of 10.5 too. We experienced one case of liver necrosis, and the other complications were transient.CONCLUSION： The microcatheter techniques are very effective methods for achieving a higher success rate of BRTO procedures,

关键词： Balloon-occluded retrograde transvenousobliteration Gastric varices Microcatheter Portal hyper-tension Ethanolamine oleate

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Electron Transfer Rate beyond the Perturbation Theory

Electron Transfer Rate beyond the Perturbation Theory

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第九届全国化学动力学会议

作者： hiroki Nakamura Department of Theoretical Studies Institute for Molecular Science MyodaijiOkazaki 444-8585Japan

＜正＞We consider a problem of calculating both thermal and microcanonical rate constant for nonadiabatic chemical reactions. Instead of using the conventional transition state theory （TST）, we use a generalized sea...

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Impact Analysis of Urban Rail Transport on Energy Demand and CO2 Emissions A Case Study of Mass Rapid Transit System in Delhi, India

Impact Analysis of Urban Rail Transport on Energy Demand and...

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2011 World Congress on Engineering and Technology(CET 2011)

作者： hiroki TANIKAWA Graduate School of Environmental Studies Nagoya University Nagoya Japan

Rising incomes coupled with an increasing demand for personal mobility and lack of efficient public transport systems are leading to increased dependence on motorization in developing cities and generating local and global environmental problems. Mass Rapid Transit System (MRTS) is viewed as an effective way to deal with increasing motorization and resulting CO 2 emissions. This paper concentrates on evaluating the impacts of MRTS system on energy demand and associated CO 2 emissions from passenger transport sector in Delhi using a systems dynamic approach. Three different scenario constructs are used to estimate the current trends and future budgets of energy demand and CO 2 emissions. These are "No MRTS scenario", "BAU" and "Policy control scenario". Results indicate that passenger mobility in Delhi is expected to increase at a rate of 8.7% per annum amounting to 534 billion passenger kilometer (p-km). In the BAU scenario the p-km shares of MRTS is 10.26%, which increases to 11.44% under the "Policy control scenario". This corresponds to a reduction of CO 2 emissions from 13.6 million tonnes "No MRTS scenario" by 2020, to 11.11 Million tonnes under the "Policy control" scenario.

关键词： MRTS energy demand CO 2 emissions Delhi

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