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Evaluating Pharmacological and Rehabilitation Strategies for Effective Management of Bipolar Disorder: A Comprehensive Clinical Study

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Advances in Bioscience and Biotechnology 2024年第7期15卷 406-431页

作者： Rocco de Filippis abdullah Al Foysal Department of Neuroscience Institute of Psychopathology Rome Italy Department of Computer Engineering (AI) University of Genova Genova Italy

Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.

关键词： Bipolar Disorder (BD) Pharmacotherapy (PT) Rehabilitation Interventions (RI) Hamilton Depression Scale (HAM-D) Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Mania Scale (MS) Machine learning (ML) and Artificial Intelligence (AI).

A Comprehensive Classification and Analysis of Geomagnetic Storms Over Solar Cycle 24

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Research in Astronomy and Astrophysics 2024年第8期24卷 75-84页

作者： Raja Adibah Raja Halim Shah Nurul Shazana Abdul Hamid Mardina abdullah Adlyka Annuar Idahwati Sarudin Zahira Mohd Radzi Akimasa Yoshikawa Department of Applied Physics Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiMalaysia Space Science Centre(ANGKASA) Institute of Climate ChangeUniversiti Kebangsaan Malaysia43600 BangiMalaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 BangiMalaysia School of Physics Universiti Sains Malaysia11800 USMPulau PinangMalaysia Malaysian Space Agency(MYSA) Kuala Lumpur50480Malaysia International Research Center for Space and Planetary Environmental Science(i-SPES) Kyushu University819-0395 FukuokaJapan

A geomagnetic storm is a global disturbance of Earth?s magnetosphere,occurring as a result of the interaction with magnetic plasma ejected from the *** considerable research,a comprehensive classification of storms for a complete solar cycle has not yet been fully developed,as most previous studies have been limited to specific storm *** study,therefore,attempted to present complete statistics for solar cycle 24,detailing the occurrence of geomagnetic storm events and classifying them by type of intensity(moderate,intense,and severe),type of complete interval(normal or complex),duration of the recovery phase(rapid or long),and the number of steps in the storm?s *** analysis was applied to data from ground-based magnetometers,which measured the Dst index as provided by the World Data Center for Geomagnetism,Kyoto,*** study identified 211 storm events,comprising moderate(177 events),intense(33 events),and severe(1 event)*** 36%of ICMEs and 23%of CIRs are found to be geoeffective,which caused geomagnetic *** to four-step development of geomagnetic storms was exhibited during the main phase for this solar *** showed the geomagnetic storms developed one or more steps in the main phase,which were probably related to the driver that triggered the geomagnetic storms.A case study was additionally conducted to observe the variations of the ionospheric disturbance dynamo(Ddyn)phenomenon that resulted from the geomagnetic storm event of 2015July *** attenuation of the Ddyn in the equatorial region was analyzed using the H component of geomagnetic field data from stations in the Asian sector(Malaysia and India).The variations in the Ddyn signatures were observed at both stations,with the TIR station(India)showing higher intensity than the LKW station(Malaysia).

关键词： (Sun)sunspots-Sun activity-(Sun)solar-terrestrial relations-Sun coronal mass ejections(CMEs)

Harnessing the Power of Artificial Intelligence in Neuromuscular Disease Rehabilitation: A Comprehensive Review and Algorithmic Approach

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Advances in Bioscience and Biotechnology 2024年第5期15卷 289-309页

作者： Rocco de Filippis abdullah Al Foysal Institute of Psychopathology Rome Italy Computer Engineering (AI) University of Genova Genova Italy

