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World Journal of Immunology 2016年第1期6卷 19-38页

作者： Rositsa Tsekovska Angelina Sredovska-Bozhinov Toshimitsu Niwa Ivan ivanov Roumyana Mironova Institute of Molecular Biology Roumen Tsanev Bulgarian Academy of Sciences MIT University Nagoya University Graduate School of Medicine

The recombinant DNA technology enabled the produ-ction of a variety of human therapeutic proteins. Accumulated clinical experience, however, indicates that the formation of antibodies against such proteins is a general phenomenon rather than an exception. The immunogenicity of therapeutic proteins results in inefficient therapy and in the development of undesired, sometimes life-threatening, side reactions. The human proteins, designed for clinical application, usually have the same amino acid sequence as their native prototypes and it is not yet fully clear what the reasons for their immunogenicity are. In previous studies we have demonstrated for the first time that interferon-b （IFN-b） pharmaceuticals, used for treatment of patients with multiple sclerosis, do contain advanced glycation end products （AGEs） that contribute to IFN-b immunogenicity. AGEs are the fnal products of a chemical reaction known as the Maillard reaction or glycation, which implication in protein drugs’ immunogenicity has been overlooked so far. Therefore, the aim of the present article is to provide a comprehensive overview on the Maillard reaction with emphasis on experimental data and theoretical consideration telling us why the Maillard reaction warrants special attention in the context of the well-documented protein drugs’ immunogenicity.

关键词： Maillard reaction Glycation Advanced glycation end products Protein therapeutics Interferon-β Immunogenicity

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C_p/CuCd电接触材料制备工艺的研究

电工合金 2000年第3期 25-33页

作者：邵文柱崔玉胜王岩谷文伟杨德庄 v.v.ivanov 哈尔滨工业大学材料学院 150001 俄罗斯克拉斯诺雅尔斯克国立大学固体物理研究所 660022

本文系统研究了在 Cp/ Cu Cd电接触材料制备过程中 ,原始粉末状态、压制压力、烧结温度等工艺参数对材料相对密度的影响。结果表明 ,原始粉末的差异对制备工艺的全过程均产生规律性的影响。压制压力对压坯密度的影响符合粉末冶金材料的... 详细信息

本文系统研究了在 Cp/ Cu Cd电接触材料制备过程中 ,原始粉末状态、压制压力、烧结温度等工艺参数对材料相对密度的影响。结果表明 ,原始粉末的差异对制备工艺的全过程均产生规律性的影响。压制压力对压坯密度的影响符合粉末冶金材料的一般压制规律。在烧结过程中 ,镉和孔隙扩散对烧结密实化过程起着重要作用。通过组织和性能对比 ,分析了后续加工工艺方法的优缺点。

关键词：电接触材料压制烧结扩散制备工艺

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微生物在油藏中的地球化学活动——提高采油

生物工程进展 1990年第5期10卷 53-55页

作者： M.v.ivanov S.S Belyaev T.N.Nazina E.P.Rozanova 王修垣

微生物提高采油方法的发展是以研究栖息在油层中的微生物的地球化学活动及其生物学为基础的。苏联开始研究石油微生物区系可追溯到1926年,在那年首先在油层水中发现了细菌。这种新生境的分析揭示了微生物在油藏中的分布有一定的规律。... 详细信息

微生物提高采油方法的发展是以研究栖息在油层中的微生物的地球化学活动及其生物学为基础的。苏联开始研究石油微生物区系可追溯到1926年,在那年首先在油层水中发现了细菌。这种新生境的分析揭示了微生物在油藏中的分布有一定的规律。曾指出,注入地表水是决定微生物在这种生态系中分布情况的主要因子。

关键词：微生物油藏地球化学采油

Postglacial incision-infill cycles at the Borisoglebsk Upland: Correlations between interfluve headwaters and fluvial network

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International Soil and Water Conservation Research 2019年第2期7卷 184-195页

作者： Yuliya v.Shishkina Ekaterina v.Garankina vladimir R.Belyaev Ilya G.Shorkunov Pavel v.Andreev Aleksey I.Bondar viktoria I.Potapova Tatiana A.verlova Faculty of Geography Department of Geomorphology and Palaeogeography and Laboratory for Soil Erosion and Fluvial ProcessesLomonosov Moscow State UniversityLeninskie Gory1Moscow 119991Russia Institute of Geography Department of Soil Geography and EvolutionRussian Academy of SciencesStaromonetnyj Lane29Moscow 119017Russia Institute of Earth Sciences of Saint-Petersburg State University St.PetersburgUniversitetskaya nab.7-9 199034Russia

