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Segmentation of Head and Neck Tumors Using Dual PET/CT Imaging:Comparative Analysis of 2D,2.5D,and 3D Approaches Using UNet Transformer

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Computer Modeling in Engineering & Sciences 2024年第12期141卷 2351-2373页

作者： Mohammed A.Mahdi Shahanawaj Ahamad Sawsan a.saad Alaa Dafhalla Alawi Alqushaibi Rizwan Qureshi Information and Computer Science Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia Software Engineering Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia Computer Engineering Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia Department of Computer and Information Sciences Universiti Teknologi PetronasSeri Iskandar32610Malaysia Center for Research in Computer Vision(CRCV) University of Central FloridaOrlandoFL 32816USA

The segmentation of head and neck(H&N)tumors in dual Positron Emission Tomography/Computed Tomogra-phy(PET/CT)imaging is a critical task in medical imaging,providing essential information for diagnosis,treatment planning,and outcome *** by the need for more accurate and robust segmentation methods,this study addresses key research gaps in the application of deep learning techniques to multimodal medical ***,it investigates the limitations of existing 2D and 3D models in capturing complex tumor structures and proposes an innovative 2.5D UNet Transformer model as a *** primary research questions guiding this study are:(1)How can the integration of convolutional neural networks(CNNs)and transformer networks enhance segmentation accuracy in dual PET/CT imaging?(2)What are the comparative advantages of 2D,2.5D,and 3D model configurations in this context?To answer these questions,we aimed to develop and evaluate advanced deep-learning models that leverage the strengths of both CNNs and *** proposed methodology involved a comprehensive preprocessing pipeline,including normalization,contrast enhancement,and resampling,followed by segmentation using 2D,2.5D,and 3D UNet Transformer *** models were trained and tested on three diverse datasets:HeckTor2022,AutoPET2023,and *** was assessed using metrics such as Dice Similarity Coefficient,Jaccard Index,Average Surface Distance(ASD),and Relative Absolute Volume Difference(RAVD).The findings demonstrate that the 2.5D UNet Transformer model consistently outperformed the 2D and 3D models across most metrics,achieving the highest Dice and Jaccard values,indicating superior segmentation *** instance,on the HeckTor2022 dataset,the 2.5D model achieved a Dice score of 81.777 and a Jaccard index of 0.705,surpassing other model *** 3D model showed strong boundary delineation performance but exhibited variability across datasets,while the

关键词： PET/CT imaging tumor segmentation weighted fusion transformer multi-modal imaging deep learning neural networks clinical oncology

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Enhancing Arabic Cyberbullying Detection with End-to-End Transformer Model

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Computer Modeling in Engineering & Sciences 2024年第11期141卷 1651-1671页

作者： Mohamed A.Mahdi Suliman Mohamed Fati Mohamed A.G.Hazber Shahanawaj Ahamad Sawsan a.saad Information and Computer Science Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia Information Systems Department College of Computer and Information SciencesPrince Sultan UniversityRiyadh11586Saudi Arabia Software Engineering Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia Computer Engineering Department College of Computer Science and EngineeringUniversity of Ha’ilHa’il55476Saudi Arabia

Cyberbullying,a critical concern for digital safety,necessitates effective linguistic analysis tools that can navigate the complexities of language use in online *** tackle this challenge,our study introduces a new approach employing Bidirectional Encoder Representations from the Transformers(BERT)base model(cased),originally pretrained in *** model is uniquely adapted to recognize the intricate nuances of Arabic online communication,a key aspect often overlooked in conventional cyberbullying detection *** model is an end-to-end solution that has been fine-tuned on a diverse dataset of Arabic social media(SM)tweets showing a notable increase in detection accuracy and sensitivity compared to existing *** results on a diverse Arabic dataset collected from the‘X platform’demonstrate a notable increase in detection accuracy and sensitivity compared to existing methods.E-BERT shows a substantial improvement in performance,evidenced by an accuracy of 98.45%,precision of 99.17%,recall of 99.10%,and an F1 score of 99.14%.The proposed E-BERT not only addresses a critical gap in cyberbullying detection in Arabic online forums but also sets a precedent for applying cross-lingual pretrained models in regional language applications,offering a scalable and effective framework for enhancing online safety across Arabic-speaking communities.

