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Comparative efficacy of neem and dimethyl phthalate (DMP) against malaria vector,Anopheles stephensi (diptera:culicidae)

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Asian Pacific Journal of Tropical Medicine 2008年第3期1卷 1-6页

作者： H.Vatandoos A.Khazani J.Rafinejad M.Khoobdel A.Kebriai-Zadeh MR.Abai aa.Hanafi Bojd aa.akhavan SM.Abtahi F.Rafi Department of Medical Entomology and Vector Control School of Public Health & Institute of Health ResearchTehran University of Medical Sciences Department of Toxicology Faculty of PharmacologyMedical Sciences of Tehran University

Malaria is one of the most important parasitic diseases in the world which is transmitted by the Anopheles mosquitoes. There are several methods for malaria *** of them is application of repellents on skin in malarious area as an intergrated vectro management *** study evaluated two repellents of DMP as a synthtic and locally product of neem oil as a botanical repellent against Anopheles *** modified method of K & D was used for the ***/biting rates on the shaved belly of white rabbits were counted. ED50 and ED95 values were calculated by probit statistic *** of effective dose(ED50, ED90 ) on human volunteer and white rabbit was performed using regression *** and failure time of DMP and neem oil was also ***50 value of DMP and neem oil was determined as 0.0076 and 0. 159 mg/cm respectively on white *** figures of ED90 value of DMP and neem oil was determined as 0. 046 and 1.388 mg/cm^*** and neem oil showed repellency effects against *** on human volunteers with ED50 value of 0.0037 and 0.127 mg/cm^2 ***90 value of DMP was determined as 0. 032 mg/cm^*** oil exhibited a ED90 value of 1.066 mg/cm^2 on human *** protection time of 6-7 hours for DMP and 31 minute for neem oil was *** failure times for DMP and Neem was 9 hours and 65 minutes rspectively on human *** results exhibited that plant-based repellent is generally less effective than synthetic ***,use of locally made botanical materials would be of great advantages for personal protection against mosquito biting.

关键词： neem oil DMP Anopheles stephensi

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Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring:Pioneering point-of-care and beyond

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Nano Materials Science 2024年第3期6卷 263-283页

作者： Moein Safarkhani Abdullah Aldhaher Golnaz Heidari Ehsan Nazarzadeh Zare Majid Ebrahimi Warkiani Omid akhavan YunSuk Huh Navid Rabiee NanoBio High-Tech Materials Research Center Department of Biological Sciences and BioengineeringInha UniversityIncheon22212Republic of Korea Department of Chemistry Sharif University of TechnologyTehranIran School of Natural Sciences Massey UniversityPrivate Bag 11222Palmerston North4410New Zealand School of Chemistry Damghan UniversityDamghan36716-45667Iran School of Biomedical Engineering University of Technology SydneySydneyNSW2007Australia Department of Physics Sharif University of TechnologyP.O.Box 11155-9161TehranIran Centre for Molecular Medicine and Innovative Therapeutics Murdoch UniversityPerthWA 6150Australia School of Engineering Macquarie UniversitySydneyNew South Wales2109Australia

This review explores glucose monitoring and management strategies,emphasizing the need for reliable and userfriendly wearable sensors that are the next generation of sensors for continuous glucose *** addition,examines key strategies for designing glucose sensors that are multi-functional,reliable,and cost-effective in a variety of *** unique features of effective diabetes management technology are highlighted,with a focus on using nano/biosensor devices that can quickly and accurately detect glucose levels in the blood,improving patient treatment and control of potential diabetes-related *** potential of next-generation wearable and touch-sensitive nano biomedical sensor engineering designs for providing full control in assessing implantable,continuous glucose monitoring is also *** challenges of standardizing drug or insulin delivery doses,low-cost,real-time detection of increased blood sugar levels in diabetics,and early digital health awareness controls for the adverse effects of injectable medication are identified as unmet ***,the market for biosensors is expected to expand significantly due to the rising need for portable diagnostic equipment and an ever-increasing diabetic *** paper concludes by emphasizing the need for further research and development of glucose biosensors to meet the stringent requirements for sensitivity and specificity imposed by clinical diagnostics while being cost-effective,stable,and durable.

