检索结果-南通市图书馆

维普期刊数据库

分形分析改善胰腺导管腺癌CT肿瘤大小测量:与大体病理和多参数MRI的比较

在线全文

学校读者我要写书评

暂无评论

国际医学放射学杂志 2022年第5期 616-616页

作者： F.Michallek M.A.Haouari O.Dana a.perrot S.Silvera A.Dallongeville 徐璐

摘要目的肿瘤大小的测量对于胰腺导管腺癌（PDA）的肿瘤分期和病人划分至关重要。然而，由于不能准确显示肿瘤边缘，CT经常低估肿瘤大小。基于CT的分形维数（FD）

关键词：

肝脏表面结节：结直肠癌肝转移病人化疗后肝切除术后肝功能衰竭的新预测指标

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2021年第5期 614-614页

作者： T.Yoh a.perrot A.Beaufrère C.Hobeika R.Sartoris V.Paradis 郭文文

摘要目的旨在评估结直肠癌肝转移(CLM)肝切除术后病人的肝脏表面结节(LSN)、化疗相关性肝损伤(CALI)与临床相关肝切除术后肝功能衰竭(CR-PHLF)(≥B级)三者

关键词：

Gaining access to acetyl-CoA by peroxisomal surface display

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2023年第2期8卷 224-226页

作者： Thomas perrot Sebastien Besseau Nicolas Papon Vincent Courdavault Biomolecules et Biotechnologies Vegetales BBVEA2106Universite de ToursToursFrance Univ Angers Univ BrestIRFSFR ICATF-49000AngersFrance

Synthetic biology is constantly making progress for producing compounds on ***,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisomal *** allow... 详细信息

关键词： Synthetic biology Enzymes colocalization Peroxisomal membrane Acetyl-CoA Polyketides

Expression of matrix metalloproteinases and tissue inhibitor metalloproteinases increases in X-irradiated rat ileum despite the disappearance of CD8a T cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第40期11卷 6312-6321页

作者： Carine Strup-perrot Marie-Catherine Vozenin-Brotons Marie Vandamme Christine Linard Denis Mathé Laboratoire d'étude des pathologies Radio-induites Laboratoire UPRES EA 27-10 'Radiosensibilité des tumeurs et tissus sains'

AIM： To investigate their expression and activity in the rat ileum after exposure to ionizing radiation along with that of the cellular effectors and molecular mediators involved in the regulation of MMPs. METHODS： Rats were exposed to a single 10-Gy dose of X-rays delivered to the abdomen. A combination of methods, such as zymography, immunohistochemistry and real time reverse transcriptase-polymerase chain reaction, were used to localize and quantify MMPs and the molecules involved in MMP activating and inhibitory pathways （plasmin/ plasminogen, TIMPs）, CD^8＋, as well as inflammatory （interleukin （IL）-1β, IL-8, tumor necrosis factor-s, TNF-α） and fibrogenic mediators （transforming growth factor- β1-3） within ileal tissue at 1, 3, and 7 d after irradiation. RESULTS： A marked increase in MMP-2 and -14 mRNA and protein levels associated with an increased activity of MMP-2 was observed in irradiated ileal tissue. MMP-2 and -14 expression was mainly observed in inflammatory, epithelial, and mesenchymal cells, whereas a slight increase in MMP-3 expression was detected in the few infiltrating macrophages at d i after irradiation. Conversely, MMP-1, -7, and -9 mRNA levels were not found to be affected by abdominal irradiation. Irradiation was found to induce disappearance of CD^8＋ cells. Furthermore, we have observed that TNF-α and IL-1β protein levels increased 6 h after irradiation, whereas those of IL-8 only increased after 3 d and was concomitant with neutrophil infiltration. In addition, the expressions of molecules involved in MMP activating and inhibitory pathways （urokinase-type plasminogen activator andtissue-type plasminogen activator; TIMP-1, TIMP-2, and plasminogen activator-inhibitor-i） were found to be increased after abdominal irradiation. CONCLUSION： This study showed that abdominal irradiation induces an acute remodeling of the ileum associated with an increased expression of MMPs and TIMPs that do not involve CD^8＋ T cells but involve mesenchymal and epi

