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Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study

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World Journal of Gastroenterology 2007年第47期13卷 6356-6364页

作者： EM Jung DA Clevert ag schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung Department of Diagnostic Radiology University Hospital RegensburgFranz-Josef Strauss-Allee 11Regensburg 93043Germany Department of Radiology Ultrasound SectionGroβhadern HospitalLudwig Maximilian University of MunichMarchioninistr15Mnchen 81377Germany Department of Trauma Surgery Passau HospitalInnstraβe 76Passau 94034Germany Institutes of Radiology Nuclear Medicine and UltrasoundPirmasens HospitalGermany Center for Biomaterial Development Institute of Polymer ResearchGKSSKantstr55Teltow 14513Germany

AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the poss

关键词： Liver tumors Malignant tumor Contrast harmonic imaging Quantitative contrast enhancement

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16层CT横轴面和冠状面成像对颈部淋巴结病变的检出率和诊断准确性

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放射学实践 2006年第3期21卷 275-275页

作者： schreyer ag Scheibl K Zorger N 杨岷（译）夏黎明（校）不详华中科技大学同济医学院附属同济医院

目的:MSCT扫描的优势在于能获得各向同性的容积扫描数据,从而使横轴面和冠状面重组图像具有较高的空间分辨力。通过与16层MSCT常规横轴面图像比较,本文旨在探讨冠状面重组图像对颈部淋巴结病变的准确性和检出率。方法:前瞻性对24例淋巴... 详细信息

目的:MSCT扫描的优势在于能获得各向同性的容积扫描数据,从而使横轴面和冠状面重组图像具有较高的空间分辨力。通过与16层MSCT常规横轴面图像比较,本文旨在探讨冠状面重组图像对颈部淋巴结病变的准确性和检出率。方法:前瞻性对24例淋巴瘤患者行颈部MSCT增强扫描,采用盲法,由4位医生分析每例患者的横轴面和冠状面重组图像。颈部淋巴结直径>10mm者为阳性,并按其解剖学部位(如颈深淋巴结链、颌下、项部)分组计数。分别记录横轴面和冠状面图像分析所用时间,并将两者的检出率分别与最终诊断结果(经4位读片者商讨并达成一致)进行比较。[第一段]

关键词：颈部淋巴结病变 MSCT扫描诊断准确性冠状面检出率 SCT增强扫描重组图像成像空间分辨力容积扫描

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