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急性早幼粒细胞白血病中复杂三元易位的细胞遗传学和分子特点(英文)

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北京大学学报（医学版） 2009年第4期41卷 477-479页

作者： christopher E. FREEMAN Danielle D. MERCER Yi YE john VAN BRUNT Ⅲ Marilyn M. LI Human Genetics Program Hayward Genetics Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Department of Pediatrics Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA Tulane Cancer Center Tulane University Health Sciences Center 1430 Tulane Avenue New Orleans LA

The most frequent chromosomal rearrangement reported in acute promyelocytic leukemia (APL) is t(15;17)(q22;q21). The t(15;17) generates the PML/RARA fusion gene that blocks the transcription of genes involved in myeloid cell differentiation. A small number of simple and complex variants of the classical t(15;17) have been reported. We report two complex three-way translocation variants,t(3;17;15)(q27;q21;q22) and t(8;17;15)(q24.3;q12;q22) in which the PML/RARA fusion gene has been created on the derivative 15 chromosomes. Many of these variant translocations are suspected by conventional cytogenetics but need to be confirmed with additional molecular testing. We discuss the importance of supplementing conventional cytogenetic testing with FISH and RT-PCR to accurately diagnose APL variant patients.

关键词：白血病,早幼粒细胞,急性易位,遗传细胞遗传学

Applied linear statistical models 5th ed

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丛书名： The McGraw-Hill/Irwin series operations and decision sciences

2005年

作者： Michael H Kutner christopher J. Nachtsheim john Neter William Li

来源：畅想之星图书光盘版（南... 评论

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由心出发的设计,克里斯托弗·约翰·罗杰斯

艺术与设计 2022年第1期11卷 168-171页

作者：吉丽 christopher john ROGERS(图) 不详

近期,CFDA时尚大奖(CFDA Fashion Awards)公布2021年获奖名单,其中美国年度女装设计师奖(American Womenswear Designer of the Year)获奖者是克里斯托弗·约翰·罗杰斯(christopher john Rogers)。克里斯托弗·约翰·罗杰斯曾就读于萨... 详细信息

近期,CFDA时尚大奖(CFDA Fashion Awards)公布2021年获奖名单,其中美国年度女装设计师奖(American Womenswear Designer of the Year)获奖者是克里斯托弗·约翰·罗杰斯(christopher john Rogers)。克里斯托弗·约翰·罗杰斯曾就读于萨凡纳艺术与设计学院,上学期间成立了品牌CJR。

关键词：克里斯托弗约翰·罗杰斯艺术与设计

ESI,专业化的虚拟仿真技术推动数字化造船

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舰船科学技术 2011年第4期33卷 7-10页

作者： christopher St.john

在工程仿真领域,有一家以提供专业化的仿真解决方案享誉业界的公司引起了记者的注意,这家公司何以能在激烈的全球CAE行业中赢得越来越多的市场?其解决方案的特点是什么?其未来发展和技术研发方向是什么?面对中国技术创新的巨大机遇,以... 详细信息

在工程仿真领域,有一家以提供专业化的仿真解决方案享誉业界的公司引起了记者的注意,这家公司何以能在激烈的全球CAE行业中赢得越来越多的市场?其解决方案的特点是什么?其未来发展和技术研发方向是什么?面对中国技术创新的巨大机遇,以及中国已成为造船大国并向造船强国转型的时机下,该公司如何布局中国的CAE市场?其仿真技术和方案能给中国船舶工业转型过程技术创新带来什么益处?带着这些问题,在一个初冬的早晨,本刊记者对这家的全球运营官***博士进行了专访。

关键词：虚拟仿真技术数字化造船专业化 ESI 技术创新工程仿真船舶工业 CAE

Research advances on internal processes affecting tropical cyclone intensity change from 2018–2022

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Tropical Cyclone Research and Review 2023年第1期12卷 10-29页

作者： Xiaomin Chen christopher M.Rozoff Robert F.Rogers Kristen L.Corbosiero Dandan Tao Jian-Feng Gu Falko Judt Eric A.Hendricks Yuqing Wang Michael M.Bell Daniel P.Stern Kate D.Musgrave john A.Knaff john Kaplan NOAA/OAR/Atlantic Oceanographic and Meteorological Laboratory MiamiUSA University of Alabama in Huntsville HuntsvilleUSA National Center for Atmospheric Research BoulderUSA University at Albany/State University of New York AlbanyUSA University of Bergen BergenNorway Nanjing University NanjingChina University of Reading ReadingUK University of Hawaii at Manoa HonoluluUSA Colorado State University Fort CollinsUSA University Corporation for Atmospheric Research MontereyUSA NOAA Center for Satellite Applications and Research Fort CollinsUSA Department of Atmospheric and Earth Science University of Alabama in HuntsvilleHuntsvilleUSA