The article discusses postglacial landscape transformation in the Northern Hemisphere Middle Pleistocene glaciation area located in the center of the Russian *** attempted to verify the regional paleogeographic model by reconstructing the Late Pleistocene incision-infill cycles at the Eastern Borisoglebsk Upland based on a comparison of inactive interfluves headwaters and actual fluvial network *** study was also aimed to determine the past extent of fluvial *** research of the actual and buried topography,Ethology and pedogenic properties of surface deposits was carrid out with remote sensing data interpretation,DGPS survey,and detailed description of geological cores *** study was followed by analysis of grain size,chemical and organic contents,microstructure,and numerical *** the available results,we propose a scenario of the fluvial network transformation at the Eastem Borisoglebsk Upland over the last 150 *** least four fluvial incision stages were determined while network extent has significantly changed through the Late *** can be generally associated with the regional base level decrease-Late Moscow,Late valdai and Late Holocene and accompanying isolation of the Nero Lake terraces of 130 m,100-105 m and 95-98 *** stages were separated by landscape stability or aggradation periods those were asynchronous at the middle and upper parts of the fluvial *** main agent of initial valley infill appears to be local lacustrine sedimentation altered by alluvial and colluvial deposition towards the second half of *** landscape conditions variability emphasize the importance of comprehensive local correlations for regional retrospective models.

关键词： Interfluve headwaters Fluvial Incision-Infill Cycle Pleistocene

基于半导体压力传感原理的钐一硫化物在冻土区压力测量中的应用(英文)

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黑龙江大学工程学报 2014年第3期5卷 199-201页

作者： Bolshev K.N. ivanov v.A. Kaminskii v.v. Lebedev M.P. Stepanov A.A. 俄罗斯科学院西伯利亚分院北极物理技术研究所

提出了利用半导体压力传感器自动化装置进行冻土区压力测量的方法。传感器的运行原理是依靠半导体导电层电阻变化与压力和温度变动之间的相关关系,从而在传感器温度已知的条件下,对压力进行估算。实验结果验证了这种方法的可行性。

关键词：钐一硫化物压力传感器低温压力

Cd0.21Hg0.79Te中的产生～复合噪声

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红外技术 1981年第4期 26-31页

作者： M.G.Andrukhlv ,v.I.ivanov-Omskll ,v.K.Ogordnlkov ,汤锦亚

我们对Cd0.21Hg0.79Te晶体中的g—r噪声进行了研究,对补偿过的和未经补偿的n型样品和P型样品进行了测量。研究结果表明,窄禁带Cd0.21Hg0.79Te半导体中的噪声源与CMT材料的导电类型、补偿程度以及温度有关。在n型未补偿样品的本征区域以... 详细信息

我们对Cd0.21Hg0.79Te晶体中的g—r噪声进行了研究,对补偿过的和未经补偿的n型样品和P型样品进行了测量。研究结果表明,窄禁带Cd0.21Hg0.79Te半导体中的噪声源与CMT材料的导电类型、补偿程度以及温度有关。在n型未补偿样品的本征区域以及非本征区域内,g—r噪声是由带间的跃迁决定的。在n型补偿样品的非本征区域和P型样品内,g—r噪声是由杂质能级与能带间的跃迁引起的。

关键词：电子跃迁噪声电流频谱密度非本征能级导带 Cd 辐射跃迁空带能带结构晶体 Hg 噪声噪音

Intestinal microbiome changes in an infant with right atrial isomerism and recurrent necrotizing enterocolitis:A case report and review of literature

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World Journal of Clinical Cases 2022年第29期10卷 10583-10599页

作者： Aleksandra Kaplina Ekaterina Zaikova Artem ivanov Yulia volkova Tatiana Alkhova vladimir Nikiforov Alexander Latypov Marina Khavkina Tatiana Fedoseeva Tatiana Pervunina Yulia Skorobogatova Svetlana volkova vladimir Ulyantsev Olga Kalinina Stanislav Sitkin Natalia Petrova Research Laboratory of Physiology and Diseases of Newborns Almazov National Medical Research CentreSt.Petersburg 197341Russia Research Laboratory of Autoimmune and Autoinflammatory Diseases Almazov National Medical Research CentreSt.Petersburg 197341Russia vladimir Ulyantsev International Laboratory of Computer TechnologiesITMO UniversitySt.Petersburg 197101Russia Department of Cardiovascular Surgery for Children Almazov National Medical Research CentreSt.Petersburg 197341Russia Department of Neonatal Physiology with an ICU Ward Almazov National Medical Research CentreSt.Petersburg 197341Russia Pediatric Cardiac Intensive Care Unit Almazov National Medical Research CentreSt.Petersburg 197341Russia Neonatal and Preterm Special Care Unit(2nd Stage Care) Almazov National Medical Research CentreSt.Petersburg 197341Russia Institute of Perinatology and Pediatrics Almazov National Medical Research CentreSt.Petersburg 197341Russia Express Laboratory of Perinatal Centre Almazov National Medical Research CentreSt.Petersburg 197341Russia Clinical Diagnostic Laboratory Almazov National Medical Research CentreSt.Petersburg 197341Russia Epigenetics and Metagenomics Group Institute of Perinatology and PediatricsAlmazov National Medical Research CentreSt.Petersburg 197341Russia Department of Internal Diseases Gastroenterology and DieteticsNorth-Western State Medical University named after I.I.MechnikovSt.Petersburg 191015Russia

