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Small is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism

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Signal Transduction and Targeted Therapy 2020年第1期5卷 299-300页

作者： Angela M.otto Munich Institute of BioEngineering Technical University of Munich85748 GarchingGermany

Even though the mTOR complex has been known for decades as a nutrient sensor,being thus in focus for drug targeting in metabolic disease and cancer metabolism,it has remained puzzling how it is able to get a sense of glucose availability in ***,a small metabolite of the glycolytic pathway,dihydroxyacetone phosphate,has been identified by Sabatini and his coworkers,who show how mTORC1-activity is regulated in glucose-starved and replenished cancer cells.

关键词： metabolism cancer mTORC1

Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

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Bioactive Materials 2024年第1期31卷 440-462页

作者： Prashant Sharma Mario otto Department of Child Health University of Arizona College of Medicine-PhoenixABC1 Building425 N 5th StreetPhoenixAZ85004USA Center for Cancer and Blood Disorders(CCBD) Phoenix Children’s1919 E Thomas RdPhoenixAZ85016USA

Cancer immunotherapy has gained momentum for treating malignant tumors over the past *** blockade and chimeric antigen receptor cell therapy(CAR-T)have shown considerable potency against liquid and solid ***,the tumor microenvironment(TME)is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment *** in the design and engineering of nanomaterials have opened new avenues to modulate the *** in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different *** will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer *** addition,we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.

关键词： Tumor microenvironment Nanocomposites Immunotherapeutic Cancer Immunosuppressive

Aspects of surface and environment protection in German mining areas

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Mining Science and Technology 2009年第5期19卷 615-619页

作者： FRANK otto Technische Fachhochschule Georg Agricola zu Bochum University of Applied Sciences

Hard coal mining in the German Ruhr district has a tradition of more than 200 years. Starting in the south near the river Ruhr with mining of seams near to the surface, mining wandered to the north with coal seams deeper and deeper. In the same way all environmental effects of mining wandered from south to north, as there are abandoned mining sites, contaminated areas, burning mining dumps, subsided areas and gas accesses at day ground. This all happened in a very high populated area with more than four million inhabitants. Therefore Germany has a long tradition in solving environmental problems of mining activities. The very good interaction of mine authority, mining companies and the mine workers’ union is the main reason why the problems of decreasing mining activities in Germany were solved without economic, environmental or social hazards.

关键词： abandoned mining sites contaminated areas subsidence burning mining dumps gas accesses at day ground

Resolvent Estimates and Quantification of Nonlinear Stability

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Acta Mathematica Sinica,English Series 2000年第1期16卷 1-20页

作者： Heinz-otto Kreiss Jens Lorenz Department of Mathematics UCLALos AngelesCA 90095USA Department of Mathematics and Statistics UNMAlbuquerqueNM 87131USA

The aim of this paper is to clarify the role played by resolvent estimates for nonlinear *** will give examples showing that a large resolvent may lead to a small domain of nonlinear *** other examples the resolvent is large,but the domain of nonlinear stability is completely *** case prevails depends on the details of the problem. We will also show that the size of the resolvent depends in an essential way on the norms that are used.

关键词： Resolvent estimates Nonlinear stability Pseudospectrum Convection-dominated flow

Symmetric Periodic Orbits and Uniruled Real Liouville Domains

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Chinese Annals of Mathematics,Series B 2016年第4期37卷 607-624页

作者： Urs FRAUENFELDER otto van KOERT Department of Mathematics University of Augsburg Department of Mathematics and Research Institute of Mathematics Seoul National University

A real Liouville domain is a Liouville domain with an exact anti-symplectic involution. The authors call a real Liouville domain uniruled if there exists an invariant finite energy plane through every real point. Asymptotically, an invariant finite energy plane converges to a symmetric periodic orbit. In this note, they work out a criterion which guarantees uniruledness for real Liouville domains.

