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Hepatotoxic Alterations Induced by Subchronic Exposure of Rats to Formulated Fenvalerate (20% EC) by Nose Only Inhalation

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Biomedical and Environmental Sciences 2004年第3期17卷 309-314页

作者： U.MANI a.k.prasad V.SURESHkUMAR P.kUMAR kEWAL LAL B.k.MAJI k.k.DUTTA Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India Inhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 IndiaInhalation Toxicology Laboratory and Animal House Industrial Toxicology Research Centre M. G. Marg P. Box. No.80 Lucknow-226 001 India

Objective Fenvalerate (20% EC) is a synthetic pyrethroid, which is commonly used in India by farmers for the protection of many food and vegetable crops against a wide variety of insects. However, its inhalation toxicity data is very limited in the literature due to the fact that the exposure levels associated with these effects were usually not reported. Hence, inhalation exposure was carried out to investigate the hepatotoxic effects. Method Adult male rats were exposed to fen for 4 h/day, 5 days a week for 90 days by using Flow Past Nose Only Inhalation Chamber. Sham treated control rats were exposed to compressed air in the inhalation chamber for the same period. Results The results indicated hepatomegaly, increased activities of serum clinical enzymes (indicative of liver damage/dysfunction) along with pronounced histopathological damage of liver. Conclusion The hepatotoxic potential of formulated Fen (20% EC) in rats exposed by nose only inhalation is being reported for the first time and warrant adequate safety measures for human beings exposed to this insecticide, particularly by inhalation route.

关键词： Fenvalerate Rat Inhalation Hepatotoxicity

Multi-Scale Dilated Convolution Network for SPECT-MPI Cardiovascular Disease Classification with Adaptive Denoising and Attenuation Correction

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 299-327页

作者： A.Robert Singh Suganya Athisayamani Gyanendra prasad Joshi Bhanu Shrestha Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia School of Computing Sastra Deemed to be UniversityThanjavur613401Tamil NaduIndia Department of Artificial Intelligence&Software Kangwon National UniversitySamcheok25913Republic of Korea Department of Information Convergence System Graduate School of Smart ConvergenceKwangwoon UniversitySeoul01897Republic of Korea

Myocardial perfusion imaging(MPI),which uses single-photon emission computed tomography(SPECT),is a well-known estimating tool for medical diagnosis,employing the classification of images to show situations in coronary artery disease(CAD).The automatic classification of SPECT images for different techniques has achieved near-optimal accuracy when using convolutional neural networks(CNNs).This paper uses a SPECT classification framework with three steps:1)Image denoising,2)Attenuation correction,and 3)Image *** denoising is done by a U-Net architecture that ensures effective image *** correction is implemented by a convolution neural network model that can remove the attenuation that affects the feature extraction process of ***,a novel multi-scale diluted convolution(MSDC)network is *** merges the features extracted in different scales and makes the model learn the features more *** scales of filters with size 3×3 are used to extract *** three steps are compared with state-of-the-art *** proposed denoising architecture ensures a high-quality image with the highest peak signal-to-noise ratio(PSNR)value of *** proposed classification method is compared with the five different CNN models,and the proposed method ensures better classification with an accuracy of 96%,precision of 87%,sensitivity of 87%,specificity of 89%,and F1-score of 87%.To demonstrate the importance of preprocessing,the classification model was analyzed without denoising and attenuation correction.

关键词： SPECT-MPI CAD MSDC denoising attenuation correction classification

Three-Stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 155-183页

作者： Suganya Athisayamani A.Robert Singh Gyanendra prasad Joshi Woong Cho School of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and Software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Intricacies during pregnancy with gestational diabetes mellitus

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World Journal of Clinical Cases 2025年第1期13卷 62-64页

作者： Richa Rattan Rimesh Pal Parul Chawla Gupta Arvind kumar Morya Ripunjay prasad Department of Endocrinology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology RP Eye InstituteDelhi 110001India

The study by Cao et al aimed to identify early second-trimester biomarkers that could predict gestational diabetes mellitus(GDM)development using advanced proteomic techniques,such as Isobaric tags for relative and absolute quantitation isobaric tags for relative and absolute quantitation and liquid chromatography-mass spectrometry liquid chromatography-mass *** analysis revealed 47 differentially expressed proteins in the GDM group,with retinol-binding protein 4 and angiopoietin-like 8 showing significantly elevated serum levels compared to *** these findings are promising,the study is limited by its small sample size(n=4 per group)and lacks essential details on the reproducibility and reliability of the protein quantification methods ***,the absence of experimental validation weakens the interpretation of the protein-protein interaction network identified through bioinformatics *** study's focus on second-trimester biomarkers raises concerns about whether this is a sufficiently early period to implement preventive interventions for *** GDM risk during the first trimester or pre-conceptional period may offer more clinical *** its limitations,the study presents valuable insights into potential GDM biomarkers,but larger,well-validated studies are needed to establish their predictive utility and generalizability.