This contribution summarizes the significant progress in a variety of topic areas related to internal tropical cyclone(TC)intensity change processes over 2018–2022 from the WMO Tenth International Workshop on Tropical Cyclones(IWTC-10).These topic areas include surface and boundary layer processes;TC internal structure and microphysical processes;and,radiation interactions with *** studies better frame the uncertainty in the surface drag and enthalpy coefficients at high wind *** parameters greatly impact TC intensity and it is therefore important that more direct measurements of these boundary layer parameters are *** significant scientific strides have been made in TC boundary *** advancements have been achieved through improved coupled models,large-eddy simulations,theoretical advance-ments,and detailed *** is now clear that the research field needs to better represent the eddy viscosity throughout the depth of the boundary ***,detailed study of coherent structures in TC boundary layers will likely be a propitious direction for the research ***,in-depth observational field campaigns and assiduous data analysis have made significant headway into verifying theory and modeling studies of intensification processes related to TC vortex alignment,efficient latent heating distributions,and overall 3D *** efforts have also been made to better understand the intricate roles radiative processes play in TC evolution and intensity ***,some promising progress has been made in the development of time-dependent theories of TC intensification and the predictability of internal TC intensity ***,there have been well-earned gains in the understanding of intensity change processes intrinsic to the TC system,but the journey is not *** paper highlights some of the most relevant and important research areas that are still shedding new light into internal fa

关键词： Tropical cyclone Intensity Internal dynamics Boundary-layer processes Observations Predictability

寒带森林中最大冠层高度与群落系统发育结构相关

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Journal of Plant Ecology 2023年第4期16卷 64-77页

作者： Ling-Feng Mao Yu-Ran Dong Bing-Bing Xing You-Hua Chen Jacqueline Dennett christopher Bater john J.Stadt Scott ENielsen Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Department of Renewable Resources University of AlbertaEdmontonAB T6G 2H1Canada Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041China Forest Management Branch Forestry DivisionAlberta Agriculture and ForestryEdmontonAB T5K 2M4Canada

了解最大冠层高度和森林群落构建的关系至关重要,但相关研究较少。最大冠层高度受到不同生态过程(如生态位分化和环境过滤),以及历史和随机因素的影响。然而,对影响冠层最大高度的生态过程的实证研究仍较少。本研究旨在揭示最大冠层高... 详细信息

了解最大冠层高度和森林群落构建的关系至关重要,但相关研究较少。最大冠层高度受到不同生态过程(如生态位分化和环境过滤),以及历史和随机因素的影响。然而,对影响冠层最大高度的生态过程的实证研究仍较少。本研究旨在揭示最大冠层高度与群落系统发育结构之间的关系。首先,我们从一项加拿大阿尔伯塔省东北部北方森林样方调查数据集(466个50 m×50 m的采样点)中调查了最大树冠高度。在此基础上,以净谱系亲缘关系指数(NRI)和净最近种间亲缘关系指数(NTI)表征样方中种子植物的系统发育结构,探讨了机载激光雷达测量的最大冠层高度与群落系统发育结构的关系。研究结果表明,最大冠层高度越高,主要进化分枝间的系统发育越聚集,这说明北方森林中存在非生物因子驱动的环境过滤。然而我们也发现,在每个主要演化分支内部,最大冠层高度更高的群落中系统发育结构更发散,这意味着其生态位分化更强烈。总之,最大冠层高度越高的群落可能经历了更强烈的历史非生物环境过滤和近期的生态位分化。这些发现将有助于森林生物多样性的监测和管理。

关键词：森林群落系统发育结构生态位分化竞争层次结构环境过滤随机过程群落构建

Characterizing Thermal Augmentation of Convection-Enhanced Drug Delivery with the Fiberoptic Microneedle Device

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Engineering 2015年第3期1卷 344-350页

作者： R.Lyle Hood Rudy T.Andriani Tobias E.Ecker john L.Robertson christopher G.Rylander Department of Nanomedicine Houston Methodist Research Institute Department of Mechanical Engineering Virginia Tech School of Biomedical Engineering Virginia Tech Department of Mechanical Engineering University of Texas