关键词： Symmetric periodic orbits Real symplectic manifolds Real uniruledness

Experimental models of non-alcoholic fatty liver disease in rats

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World Journal of Gastroenterology 2014年第26期20卷 8364-8376页

作者： otto Kucera Zuzana Cervinkova Department of Physiology Charles University in PragueFaculty of Medicine in Hradec Kralove

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the Western world,and it persists at a high *** is characterised by the accumulation of triglycerides in the liver and includes a spectrum of histopathological findings,ranging from simple fatty liver through non-alcoholic steatohepatitis(NASH)to fibrosis and ultimately cirrhosis,which may progress to hepatocellular *** pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin *** the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal *** ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different *** the past several years,great emphasis has been placed on the development of an appropriate model for human *** paper reviews the widely used experimental models of NAFLD in *** discuss nutritional,genetic and combined models of NAFLD and their pros and *** choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic *** the legislative,ethical,economical and health factors of NAFLD,animal models are essential tools for the research of this disease.

关键词： Animal model High-fat diet Methionine- and choline-deficient diet Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Otsuka-Long-Evans-Tokushima fatty rats Zucker rats

Reduction of Unneccessary Dotted Rules in the Earley—Algorithm

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Journal of Computer Science & Technology 1989年第4期4卷 344-352页

作者： HaraldE.otto TechnicalUniversityofDarmstadt FRG

With the high developed hardware from the PC's today,there arise possibilities to implement programming environments on such kind of *** rduces the amount of calculaiton time and required memory space from implemented *** optimization approaches in the algorithm design are *** purpose of this work is to explore and analyse possibilities to reduce the required memory space through elimination of superfluonus grammar rules created during the process of recognition.

关键词：程序设计环境算法设计语法表示

Colorectal cancer screening in patients at moderately increased risk due to family history

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World Journal of Gastrointestinal Oncology 2012年第6期4卷 125-130页

作者： otto S Lin C3-Gas Gastroenterology Section Virginia Mason Medical Center Seattle WA 98101 United States University of Washington School of Medicine Seattle WA 98101 United States

Patients with a positive family history have an increased risk of colorectal cancer (CRC) and, in many countries, more intensive screening regimens, sometimes involving the use of colonoscopy as opposed to sigmoidoscopy or fecal occult blood testing, are recommended. This review discusses current screening guidelines in the United States and other countries, data on the magnitude of CRC risk in the presence of a family history and the efficacy of recommended screening programs, as well as ancillary issues such as compliance, cost-effectiveness and accuracy of family history ascertainment. We focus on the relatively common 'sporadic' family histories of CRC, which typically imparts a mild to moderate elevation in the risk for CRC development in the proband. Defined familial syndromes associated with extremely high risks of CRC, such as hereditary non-polyposis colorectal syndrome or familial adenomatous polyposis, require specialized management approaches and are beyond the scope of this article. We will also not discuss colonoscopic surveillance in patients with a personal history of adenomas or CRC.

关键词： Colon cancer screening Family history Colonoscopy Colon polyp

Application of semi-analytical finite element method to analyze the bearing capacity of asphalt pavements under moving loads

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Frontiers of Structural and Civil Engineering 2018年第2期12卷 215-221页

作者： Pengfei LIU Dawei WANG Frederic otto Markus OESER Institute of Highway Engineering RWTH Aachen University Aachen D52074 Germany

To facilitate long term infrastructure asset management systems, it is necessary to determine the bearing capacity of pavements. Currently it is common to conduct such measurements in a stationary manner, however the evaluation with stationary loading does not correspond to reality a tendency towards continuous and high speed measurements in recent years can be observed. The computational program SAFEM was developed with the objective of evaluating the dynamic response of asphalt under moving loads and is based on a semi-analytic element method. In this research project SAFEM is compared to commercial finite element software ABAQUS and field measurements to verify the computational accuracy. The computational accuracy of SAFEM was found to be high enough to be viable whilst boasting a computational time far shorter than ABAQUS. Thus, SAFEM appears to be a feasible approach to determine the dynamic response of pavements under dynamic loads and is a useful tool for infrastructure administrations to analyze the pavement bearing capacity.

关键词： semi-analytical finite element method bearing capacity asphalt pavements moving loads dynamic response