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Ballistic response of armour plates using Generative Adversarial Networks

Defence Technology（防务技术） 2022年第9期18卷 1513-1522页

作者： S.Thompson F.Teixeira-Dias M.Paulino a.hamilton Institute for Infrastructure and Environment(IIE) School of EngineeringThe University of Edinburgh Alexander Graham Bell BuildingThe King's BuildingsEdinburghEH93FGUnited Kingdom School of Engineering Faculty of ScienceEngineering and Built EnvironmentDeakin University Waurn PondsVictoria3220Australia Data Science and AI EngineeringGroup Chief Information O CeLloyds Banking Group69 Morrison StEdinburghEH38BWUnited Kingdom

It is important to understand how ballistic materials respond to impact from projectiles such that informed decisions can be made in the design process of protective armour systems. Ballistic testing is a standards-based process where materials are tested to determine whether they meet protection, safety and performance criteria. For the V50ballistic test, projectiles are fired at different velocities to determine a key design parameter known as the ballistic limit velocity(BLV), the velocity above which projectiles perforate the target. These tests, however, are destructive by nature and as such there can be considerable associated costs, especially when studying complex armour materials and systems. This study proposes a unique solution to the problem using a recent class of machine learning system known as the Generative Adversarial Network(GAN). The GAN can be used to generate new ballistic samples as opposed to performing additional destructive experiments. A GAN network architecture is tested and trained on three different ballistic data sets, and their performance is compared. The trained networks were able to successfully produce ballistic curves with an overall RMSE of between 10 and 20 % and predicted the V50BLV in each case with an error of less than 5 %. The results demonstrate that it is possible to train generative networks on a limited number of ballistic samples and use the trained network to generate many new samples representative of the data that it was trained on. The paper spotlights the benefits that generative networks can bring to ballistic applications and provides an alternative to expensive testing during the early stages of the design process.

关键词： Machine learning Generative Adversarial Networks GAN Terminal ballistics Armour systems

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A Historical Perspective on Development of Systems Engineering Discipline:A Review and Analysis

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Journal of Systems Science and Systems Engineering 2020年第1期29卷 1-35页

作者： Niamat Ullah Ibne Hossain Raed M.Jaradat Michael a.hamilton Charles B.Keating Simon R.Goerger Department of Industrial and Systems Engineering Mississippi State UniversityPO Box 9542Mississippi State 39762USA Department of Industrial and Systems Engineering Mississippi State UniversityPO Box 9542Mississippi State39762USA Institute for Systems Engineering Research(ISER) Mississippi State University 3909 Halls Ferry RdVicksburgMS 39180 Department of Engineering Management&Systems Engineering Old Dominion UniversityNorfolkVA 23529 eInstitute for Systems Engineering Research(ISER) U.S Army Engineer Research Development Center(ERDC)3909 Halls Ferry RdVicksburgMS 39180

Since its inception,Systems Engineering(SE)has developed as a distinctive discipline,and there has been significant progress in this field in the past two *** to other engineering disciplines,SE is not affirmed by a set of underlying fundamental propositions,instead it has emerged as a set of best practices to deal with intricacies stemming from the stochastic nature of engineering complex systems and addressing their *** the existing methodologies and paradigms(dominant patterns of thought and concepts)of SE are very diverse and somewhat *** appears to create some confusion regarding the design,deployment,operation,and application of *** purpose of this paper is 1)to delineate the development of SE from 1926-2017 based on insights derived from a histogram analysis,2)to discuss the different paradigms and school of thoughts related to SE,3)to derive a set of fundamental attributes of SE using advanced coding techniques and analysis,and 4)to present a newly developed instrument that could assess the performance of systems *** than Two hundred and fifty different sources have been reviewed in this research in order to demonstrate the development trajectory of the SE discipline based on the frequency of publication.

关键词： Systems Engineering(SE) history development systems engineering attributes performance measures

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New U-Pb Ages for Mafic Dykes of SE Greenland

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 81-82页

作者： Mimmi K.M.NILSSON Michael a.hamilton Department of Geology Lund University Department of Earth Sciences University of Toronto

The North Atlantic Craton(NAC)represents one of approximately three dozen preserved Archean cratonic fragments now dispersed globally,but its affinity to formerly neighboring supercontinent cratonic blocks

关键词： Pb New U-Pb Ages for Mafic Dykes of SE Greenland SE

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Minto Large Igneous Province: A 2.00 Ga Mafic Magmatic Event in the Eastern Superior Craton Based on U-Pb Baddeleyite Geochronology and Paleomagnetism

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 69-70页

作者： Michael a.hamilton Jean GOUTIER Kenneth L.BUCHAN Jack Satterly Geochronology Lab Dept.of Earth Sciences University of Toronto Géologie Québec - Ministère de l'énergie et des Ressources naturelles Geological Survey of Canada

A precise U-Pb baddeleyite age of 1999±2 Ma has been obtained for the NNW trending Lac Shpogan dyke swarm of the James Bay area of the eastern Superior *** the age of the swarm was only

