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Lack of evidence for germline WWP1 pathogenic variants in gastrointestinal polyposis and other phenotypes suggestive of PTEN-hamartoma-tumor syndrome

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Genes & Diseases 2024年第2期11卷 524-527页

作者： Noemi Gonzalez-Abuin Tirso pons Teresa Fuster Isabel Quintana Mariona Terradas Gemma Aiza Joan Brunet Gabriel Capellá Heather Hampel Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Department of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Centro de Investigación Biomédica en Red de Cáncer (CIBERONC) Madrid 28029Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Division of Clinical Cancer Genomics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Germline activating variants in WWP1,which encodes an E3 ubiquitin ligase that antagonizes PTEN tumor suppressive function,have been proposed as an alternative mechanism of PTEN inactivation in PTEN-hamartoma-tumor syndrome(PHTS)-like patients with wildtype PTEN.1 More specifically,heterozygous,potentially activating wwP1 variants were first identified by Lee et al in patients affected with gastrointestinal oligopolyposis,including adenomatous,hyperplastic/serrated,and hamartomatous polyps,and occasionally with colorectal cancer(Table 1).Subsequently,based on the PHTS phenotypic features,wWP1 mutational screening was performed in patients with thyroid nodules,2 or normocephalic autism spectrum disorder(ASD),3 where germline WWP1 variants were also identified(Table S1).

关键词： WWP1 gastrointestinal polyposis

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.Munley Erick E.pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible Philip A.Efron Alicia M.Mohr Department of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male Sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHS),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesponse postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Differences of silicon photodiode spectral reflectance among the same batch

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Optoelectronics Letters 2008年第5期4卷 347-350页

作者： A.L.Muoz Zurita J.Campos Acosta a.pons Aglio A.Shcherbakov Department of Optics National Institute for AstrophysicsOptics and ElectronicsA.P.51 y 216Puebla72000México. CSIC-Institute for Applied Physics C.P.28006MadridSpain.

Photodiode＇s reflectance plays an important role regarding the relation between responsivity and the incident flux. In this work we analyze how the spectral reflectance changes among photodiodes from the same manufacturer and batch and how the reflectance of three standard photodiodes has drifted during six years. The results show that the reflectance changes from diode to diode within the same batch and also show that the reflectance ofphotodiodes changes on time. This ageing is spectraUy dependent.

关键词：硅发光二极管光谱反射率响应度

Vanadium mineralization at Los Chihuidos sediment-hosted Cu-V deposit,Neuquén Basin,Argentina:An approach to vanadium ore forming processes

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Geoscience Frontiers 2024年第1期15卷 225-246页

作者： Ana L.Rainoldi Daniel Beaufort Marta B.Franchini Adolfo Giusiano Sabine Petit Patricia Patrier M.Josefina.pons Dpto.de Geología Universidad Nacional del Sur(UNS)8000 Bahía BlancaArgentina Consejo Nacional de Investigaciones Científicas y Técnicas Centro Patagónico de Estudios MetalogenéticosArgentina Universitéde Poitiers IC2MPCNRS-UMR 7285HydrasaF-86022 Poitiers CedexFrance Universidad Nacional del Comahue Facultad de IngenieríaDepartamento de Geología y Petróleo8300 NeuquénArgentina Consultant Geologist 8300 NeuquénArgentina Universidad Nacional de Río Negro Instituto de Investigación en Paleobiología y GeologíaRío NegroArgentina