关键词： Matrix metalloproteinases Irradiation Ileum T cells Cytokines

Neuroendocrine Differentiation in the Progression of Prostate Cancer: An Update on Recent Developments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Urology 2012年第3期2卷 173-182页

作者： Valérie perrot Laboratory M.E.R.C.I.-EA 3829 Institute of Research and Biomedical Innovation (IRIB) University of Rouen Rouen France

Neuroendocrine (NE) differentiation, either benign or malignant, is the hallmark of prostate cancer (PCa). Clusters of malignant NE cells are found in most prostate cancer cases. NE differentiation is among the non-mutually exclusive theories proposed to explain the progression to androgen independence of PCa. NE differentiation is usually associated with an increased aggressivity and invasiveness of prostate tumors and a poor prognosis. This review aims to present an overview of current knowledge on neuroendocrine differentiation in PCa to improve our understanding of tumour progression and androgen independence. The NE component represents an important therapeutic axis. Development of new generation of drugs that selectively target NE-like cells may lead to the development of new therapeutic modalities for advanced and hormone-refractory PCa.

关键词： Prostate Cancer Hormonal Therapy Neuroendocrine Neuroendocrine Differentiation Neuropeptides Chromogranin A Tumorigenesis Adenocarcinoma

First Report of a Successful Development of Yam Hybrids(Dioscorea alata L.)from Lyophilized and Long-Term Stored Pollens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

国际实验植物学杂志(英文) 2023年第10期92卷 2861-2874页

作者： Erick Malédon Elie Nudol Christophe perrot Marie-Claire Gravillon Ronan Rivallan Denis Cornet Hâna Chair Komivi Dossa CIRAD UMR AGAP InstitutPetit BourgGuadeloupe97170France UMR AGAP Institut Univ MontpellierCIRADINRAEInstitut AgroMontpellierF-34398France CIRAD UMR AGAP InstitutMontpellierF-34398France

Various biological constraints including erratic and asynchronous flowering between male and female plants hinder successful hybrid development and genetic gains in greater yam breeding ***,pollen storage has gained much attention to facilitate artificial pollinations and increase the genetic *** 4-year study aimed at developing a practical long-term pollen storage technique for the successful development of yam *** pollens were collected from two Dioscorea alata males,then lyophilized(two lyophilization treatments were applied),followed by storage at room temperature(24℃–25℃)for 12 ***,the lyophilized and stored pollens were tested for viability by crossing with four female *** results showed that lyophilization is effective for achieving viable pollens after 12 months of *** 1(48 h drying)showed higher pollen germination and fertility rates than Treatment 2(72 h drying).Although we observed a reduction in viability of lyophilized pollens after 12 months of storage,we generated hybrid seedlings with success rates from 12%to 21%compared to 21%–31%when using fresh *** testing based on molecular genotyping confirmed the hybrid status of the obtained seedlings,which grew well in a *** is a practical approach for a long-term storage of greater yam pollen *** protocol will positively impact yam breeding programs particularly in developing countries.

关键词： Yam freeze-drying pollen conservation genetic gain

Line-field confocal optical coherence tomography for three-dimensional skin imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2020年第4期13卷 381-392页

作者： Jonas OGIEN Anthony DAURES Maxime CAZALAS Jean-Luc perrot Arnaud DUBOIS DAMAE Medical Paris 75013.France CHU St-Etienne Service DermatologieSaint-Etienne 42055France Universite Paris-Saclay Institut d'Optique Graduate SchoolCNRSLaboratoire Charles FabryPalaiseau 91127France

This paper reports on the latest advances in line-field confocal optical cohere nee tomography(LC-OCT),a recently invented imaging technology that now allows the generation of either horizontal(x×y)section images at an adjustable depth or vertical(x×z)section images at an adjustable lateral position,as well as thre dimensional *** both two-dimensional imaging modes,images are acquired in real-time,with real-time control of the depth and lateral ***-dimensional(x×y×z)images are acquired from a stack of horizontal section *** device is in the form of a portable *** handle of the probe has a button and a scroll wheel allowing the user to control the imaging *** a supercontinuum laser as a broadband light source and a high numerical microscope objective,an isotropic spatial resolution of^1|im is *** field of view of the three-dimensional images is 1.2 mm×0.5 mm×0.5 mm(x×y×z).Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.

