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Frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity in the Kyrgyz population

Family Medicine and Community Health 2013年第1期1卷 23-29页

作者： MIRRAKHIMOV ERKIN LUNEGOVA OLGA MIRRAKHIMOV AIBEK KERIMKULOVA ALINA STAROV NURDIN ZALESSKAYA YULIYA abilova saamai NABIEV MALIK ALIBAEVA NAZIRA ALDASHEV ALMAZ Kyrgyz state medical academy BishkekKyrgyzstan National center of cardiology and internal medicine BishkekKyrgyzstan Scientific-research institute of molecular biology and medicine BishkekKyrgyzstan

Objective:To examine the frequency of C825T G protein β3 subunit gene polymorphism and its association with obesity of ethnic ***:The study enrolled 210 people,89 patients(35 females,54 males)with obesity(BMI≥30 kg/m2)and 121 practically healthy patients(38 females,83 males)with normal body weight and no signs of type 2 diabetes(group of control),who were not observed before by a *** blood pressure,anthropometry,glucose and lipid profile were examined among all *** DNA was extracted from peripheral blood cells.G proteinβ3 subunit C825T polymorphism was determined by polymerase chain reaction(PCR).Results:TT and CT genotypes carriers were grouped together in one group because the TT genotype was ***+TT genotype frequency in the group with obesity made 0.72 and was significantly higher than that in the control group-0.52(χ2-8.44;P=0.004;odds ratio-2.55;95%CI 1.31-4.23).The statistical analysis revealed that hypertension(45%vs.31.3%,P=0.049)and obesity(51.2%vs.30%,P<0.01)occurred significantly more often in CT+TT genotype carriers than in the CC *** results of the multivariate logistic regression analysis showed that the presence of 825T allele(exp β-2.89;95%CI 1.25-6.7;P=0.013),along with the occasional consumption of vegetables(exp β-3.47;95%CI 1.52-7.94;P=0.003)was the significant risk factor for obesity,regardless of gender,age and level of physical *** the construction of the similar regression model for hypertension,the statistically significant role of 825T allele was lost after adjustment for obesity as an independent ***:G protein β3 subunit gene C825T allele in the Kyrgyz ethnic group has an association with obesity.

关键词： G proteinβ3 subunit C825T polymorphism Obesity Hypertension

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