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场致发射与二次电子倍增效应的程序开发

强激光与粒子束 2012年第5期24卷 1244-1246页

作者：王川 andreas adelmann 张天爵姜兴东中国原子能科学研究院北京102413 Paul Scherrer Institut 5232Villigen PSISwitzerland

与瑞士保罗希尔研究所合作,在双方合作开发的通用加速器模拟程序库OPAL中添加了3维复杂几何处理模块及场致发射与二次电子发射模块,使得OPAL具备了进行3维复杂结构中场致发射与二次电子倍增效应模拟的能力,可用于优化复杂高频/微波器件... 详细信息

与瑞士保罗希尔研究所合作,在双方合作开发的通用加速器模拟程序库OPAL中添加了3维复杂几何处理模块及场致发射与二次电子发射模块,使得OPAL具备了进行3维复杂结构中场致发射与二次电子倍增效应模拟的能力,可用于优化复杂高频/微波器件的结构设计从而抑制暗电流发射或二次电子倍增效应。

关键词：场致发射二次电子倍增程序开发高频谐振腔

High performance computation on beam dynamics problems in high intensity compact cyclotrons

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High performance computation on beam dynamics problems in hi...

Conceptual Design of an 800 MeV High Power Proton Cyclotron

第一届中国粒子加速器会议

作者： YANG JianJun ZHANG TianJue LIN YuZheng adelmann andreas WANG Feng AN ShiZhong China Institute of Atomic Energy Department of Engineering Physics Tsinghua University Paul Scherrer Institut

This paper presents the research progress in the beam dynamics problems for future high intensity compact cyclotrons by utilizing the state-of-the-art high performance computation technology.A "Start-to-Stop" model,which includes both the interaction of the internal particles of a single bunch and the mutual interaction of neighboring multiple bunches in the radial direction, is established for compact cyclotrons with multi-turn *** model is then implemented in OPAL-CYCL,which is a 3D object-oriented parallel code for large scale particle simulations in *** addition,to meet the running requirement of parallel computation,we have constructed a small scale HPC cluster system and tested its ***,the high intensity beam dynamics problems in the 100 MeV compact cyclotron,which is being constructed at CIAE,are studied using this code and some conclusions are drawn.

关键词： compact cyclotron space charge effects parallel computation beam dynamics cluster system

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Conceptual Design of an 800 MeV High Power Proton Cyclotron

强流紧凑回旋加速器中径向相邻多束团作用的三维模拟研究

作者： ZHANG Tian-jue YANG Jian-jun LI Ming XIA Le AN Shi-zhong YIN Zhi-guo ZHONG Jun-qing FANG Yang Werner Joho andreas adelmann Peter Sigg Paul Scherrer Institute Switzerland

China is speeding up the construction of nuclear power plants over the last few *** amount of nuclear powers in China is predicted to increase significantly in the next decade.20 nuclear power units have been under construction by the end of 2009,with a total capacity of 21.92 *** to the current plan,the power generating capacity of China’s nuclear power units in operation by 2020 will be 70-80 *** the existing problems *** waste in China,it is imperative to start tackling the problems of nuclear waste management as soon as *** system is an advanced clean

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强流紧凑回旋加速器中径向相邻多束团作用的三维模拟研究

Microglia:a promising therapeutic target in spinal cord injury

作者：杨建俊张天爵林郁正 andreas adelmann 安世忠清华大学工程物理系 Paul Scherrer Institute

＜正＞1物理模型和核心算法的研究在圈间距比较小的紧凑型强流回旋加速器中,空间电荷效应不仅来源于单个束团自身的空间电荷场,随着束流强度的增大,径向相邻多束团作用也变得越来越重要,尤其在大半径区域,径向相邻的多个束团会发生部分...

＜正＞1物理模型和核心算法的研究在圈间距比较小的紧凑型强流回旋加速器中,空间电荷效应不仅来源于单个束团自身的空间电荷场,随着束流强度的增大,径向相邻多束团作用也变得越来越重要,尤其在大半径区域,径向相邻的多个束团会发生部分重叠。图1为回旋加速器中径向多束团轨迹示意图。在中国原子能科学研究院正在建造的100 MeV强流质子回旋加速器CYCIAE-100,为了得到高引出流强,高频接受度设计为40°,且由于空间限制,没有安装平顶腔抑制高频加速过程中的能散,导致在大半径区域束团圈间距远小于束团尺寸,因此在引出区域径向相邻的十几圈束团会发生重叠,相邻束团作用可能比较显著。根据调研结果,强流回旋加速器中相邻多束团作用的研究目前尚未深入开展。由于问题的复杂性,我们不可能通过解析方法来定量的评估相邻束团作用。尽管如此,高性能并行计算为这一问题的深入研究提供了可能性。

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi andreas H.Teuschl-Woller David Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Simulation of microswimmer hydrodynamics with multiparticle collision dynamics

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Chinese Physics B 2020年第7期29卷 55-61页

作者： andreas Zottl Institute for Theoretical Physics TU WienWiedner Hauptstraße 8-101040 WienAustria

In this review we discuss the recent progress in the simulation of soft active matter systems and in particular the hydrodynamics of microswimmers using the method of multiparticle collision dynamics,which solves the hydrodynamic flows around active objects on a coarse-grained *** first present a brief overview of the basic simulation method and the coupling between microswimmers and *** then review the current achievements in simulating flexible and rigid microswimmers using multiparticle collision dynamics,and briefly conclude and discuss possible future directions.

关键词： active matter multiparticle collision dynamics microswimmers coarse-grained hydrodynamic simulations

Tunable structural colors on display

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Light(Science & Applications) 2022年第6期11卷 1036-1037页

作者： andreas Tittl Chair in Hybrid Nanosystems Nanoinstitute MunichFaculty of PhysicsLudwig-Maximilians-Universitat MünchenKoniginstraβe 1080539 MünchenGermany

Structural coloration takes inspiration from the bright hues found in nature to control the reflection and transmission of light from artificially structured *** them with active electrical tuning heralds breakthrough... 详细信息

关键词： materials tuning breakthrough

Geoscience material structures prediction via CALYPSO methodology

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Chinese Physics B 2019年第10期28卷 38-49页

作者： andreas Hermann Centre for Science at Extreme Conditions and SUPA School of Physics and Astronomy The University of Edinburgh

Many properties of planets such as their interior structure and thermal evolution depend on the high-pressure properties of their constituent materials. This paper reviews how crystal structure prediction methodology can help shed light on the transformations materials undergo at the extreme conditions inside planets. The discussion focuses on three areas:(i) the propensity of iron to form compounds with volatile elements at planetary core conditions(important to understand the chemical makeup of Earth's inner core),(ii) the chemistry of mixtures of planetary ices(relevant for the mantle regions of giant icy planets), and(iii) examples of mantle minerals. In all cases the abilities and current limitations of crystal structure prediction are discussed across a range of example studies.

关键词： crystal structure prediction core materials planetary ices hydrous minerals