Convection-enhanced delivery （CED） is a promising technique leveraging pressure-driven flow to increase penetration of infused drugs into interstitial spaces. We have developed a fiberoptic microneedle device for inducing local sub-lethal hyperthermia to further improve CED drug distribution volumes, and this study seeks to quantitatively characterize this approach in agarose tissue phantoms. Infusions of dye were conducted in 0.6% （w/w） agarose tissue phantoms with isothermal conditions at 15 ℃, 20℃, 25 ℃, and 30 ℃. Infusion metrics were quantified using a custom shadowgraphy setup and image- processing algorithm. These data were used to build an empirical predictive temporal model of distribution volume as a function of phantom temperature. A second set of proof- of-concept experiments was conducted to evaluate a novel fiberoptic device capable of generating local photothermal heating during fluid infusion. The isothermal infusions showed a positive correlation between temperature and distribution volume, with the volume at 30℃ showing a 7-fold increase at 100 min over the 15 ℃ isothermal case. Infusions during photothermal heating （1064 nm at 500 mW） showed a similar effect with a 3.5-fold increase at 4 h over the control （0 mW）. These results and analyses serve to provide insight into and characterization of heat-mediated enhancement of volumetric dispersal.

关键词： near-infrared laser thermochemotherapy agarose photothermal heating micro-catheter malignant glioma

Slice-Selective Transmit Array Pulses for Improvement in Excitation Uniformity and Reduction of SAR

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Journal of Electromagnetic Analysis and Applications 2013年第5期5卷 205-212页

作者： BuSik Park Kyunghyun Sung john McGarrity Suk-hoon Oh Zhipeng Cao Zhangwei Wang christopher M. Collins 1Department of Bioengineering The Pennsylvania State University College of Medicine Hershey USA 2Department of Radiology The Pennsylvania State University College of Medicine Hershey USA 3Department of Radiology Stanford University Stanford USA Department of Bioengineering The Pennsylvania State University College of Medicine Hershey USA GE Healthcare Aurora USA

To overcome challenges of inhomogeneous transmit B1 distribution and high specific energy absorption rate (SAR) in MRI, we compare slice-selective array-optimized composite pulse and RF shimming designed to both improve B1 uniformity and reduce SAR using an 8-channel transmit head array loaded with a head model at various RF pulse excitation times, and compare results with standard quadrature voltage distribution at 3T (128 MHz) and 7T (300 MHz). The excitation uniformity was estimated throughout the 3D brain region and SAR was calculated for the whole head. The optimized composite pulse could produce significantly better homogeneity and significantly better homogeneity when SAR was not constrained, and both significantly better homogeneity and lower SAR when the pulse duration was allowed to be twice that of the quadrature or RF shimmed pulse. When the total pulse durations were constrained to the same length, the relative advantages of the optimized composite pulse for producing better homogeneity and lower SAR simultaneously were diminished. Using the optimization results, the slice-selective composite pulse sequence was implemented on a 3D MRI simulator currently under development, and showed both effective slice selection and improvement in excitation uniformity compared to a conventional quadrature driving method.

关键词： MRI Composite Pulse RF Shimming SAR MRI Simulator

A Risk Coefficient for Radiation-Induced Dementia

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Advances in Alzheimer's Disease 2018年第2期7卷 13-35页

作者： christopher Busby Environmental Research SIA 1117 Latvian Academy of Sciences Riga Latvija

The effect of ionising radiation exposure on dementia is approached by applying the causation models of john Stuart Mill and of Sir Austin Bradford Hill to mechanism and epidemiological evidence. Since ionizing radiation is known to kill brain cells in laboratory culture and to affect hippocampal neurogenesis in animal experiments at modest doses, it is reasonable to assume that exposure to radiation must affect neurological integrity and hence dementia rates in those who are exposed. There is persuasive evidence from the epidemiological studies of a large cohort of female nuclear workers that ionising radiation exposure is associated with significant low dose region dose-dependent increases in rates of dementia. Using results from these studies, the Probability of Causation approach (PC), conventionally employed for assessing cancer risk following radiation exposure, is extended to dementia to find a risk coefficient for all ages of 60 per Sievert cumulative exposure over the range 0-100 mSv. The finding suggests that natural background external exposures to ionizing radiation are partly responsible for the development of dementia in human populations. A simple general model for dementia is proposed.

关键词： Radiation Alzheimer Dementia