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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 58-72页

作者： T.Koyama M.Chijimatsu H.Shimizu S.Nakama T.Fujita a.kobayashi Y.Ohnishi Department of Urban Management Kyoto University Hazama Corporation Institute of Fluid Science Tohoku University Japan Atomic Energy Agency (JAEA) Faculty of Environmental and Urban Engineering Kansai University Kyoto University

In this paper, the coupled thermo-mechanical （TM） processes in the AEspoe Pillar Stability Experiment （APSE） carried out by the Swedish Nuclear Fuel and Waste Management Company （SKB） were simulated using both continuum and discontinuum based numerical methods. Two-dimensional （2D） and three- dimensional （3D） finite element method （FEM） and 2D distinct element method （DEM） with particles were used. The main objective for the large scale in situ experiment is to investigate the yielding strength of crystalline rock and the formation of the excavation disturbed/damaged zone （EDZ） during excavation of two boreholes, pressurizing of one of the boreholes and heating. For the DEM simulations, the heat flow algorithm was newly introduced into the original code. The calculated stress, displacement and temperature distributions were compared with the ones obtained from in situ measurements and FEM simulations. A parametric study for initial microcracks was also performed to reproduce the spalling phenomena observed in the APSE.

关键词： Coupled thermo-mechanical (TM)processesAspoe Pillar Stability Experiment (APSE)Excavation disturbed/damaged zone (EDZ)Finite element method (FEM)Distinct element method (DEM)

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省油的重型卡车柴油机的发展与设计思想

车用发动机 1984年第3期 9-18+37页

作者： a.kobayashi,范思诚日野汽车公司日

由于油价的上涨,重型卡车节油的要求日益严格。为了满足这些要求,已作了很多努力,如减少车辆的空气阻力、传动装置与发动机性能的优选、改进发动机燃烧等。但是,降低油耗的要求估计会变得更严格。于是,作者研究了一种新的重型卡车柴油... 详细信息

由于油价的上涨,重型卡车节油的要求日益严格。为了满足这些要求,已作了很多努力,如减少车辆的空气阻力、传动装置与发动机性能的优选、改进发动机燃烧等。但是,降低油耗的要求估计会变得更严格。于是,作者研究了一种新的重型卡车柴油机的设计思想来满足这方面的要求。谋求省油的发动机的基本设想是,发动机要尽可能地小,还要采用较高增压度的涡轮增压来获得足够高的输出功率。但是,一般涡轮增压发动机存在一些不能令人满意的问题,诸如加速性差、低速扭矩不足、热负荷与机械负荷增加、发动机制动扭矩不足与冷起动性不良等,因此还应寻求改进这些问题的种种措施。为此,采用了底盘安装式空-空中冷器、惯性增压进气系统、大弯度后掠式涡轮增压器叶轮与电子控制喷油定时装置等,新的设计技术还采用了新材料与新结构。这台发动机安装在总重约20000公斤(44000磅)级长途卡车上,取得了预期的较好的里程油耗。

关键词：非增压发动机增压度扭矩低速涡轮增压发动机涡轮增压器中冷器卡车柴油机设计思想

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新型直列3缸1.2L机械增压汽油机

汽车与新动力 2014年第1期46卷 7-12页

作者： a.kobayashi T.Satou H.Isaji S.Takahashi T.Miyamoto 虞展

介绍新型1.2 L 3缸HR12DDR型汽油机,其开发目标是达到欧洲B级车市场最低的二氧化碳排放,并通过优异的动力输出性能来满足用户的驾驶乐趣。同时,该汽油机的开发目的也是为了满足日趋收紧的法规要求,以及将来取代轿车柴油机。2011年,该汽... 详细信息

介绍新型1.2 L 3缸HR12DDR型汽油机,其开发目标是达到欧洲B级车市场最低的二氧化碳排放,并通过优异的动力输出性能来满足用户的驾驶乐趣。同时,该汽油机的开发目的也是为了满足日趋收紧的法规要求,以及将来取代轿车柴油机。2011年,该汽油机已被应用在日产汽车欧洲市场的Micra车型上,达到了新欧洲行驶循环的二氧化碳排放限值95 g/km。为了降低燃油消耗率,通过提高压缩比,最大限度地提高热效率,并尽可能降低机械摩擦损失。通过汽油直接喷射系统优化燃烧。选择带有旁通阀和电磁离合器的机械增压系统,在不牺牲动力性的前提下实现更好的燃油经济性。详细介绍了HR12DDR型汽油机及其应用的技术亮点。

关键词：小排量汽油机机械增压低二氧化碳排放高动力输出电磁离合器旁通阀

Involvement of gonadal soma-derived factor in the reproduction of teleosts

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Aquaculture and Fisheries 2024年第3期9卷 417-421页

作者： Tohru kobayashi Laboratory of Molecular Reproductive Biology Institute for Environmental SciencesUniversity of ShizuokaShizuoka422-8526Japan Graduate School of Pharmaceutical and Nutritional Sciences University of ShizuokaShizuoka422-8526Japan

Gonadal soma-derived factor(Gsdf)is a member of the transforming growth factor beta(TGF-β)superfamily and a teleost-specific *** studies suggested that Gsdf promotes spermatogonial proliferation;however recent reports have shed light on its role in sex differentiation based on expression profiles and gain-and loss-of-function *** paper discusses the involvement of Gsdf in gonadal sex differentiation and sex changes in teleosts.

