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Hepatoprotective effects of S-adenosyl-L-methionine against alcohol-and cytochrome P450 2E1-induced liver injury

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World Journal of Gastroenterology 2010年第11期16卷 1366-1376页

作者： Arthur i Cederbaum Department of Pharmacology and Systems Therapeutics Box 1603 Mount Sinai School of Medicine One Gustave Levy Place

S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection.

关键词： Cytochrome P450 2E1 S-adenosyl-L-methionine Ethanol Toxic hepatitis Oxidative stress

Characterization of Arithmetic Functions that Preserve the Sum-of-squares Operation

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Acta Mathematica Sinica,English Series 2014年第4期30卷 689-695页

作者： Bojan BAi Department of Mathematics and informatics University of Novi Sad

We characterize all functions f ： N → C such that f（m^2 ＋ n^2） = f（m）^2 ＋ f（n）^2 for all m, n ∈ N. it turns out that all such functions can be grouped into three families, namely f ≡ 0, f（n） = ±n （subject to some restrictions on when the choice of the sign is possible） and f（n） =±l/2（again subject to some restrictions on when the choice of the sign is possible）.

关键词： Arithmetic function functional equation sum of squares

Effect of the high-power electromagnetic pulses on the reactivity of the coal-water slurry in hot environment

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Chinese Journal of Chemical Engineering 2020年第12期28卷 3145-3151页

作者： M.V.Belonogov R.i.Taburchinov R.i.Egorov National Research Tomsk Polytechnic University TomskRussian Federation

An effect of the high-power electromagnetic pulses onto the droplet of coal-water slurry inside the furnace was *** contrary to the previously investigated laser-induced fuel atomization that occurs at the room temperature,the pre-heated(to 400 K)slurry becomes dry enough to prevent the explosion-like steam ***,fuel does not atomize and the ignition does not ***,the absorption of several laser pulses leads to evident sintering of irradiated surface with following increase of the ignition delay time for up to 24%.Variation of the pulse energy in range 48-118 mJ(corresponding intensity up to 2.4 J·cm^-2)leads to certain variation of the increase of ignition *** strong pulsed overheating of the coal water slurry which does not initiate the fine atomization of the fuel generally makes its ignition longer.

关键词： Waste-derived fuels Coal-water slurry Auto-ignition ignition delay time High-power laser pulse

Host-guest complexes of cucubit[8]uril with phenanthrolines and some methyl derivatives

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Science China Chemistry 2005年第4期48卷 305-314页

作者： DAY Anthony i Chemistry Discipline School of Physical Environmental and Mathematical SciencesUniversity College UNSWAustralian Defence Force AcademyCanberraACT2600 Australia

The host-guest relationship between cucurbit[8]uril,phenanthrolines and some methyl substituted 1,10-phenanthrolines has been investigated by using 1H NMR spectroscopy and fluorescence *** results showed that phenanthrolines as molecular guests bind in the cavity and portal of cucurbit[8]uril in a ratio of 2:1 (guest to host).The phenanthroline isomers 1,10-,1,7-and 4,7-showed red shifts between 47 and 108 nm and pronounced in-creases in fluorescent *** same isomers produced inclusion complexes with cucur-bit[8]uril which had moderate to fast exchange rates on the 1H NMR time *** methyl substituted 1,10-phenanthrolines studied gave stable inclusion complexes in a ratio of 2:1 which showed slow exchange *** guests formed p-p stacked pairs which were cavity bound but also partly protruded from only one portal forming unsymmetrical host-guest *** addition,these p-p stacked pairs formed orientation isomers within the confines of the cucur-bit[8]uril cavity.

关键词： 1H NMR technique, fluorescence, cucurbituril, phenanthroline, host-guest, orientation isomers.

A precise monitoring of snow surface height in the region of Lambert Glacier basin-Amery ice Shelf,East Antarctica

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Science China Earth Sciences 2005年第1期48卷 100-111页

作者： i.Allison Australian Antarctic Division and Antarctic Climate and Ecosystems CRC

The net surface snow accumulation on the Antarctic ice sheet is determined by a combination of precipitation, sublimation and wind redistribution. We present a one-year record of hourly snow-height measurements at LGB69 (70°50'S, 77°04'E, 1850 m a.s.l.). east side of Lambert Glacier basin (LGB), and 4 year record at G3 (70°53'S, 69°52'E, 84 m a.s.l.), Amery ice Shelf (AiS). The measurements were made with ultrasonic sensors mounted on automatic weather stations installed at two sites. The snow accumulation at LGB69 is approximately 70 cm. Throughout the winter, between April and September, there was little change in surface snow height (SSH) at the two sites. The negative SSH change is due to densification at LGB69, and is due to both ablation and densification at G3. The strongest accumulation at two sites occurred during the period between October and March (accounting for 101.6% at LGB69), with four episodic increasing events occurring during 2002 for LGB69, and eight events during 1999-2002 for G3 (2 to 3 events per year). At LGB69, these episodic events coincided with obvious humidity 'pulses' and decreases of incoming solar radiation as recorded by the AWS. Observations of the total cloud amount at Davis station, 160 km NNE of LGB69, showed good correlation with major accumulation events recorded at LGB69. There was an obvious anti-correlation between the lowest cloud height at Davis and the daily accumulation rate at LGB69. Although there was no correlation over the total year between wind speed and accumulation at LGB69, large individual accumulation events are associated with episodes of strong wind (>7 m/s), we estimate drift snow may contribute to total SSH up to 35%. Strong accumulation events at LGB69 are associated with major storms in the region and inland transport of moist air masses from the coast.

关键词： Antarctica, Lambert Glacier basin, Amery ice Shelf, accumulation, katabatic wind.