关键词： Cyberbullying offensive detection Bidirectional Encoder Representations from the Transformers(BERT) continuous bag of words Social Media natural language processing

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Synergistic impacts of rifampicin and doxorubicin against thioacetamide-induced hepatocellular carcinoma in rats

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Liver Research 2023年第4期7卷 352-360页

作者： Zahraa R.Elshahawy Entsar a.saad Rana R.El-Sadda Chemistry Department Faculty of ScienceDamietta UniversityDamiettaEgypt Gastroenterology Surgical Center Faculty of MedicineMansoura UniversityMansouraEgypt

Background and aims:Combination therapy is a promising new strategy that has been proposed to increase the efficacy of cancer *** aimed to investigate the anti-cancer activity of rifampicin monotherapy and its combination with doxorubicin against hepatocellular carcinoma(HCC).Materials and methods:The in vitro half maximal inhibitory concentration(IC50)and selectivity index(SI)of the drugs under investigation against HepG2 and human lung fibroblast(WI38)cell lines were *** the in vivo experiment,male Sprague-Dawley albino rats were injected with thioacetamide at 200 mg/kg twice a week for 90 days;HCC development was confirmed *** HCC induction,the rats were treated with intraperitoneal doxorubicin,rifampicin,or their combination for 45 or 90 *** sacrifice,the livers were examined *** levels of aminotransferases,albumin,bilirubin,malondialdehyde,superoxide dismutase(SOD),catalase(CAT),total antioxidant capacity(TAC),and nitric oxide were measured by ***,cancer antigen 19-9,tumor necrosis factor-alpha,interleukin-6,Bcl-2-associated X protein,caspase 3,caspase 8,and p53 were estimated using ***:In vitro,the combination of doxorubicin and rifampicin showed the highest SI of *** vivo,among the measured markers,the levels of TAC,CAT,SOD,and p53 decreased(P<0.001)and the rest of the measured marker levels increased(P<0.001)in the HCC-bearing rats;after treatment in all groups,all these changes improved toward normal in a time-dependent *** combination of doxorubicin and rifampicin optimized the effects of the two individual drugs and exerted the best antioxidant ***:In general,compared with rifampicin or doxorubicin alone,combination therapy has favorable *** on our results,the combination of rifampicin and doxorubicin might be applicable for HCC chemotherapy.

关键词： Hepatocellular carcinoma(HCC) Rifampicin Doxorubicin Bcl-2-associated X protein(Bax) Caspase Protein 53(p53) Thioacetamide

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Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy

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BIOCELL 2019年第2期43卷 73-79页

作者： ENTSAR a.saad REDA S.EL-DEMERDASH EMAN M.ABD EI-FATTAH Chemistry Department Faculty of ScienceDamietta UniversityDamiettaEgypt Urology&Nephrology Center Faculty of MedicineMansoura UniversityEgypt

Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical *** aimed to evaluate the effect of mesenchymal stem cells(MSCs)injection or of captopril to counteract the cisplatin-induction of *** isolation,preparation and tracking,transforming growth factor-β(TGF-β)and interleukin-10(IL-10)expressions,kidney function tests,oxidative stress state,and histological examinations were ***-induced nephropathy was indicated biochemically and confirmed *** treatment showed normal kidney architecture and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function *** treated with cisplatin+captopril showed noticeable kidney histopathological *** positive impact of MSCs in amelioration of cisplatin-induced nephropathy via their ability to motivate functional and structural renal repair is evidenced.