BACKGROUND Necrotizing enterocolitis(NEC)is a multifactorial disease that predominantly affects premature *** dysbiosis plays a critical role in NEC pathogenesis in premature *** main risk factor for NEC in term infants is mesenteric hypoperfusion associated with ductaldependent congenital heart disease(CHD)that eventually leads to intestinal *** incidence of NEC in neonates with critical CHD is 6.8%-13%.However,the role of the intestinal microbiome in NEC pathogenesis in infants with ductal-dependent CHD remains *** SUMMARY A male term neonate with right atrial isomerism underwent modified Blalock-Taussig shunt placement on the 14^(th)day of life and had persistent mesenteric hypoperfusion after *** patient had episodes of NEC stageⅡA on the 1^(st)and 28^(th)days after cardiac *** microbial composition was analyzed before and after cardiac surgery by sequencing region v4 of the 16S rRNA *** surgery,species belonging to genera veillonella and Clostridia and class Gammaproteobacteria were detected,Bifidobacteriaceae showed a low *** first NEC episode was associated with postoperative hemodynamic instability,intestinal ischemiareperfusion injury during cardiopulmonary bypass,and a high abundance of Clostridium paraputrificum(Clostridium sensu stricto I)(56.1%).Antibacterial therapy after the first NEC episode resulted in increased abundance of Gammaproteobacteria,decreased abundance of Firmicutes,and low alpha *** changes in the microbial composition promoted the growth of Clostridium sensu strictoⅠ(72.0%)before the second NEC *** A high abundance of Clostridium sensu strictoⅠand mesenteric hypoperfusion may have contributed to NEC in the present case.

关键词： Necrotizing enterocolitis Congenital heart disease Ivemark syndrome Heterotaxy Right atrial isomerism Intestinal microbiome Case report

Effectiveness and safety of COvID-19 vaccines in patients with oncological diseases:State-of-the-art

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World Journal of Clinical Oncology 2023年第9期14卷 343-356页

作者： Nedelcho ivanov Boris Krastev Dimitrina Georgieva Miteva Hristiana Batselova Radostina Alexandrova Tsvetelina velikova Department of Clinical Immunology with Stem Cell Bank University Hospital AlexanrovskaSofia 1431Bulgaria Medical Center Nadezhda Medical Center NadezhdaSofia 1407Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital St.GeorgePlovdiv 6000Bulgaria Department of Pathology Institute of Experimental MorphologyPathology and Anthropology with MuseumBulgarian Academy of SciencesSofia 1000Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Although the coronavirus disease 2019(COvID-19)pandemic was declared to be no longer“a public health emergency of international concern”with its wide range of clinical manifestations and late complications,severe acute respiratory syndrome coronavirus 2 infection proved to be a serious threat,especially to the elderly and patients with *** with oncologic diseases are vulnerable to severe infection and ***,patients with oncohematological diseases have a higher risk of severe COvID-19 and impaired post-vaccination ***,cancer patients are usually excluded from vaccine trials and investigations of post-vaccinal immune responses and the effectiveness of the *** aimed to elucidate to what extent patients with cancer are at increased risk of developing severe COvID-19 and what is their overall case fatality *** also present the current concept and evidence on the effectiveness and safety of COvID-19 vaccines,including boosters,in oncology *** conclusion,despite the considerably higher mortality in the cancer patient group than the general population,countries with high vaccination rates have demonstrated trends toward improved survival of cancer patients early and late in the pandemic.

关键词： COvID-19 COvID-19 vaccines RNA vaccines Cancer Oncological Safety Efficacy Immunogenicity

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空气-等离子镀覆技术的进展

热处理 2014年第1期29卷 8-14页

作者： В.Я.Фролов Г.К.Петров Б.А.Юшин Д.В.Иванов СПбГПУ г.Санкт-Петербург

空气-等离子喷涂工艺在许多领域得到了应用。近年来,国立圣彼得堡综合技术大学在等离子体发生器的创建和涂覆工艺方面进行了研究,业已研制成多种涂层,既可用于新制零件的防护,也可用于磨损件的修复。国立圣彼得堡综合技术大学和雷波尼茨... 详细信息

空气-等离子喷涂工艺在许多领域得到了应用。近年来,国立圣彼得堡综合技术大学在等离子体发生器的创建和涂覆工艺方面进行了研究,业已研制成多种涂层,既可用于新制零件的防护,也可用于磨损件的修复。国立圣彼得堡综合技术大学和雷波尼茨(INP Greifswald)等离子体及工艺研究院联合进行的理论和试验研究,可显著减少研发等离子体发生器和空气-等离子涂覆工艺的试验工作量。

关键词：空气-电弧涂覆电弧等离子体发生器耐磨涂层修复涂层耐蚀涂层绝热涂层绝缘涂层保护-装饰涂层