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林业部门的民主分权:非洲、亚洲和拉丁美洲的经验教训

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林业经济 2008年第2期 65-69,75页

作者： Anne m.larson 宰步龙（译）国际林业研究中心印度尼西亚茂物安徽省林业厅合肥230001

总结了约20个发展中国家林业部门分权管理的研究结果,并通过对在森林治理中起到主要作用的机构和参与者的分析,探讨了成功和失败的范例和主要的因素。本研究表明,执行民主分权的案例并不多见,表现在：真正的决策权力、森林资源及其效益... 详细信息

总结了约20个发展中国家林业部门分权管理的研究结果,并通过对在森林治理中起到主要作用的机构和参与者的分析,探讨了成功和失败的范例和主要的因素。本研究表明,执行民主分权的案例并不多见,表现在：真正的决策权力、森林资源及其效益仍然是集权管理、选处理的当地参与者往往不具有代表性或不负责任。现行政策有时伤害了当地的穷人。本文强调了全国性的对话和对公民社会特别是边缘群体的授权的重要性。研究结果证明,林业分权管理应当始于与当地民众一起工作,建立和完善他们已有的机制;具有代表性和负责任的地方政府将成为这一过程最适合的对话者。

关键词：民主分权森林治理经验教训授权

林业部门的民主分权：非洲、亚洲和拉丁美洲的经验教训(续)

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林业经济 2008年第3期 70-76页

作者： Anne m.larson（）宰步龙（译）国际林业研究中心印度尼西亚茂物安徽省林业厅合肥230001

总结了约20个发展中国家林业部门分权管理的研究结果，并通过对在森林治理中起到主要作用的机构和参与者的分析，探讨了成功和失败的范例和主要的因素。研究表明，执行民主分权的案例并不多见，表现在：真正的决策权力、森林资源及其效... 详细信息

总结了约20个发展中国家林业部门分权管理的研究结果，并通过对在森林治理中起到主要作用的机构和参与者的分析，探讨了成功和失败的范例和主要的因素。研究表明，执行民主分权的案例并不多见，表现在：真正的决策权力、森林资源及其效益仍然是集权管理、选择处理的当地参与者往往不具有代表性或不负责任。现行政策有时伤害了当地的穷人。强调了伞国性的对话和对公民社会特别是边缘群体的授权的重要性。研究结果证明，林业分权管理应当始于与当地民众一起工作，建立和完善他们已有的机制；具有代表性和负责任的地方政府将成为这一过程最适合的对话者。

关键词：民主分权森林治理经验教训授权

Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： Tim Akhurst mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven m.larson Yuman Fong Department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter macCallum Cancer Centre VictoriaAustralia Department of Epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in ***,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(m)liver tumors were particularly poorly detected by *** area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDG-PET is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of *** high yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： Positron emission tomography(PET) computed tomography(CT) colorectal hepatic metastases surgery

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露天矿采用移动式破碎和运输降低生产费用

中国矿山工程 1988年第4期 25-31页

作者： Kurt m.larson 王家骧

未来的运输费用预测导致福斯特·耶欧曼有限公司(Foster Yeoman Ltd.)在其英国萨迈塞特的托尔·沃克斯(Torr Works)采石场正在发展一种全移动式破碎和运输系统。这个系统的实际生产能力为2500t/h.并有一台 O&K 制造的迈步式车架,一台富... 详细信息

未来的运输费用预测导致福斯特·耶欧曼有限公司(Foster Yeoman Ltd.)在其英国萨迈塞特的托尔·沃克斯(Torr Works)采石场正在发展一种全移动式破碎和运输系统。这个系统的实际生产能力为2500t/h.并有一台 O&K 制造的迈步式车架,一台富勒-特瑞洛54×74TC 旋回破碎机和由福斯特·耶欧曼设计和制造的独特的移动式运输机。这个年产600万吨石灰石的采石场用单台阶作业,在回采工作面用两台卡特皮勒992C 型装载铲供料。整个系统根据日常的回采工作面的位置移动。