关键词： Glucose sensor Biosensor Wearable devices Noninvasive Real-time monitoring

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Modelling the development of biological structures displaying longitudinal geometries in vitro:culturing pluripotent stem cells on plasma-treated,growth factor-coupled polycaprolactone fibres

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Engineered Regeneration 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem Stuart T.Fraser Syamak Farajikhah Rachel A.Shparberg Michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Institute University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunter Medical Research Institute(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological structures such as nerves,blood and lymphatic vessels,and muscle fibres exhibit longitudinal ge-ometries with distinct cell types extending along both the length and width of internal linear *** these three-dimensional structures in vitro is challenging:the best-defined stem-cell differentiation systems are mono-layer cultures or organoids using pluripotent stem *** stem cells can differentiate into functionally mature cells depending on the signals received,holding great promise for regenerative ***,the integration of in vitro differentiated cell types into diseased tissue remains a *** scaffolds can bridge this gap if the appropriate signalling systems are incorporated into the ***,we have taken a biomimicry approach to generate longitudinal structures in *** this approach,mouse embryonic stem cells are directed to differentiate to specific cell types on the surface of polycaprolactone(PCL)fibres treated by plasma-immersion ion implantation and to which with lineage-specifying molecules have been covalently *** demonstrate the simplicity and utility of our method for efficiently generating high yields of the following cell types from these pluripotent stem cells:neurons,vascular endothelial cells,osteoclasts,adipocytes,and cells of the erythroid,myeloid,and lymphoid *** arranged plasma-treated scaffolds with differentiated cell types could ultimately serve as a means for the repair or treatment of diseased or damaged tissue.

关键词： Pluripotent stem cells Lineage commitment Growth factors Biomaterial engineering Plasma-immersion ion implantation Covalent biomolecule attachment Polycaprolactone

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Unusual presentation of disseminated cutaneous leishmaniasis due to Leishmania *** reports of four Iranian patients

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Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 333-336页

作者： Hajjaran H Mohebali M akhavan aa Taheri A Barikbin B Soheila Nassiri S Department of Medical Parasitology and Mycology School of Public HealthTehran University of Medical Sciences Department of Medical Entomology and Vector Control School of Public HealthTehran University of Medical Sciences Khanevadeh Hospital Department of Dermatology Skin Research CenterShaheed Beheshti University of Medical Sciences

We report four disseminated cutaneous leishmaniasis(DCL) cases referred to leishmaniasis laboratory at the School of Public Health,Tehran University of Medical Sciences with multiple nodular,ulcerative and crusted lesions extended on the face,trunk,and *** of the patients had any complication and historical involvement in their immunological system conditions that suggest as the criteria for *** smears of ulcers were positive for Leishmania *** parasite was isolated from the active lesions and identified as Leishmania major(L major) using PCR-RFLP assay and sequencing analysis.

关键词： Disseminated cutaneous leishmaniasis (DCL) Leishmania major PCR-RFLP Iran

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Nanoscale graphene oxide sheets as highly efficient carbocatalysts in green oxidation of benzylic alcohols and aromatic aldehydes

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Chinese Journal of Catalysis 2017年第4期38卷 745-757页

作者： Alireza Sedrpoushan Masoud Heidari Omid akhavan Department of Chemical Technologies Iranian Research Organization for Science and Technology (IROST) P.O. Box 33535‐111 Tehran Iran Department of Physics Sharif University of Technology P.O. Box 11155‐9161 Tehran Iran Institute for Nanoscience and Nanotechnology Sharif University of Technology P.O. Box 14588‐89694 Tehran Iran