Neuromuscular diseases present profound challenges to individuals and healthcare systems worldwide, profoundly impacting motor functions. This research provides a comprehensive exploration of how artificial intelligence (AI) technology is revolutionizing rehabilitation for individuals with neuromuscular disorders. Through an extensive review, this paper elucidates a wide array of AI-driven interventions spanning robotic-assisted therapy, virtual reality rehabilitation, and intricately tailored machine learning algorithms. The aim is to delve into the nuanced applications of AI, unlocking its transformative potential in optimizing personalized treatment plans for those grappling with the complexities of neuromuscular diseases. By examining the multifaceted intersection of AI and rehabilitation, this paper not only contributes to our understanding of cutting-edge advancements but also envisions a future where technological innovations play a pivotal role in alleviating the challenges posed by neuromuscular diseases. From employing neural-fuzzy adaptive controllers for precise trajectory tracking amidst uncertainties to utilizing machine learning algorithms for recognizing patient motor intentions and adapting training accordingly, this research encompasses a holistic approach towards harnessing AI for enhanced rehabilitation outcomes. By embracing the synergy between AI and rehabilitation, we pave the way for a future where individuals with neuromuscular disorders can access tailored, effective, and technologically-driven interventions to improve their quality of life and functional independence.

关键词： Neuromuscular Diseases Rehabilitation Artificial Intelligence Machine Learning Robotic-Assisted Therapy Virtual Reality Personalized Treatment Motor Function Assistive Technologies Algorithmic Rehabilitation

Origin of the synergistic effects of bimetallic nanoparticles coupled with a metal oxide heterostructure for accelerating catalytic performance

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SusMat 2024年第3期4卷 227-239页

作者： Wail Al Zoubi abdullah Al Mahmud Farah Hazmatulhaq Mohammad R.Thalji Stefano Leoni Jee-Hyun Kang Young Gun Ko Integrated Materials Chemistry Laboratory School of Materials Science and EngineeringYeungnam UniversityGyeongsanRepublic of Korea School of Chemical Engineering Yeungnam University280 Daehak-roGyeongsanGyeongbukRepublic of Korea Korea Institute of Energy Technology(KENTECH) 200 Hyeokshin-roJeollanam-doNajuRepublic of Korea Cardiff University School of ChemistryCF103AT CardiffUnited Kingdom

Precisely tuning bicomponent intimacy during reactions by traditional methods remains a formidable challenge in the fabrication of highly active and stable catalysts because of the difficulty in constructing well-defined catalytic systems and the occurrence of agglomeration during *** overcome these limitations,a PtRuPNiO@TiO_(x)catalyst on a Ti plate was prepared by ultrasound-assisted low-voltage plasma *** method involves the oxidation of pure Ti metal and co-reduction of strong metals at 3000◦C,followed by sonochemical ultrasonication under ambient conditions in an aqueous *** intimacy of the bimetals in PtRuPNiO@TiOx is tuned,and the metal nanoparticles are uniformly distributed on the porous titania coating via strong metal-support interactions by leveraging the instantaneous high-energy input from the plasma discharge and ultrasonic *** intimacy of PtRuPNiO@TiO_(x)increases the electron density on the Pt ***,the paired sites exhibit a high hydrogen evolution reaction activity(an overpotential of 220 mV at a current density of 10 mA cm^(−2)and Tafel slope of 186 mV dec^(−1)),excellent activity in the hydrogenation of 4-nitrophenol with a robust stability for up to 20 cycles,and the ability to contrast stated catalysts without ultrasonication and plasma *** study facilitates industrially important reactions through synergistic chemical interactions.

关键词： bimetals nanoparticles oxides heterostructures hydrogenation

Assessing the pomfret stock for setting catch limits in the northern Bay of Bengal,Bangladesh

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Aquaculture and Fisheries 2024年第2期9卷 324-335页

作者： Mohammed Shahidul Alam Qun Liu Md Mostafa Monwar Md Enamul Hoque Suman Barua Md Leion Hassan abdullah Munzer College of Fisheries Ocean University of ChinaQingdao266003China Department of Fisheries University of ChittagongChattogram4331Bangladesh Institute of Marine Sciences University of ChittagongChattogram4331Bangladesh Department of Oceanography University of ChittagongChattogram4331Bangladesh Department of Fisheries Ministry of Fisheries and LivestockDhaka1215Bangladesh