Single and multi domain buckled germanene phases on Al(111)surface

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Nano Research 2019年第12期12卷 2988-2996页

作者： Dmitriy A.Muzychenko Sergey i.Oreshkin Vladimir i.Panov Chris Van Haesendonck Andrey i.Oreshkin Faculty of Physics Lomonosov Moscow State University119991 MoscowRussia Sternberg Astronomical institute Lomonosov Moscow State University119234 MoscowRussia Solid-State Physics and Magnetism Section KU LeuvenBE-3001 LeuvenBelgium

The simultaneous formati on of single domain(3×3)and multi domai n(√7×√7)R(±19.1°)germa nene phases on Al(111)surface in thesub-monolayer range was studied using seanning tunneling microscopy(STM)and density functional theory(DFT)based *** results revealed that both germa nene phases nu cleate and grow in dependently from each other and regardless of Al substratetemperature within significantly expanded range Ts=27-200℃.Our results unambiguously showed that STM images with hexagonalcontrast yield correct-resolved structure for both germanene phases,while honeycomb contrast is a result of an artificial tip-induced STM ***-principles calculations suggested atomic models with strongly buckled germanene(2×2)/Al(111)(3×3)and(√3×√3)R30°/Al(111)(√7×√7)R(±19.1°)with one of eight and one of six Ge atoms protruding upward respectively,that consistently describe the experimentally observed STM images both for single and multi domai n surface *** to the DFT based simulati ons both germa nene(2×2)and(√3×√3)R30°superstructures have a stretched lattice strain with respect to the ideal free-standing germa nene by 6.2%and 13.9%,***,numerous small domains separated by domain boundaries in the(√3×√3)R30°/Al(111)(√7×√7)R(±19.1°)germanenephase tend to reduce the surface energy and prevent the formation of extended single domains,in contrast to the(2×2)/Al(111)(3×3)***,our experimental results showed that the nucleation and growth of germa nene on Al(111)surface yield strong modifications of Alsurface even at room temperature(RT),which may be contributed to the formation of Al-Ge alloy due to Ge surface solid-states reactivitythat was ignored in recent *** is already evident from our present findings that the role of Al atoms in the formation of(3×3)and(√7×√7)R(±19.1°)germa nene phases is worthy to be carefully studied in the future,which could be an important knowledge for large-quantityfabrication of germane

关键词： germanene two-dimensional(2D)materials scanning tunneling microscopy density functional theory aluminum

On Evaluation of Overlap integrals with Noninteger Principal Quantum Numbers

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Communications in Theoretical Physics 2004年第5X期42卷 753-756页

作者： i.i.Guseinov B.A.Mamedov DepartmentofPhysics FacultyofArtsandSciencesOnsekizMartUniversityCanakkaleTurkey DepartmentofPhysics FacultyofArtsandSciencesGaziosmanpasaUniversityTokatTurkey

By use of complete orthonormal sets of ψα exponential-type orbitals (ψα-ETOs, α = 1, 0,-1,-2, ...) the series expansion formulas for the noninteger n* Slater-type orbitals (NiSTOs) in terms of integer n Slater-type orbitals(iSTOs) are derived. These formulas enable us to express the overlap integrals with NiSTOs through the overlap integrals over iSTOs with the same and different screening constants. By calculating concrete cases the convergence of the series for arbitrary values of noninteger principal quantum numbers and screening constants of NiSTOs and internuclear distances is tested. The accuracy of the results is quite high for quantum numbers, screening constants and location of STOs.

关键词：指数轨道游标量子数迭代积分 NiSTOS 原子核

Simulation of detection and scattering of sound waves by the lateral line of a fish

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Chinese Physics B 2022年第2期31卷 398-404页

作者： V M Adamyan i Y Popov i V Blinova V V Zavalniuk Odessa i.i.Mechnikov National University Dvoryanskaya Str.2Odesa65082Ukraine iTMO University Kronverkskiy49Saint Petersburg197101Russia Odessa Military Academy 10 Fontanska RoadOdesa 65009Ukraine

A solvable model of lateral line of a fish based on a wave equation with additional boundary conditions on a set of isolated points is *** the framework of this model it is shown that the ratio of pressures on lateral lines on different fish flanks,as well as the cross section of sound scattering on both the lines,strongly depends on angles of incidence of incoming sound *** strong angular dependence of the pressure ratio seems to be sufficient for the fish to determine the directions from which the sound is coming.

关键词： acoustic equation point self-adjoint perturbations of Laplace operator scattering lateral line

Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2012年第30期18卷 3945-3954页

作者： Neven Bari ivan Leroti Lea Smiri-Duvnjak Vedran Tomai Marko Duvnjak Division of Gastroenterology and Hepatology Department of Medicine"Sestre milosrdnice" University Hospital Center10000 ZagrebCroatia Vuk Vrhovac University Clinic for Diabetes Endocrinology and Metabolic Diseases10000 ZagrebCroatia

High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology *** methods have been investigated in the recent years,including imaging methods like ultrasound and magnetic resonance imaging,different forms of liver stiffness measurement,various biomarkers of necroinflammatory processes (acute phase reactants,cytokines,markers of apoptosis),hyaluronic acid and other biomarkers of liver *** tests,scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis *** all of the cases,performance of noninvasive methods was compared with liver biopsy,which is still considered to be a gold standard in diagnosis,but is by itself far from a perfect comparative *** present here the overview of the published data on various noninvasive diagnostic tools,some of which appear to be very promising,and we address as well some of still unresolved issues in this interesting field.

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Liver biopsy Biomarkers Transient elastography Cytokeratin-18 Oxidative stress insulin resistance Hyaluronic acid