Nanoscale graphene oxide(NGO)sheets were synthesized and used as carbocatalysts for effectiveoxidation of benzylic alcohols and aromatic *** oxidation of alcohols in the presence ofH2O2at80°C,the NGOs(20%mass fraction)as carbocatalysts showed selectivity toward *** rate and yield of this reaction strongly depended on the nature of substituents on the ***4‐nitrobenzyl alcohol,<10%of it was converted into the corresponding carboxylic acid *** contrast,4‐methoxybenzyl alcohol and diphenylmethanol were completely converted into thecorresponding carboxylic acid and ketone after only9and3h,*** conversion ratesfor oxidation of aromatic aldehydes by NGO carbocatalysts were higher than those for alcohol *** all the aldehydes,complete conversion to the corresponding carboxylic acids wasachieved using7%(mass fraction)of NGO at70°C within2–*** mechanisms for NGOcarbocatalyst structure‐dependent oxidation of benzyl alcohols and structure‐independent oxidationof aromatic aldehydes are discussed.

关键词： Carbocatalyst Nanoscale graphene oxide Green chemistry Oxidation Metal‐free catalyst Colloidal dispersion

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Photocatalytic activity of CuO nanoparticles incorporated in mesoporous structure prepared from bis(2-aminonicotinato) copper(Ⅱ) microflakes

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Transactions of Nonferrous Metals Society of China 2015年第11期25卷 3634-3642页

作者： Azadeh TADJARODI Omid akhavan Keyvan BIJANZAD Research Laboratory of Inorganic Materials Synthesis Department of Chemistry Iran University of Science and Technology Department of Physics Sharif University of Technology Institute for Nanoscience and Nanotechnology Sharif University of Technology

An easy method for preparing CuO nanoparticles incorporated in a mesoporous structure was presented based on the thermal decomposition of a copper complex. The novel copper coordination compound of [Cu(anic)2]·0.75H2O (anic= 2-aminonicotinate) with the microflake morphology was synthesized through the reaction of 2-aminonicotinic acid (Hanic) and copper(II) nitrate. Using elemental analysis and Fourier transform infrared (FTIR) spectroscopy, the chemical composition of CuC12H11.5N4O4.75 was proposed. Calcination process at 550 °C for 4 h transformed the microflakes into CuO nanoparticles incorporated in a mesoporous structure. The FTIR peaks assigned to 2-aminonicotinate were completely removed after calcination, confirming CuO formation. X-ray diffraction (XRD) analysis also confirmed the generation of pure and crystalline CuO. SEM showed CuO nanoparticles with the average diameter of 75 nm. The diffuse reflectance spectrum (DRS) of the CuO nanoparticles showed a band gap energy of −1.58 eV. The degradation efficiency toward rhodamine B was almost 100 % after 5 h illumination when both CuO and H2O2 were utilized. The results show that the product can be used as an efficient photocatalyst for water treatment.

关键词： copper oxide nanostructure 2-aminonicotinic acid photocatalyst thermal decomposition degradation efficiency

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Techno-economic optimization of a sustainable system to cogenerate power and water for remote areas

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Clean Energy 2023年第3期7卷 602-619页

作者： Sina akhavan Shams Rouhollah Ahmadi School of New Technologies Iran University of Science&TechnologyTehranIran

In this study,a new water and power cogeneration plant,employing photovoltaic(PV)and photovoltaic-thermal(PVT)panels simultaneously,is designed and optimized for a village struggling to provide energy and potable water in *** system includes a solar energy unit to generate clean electricity and heat,and a reverse osmosis unit to produce drinking ***-economic optimization is performed by implementing a genetic algorithm,and a comprehensive water and energy management strategy is designed and presented in detail,expandable for future works.A new method,the logarithmic model,is used to calculate the depth of discharge(DOD)of lithium-ion batteries,which was previously a fixed and predetermined value in previous *** indices,the constraints of the optimization process,are also introduced to measure the reliabilities of different *** effects of the system components on total cost are investigated and a comprehensive sensitivity analysis is performed to find the best solution to increase the penetration of renewable-energy *** results reveal that considering the depth of discharge of batteries and water storage tank capacity as decision variables reduces the system’s life-cycle cost(by 5.1%for changeable DODs).Furthermore,the simultaneous use of PV and PVT panels decreases the life-cycle cost considerably by≤19%compared with the use of only PVT ***,the cost of the battery causes a decrease in the cost of electricity storage and the cost of producing and storing fresh water.

