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The analysis of composite laminated beams using a 2D interpolating meshless technique

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Acta mechanica Sinica 2018年第1期34卷 99-116页

作者： S.H.m.Sadek j.Belinha m.P.L.Parente R.m.Natal jorge j.m.A.César de Sá a.j.m.ferreira Department of mechanical Engineering Faculty of EngineeringUniversity of Porto Institute of mechanical Engineering and Industrial management University of Porto

Laminated composite materials are widely implemented in several engineering constructions. For its relative light weight, these materials are suitable for aerospace, military, marine, and automotive structural applications. To obtain safe and economical structures, the modelling analysis accuracy is highly relevant. Since meshless methods in the recent years achieved a remarkable progress in computational mechanics, the present work uses one of the most flexible and stable interpolation meshless technique available in the literature—the Radial Point Interpolation method(RPIm).Here, a 2 D approach is considered to numerically analyse composite laminated beams. Both the meshless formulation and the equilibrium equations ruling the studied physical phenomenon are presented with detail. Several benchmark beam examples are studied and the results are compared with exact solutions available in the literature and the results obtained from a commercial finite element software. The results show the efficiency and accuracy of the proposed numeric technique.

关键词： Radial point interpolators RPIm Laminated beam meshless method

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

ENERGY ESTImATES FOR DELAY DIFFUSION-REACTION EQUATIONS

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journal of Computational mathematics 2008年第4期26卷 536-553页

作者： j.A.ferreira P.m.daSilva CmUC-Departamento Departamento

In this paper we consider nonlinear delay diffusion-reaction equations with initial and Dirichlet boundary conditions. The behaviour and the stability of the solution of such initial boundary value problems （IBVPs） are studied using the energy method. Simple numerical methods are considered for the computation of numerical approximations to the solution of the nonlinear IBVPs. Using the discrete energy method we study the stability and convergence of the numerical approximations. Numerical experiments are carried out to illustrate our theoretical results.

关键词： Delay diffusion reaction equation Energy method Stability Convergence.

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Droplet-based bioprinting enables the fabrication of cell–hydrogel–microfibre composite tissue precursors

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Bio-Design and manufacturing 2022年第3期5卷 512-528页

作者： marcin Kotlarz Ana m.ferreira Piergiorgio Gentile Stephen j.Russell Kenneth Dalgarno School of Engineering Newcastle UniversityNewcastle upon Tyne NE17RUUK School of Design University of LeedsLeeds LS29JTUK

Composites offer the option of coupling the individual benefits of their constituents to achieve unique material properties,which can be of extra value in many tissue engineering *** combining hydrogelswith fibre-based scaffolds can create tissue constructs with enhanced biological and structural ***,developing efficient and scalable approaches to manufacture such composites is ***,we use a droplet-based bioprinting system called reactive jet impingement(RejI)to integrate a cell-laden hydrogel with a microfibrous *** system uses microvalves connected to different bioink reservoirs and directed to continuously jet bioink droplets at one another in mid-air,where the droplets react and form a hydrogel that lands on a microfibrous ***–hydrogel–fibre composites are produced by embedding human dermal fibroblasts at two different concentrations(5×10^(6) and 30×10^(6) cells/mL)in a collagen–alginate–fibrin hydrogel matrix and bioprinted onto a fibre-based *** results show that both types of cell–hydrogel–microfibre composite maintain high cell viability and promote cell–cell and cell–biomaterial *** lower fibroblast density triggers cell proliferation,whereas the higher fibroblast density facilitates faster cellular organisation and infiltration into the ***,the fibrous component of the composite is characterised by high swelling properties and the quick release of calcium *** data indicate that the created composite constructs offer an efficient way to create highly functional tissue precursors for laminar tissue engineering,particularly for wound healing and skin tissue engineering applications.

关键词： Bioprinting Hydrogel–fibre composites High-cell-density hydrogels Composite manufacturing

Enhancing production monitoring: A back allocation methodology to estimate well flow rates and assist well test scheduling

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Petroleum Research 2024年第3期9卷 369-379页

作者： G.S.Chaves V.j.m.ferreira Filho Universidade Federal Do Rio de janeiro Brazil