关键词：运输机组件破碎机粗碎机板式给矿机福斯特工作面搬运车货车细粒物料

利用全球定位系统(GPS)确定澳大利亚、太平洋及南极洲板块间的相对运动

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地质科学译丛 1995年第4期12卷 23-26页

作者： Kristine m.larson 曲赞 Department of Aerospace Engineering University of Colorado Boulder

为了确定板块运动的速度,我们在位于澳大利亚、太平洋及南极洲三大板块的七个测站上实施了近三年的GPS测量。用这一方法得出的板块运动速度与板块模拟预测和其它空间大地测量得出的结果相同。到目前为止,我们还没发现澳大利亚板块内部... 详细信息

为了确定板块运动的速度,我们在位于澳大利亚、太平洋及南极洲三大板块的七个测站上实施了近三年的GPS测量。用这一方法得出的板块运动速度与板块模拟预测和其它空间大地测量得出的结果相同。到目前为止,我们还没发现澳大利亚板块内部变形的证据。位于澳大利亚板块与太平洋板块边界带的新西兰首都惠灵顿相对于澳大利亚板块每年向南西西方向移动20±5mm。该速度介于对这两个板块所预测的速度之间。澳大利亚-南极洲板块和太平洋-南极洲板块的相对欧拉向量值与NUVEL-IA模型的预测值相同,并位于一个标准偏差范围内。

关键词： GPS 板块运动澳大利亚太平洋南极洲

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预靶向:放射免疫治疗的进阶之路

中华核医学与分子影像杂志 2022年第12期42卷 759-768页

作者：葛雨秋(译) 付海田(译) 郁春景(审校) Sarah m.Cheal Sebastian K.Chung Brett A.Vaughn Nai-Kong V.Cheung Steven m.larson 江南大学无锡医学院无锡214122 江南大学附属医院核医学科无锡214122 molecular Pharmacology Program Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Surgery Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Pediatrics Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Radiology Memorial Sloan Kettering Cancer CenterNew YorkNew York

预靶向放射免疫诊断(PRID)和预靶向放射免疫治疗(PRIT)旨在利用药用放射性核素有效标记抗肿瘤靶向抗体而分别应用于提高肿瘤显像的对比度和肿瘤治疗指数(TI)。与传统的放射性免疫偶联物不同,预靶向策略将肿瘤靶向步骤与有效载荷步骤分开... 详细信息

预靶向放射免疫诊断(PRID)和预靶向放射免疫治疗(PRIT)旨在利用药用放射性核素有效标记抗肿瘤靶向抗体而分别应用于提高肿瘤显像的对比度和肿瘤治疗指数(TI)。与传统的放射性免疫偶联物不同,预靶向策略将肿瘤靶向步骤与有效载荷步骤分开,在减少正常组织暴露的同时提高了肿瘤的摄取量。预靶向策略的关键参数除了对比度和TI外,还包括抗体的免疫原性和特异性、放射性核素的适用性以及在临床中使用的便利性。预靶向的每个步骤都可以单独优化,且作为模块化系统,预靶向策略可广泛地应用于不同的肿瘤靶点、肿瘤类型或放射性核素。然而,尽管预靶向的多功能性为肿瘤的诊疗提供了巨大的应用潜能,但其过程复杂,在临床转化及如何在患者体内达到最佳使用效果方面面临着较大的挑战。该文旨在简要回顾预靶向策略的起源和发展过程,重点阐述目前已被广泛研究的2种蛋白质递送系统(生物素-链霉亲和素及半抗原-双特异性单克隆抗体)、放射性半抗原和放射性核素。此外,该文还将重点阐述预靶向研究领域的创新成果,包括使用生物正交化学和新型蛋白质载体(如自组装-解组装蛋白质和亲和体分子)进行的预靶向。该文并不是对过去30年PRID和PRIT全面的回顾,而是突出阐述了预靶向发展过程中的里程碑成果,并从TI和毒性方面评价其在临床前模型和临床试验中的应用。相信预靶向策略能够帮助人们认识肿瘤临床诊疗一体化实施的障碍,重新激发人们对放射免疫疗法的兴趣,并指导预靶向研究的进一步发展。

关键词：普通外科肿瘤学放射性核素治疗放射性药物多重步骤预靶向放射免疫治疗放射免疫治疗

Dog10K: the International Consortium of Canine Genome Sequencing

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National Science Review 2019年第4期6卷 611-613页