关键词： renewable hybrid system integrated water and power system PV-PVT-RO-battery system genetic algorithm optimization

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Robust nonlinear control for nuclear reactors using sliding mode observer to estimate the xenon concentration

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Nuclear Science and Techniques 2016年第2期27卷 106-114页

作者： G.R.Ansarifar H.R.akhavan Department of Nuclear Engineering Faculty of Advanced Sciences and Technologies University of Isfahan

This paper presents findings on the sliding mode controller for a nuclear reactor. One of the important operations in nuclear power plants is load following. In this paper, a sliding mode control system, which is a robust nonlinear controller, is designed to control the pressurizedwater reactor power. The reactor core is simulated based on the point kinetics equations and six delayed neutron groups. Considering neutron absorber poisons and regarding the limitations of the xenon concentration measurement, a sliding mode observer is designed to estimate its value, and finally, a sliding mode control based on the sliding mode observer is presented to control the core power of reactor. The stability analysis is given by means Lyapunov approach; thus, the control system is guaranteed to be stable within a large range. The employed method is easy to implement in practical applications, and moreover,the sliding mode control exhibits the desired dynamic properties during the entire output-tracking process independent of perturbations. Simulation results are presented to demonstrate the effectiveness of the proposed observerbased controller in terms of performance, robustness and stability.

关键词：鲁棒非线性控制滑模观测器核反应堆估计氙气气浓度非线性鲁棒控制器滑模控制系统

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Squamous cell carcinoma of hypopharynx in a patient with history of celiac disease

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The Chinese-German Journal of Clinical Oncology 2012年第6期11卷 367-368页

作者： A akhavan A Seifadini Shahid Ramezanzadeh Radiation Oncology Center of Yazd Islamic Azad University of Yazd

Celiac disease is a gluten-related malabsorption in small intestine occurring in genetically susceptible patients. In this disease the risk of many malignancies is increased the most important of which being non-Hodgkin lymphoma of small intestine. Other malignancies include adenocarcinoma of small intestine and squamous cell carcinoma of esophagus and melanoma. As to our knowledge so far only one case of ceJiac disease associated with hypopharyngeaJ squamous ceil car- cinoma has been reported. In this article we presented a patient suffering from celiac disease with squamous cell carcinoma of hypopharynx. She underwent chemotherapy and radiation therapy, unfortunately however she died because of progress of disease. So, in patients with celiac disease we should pay attention to various malignancies and when cases of cancers are accompanied by malabsorption we must think of celiac disease involvement.

关键词： celiac disease malignancies squamous cell carcinoma hypopharynx chemotherapy radiotherapy

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Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 667-681页

作者： Yue Zhang Jingwen Gao Na Li Peng Xu Shimeng Qu Jinqian Cheng Mingrui Wang Xueru Li Yaheng Song Fan Xiao Xinyu Yang Jihong Liu Hao Hong Ronghao Mu Xiaotian Li Youmei Wang Hui Xu Yuan Xie Tianming Gao Guangji Wang Jiye aa Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesResearch Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical SciencesChina Pharmaceutical UniversityNanjing 210009China Key Laboratory of Drug Monitoring and Control Drug Intelligence and Forensic CenterMinistry of Public SecurityBeijing 100193China School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Foreign Languages China Pharmaceutical UniversityNanjing 211198China Department of Neurobiology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pharmacology China Pharmaceutical UniversityNanjing 211198China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Studies have suggested that the nucleus accumbens(NAc)is implicated in the pathophysiology of major depression;however,the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been ***,we identified a specific reduction of cyclic adenosine monophosphate(cAMP)in the subset of dopamine D1 receptor medium spiny neurons(D1-MSNs)in the NAc that promoted stress susceptibility,while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like *** treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons(D2-MSNs)of depressed mice,however,the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc *** discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration,but not a lower *** fast onset property of crocin was verified through multicenter ***,crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on *** findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc,and provide a potential rapid antidepressant drug candidate,crocin.

关键词： CAMP Nucleus accumbens Depression D1-MSN D2-MSN

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