关键词： Histopathology IL-10 Minerals Nephropathy Oxidative stress PCR Repair TGF-β

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Effects of cucumber mosaic virus-infected chilli plants on non-vector Bemisia tabaci (Hemiptera Aleyrodidae)

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Insect Science 2019年第1期26卷 76-85页

作者： Khalid a.saad M.N.Mohamad Roff Rebecca H.Hallett Idris B.Abd-Ghani Faculty of Science and Technology School of Environmental and Natural Resource SciencesNational University MalaysiaBangi SelangorMalaysia Horticulture Research Centre HeadquartersMARDI-UPMSerdang SelangorMalaysia School of Environmental Sciences University of GuelphGuelphOntarioCanada

Plant virus infections are known to alter host plant attractiveness and suitability for insect *** study was conducted to determine how cucumber mosaic virus (CMV)-infected chilli plants affect the fitness and settling preferences ofnonvector whitefly,Bemisia tabaci adults under dual-choice conditions with volatile organic compounds analyzed using solid phase microextraction coupled with gas chromatography-mass spectrometry (GC-MS).Results showed that the presence of CIVIV in chilli plants substantially affects the settling preferences of the ***,which preferred to settle on noninfected *** of the egg stage and the longevity and fecundity of adult *** on CMV-infected chilli plants were not markedly different from those on noninfected chilli *** contrast,the developmental time from egg to adult was significantly reduced in CMV-infected chilli plants compared to the noninfected *** results also showed that CMV-infected chilli plants released significantly more linalool and phenylacetaldehyde than noninfected ***,it was suggested that the behavioral response of *** might be modified by CMV-infected plants,which alter the release of specific headspace *** on these results,the modification of plant volatile profiles may help in enhancing the effectiveness of biological control and the protection of crop plants against ***.

关键词： Bromoviridae Capsicum anmium cucumovirus in sect-pathogen interactions whitefly

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Associations between CD133,CK19 and G2/M in cirrhotic HCV(genotype-4)patients with or without accompanying tumor

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BIOCELL 2018年第2期42卷 55-60页

作者： Hoda M.EL-EMSHATY Entsar a.saad Mona S.GOUIDA Zahraa R.ELSHAHAWY Gastroenterology Surgical Center Faculty of MedicineMansoura UniversityEgypt Chemistry Department Faculty of ScienceDamietta UniversityDamiettaEgypt Mansoura Children Hospital Faculty of MedicineMansoura UniversityEgypt

Hepatitis C virus(HCV)-cirrhotic patients have the highest threat of developing hepatocellular carcinoma(HCC)and may be at risk of extra hepatic *** present study was designed to investigate CD133 and CK19 in HCV(genotype-4)-cirrhotic patients with/without HCC or extra hepatic cancer,to assess the degree of their correlation with cell cycle abnormalities and finally to assess the role of their combination as diagnostic tool for discrimination of cirrhotic patients with HCC from those with extra hepatic *** study included 77 HCV-cirrhotic patients and 20 healthy non-disease control *** were categorized histo-pathologically into:24 have only liver cirrhosis,26 with HCC,and 27 patients with extra hepatic *** cycle abnormalities,CD133 and CK19 were determined by flow cytometry ***133 and CK19 showed marked elevation in HCC and extra hepatic cancer compared with liver cirrhosis and control subjects(p<0.0001).Positive associations were noted between CK19,CD133 and G2/*** were gradually increased with progression from liver cirrhosis to *** of the three showed the best AUC(0.978)and accuracy(92.5%)for discrimination of HCC from extra hepatic *** CD133 with G2/M and CK19 comprises an excellent diagnostic panel for discrimination of HCV-cirrhotic patients with HCC from those with extra hepatic cancer.