作者： Guo-Dong Wang Greger larson Jeffrey m.Kidd Bridgett m.von Holdt Elaine A.Ostrander Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Network School of Archaeology University of Oxford Department of Human Genetics and Department of Computational medicine and Bioinformatics University of Michigan Medical School Ecology & Evolutionary Biology Princeton University National Human Genome Research Institute National Institutes of Health

Dogs (Canis lupus familiaris) were the first species to enter into a domestic relationship with people [1] and are a source of fascination all over the world, not only due to their history of domestication and dispersal along with human beings [2],but also because of their diverse phenotypes and behaviors, driven by both artificial and natural selection [3]. Dogs

关键词： the International Consortium of Canine Genome Sequencing Dog10K

Investigating low dispersion isotope dissolution Lu-Hf garnet dates via in situ Lu-Hf geochronology,Kanchenjunga Himal

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Geoscience Frontiers 2024年第3期15卷 137-145页

作者： Kyle P.larson John m.Cottle mark Button Brendan Dyck Iva Lihter Sudip Shrestha Department of Earth Environmental and Geographic SciencesUniversity of British ColumbiaOkanaganKelownaCanada Department of Earth Science University of CaliforniaSanta BarbaraUSA Fipke Laboratory for Trace Element Research University of British ColumbiaOkanaganKelownaCanada

Re-examination of three specimens from the Kanchenjunga Himal of Nepal via in situ Lu-Hf garnet geochronology yields evidence of multiple garnet growth *** analyses from grain cores in two specimens define Paleozoic regressions whereas analyses from grain rims in the same specimens define low-precision regressions consistent with the timing of Himalayan *** dates contrast with previously published low dispersion,ca.290 ma isotope dissolution(ID)Lu-Hf garnet dates for the same *** of Lu and spot age distribution in representative grains from the specimens examined yields calculated dates that approximate the Permian-age regressions through the original ID *** findings demonstrate that it is possible to generate low dispersion ID Lu-Hf data from multigenerational garnet with significantly different-age growth events when approximately equal proportions of the different age reservoirs are included in multi-component aliquots.

关键词： Lu-Hf geochronology In situ Lu-Hf geochronology Kanchenjunga Himal

Timing of metamorphism and deformation in the Swat valley, northern Pakistan:Insight into garnet-monazite HREE partitioning

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Geoscience Frontiers 2019年第3期10卷 849-861页

作者： Kyle P.larson Asghar Ali Sudip Shrestha mathieu Soret John m.Cottle Rafique Ahmad University of British Columbia Okanagan Earth Environmental and Geographic Sciences University of Peshawar Department of Geology University of Califomia Santa Barbara Department of Earth Sciences The Bacha Khan University Department of Geology

New metamorphic petrology and geochronology from the Loe Sar dome in the Swat region of northern Pakistan place refined constraints on the pressure, temperature and timing of metamorphism and deformation in that part of the Himalayan orogen. Thermodynamic modelling and monazite petrochronology indicate that metamorphism in the area followed a prograde evolution from ～525 ± 25 ℃and 6 士 0.5 kbar to ～610 ± 25 ℃ and 9 士 0.5 kbar, between ca. 39 ma and 28 ma. Partitioning of heavy rare earth elements between garnet rims and 30-28 ma monazite are interpreted to indicate coeval crystallization at peak conditions. microtextural relationships indicate that garnet rim growth post-dated the development of the main foliation in the area. The regional foliation is folded about large-scale N-S trending fold axes and overprinting E-W trending folds to form km-scale domal culminations. The textural relationships observed indicate that final dome development must be younger than the 30-28 ma monazite that grew with garnet rims post-regional foliation development, but pre-doming-related deformation. This new timing constraint helps resolve discrepancy between previous interpretations,which have alternately suggested that N-S trending regional folds must be either pre-or post-early Oligocene. Finally, when combined with existing hornblende and white mica cooling ages, these new data indicate that the study area was exhumed rapidly following peak metamorphism.

关键词： Pakistan Himalaya monazite petrochronology metamorphism Phase equilibria modelling Deformation