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Extracorporeal blood purification strategies in sepsis and septic shock:An insight into recent advancements

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World Journal of Critical Care Medicine 2023年第2期12卷 71-88页

作者： Yatin Mehta Rajib Paul abdul samad Ansari Tanmay Banerjee Serdar Gunaydin Amir Ahmad Nassiri Federico Pappalardo Vedran Premužić Prachee Sathe Vinod Singh Emilio Rey Vela Institute of Critical Care and Anesthesiology Medanta the MedicityGurugram 12201India Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Internal Medicine&Critical Care Medica Institute of Critical Care MedicineMedica Superspecialty HospitalKolkata 700099India Department of Cardiovascular Surgery University of Health SciencesAnkara City Hospital CampusAnkara 06933Turkey Department of Nephrology Shahid Beheshti University of Medical SciencesTehran 19839-63113Iran Cardiothoracic and Vascular Anesthesia and Intensive Care AO SS Antonio e Biagio e Cesare ArrigoAlessandria 15121Italy Department of Nephrology Clinical Hospital ZagrebClinic for internal diseasesZagreb 10000Croatia Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Institute of critical care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Cardiac Surgery Intensive Care Unit Samaritan University HospitalBogotá11Colombia

BACKGROUND Despite various therapies to treat sepsis,it is one of the leading causes of mortality in the intensive care unit patients *** about the pathophysiology of sepsis has sparked interest in extracorporeal therapies(ECT)which are intended to balance the dysregulation of the immune system by removing excessive levels of inflammatory *** To review recent data on the use of ECT in sepsis and to assess their effects on various inflammatory and clinical *** In this review,an extensive English literature search was conducted from the last two decades to identify the use of ECT in sepsis.A total of 68 articles from peer-reviewed and indexed journals were selected excluding publications with only *** Results showed that ECT techniques such as high-volume hemofiltration,coupled plasma adsorption/filtration,resin or polymer adsorbers,and CytoSorb®are emerging as adjunct therapies to improve hemodynamic stability in ***®has the most published data in regard to the use in the field of septic shock with reports on improved survival rates and lowered sequential organ failure assessment scores,lactate levels,total leucocyte count,platelet count,interleukin-IL-6,IL-10,and TNF *** Clinical acceptance of ECT in sepsis and septic shock is currently still limited due to a lack of large random clinical *** addition to patient-tailored therapies,future research developments with therapies targeting the cellular level of the immune response are expected.

关键词： CytoSorb® Hemadsorbers Inflammatory mediators Extracorporeal therapies Sepsis

Survey on Clustering Techniques for Image Categorization Dataset

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Survey on Clustering Techniques for Image Categorization Dat...

Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

Content Based Image Retrieval,CBIR,performed an automated classification task for a queried *** could relieve a user from the laborious and timeconsuming metadata assigning for an image while working on massive image *** an image,user’s definition or description is subjective where it could belong to different categories as defined by different *** based categorization and computer-based categorization might produce different results due to different categorization criteria that rely on dataset structure and the clustering *** paper is aimed to exhibit an idea for planning the dataset structure and choosing the clustering algorithm for CBIR *** are 5 sections arranged in this paper;CBIR and QBE concepts are introduced in Section 1,related image categorization research is listed in Section 2,the 5 type of image clustering are described in Section 3,comparative analysis in Section 4,and Section 5 conclude this *** of this paper will be benefiting CBIR developer for various applications.

关键词： Categorization CBIR Classifications Clustering Dataset

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： Nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati Ramli Habibah Faroque Farisha Nur Abd samad abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst *** is because of weak immunity and lack of knowledge on proper hand *** quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,*** A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control *** the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based *** numbers of absent days of all the children were recorded for 2 months before the intervention and during the *** In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention *** These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further.

关键词： Absenteeism Hand hygiene Povidone-iodine Pre-school children

Risk Factors Associated with Anthracycline Induced Cardiac Dysfunction in Pediatric Patients

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World Journal of Cardiovascular Diseases 2014年第7期4卷 377-383页

作者： abdul Sattar Shaikh Muhammad Matloob Alam Shazia samad Mohsin Qalab Abbas Zehra Fadoo Mehnaz Atiq Department of Paediatrics and Child Health Aga Khan University Hospital Karachi Pakistan Department of Pediatrics Liaquat National Hospital and Medical College Karachi Pakistan

Anthracyclines (i.e., doxorubicin, daunorubicin) have significant impact on outcome in many pediatric chemotherapy protocols and therefore remain the mainstay of treatment. The objective of this study was to identify the risk factors for anthracycline induced cardiac dysfunction in pediatric patients. Multiple logistic regression model was applied to assess the risk factors for development of cardiac dysfunction. 110 pediatric oncology patients were available for final analysis. 75 (66%) children were males and mean age was 74 ± 44 months. ALL (n = 70, 64%) was the most common primary diagnosis followed by lymphoma (n = 19;17%) and AML (n = 12, 11%). Daunorubicin alone or in combination with doxorubicin was used in (n = 94, 85%) patients and cumulative dose n = 95;86%) children. 24 (22%) children received radiation therapy as per protocol and sepsis were observed in 47 (43%) cases. Post anthracycline, 15 (14%) children had cardiac dysfunction within a month;out of them 10/15 (67%) had isolated diastolic dysfunction, while 28 (25%) developed dysfunction within a year. 19 (17%) had pericardial effusion. 11 expired and out of them, 7 had significant cardiac dysfunction. Cumulative dose > 300 mg/m2 (p p = 0.009;AOR 3.5) and sepsis (p = 0.002;AOR 2.6) were found to be independent risk factors associated anthracycline induced cardiac dysfunction. At univariant level use of daunorubicin alone or in combination therapy (p p 0.048, OR 9.7) were also found statistically significant. In conclusion anthracycline induced cardiac dysfunction is mostly related to cumulative dose > 300 mg/m2, use of Daunorubicin alone or in combination with doxorubicin, mode of delivery, radiation therapy and sepsis. Regular long term follow-up with cardiologist is the key point for early diagnosis and therapy for a long term survival.

关键词： Anthracycline Cardiac Dysfunction Risk Factors Pediatric Oncology