关键词： Cell cycle Diagnostic performance Liver Panel

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Enhancing Deepfake Detection:Proactive Forensics Techniques Using Digital Watermarking

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Computers, Materials & Continua 2025年第1期82卷 73-102页

作者： Zhimao Lai saad Arif Cong Feng Guangjun Liao Chuntao Wang School of Automation Guangdong University and TechnologyGuangzhou510006China School of Immigration Administration(Guangzhou) China People’s Police UniversityGuangzhou510663China Department of Mechanical Engineering College of EngineeringKing Faisal UniversityAl Ahsa31982Saudi Arabia Cyber Police Division Guangzhou Public Security BureauGuangzhou510030China School of Forensic Science and Technology Guangdong Police CollegeGuangzhou510320China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou510642China

With the rapid advancement of visual generative models such as Generative Adversarial Networks(GANs)and stable Diffusion,the creation of highly realistic Deepfake through automated forgery has significantly *** paper examines the advancements inDeepfake detection and defense technologies,emphasizing the shift from passive detection methods to proactive digital watermarking *** detection methods,which involve extracting features from images or videos to identify forgeries,encounter challenges such as poor performance against unknown manipulation techniques and susceptibility to counter-forensic *** contrast,proactive digital watermarking techniques embed specificmarkers into images or videos,facilitating real-time detection and traceability,thereby providing a preemptive defense againstDeepfake *** offer a comprehensive analysis of digitalwatermarking-based forensic techniques,discussing their advantages over passivemethods and highlighting four key benefits:real-time detection,embedded defense,resistance to tampering,and provision of legal ***,the paper identifies gaps in the literature concerning proactive forensic techniques and suggests future research directions,including cross-domain watermarking and adaptive watermarking *** systematically classifying and comparing existing techniques,this review aims to contribute valuable insights for the development of more effective proactive defense strategies in Deepfake forensics.

关键词： Deepfake proactive forensics digital watermarking traceability detection techniques

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利用CT检测人体单肾肾小球滤过率

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国际医学放射学杂志 2015年第5期 482-483页

作者： S.H.Kwon a.saad S.M.Herrmann S.C.Textor L.O.Lerman 范淑璇 Division of Nephrology and Hypertension Mayo Clinic

摘要目的检测利用64层CT推导出人体单肾肾小球滤过率(GFR)与通过碘对比剂清除率得到的数值一致这一假设,并以碘对比剂清除率作为参考标准。材料与方法伦理委员会批准本项符合HIPAA的研究,并获得了知情同意书。在受控条件下(包括钠摄取... 详细信息

摘要目的检测利用64层CT推导出人体单肾肾小球滤过率(GFR)与通过碘对比剂清除率得到的数值一致这一假设,并以碘对比剂清除率作为参考标准。材料与方法伦理委员会批准本项符合HIPAA的研究,并获得了知情同意书。在受控条件下(包括钠摄取及肾素-血管紧张素受阻)前

关键词：单肾 GFR 孤立肾碘对比剂肾小球肾单位 CT 滤过

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis

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Traditional Medicine Research 2025年第2期10卷 30-36页

作者： Abdur Rauf Zuneera Akram Naveed Muhammad Najla AlMasoud Taghrid saad Alomar Saima Naz Abdul Wadood Chandni Hayat Marcello Iriti Department of Chemistry University of SwabiAmbar 23561Pakistan Department of Pharmacology Faculty of Pharmaceutical SciencesBaqai Medical UniversityKarachi 74600Pakistan Department of Pharmacy Abdul Wali Khan University MardanMardan 23200Pakistan Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Biotechnology BKUC-Bacha Khan University CharsaddaCharsadda 24620Pakistan Department of Biochemistry Abdul Wali Khan University MardanMardan 23200Pakistan Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20129Italy National Interuniversity Consortium of Materials Science and Technology(INSTM) Firenze 50121Italy

Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and *** study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia ***:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were *** docking studies were conducted using a molecular operating ***:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µ*** antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%*** docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/***:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications.

关键词： Pistacia chinensis Bunge antioxidant DPPH assay antilipoxygenase docking analysis

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