Vanadium mineralization at Los Chihuidos deposit of the Neuquén Basin is linked to the development of a redox front system related to the inflow of hydrocarbons into the red sandstone of the Huincul *** of hydrocarbons with oxidized red beds and connate water generated redox reactions where hematite was dissolved due to iron reduction resulting in the discoloration of the red *** the contact between oxidized red sandstone and reduced white sandstone,precipitation of specific mineral phases resulted in the V ore with minor amounts of *** the implementation of the redox interface,abundant V-montmorillonite and V-hematite precipitated at the more oxidizing conditions and Cu-V-corrensite-type at the more reducing conditions of the redox *** the redox front advanced with fluids constantly migrating into the reservoir,more reducing conditions were stablished,promoting chloritization and minor illitization with V-Cu incorporation and continuous upgrading of the *** ore mineralogy consists of clay minerals including V-bearing montmorillonite,Cu-V-corrensite-type,V-di-trioctahedral chlorite and Cu-tri-trioctahedral chlorite with minor V-illite-smectite mixed-layer minerals and associated secondary *** over illitization was favored due to high amounts of Fe and Mg in detrital clasts and in connate fluids and by low K availability related to low amounts of detrital *** spatial transition of V and/or Cu bearing clay minerals observed through the mineralized redox front at Los Chihuidos deposit(kaolinite→smectite→illite/smectite→corrensite-type→di-trioctahedral-chlorite→tri-trioctahedral-chlorite)and the related variation of V-Cu concentrations in bulk rock are indicative of increasing pH and decreasing Eh of resident solutions from red to white sandstones during the hypogene mineralization *** influx of Cu-rich oxidized basinal brines precipitated main copper ore with Cu-sulfides in the white sandst

关键词： Clay minerals V-chlorite Redox front Bleaching Hydrocarbons

文化的聚落Antipode音乐、青年、文化中心及图书馆

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室内设计与装修 2024年第8期 92-98页

作者： [法国]Dominique Coulon&associés Eugeni pons(摄影) 秋落(编译) Dominique Coulon & associés

Antipode文化中心位于La Courrouze生态区新协调的开发区内,距离雷恩历史中心不到2 km,拥有便利的有轨电车和软交通连接。项目建在兵工厂的遗址上,周围空旷。为了延续人们对它的记忆,规划师Secchi和Vigano尝试了各种方案,将一些墙壁以... 详细信息

Antipode文化中心位于La Courrouze生态区新协调的开发区内,距离雷恩历史中心不到2 km,拥有便利的有轨电车和软交通连接。项目建在兵工厂的遗址上,周围空旷。为了延续人们对它的记忆,规划师Secchi和Vigano尝试了各种方案,将一些墙壁以及点缀地平线的大树保留了下来,使穿插在场域里的建筑像大大小小被植被淹没的岛。

关键词：有轨电车生态区规划师文化地平线

True cicadas (Cicadidae) as prey for the birds of the Western Palearctic: a review

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Avian Research 2020年第2期11卷 174-182页

作者： Pere pons Departament de Ciències Ambientals Universitat de Girona

Background:True cicadas(Cicadidae)are large and temporarily abundant *** availability may produce demographic and behavioural effects on bird populations,as happens with forest avifauna feeding on periodical cicadas in North *** Europe,the Near East and North Africa,knowledge of cicada predation by birds is ***:To help fill this gap,I consulted Cramp’s Birds of the Western Palearctic,conducted a search of online databases and used search engines to generate a database of Western Palearctic birds known to eat ***:A total of 105 species(16%of those occurring in the region)belonging to 13 orders,and comprising 20 of the 33 passerine families,were found to consume cicadas.I estimated that 69 of these bird species are known to consume cicadas within the limits of the Western *** terrestrial birds predate on cicadas,preferably on *** predators include cuckoos,owls,bee-eaters,woodpeckers,falcons,reed-warblers,larks,crows and jays,buntings,shrikes,pipits and wagtails,flycatchers and chats,tits,sparrows,leaf-warblers,starlings,warblers and thrushes,but also terns and *** are consumed by some passerines,owls and *** can make up as much as 70%of food items delivered to *** of stomach contents and neck collar samples are the most common methods used in diet ***:Available knowledge is biased towards species that have been more intensively studied,and often lack proper quantification of prey *** studies about the relative importance of cicadas as prey for birds in the Western Palearctic are needed.I suggest using non-invasive studies based on pellets and droppings and prioritizing declining bird species.

关键词： Bird species Cicadidae Cramp’s handbook Diet studies Predator-prey relationships