关键词： Teleosts Medaka Gsdf Sex determination Sex differentiation Sex change Pituitary

Comparison of incidence of acute kidney injury after robot-assisted radical prostatectomy with that after open retropubic and extraperitoneal laparoscopic radical prostatectomies in patients with prostate cancer

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Current Urology 2024年第2期18卷 139-143页

作者： Shunsuke Sato Toshiaki Tanaka Takeshi Maehana Kohei Hashimoto Ko kobayashi Naoya Masumori Department of Urology Sapporo Medical UniversitySapporoJapan

Background:We retrospectively evaluated the postoperative renal function in patients who had undergone radical prostatectomy to compare the incidences of postoperative acute kidney injury(AKI)among the patients who had undergone robot-assisted radical prostatectomy(RARP),retropubic radical prostatectomy(RRP),and extraperitoneal laparoscopic radical prostatectomy(exLRP).Materials and methods:Patients with prostate cancer who had undergone radical prostatectomy at our institution between 2008 and 2014 were ***-assisted radical prostatectomy was performed using an intraperitoneal approach in a 25-degree Trendelenburg position,whereas other procedures were performed with the patient in the supine *** evaluated the serum creatinine levels and estimated glomerular filtration rates immediately after surgery and on postoperative day *** evaluated the incidence of AKI after prostatectomy using the Acute Kidney Injury Network criteria of the Kidney Disease:Improving Global Outcomes ***:A total of 150 consecutive patients were included,with each of the 3 groups(RARP,RRP,and exLRP)comprising 50 *** AKI was observed in 15(30.0%),1(2.0%),and 3(6.0%)patients in the RARP,RRP,and exLRP groups,*** 1 AKI was observed in all the patients except *** incidence of AKI in RARP group was significantly higher than that in the other groups(p<0.001).In the RARP group,the serum creatinine level was significantly elevated immediately after the surgery;however,it returned to baseline on postoperative day *** procedures were the only independent factor associated with AKI ***:This study suggest that compared with RRP and exLRP,RARP is associated with a higher incidence of postoperative AKI,although most patients recover ***-abdominal pneumoperitoneum may contribute to AKI onset.

关键词： Acute kidney injury Renal function Prostatectomy

Fundamental Study on Response Properties of Structures Constructed on Lunar Regolith

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Open Journal of Earthquake Research 2024年第1期13卷 27-40页

作者： Yuji Miyamoto Takaharu Nakano Toshio kobayashi Department of Architecture and Civil Engineering Fukui University of Technology Fukui Japan Graduate School of Engineering Osaka University Osaka Japan SANSEI Inc. Tokyo Japan

The Artemis Program, for constructing the lunar base, is in progress. How to design and construct architectural and civil engineering structures in the lunar environment has become an important issue. The lunar surface is covered with soft sand, called regolith, and it is required to protect lunar bases and structures, as well as internal precision equipment, against vibrational disturbances such as moonquakes and meteorite collisions. Therefore, in this study, the static and cyclic triaxial compression tests of the regolith simulant were conducted. The reference strain and equivalent damping factor of the regolith simulant were smaller compared to sandy soil on Earth. In addition, a shaking table test using model specimens was conducted on the response properties of regolith ground alone and structures set on regolith ground. The buried foundation and pile foundation notably suppressed the horizontal response attributed to the rocking component compared to a direct foundation.

关键词： Lunar Development Regolith Soil-Structure Interaction Triaxial Compression Test Shaking Table Test

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肝门部胆管癌R0切除后复发模式

肝胆外科杂志 2010年第6期18卷 403-403页

作者： a.kobayashi S.Miwa T.Nakata S.Miyagawa 王平刘付宝

背景：手术切除是肝门部胆管癌患者获得长期生存唯一手段。随着外科技术和围手术期处理的进步,肝门部胆管癌患者短期存活发生巨大改变。但由于术后高的复发率使患者的长期存率仍低。但对肝门部胆管癌根治性切除后复发模式研究较少。

关键词：肝门部胆管癌复发模式切除后围手术期处理癌患者长期生存手术切除外科技术

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TiO₂-PES Fibrous Composite Material for Ammonia Removal Using UV-A Photocatalyst

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Journal of Materials Science and Chemical Engineering 2024年第1期12卷 1-19页

作者： Anh Phuong Le Thi Masaru Ohshiro Takaomi kobayashi Department of Science and Technology Innovation Nagaoka University of Technology Nagaoka Japan Kasai Corporation Niigata Japan