关键词： Gestational diabetes mellitus Biomarkers Differentially expressed proteins Retinol-binding protein 4 Angiopoietin-like 8 Proteomics Lifestyle interventions Early prediction

Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the Heterogeneous Attention Transformer(HAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,Honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Effect of multiple rings on side force over an ogive-cylinder body at subsonic speed

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Chinese Journal of Aeronautics 2018年第6期31卷 1181-1188页

作者： Priyank kUMAR J.k.prasad Department of Space Engineering & Rocketry Birla Institute of Technology

Experiments and computations were performed over an ogive-cylinder body having an lift-to-drag ratio of 16 at a diameter Reynolds number of 29000. The side force on the slender body augments with increasing angles of attack for the case without a ring. This increase was mainly due to the increase in the asymmetry of the existing vortex pair in the wake of the body. Attempts were made to completely reduce the existing side force at the angle of attack ranging from 35° to 45°.Three rectangular cross-sectioned circumferential rings having a height of 3% of the local diameter were placed at axial distances of 2.5, 3.5 and 4.5 times the base diameter from the tip of the body so as to reduce the side force. The results obtained indicate that inclusion of three rings completely alleviated the side force on the slender body at the angle of attack ranging from 0° to 45°. The presence of rings was found to alter the growth of the vortices that helped in the reduction of the side force. Computations performed were in reasonable agreement with the experiments.

关键词： Asymmetric vortex High angle of attack Ogive Side force Slender body Vortex lift

Nano-Enhanced Dairy Scum Biodiesel Blends:Unleashing the Power of Aluminium Oxide for Sustainable and Efficient Engine Performance

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Journal of Thermal Science 2025年第1期 283-302页

作者： Veeranna MODI prasad B.RAMPURE Sunil kumar SHETTY Madeva NAGARAL Channa keshava NAIk N Johar MGM Muhammad Irsyad ABDULLAH Abdullah I.AL-MANSOUR Shamshad ALAM kLE College of Engineering and Technology ChikodiVisvesvaraya Technological University Nitte (Deemed to be University) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research and Design Centre HAL Department of Mechanical Engineering BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Management and Science University Department of Civil Engineering College of EngineeringKing Saud University

This study investigates the effect of aluminium oxide nanoparticlesaddition to biodiesel blends made from dairy milk scum on performance and combustion characteristics of the diesel *** dispersion of Al2O3nanoparticles in B20 blends at different concentrations was done with the help of *** number of blends were prepared for the *** Machine learning algorithms(Random Forest（RF）and CatBoost) was used for the *** results show that in comparison to biodiesel blends without nanoparticles,the kinematic viscosity and density is higher for fuel blends with *** these Fuel blends have higher calorific *** blends exhibited reduced Brake Specific Fuel Consumption（BSFC） of2.85% than the blends without nano particles(Dairy Scum Methyl Ester Biodiesel 20%+Neat Diesel 80%（in volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon,and increased NOxemissions compared to conventional diesel,contributing to the development of environmentally friendly and renewable biofuel blends with *** B20NP30 is the optimal blend for performance and emission *** study concludes with findings on enhanced Brake Thermal Efficiency（BTE） of 26.29% in 3×10-5（in volume） Al2O3nanoparticle-blended DSME B20 and other DSME B20 fuel blends,emphasizing the importance of optimal nanoparticle *** correlation matrix shows how engine load,efficiency measures（BTE,BSFC）,and emissions（CO,CO2,NOx,Smoke） are connected in complex *** results help us understand the complicated dynamics of engine performance and emission characteristics ***'s diagram for BTE and BSFC shows that CatBoost-based BTE models perform superior to RF-based models during the training as well as testing *** results were obtained for CO and CO2emission results.

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Slurry wear characteristics of zinc-based alloys： Effects of sand content of slurry, silicon addition to alloy system and traversal distance

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中国有色金属学会会刊：英文版 2009年第2期19卷 277-286页

作者： B.k. prasad, O.P. MODI Advanced Materials and Processes Research Institute （CSIR） Bhopal-462026 India

这调查处理在泥浆上与标本和泥浆作文以及遍历距离的效果相关的观察穿基于锌的合金的反应。合金的作文被把 4% 硅加到它改变。泥浆作文通过在被推迟在的 060% 的范围改变沙粒子的集中被改变(液体) 电解质。电解质包含了集中的硫的酸在水... 详细信息

这调查处理在泥浆上与标本和泥浆作文以及遍历距离的效果相关的观察穿基于锌的合金的反应。合金的作文被把 4% 硅加到它改变。泥浆作文通过在被推迟在的 060% 的范围改变沙粒子的集中被改变(液体) 电解质。电解质包含了集中的硫的酸在水的 10 L 溶解了的 4 g 钠氯化物和 5 mL。泥浆穿测试在 15500 km 的遍历距离范围上以 7.02 m/s 的速度被进行。wear 率开始与遍历距离增加了，达到了最大值并且不管标本和测试环境，此后减少了。然而， wear 率山峰比液体唯一的媒介在加沙环境的液体是不太突出的。进一步，在液体唯一的媒介的 wear 率山峰在包含泥浆的沙比那座出现在更短的遍历距离。到电解质的沙粒子的增加把样品的 wear 率归结为取决于泥浆的沙集中的 5%15% 。而且，中介(40%) 沙内容导致了最大值穿率什么时候与相比在加沙媒介的液体。然而，这最大值是静止的不到在里面液体唯一的媒介。包含更高受不了的合金的硅比当在液体唯一的媒介测试了时，免费合金取样的硅穿率。相反，而混合回答在包含 60% 沙的泥浆被注意，趋势加 20% 和 40% 沙环境在液体逆行。在后者盒子中，当一个相反的趋势在更长的遍历距离被观察时，硅的存在开始证明有害。样品的 wear 反应在试验性的条件的一个给定的集合以他们象硅和占优势的材料移动机制一样的 microconstituents 的特定的特征被讨论。合金的观察行为也通过他们的影响表面和表面下的区域的特征进一步被证实。

关键词：锌基合金磨损特性硅合金泥浆加砂远程系统渣浆泵测试环境