Production flow rates are crucial to make operational decisions,monitor,manage,and optimize oil and gas *** rates also have a financial importance to correctly allocate production to fiscal purposes required by regulatory agencies or to allocate production in fields owned by multiple *** its significance,usually only the total field production is measured in real time,which requires an alternative way to estimate wells'*** address these challenges,this work presents a back allocation methodology that leverages real-time instrumentation,simulations,algorithms,and mathe-matical programming modeling to enhance well monitoring and assist in well test *** methodology comprises four modules:simulation,classification,error calculation,and *** modules work together to characterize the flowline,wellbore,and reservoir,verify simulation outputs,minimize errors,and calculate flow rates while honoring the total platform flow *** well status generated through the classification module provides valuable information about the current condition of each well(*** the well is deviating from the latest well test parameters),aiding in decision-making for well testing scheduling and *** effectiveness of the methodology is demonstrated through its application to a representative offshore oil field with 14 producing wells and two years of daily production *** results highlight the robustness of the methodology in properly classifying the wells and obtaining flow rates that honor the total platform flow ***,the methodology supports well test scheduling and provides reliable indicators for well *** uti-lizing real-time data and advanced modeling techniques,this methodology enhances production monitoring and facilitates informed operational decision-making in the oil and gas industry.

关键词： Production estimation Real-time production Production monitoring Back allocation Well test scheduling Flow rate estimation

A Chopper Negative-R Delta-Sigma ADC for Audio mEmS Sensors

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Computer modeling in Engineering & Sciences 2022年第2期130卷 607-631页

作者： jamel Nebhen Pietro m.ferreira College of Computer Engineering and Sciences Prince Sattam bin Abdulaziz UniversityAlkharj11942Saudi Arabia Universit´e Paris-Saclay Centrale SupelecCNRSLaboratory de G´enie Electrique et Electronique de ParisGif-sur-Yvette91192France Sorbonne Universite CNRSLab.de Genie Electrique et Electronique de ParisParis75252France

This paper presents a proposed low-noise and high-sensitivity Internet of Thing(IoT)system based on an m&NEmS *** IoT device consists of an m&NEmS resistive accelerometer associated with an electronic readout circuit,which is a silicon nanowire and a Continuous-Time(CT)△∑*** first integrator of the△∑ADC is based on a positive feedback DC-gain enhancement two-stage amplifier due to its high linearity and low-noise *** mitigate both the offset and 1/f noise,a suggested delay-time chopper negative-R stabilization technique is applied around the first integrator.A 65-nm CmOS process implements the CT△∑*** supply voltage of the CmOS circuit is 1.2-V while 0.96-mW is the power consumption and 0.1-mm^(2) is the silicon *** m&NEmS microphone and△∑ADC complete circuit are fabricated and *** a working frequency bandwidth of 20-kHz,the measurement results of the proposed IoT system reach a signal to noise ratio(SNR)of ***,it has a measured dynamic range(DR)of 108-dB and a measured signal to noise and distortion ratio(SNDR)of 101.3-dB.

关键词： m&NEmS sensor △∑ ADC chopper negative-R IoT 1/f noise SNR

Spent coffee grounds as a renewable source of energy: An analysis of bulk powder flowability

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Particuology 2019年第2期17卷 92-100页

作者： L. massaro Sousa m.C. ferreira Drying Center for Pastes Suspensions and Seeds. Chemical Engineering Department Federal University of Sao Carlos. P.O. Box 676 13565-905 Sao Carlos Brazil

The main use for spent coffee grounds (SCG) produced in the soluble coffee industry is thermal energy generation in the industry itself. The SCG are processed using operations that are strongly dependent on powder flow behavior. In this study, we evaluated two classical flowability in dices of non-consolidated SCG powders: the angle of repose (AoR), and the Hausner ratio (HR). The influences of the mean particle diameter, particle size distribution (PSD), and water content on the AoR and HR values of SCG were analyzed for powders with a mean particle size range of 225-550 μm. For powders with a mean particle size close to 350 μm and for mixtures containing more than 40% fine particles, the HR (>1.35) and AoR (>45 °) values were characteristic of poor flowability. The AoR was sensitive to the powder PSD, and powders with similar mean particle sizes had higher AoR values when the PSD was larger. For powders w让h water contents up to 50%, the flowability indices were not greatly affected by the water content. A modified linear-mixture packing model was used to predict the packed bed void fractions for binary and ternary mixtures of the three base powders. The model was used to construct a ternary diagram to estimate the HR values of the mixtures. An equation was fitted to correlate HR and AoR. The proposed diagram and the equation provide insight into flow behavior and could be used for process design of industrial plants that handle SCG.

关键词： Spent coffee ground Biomass Flowability Hausner ratio Angle of repose