Pampus argenteus and Pampus chinensis form the high-value demersal Pomfret fishery of ***,due to a monotonic decline in catches over the last five years,it is essential to explore the current stock status concerning the removal rate to ensure the sustainability of this ***,given the reliability and minimal data requirements,this study employed an extended Bayesian State-Space Surplus Production Model,JABBA(Just Another Bayesian Biomass Assessment),to assess the stock *** results revealed that the stock biomass of the Pomfret fishery in the final year of the time series is significantly lower than BMSY,the biomass required to produce ***,this study recommends a yearly catch limit(TAC)of 10,000 metric tons to prevent further depletion of the stock ***,to avoid growth overfishing by allowing all immature fishes to reproduce at least once before being caught,this study also calculated the optimum length(Lopt)for catch for both species at which biologically maximum yield and revenue can be *** estimated Lopt is 25 cm for *** and 30 cm for ***,and not to capture fishes with lengths lower than these limits,this study further calculated the minimum mesh size limits for gill and set bag nets is 7.5 *** the mesh size regulation was estimated using length-based reference points derived from an empirical equation,this regulation can be used as an associate reference point when TAC is applied to assure the sustainability of this fishery.

关键词： Pomfret fishery Stock assessment JABBA TAC Lower length limits for catches Mesh size regulation

Interaction between Biochar and Algae on Problem Soil

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 56-68页

作者： Tazeen Fatima Khan abdullah Al Mamun Nipu Department of Soil Water and Environment University of Dhaka Dhaka Bangladesh Department of Virology International Centre for Diarrhoeal Disease Research Bangladesh (ICDDR B) Dhaka Bangladesh

An in-vitro experiment was conducted to assess the interaction between biochar and algae on a problem soil. Experiments were performed with and without algae to observe the effectiveness of algae for overcoming the challenges posed by problem soils. At the end of incubation periods, the adsorption and desorption of phosphorus (P) on a problem soil vis-á-vis algal inoculation were determined. Our results showed that different types of biochars adsorbed different amounts of P suggesting that the source of biochar played a crucial role in determining its behavior towards P. Tannery waste biochar significantly adsorbed 147% and 35% more P compared to that of the chicken litter and orange peel biochars respectively. Significant reductions in adsorption were observed when the biochar was used in combination with the algae which could be due to the beneficial effects of algae leading to the amelioration of the problem soil. Adsorption was reduced to 34%, 24% and 20% for the orange peel biochar + algae, chicken litter biochar + algae and tannery waste biochar + algae, respectively compared to the corresponding biochars present as a single solid. Phosphorus (P) desorption was also reduced significantly in presence of algal inoculation. Overall our findings suggest that the application of algae along with biochar in the problem soil could reduce the adsorption of P which would influence the availability of P.

关键词： Biochar Algae Problem Soil Interaction Phosphorus

某废弃冶炼场地土壤不同粒径组分重金属的特征及其对修复策略的启示

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Journal of Central South University 2024年第4期31卷 1076-1091页

作者：赵鹏 Muhammad adnan 肖佩文杨雪枫王海燕肖保华薛生国 State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China School of Metallurgy and Environment Central South UniversityChangsha 410083China

颗粒粒径组分对土壤重金属的分布与赋存具有重要影响,而当前对受冶炼活动影响的不同区域间土壤各粒径组分重金属分布的比较研究较少。本研究以某废弃铅冶炼场地为研究对象,选取三个土壤剖面(冶炼固废堆存区、交通区和邻近的农田),对比... 详细信息