关键词： optical coherence tomography(OCT) microscopy three-dimensional imaging dennatology

维普期刊数据库

Meckel Diverticulum Carcinoid Tumor Complicated by Ileal Invagination. About One Case at Vichy Hospital

在线全文

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2022年第4期11卷 133-137页

作者： Omar Sow Nicolas Sorbane Fetche Alice Anusca Lionel perrot Service de Chirurgie Viscérale et Digestive Centre Hospitalier de Vichy Vichy France Service de Chirurgie H&ocirc pital de la Paix Université Assane Seck de Ziguinchor Ziguinchor Senegal

Meckel’s diverticulum is a common pathology in children and rare in adults. We present a case of a 79-year-old patient in which a significant gastrointestinal bleeding, whose paraclinical explorations confirmed a fatty tumor of the terminal ileum. The exploratory coelioscopy revealed a tumor of the Meckel diverticulum complicated of intestinal invagination, resected at the same time with resection and extracorporeal anastomosis by mini coelio-guided laparotomy. Histology confirmed the presence of heterotopical tissue of the duodenal mucosa with Brunner cells and a carcinoid tumor. In conclusion, this clinical case shows that coelioscopy can be considered a very important diagnostic and therapeutic tool in this pathology especially in the elderly.

关键词： Meckel’s Diverticulum Carcinoid Tumor Invagination Cœliosurgery

Results of the Management of Gastrointestinal Stromal Tumors (GIST): About 6 Cases at the Vichy Hospital Center (France)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Therapy 2022年第7期13卷 397-404页

作者： Omar Sow Nicolas Sorbane Fetche Vermare Clarisse Annabel Bautrand Alice Anusca Lionel perrot Department of Visceral and Digestive Surgery Vichy Hospital Center Vichy France Department of Surgery H&ocirc pital de la Paix Assane Seck University Ziguinchor Senegal

The aim of our study was to analyze the results of surgical management of gastrointestinal stromal tumors (GIST) at the Vichy Hospital Center. Methodology: Between 2010 and 2020, the data of 6 patients operated at the Vichy Hospital Center for GIST were analyzed. The parameters studied were: age, sex, antecedents, discovery circumstances, imagery, surgical procedure, anatomopathological data, the follow-up and the morbidity-mortality. Results: There were 5 men and one woman with an average age of 72.16 years [58 - 80 years]. The average time of evolution was 8 months (0 - 14 months). The diagnosis was fortuitous in 2 cases. Atypical abdominal pain was the main symptom in 3 cases. One case was received in a clinical picture of peritoneal irritation syndrome. Echo-endoscopy with biopsy specimen histology made it possible to make the diagnosis in 5 cases and the surgical specimen in 1 case. The fusiform type was the predominant histological form. The stomach was the most common location. The average size of GISTs was 7.3 × 4 cm with a positive C Kit in all patients. Neoadjuvant chemotherapy was performed on one patient. Surgery was curative and was done laparoscopically on 4 patients. Adjuvant chemotherapy based on Imatinib at a rate of 400 mg/d in 3 patients was initiated. One patient presented a fistula of the esophagus-jejunal anastomosis on D6 post operation controlled by a drainage and an antibiotic therapy. Mortality was zero. During the surgery, all of the patients were followed up with surgeon, oncologist. Conclusion: GISTs are the most common mesenchymal tumors of the digestive tract with a preferential gastric location. Laparoscopic surgery, with advances in molecular biology and the introduction of targeted therapy has improved the management of these tumors in terms of morbidity and mortality.

关键词： Gastrointestinal Stromal Tumor Laparoscopic Surgery Targeted Therapy