This study focused on the development and characterization of TiO2-PES composite fibers with varying TiO2 loading amounts using a phase inversion process. The resulting composite fibers exhibited a sponge-like structure with embedded TiO2 nanoparticles within a polymer matrix. Their photocatalytic performance for ammonia removal from aqueous solutions under UV-A light exposure was thoroughly investigated. The findings revealed that PeTi8 composite fibers displayed superior adsorption capacity compared to other samples. Moreover, the study explored the impact of pH, light intensity, and catalyst dosage on the photocatalytic degradation of ammonia. Adsorption equilibrium isotherms closely followed the Langmuir model, with the results indicating a correlation between qm values of 2.49 mg/g and the porous structure of the adsorbents. The research underscored the efficacy of TiO2 composite fibers in the photocatalytic removal of aqueous under UV-A light. Notably, increasing the distance between the photocatalyst and the light source resulted in de-creased hydroxyl radical concentration, influencing photocatalytic efficiency. These findings contribute to our understanding of TiO2 composite fibers as promising photocatalysts for ammonia removal in water treatment applications.

关键词： Ammonia Removal Photocatalyst TiO2-PES Composite Fiber Fibrous Material

Unroofing Technique for Anomalous Origin of the Left Coronary Artery from the Right Sinus of Valsalva: Report of a Case

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World Journal of Cardiovascular Surgery 2024年第6期14卷 69-77页

作者： Keisuke Morimoto Futoshi kobayashi Hiromu Horie Yuki Sakaguchi Einosuke Mizuta Department of Cardiovascular Surgery Sanin Rosai Hospital Yonago Japan Department ofCardiology Sanin Rosai Hospital Yonago Japan

Anomalous origin of the left coronary artery (AOLCA) from the right sinus of Valsalva constitutes a rare congenital coronary artery anomaly. Patients with an anomalous left main coronary artery face a significantly higher risk of sudden cardiac death compared to those with an anomalous right coronary artery. The anomalous coronary artery traversing between the ascending aorta and the pulmonary artery markedly heightens the risk of myocardial ischemia, arrhythmia, and sudden death. Symptomatic patients often exhibit a longer intramural course of the coronary artery, which may necessitate earlier intervention or influence the choice of surgical repair method. Surgical intervention is advocated for patients with this anomaly, even in the absence of symptoms. For anomalous aortic origin of a coronary artery from the opposite sinus of Valsalva with an intramural course, coronary unroofing is the preferred revascularization procedure. This report presents a case of AOLCA originating from the right sinus of Valsalva, treated surgically using the unroofing technique for the aortic intramural segment of the anomalous coronary artery traversing between the great vessels. The unroofing technique is recommended for treating AOLCA with an extensive intramural course that does not involve the commissure.

关键词： Unroofing Technique Anomaly of Coronary Artery Anomalous Origin of Left Coronary Artery

Conversion surgery after gemcitabine and cisplatin plus durvalumab for advanced intrahepatic cholangiocarcinoma:A case report

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World Journal of Clinical Cases 2024年第34期12卷 6721-6727页

作者： Yu Igata Masashi Kudo Motohiro Kojima Shota Kami Keishiro Aoki Tomoyuki Satake Tatsushi kobayashi Motokazu Sugimoto Shin kobayashi Masaru Konishi Naoto Gotohda Department of Hepatobiliary and Pancreatic Surgery National Cancer Center Hospital EastKashiwa 277-8577Japan Exploratory Oncology Research and Clinical Trial Center National Cancer CenterKashiwa 277-8577Japan Department of Hepatobiliary and Pancreatic Oncology National Cancer Center Hospital EastKashiwa 277-8577Japan Department of Diagnostic Radiology National Cancer Center Hospital EastChiba 277-8577Japan

BACKGROUND The combination of immune checkpoint inhibitors and chemotherapy has shown promising results for the treatment of advanced biliary tract cancer(BTC).Based on the results of the TOPAZ-1 trial,a gemcitabine and cisplatin plus durvalumab(GCD)regimen was recently approved as first-line therapy for patients with advanced ***,post-GCD conversion surgery has not been previously ***,we describe a case of advanced intrahepatic cholangiocarcinoma(ICC)successfully treated with radical surgery after *** SUMMARY A 65-year-old female diagnosed with advanced ICC with periductal infiltration into the hepatic hilum underwent eight cycles of GCD,followed by durvalumab maintenance treatment,with mild adverse *** response was ***,a conversion surgery with extended left hepatectomy and bile duct resection was *** resection margins were negative,and the pathological diagnosis was compatible with small duct type *** patient remained disease-free for 8 months without adjuvant *** We describe the case of a patient who received successful conversion surgery after GCD treatment for advanced ICC.

关键词： Conversion surgery Intrahepatic cholangiocarcinoma Small duct type Immunotherapy Case report