颗粒粒径组分对土壤重金属的分布与赋存具有重要影响,而当前对受冶炼活动影响的不同区域间土壤各粒径组分重金属分布的比较研究较少。本研究以某废弃铅冶炼场地为研究对象,选取三个土壤剖面(冶炼固废堆存区、交通区和邻近的农田),对比研究了不同土壤颗粒粒径组分(>150、45~150和45μm)具有较高的重金属质量负载量(>50%),且废渣颗粒对土壤重金属的贡献显著,故物理分离技术可用于该场地的土壤污染修复。此外,石膏和莫来石可能是该场地受冶炼活动影响土壤的指示矿物。本研究将冶炼活动影响与土壤不同粒径组分重金属的赋存形态相关联,对修复策略具有一定的指导意义。

关键词：废弃铅冶炼场地土壤重金属颗粒粒径组分地球化学形态废渣物理分离技术

Recent advancements in the diagnosis and treatment of acral melanoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 106-122页

作者： Ahmad ALHASKAWI Sohaib Hasan abdullah EZZI Yanzhao DONG Haiying ZHOU Zewei WANG Jingtian LAI Chengjun YAO Vishnu Goutham KOTA Mohamed Hasan Abdulla Hasan ABDULLA Hui LU Department of Orthopedics the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310003China Department of Orthopaedics Third Xiangya HospitalCentral South UniversityChangsha410013China Zhejiang University School of Medicine Hangzhou310058China Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare Zhejiang UniversityHangzhou310058China

Acral melanoma(AM)is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate,largely due to the inconspicuous nature of early-stage lesions,which can lead to late *** of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas,early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities,including clinical examination,dermoscopy,histopathology,molecular testing,radiological imaging,and blood *** surgery is the preferred method of treatment for AM,other therapeutic options may be employed based on the stage and underlying etiology of the *** checkpoint inhibitors,molecular targeted therapy,radiotherapy,chemotherapy,and oncolytic virotherapy represent promising advanced treatment options for *** this review,we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM,highlighting the importance of early detection and the prompt,individualized management of this challenging disease.

关键词： Acral melanoma Acral lentiginous melanoma Acral nevus Cutaneous malignant melanoma Dermoscopy Oncolytic virotherapy

Thermal conductivity suppression in uranium-doped thorium dioxide due to phonon-spin interactions

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Journal of Materiomics 2024年第3期10卷 709-715页

作者： Zilong Hua Saqeeb adnan Amey R.Khanolkar Karl Rickert David B.Turner Timothy A.Prusnick J.Matthew Mann David H.Hurley Marat Khafizov Cody A.Dennett Materials Science and Engineering Department Idaho National LaboratoryIdaho FallsID83415USA Department of Mechanical and Aerospace Engineering The Ohio State UniversityColumbusOH43210USA KBR DaytonOH45431USA Azimuth Corporation FairbornOH45324USA Air Force Research Laboratory Wright-Patterson AFBOH45433USA Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyCambridgeMA02139USA

In this work,impact of low level of uranium(U)atom substitution on thermal conductivity of thorium dioxide(ThO_(2))is ***_(2)is an electronic insulator with a wide optical band-gap and no unpaired electrons whose thermal transport is governed by phonons.U-substitution introduces unpaired f-electrons resulting in paramagnetic behavior of UeThO_(2)at room temperature,which significantly suppresses its thermal conductivity.A single crystal of UeThO_(2)with graded composition of U is grown using a hydrothermal synthesis method,and thermal conductivity measurements are performed in re-gions with uniform composition of U at levels of 0%,6%,9%and 16%.Measured thermal conductivity profiles over 77e300 K temperature range are analyzed using an analytical expression for phonon-mediated thermal transport based on Klemens-Callaway *** dependent thermal con-ductivity is found to deviate significantly from the Rayleigh scattering trend expected for a simple substitutional point defect with a small perturbation to mass and interatomic *** the resonant scattering term,observed large suppression of thermal conductivity at low temperatures can be closely ***,the extracted phonon-spin coupling constants imply a nonlinear relation of phonon-spin interaction intensity with respect to U doping *** study reveals how phonon-spin scattering contributed by unpaired f-electrons in U atoms influences thermal transport in the UeThO_(2)system.

关键词： Phonon-spin interactions Thermal conductivity UdThO_(2)system