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Astrodynamics 2024年第2期8卷 223-236页

作者： Kaito Kosuge Hirohisa.kojima Department of Aeronautics and Astronautics Tokyo Metropolitan UniversityAsahigaoka 6-6HinoTokyo 191-0065Japan

This study involved simulations and experiments aimed at assessing the efficacy of a tether net in encapsulating space *** tether net was modeled as a spring–mass–damper system considering the influence of aerodynamic and gravitational forces and the occurrence of debris *** examine the influence of collision position and size disparity between the debris and the net on debris capture status,the entanglement nodes of the net were *** were conducted to evaluate the wrapping capabilities of the tether net,focusing specifically on debris ***,the results were compared with those of the numerical *** the experiments,radio frequency identification was used to identify the entanglement points of the tether *** studies have indicated that the ideal collision point for capturing debris using a tether net with the debris intended to be captured is located at the center of the ***,the experimental results of this study revealed that a collision position that is slightly shifted from the center of the tether net is more advantageous for capturing debris in terms of tether net entanglement.

关键词： space debris tether net entanglement debris capture active debris removal(ADR)

Real-world efficacy and safety of tofacitinib treatment in Asian patients with ulcerative colitis

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World Journal of Gastroenterology 2024年第13期30卷 1871-1886页

作者： Kentaro kojima Kenji Watanabe Mikio Kawai Soichi Yagi Koji Kaku Maiko Ikenouchi Toshiyuki Sato Koji Kamikozuru Yoko Yokoyama Tetsuya Takagawa Masahito Shimizu Shinichiro Shinzaki Department of Gastroenterology Hyogo Medical UniversityNishinomiya 663-8501Japan Department of Gastroenterology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Internal Medicine for Inflammatory Bowel Disease The University of ToyamaToyama 930-0194Japan Center for Clinical Research and Education Hyogo Medical UniversityNishinomiya 663-8501Japan

BACKGROUND Real-world data on tofacitinib(TOF)covering a period of more than 1 year for a sufficient number of Asian patients with ulcerative colitis(UC)are *** To investigate the long-term efficacy and safety of TOF treatment for UC,including clinical *** We performed a retrospective single-center observational analysis of 111 UC patients administered TOF at Hyogo Medical University as a tertiary inflammatory bowel disease *** consecutive UC patients who received TOF between May 2018 and February 2020 were *** were followed up until August *** primary outcome was the clinical response rate at week *** outcomes included clinical remission at week 8,cumulative persistence rate of TOF administration,colectomy-free survival,relapse after tapering of TOF and predictors of clinical response at week 8 and week *** The clinical response and remission rates were 66.3%and 50.5%at week 8,and 47.1%and 43.5%at week 48,*** overall cumulative clinical remission rate was 61.7%at week 48 and history of anti-tumor necrosis factor-alpha(TNF-α)agents use had no influence(P=0.25).The cumulative TOF persistence rate at week 48 was significantly lower in patients without clinical remission than in those with remission at week 8(30.9%vs 88.1%;P<0.001).Baseline partial Mayo Score was significantly lower in responders vs non-responders at week 8(odds ratio:0.61,95%confidence interval:0.45-0.82,P=0.001).Relapse occurred in 45.7%of patients after TOF tapering,and 85.7%of patients responded within 4 wk after *** 6 patients with herpes zoster(HZ)developed the infection after achieving remission by *** TOF was more effective in UC patients with mild activity at baseline and its efficacy was not affected by previous treatment with anti-TNF-α*** relapsed patients responded again after re-increase of TOF and nearly half relapsed after tapering off *** attention is needed for tapering and H

关键词： Ulcerative colitis Tofacitinib Janus kinase inhibitor Real-world Biologics

Factors Influence Hanoians’ Choice of Non-Motorized Transport Mode to Access Bus Stations

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Journal of Transportation Technologies 2024年第3期14卷 372-389页

作者： Ngo Trung Phuong Masahiko Kikuchi Aya.kojima Hisashi Kubota Graduate School of Science and Engineering Saitama University Saitama Japan Department of Engineering Affairs City Bureau Ministry of Land Infrastructure Transportation and Tourism Tokyo Japan

Hanoi’s rapid urbanization has led to a surge in private vehicle ownership, particularly motorcycles, amidst inadequate public transportation infrastructure. Despite government efforts, many still prefer motorized transport, citing mobility and safety concerns, exacerbated by insufficient pedestrian infrastructure. This study examines the motivations behind this reliance on motorized vehicles, particularly motorcycles, in Hanoi. Findings reveal safety and convenience as primary factors driving motorized transport use, especially for accessing bus stations. Economic incentives could promote non-motorized travel and public transport adoption. Policy implications highlight the importance of addressing economic factors and improving access infrastructure to manage motorized vehicle reliance and foster sustainable urban mobility in Hanoi.

