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Improvement of porous polyvinylidene fluoride-co-hexafluropropylene hollow fiber membranes for sweeping gas membrane distillation of ethylene glycol solution

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3002-3010页

作者： M.Ajdar A.Azdarpour a.mansourizadeh B.Honarvar Department of Chemical Engineering Marvdasht BranchIslamic Azad UniversityMarvdashtIran Department of Chemical Engineering Membranne Science and Technology Research Center(MSTRC)Gachsaran BranchIslamic Azad UniversityGachsaranIran Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX 76019USA

Porous polyvinylidene fluoride-co-hexafluropropylene(PVDF-HFP)hollow fiber membranes were fabricated through a wet spinning *** order to improve the membrane structure,composition of the polymer solution was adjusted by studying ternary phase diagrams of polymer/solvent/*** prepared membranes were used for sweeping gas membrane distillation(SGMD)of 20 wt% ethylene glycol(EG)aqueous *** membranes were characterized by different tests such as N2 permeation,overall porosity,critical water entry pressure(CEPw),water contact angle and collapsing *** FESEM examination,addition of 3 wt% glycerol in the PVDF-HFP solution,produced membranes with smaller finger-likes cavities,higher surface porosity and smaller pore *** the polymer concentration up to 21 wt% resulted in a dense spongy structure which could significantly reduce the N2 *** membrane prepared by 3 wt% glycerol and 17 wt% polymer demonstrated an improved structure with mean pore size of 18 nm and a high surface porosity of 872 m^−*** of 350 kPa and overall porosity of 84% were also obtained for the improved *** pressure of the membranes relatively improved by increasing the polymer *** the SGMDtest,the developed membrane represented a maximumpermeate flux of 28 kg·m^−2·h^−1 which is almost 19% higher than the flux of plain *** 120 h of a long-termSGMD operation,a gradual flux reduction of 30% was *** addition,EG rejection reduced from 100% to around 99.5% during 120 h of the operation.

关键词： PVDF-HFP hollow fiber membrane Ternary phase diagram Membrane characterization Sweeping gas membrane distillation Ethylene glycol

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Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines

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Journal of Pharmaceutical Analysis 2021年第1期11卷 108-121页

作者： Marziyeh Shalchi Tousi Houri Sepehri Sepideh Khoee Mahdi Moridi Farimani Ladan Delphi Fariba.mansourizadeh Department of Animal Biology School of BiologyCollege of ScienceUniversity of TehranTehranIran Polymer Chemistry Department School of ScienceUniversity of TehranTehranIran Department of Phytochemistry Medicinal Plants and Drugs Research InstituteShahid Beheshti UniversityTehranIran

Many studies have so far confirmed the efficiency of phytochemicals in the treatment of prostate ***,a flavonoid with a wide range of phytomedical activities,suppresses proliferation of and induces apoptosis of multiple cancer cell ***,low solubility,poor bioavailability,and rapid degradation limit its *** aim of our study was to evaluate whether the use of mPEG-b-poly(lactic-co-glycolic)acid(PLGA)coated iron oxide nanoparticles as a carrier could enhance the therapeutic efficacy of eupatorin in DU-145 and LNcaP human prostate cancer cell *** were prepared by the co-precipitation method and were fully characterized for morphology,surface charge,particle size,drug loading,encapsulation efficiency and in vitro drug-release *** inhibitory effect of nanoparticles on cell viability was evaluated by MTT *** was then determined by Hoechest staining,cell cycle analysis,NO production,annexin/propidium iodide(PI)assay,and Western *** results indicated that eupatorin was successfully entrapped in Fe_(3)O_(4)@mPEG-b-PLGA nanoparticles with an efficacy of(90.99±2.1)%.The nanoparticle’s size was around(58.5±4)nm with a negative surface charge[(-34.16±1.3)mV].In vitro release investigation showed a 30% initial burst release of eupatorin in 24 h,followed by sustained release over 200 *** MTT assay indicated that eupatorinloaded Fe_(3)O_(4)@mPEG-b-PLGA nanoparticles exhibited a significant decrease in the growth rate of DU-145 and LNcaP cells and their IC50 concentrations were 100 μM and 75 μM,***,apoptosis was confirmed by nuclear condensation,enhancement of cell population in the sub-G1 phase and increased NO ***/PI analysis demonstrated that eupatorin-loaded Fe_(3)O_(4)@mPEG-b-PLGA nanoparticles could increase apoptosis and decrease necrosis ***,Western blotting analysis confirmed these results and showed that Bax/Bcl-2 ratio and the cleaved caspase-3 level were up-

关键词： Apoptosis Eupatorin Nanoparticles Prostate cancer

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