关键词： Access Mode Choice Non-Motorized Vehicles Motorized Vehicles Bus User Urban Transport Behavior

Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki Kumi kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro kojima Shota Kami Keishiro Aoki Tomoyuki Satake Tatsushi Kobayashi Motokazu Sugimoto Shin Kobayashi Masaru Konishi Naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report

日本社会保障面临的挑战——基于人口减少社会的视角

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社会保障评论 2024年第2期8卷 39-55页

作者： [日]小岛克久万琳静日本国立社会保障·人口问题研究所信息调查部西安交通大学公共政策与管理学院

日本已成功建立了全面的社会保障体系,实现了全民医疗和全民年金等目标。该制度的演变跨越了漫长的历史,适应了每个时代的挑战。第二次世界大战结束后,日本采取政策措施为生活贫困者、儿童和残疾人建立了相应的社会救助和社会福利制度。... 详细信息

日本已成功建立了全面的社会保障体系,实现了全民医疗和全民年金等目标。该制度的演变跨越了漫长的历史,适应了每个时代的挑战。第二次世界大战结束后,日本采取政策措施为生活贫困者、儿童和残疾人建立了相应的社会救助和社会福利制度。从20世纪50年代末到70年代初,日本完善了全民医疗和全民年金等社会保障制度。自20世纪90年代起,日本开始应对出生率下降和人口老龄化问题,并对社会保障制度进行改革,以确保其可持续性。至此,日本建成了包括医疗、年金、长期护理、育儿支持和公共援助在内的全面社会保障体系以保障民生。然而,在未来老龄化社会的背景下,出生率下降、人口减少以及地区差异的存在,都给政策带来了挑战,包括财政的可持续性、基于社区的医疗和社会服务供给的发展以及应对相对贫困等政策。当前人口减少不仅在日本,在中国和韩国也已成为普遍现象。对中日韩的研究人员来说,探讨人口减少背景下的社会保障等政策选择具有重要意义。

关键词：日本社会保障制度地区差异人口减少东亚

A New CMC-AA Resin/Inorganic-gel Super Absorbent Material

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Journal of Wuhan University of Technology(Materials Science) 2006年第1期21卷 95-98页

作者：王勇 Toshinori kojima School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Industry Chemistry Faculty of Engineering Seikei UniversityJapan

A super absorbent material was prepared with the super absorbent resin （ SAR ） and inorganic gel. The SAR of the carboxymethyl cellulose grafting acrylic acid （ CMC-AA ） was copolymer synthesized using the method of inverse-phase suspension polymerization. The influences of the monomer concentration, neutralization degree, the initiator, dispersion agent, cross-linking agent, reaction and drying temperature on the grafting copolymer properties were examined. Meanwhlie, its properties was investigated and the model for absorption mechanism of this absorbent composite was proposed.

关键词： absorbent carboxymethyl cellulose acrylic acid super absorbent resin

Yield of OH radicals in water under heavy ion *** on mass,specific energy,and elapsed time

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Nuclear Science and Techniques 2007年第1期18卷 35-38页

作者： Mitsumasa TAGUCHI Takuji kojima Organic Pollutant Removal Technology Group Japan Atomic Energy Agency1233 WatanukiTakasakiGunma370-1292 Japan

Dependence of yields of OH (hydroxyl) radicals on the mass and specific energy of heavy ions and elapsed time after irradiation was investigated,to understand chemical reactions of aqueous *** yields of irradiation products of phenol,super-linearly increased with the incident energy of He,C,and Ne ions ranging from 2 to 18 MeV/*** yields of the OH radicals were estimated by analyzing the yields of the irradiation products of phenol. The yields of the OH radicals increased with the specific energy for each ion,but decreased both with the mass of each ion at the same specific energy and elapsed time after irradiation.

关键词：重离子辐射水辐射分解羟自由基产率质量耗用时间

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宋明理学的性说

杭州师范大学学报（社会科学版） 2024年第4期46卷 1-13页

作者： [日]小岛毅申绪璐(译) 东京大学人文社会系研究科日本东京113-8654 杭州师范大学哲学系浙江杭州311121

北宋王安石承继唐代韩愈彰显孟子、肯定孟子的性善说,与程颢、程颐开创的道学派学者具有共同的性论基础。与王安石、程颢强调伦理意义上的善恶只是已发阶段的概念不同,南宋朱熹依据张载的心统性情与程颐的性即理,建立性情二层构架。同时... 详细信息

北宋王安石承继唐代韩愈彰显孟子、肯定孟子的性善说,与程颢、程颐开创的道学派学者具有共同的性论基础。与王安石、程颢强调伦理意义上的善恶只是已发阶段的概念不同,南宋朱熹依据张载的心统性情与程颐的性即理,建立性情二层构架。同时,《大学》“身有所忿懥”的身、心理解反映了道学家不同的思想特色。有关性本善与无善无恶、尊德性与道问学的争论,反映了理学家不同的思想重点。尤其是尊德性与道问学对立的思想史叙事不断地再生产,直至今天仍保持着生命力。黄宗羲的《明儒学案》可为代表,这样的叙事非常稳妥,但也因此需要保持警惕。一方面这样的叙事容易忽略不同学者思想的丰富性,另一方面即使强调“朱陆和会”的学者也不可避免地局限在朱陆对立的理论前提。

关键词：性善论无善无恶朱熹王阳明陆九渊