关键词： Pb A 2.00 Ga Mafic Magmatic Event in the Eastern Superior Craton Based on U-Pb Baddeleyite Geochronology and Paleomagnetism Minto Large Igneous Province Bay Ga

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Key Dolerite Dyke Swarms of Amazonia:U-Pb Constraints on Supercontinent Cycles and Geodynamic Connections with Global LIP Events Through Time

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 84-85页

作者： Wilson TEIXEIRA Mike a.hamilton Vicente A.V.GIRARDI Frederico M.FALEIROS University of Sao Paulo Institute of Geosciences Jack Satterly Geochronology Laboratory Department of Earth SciencesUniversity of Toronto

High-resolution U–Pb(ID-TIMS,baddeleyite)ages are presented for mafic dykes from selected swarms in two important Amazonian regions:the Carajás Province in the east,and the Rio Apa block in the southwest–areas

关键词： Pb U-Pb Constraints on Supercontinent Cycles and Geodynamic Connections with Global LIP Events Through Time Key Dolerite Dyke Swarms of Amazonia LIP

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Assessment of the efficacy of an advanced tertiary sewage treatment plant to remove biologically active chemicals using endocrine and genotoxicity bioassays

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Emerging Contaminants 2021年第1期7卷 124-131页

作者： Lisa a.hamilton Fujio Shiraishi Daisuke Nakajima Michael Boake Richard P.Lim Olivier Champeau Louis A.Tremblay School of Life Sciences Faculty of ScienceUniversity of TechnologySydney(UTS)PO Box 123BroadwayNSW2007Australia National Institute for Environmental Studies 16-2 OnogawaTsukubaIbaraki305-8506Japan Veolia Water Australia Level 4Bay Centre65 Pirrama RoadPyrmontNSW2009Australia Cawthron Institute Private Bag 2Nelson7042New Zealand School of Biological Sciences University of AucklandPrivate Bag 92019Auckland1142New Zealand

There has been much effort to assess the efficacy of sewage treatment plants to remove chemicals with estrogenic activity,but other modes of toxicity have received less *** study assessed the efficacy of advanced tertiary technologies to remove estrogen receptor(ER),aryl hydrocarbon receptor(AhR),retinoic receptor(RAR)agonists and genotoxicity using recombinant gene *** sewage contained ER,AhR and RAR agonists and was *** sludge treatment removed over 69%of the ER,AhR and RAR aqueous phase *** and biologically activated carbon processes removed genotoxicity and most receptor agonists to below detection *** activity was associated with the semi-polar fraction of the aqueous phase and non-polar phase of the influent(maximum 30%).AhR and RAR activities were found in both the aqueous and particulate phases of *** RAR activity was frequently found in the polar fraction of aqueous and particulate phases of the process *** the influent,the greatest RAR activity was found in the polar fraction of the aqueous phase(>65%).Genotoxic activity was detected in all influent fractions but rapidly *** results showed that ER,AhR and RAR agonists were greatly reduced by the advanced tertiary treatment processes.

关键词： Yeast two-hybrid Analytical chemistry Estrogens Aryl hydrocarbon receptor Retinoic receptor umu genotoxicity bioassay Australia

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Mafic Dyke Swarms: Their Temporality and Bearing on the Secular Evolution of the Earth

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 12-页

作者： Michael a.hamilton Jack Satterly Geochronology Lab Dept.of Earth Sciences University of Toronto

Pioneering U-Pb isotopic studies by a small group of workers in the mid-late 1980s demonstrated the feasibility of using rare accessory mineral chronometers in mafic(gabbroic)intrusive *** examples showed that mafic l... 详细信息

关键词： Mafic Dyke Swarms Their Temporality and Bearing on the Secular Evolution of the Earth

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Age and Geochemical Characteristics of Major Mafic Dyke Swarms in the Southern Part of the Siberian Craton

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 125-126页

作者： Tatiana V.DONSKAYA Dmitry P.GLADKOCHUB Richard E.ERNST Sergei A.PISAREVSKY Anatoliy M.MAZUKABZOV Ulf SODERLUND Michael T.D.WINGATE Michael a.hamilton Elena I.DEMONTEROVA Institute of the Earth’s Crust Siberian Branch of the Russian Academy of Sciences Department of Earth Sciences Carleton University Faculty of Geology and Geography Tomsk State University Australian Research Council Centre of Excellence for Core to Crust Fluid Systems(CCFS)and the Institute for Geoscience Research(TIGe R) Department of Applied GeologyCurtin University School of Earth and Environment University of Western Australia GeoB iosphere Science Centre Department of GeologyUniversity of Lund Geological Survey of Western Australia Department of Earth Sciences University of Toronto

Several generations of mafic dyke swarms of different ages and geochemical characteristics cut Precambrian rocks of the southern part of the Siberian craton(Irkutsk Promontory).Each generation of dykes is related to a

关键词： Age and Geochemical Characteristics of Major Mafic Dyke Swarms in the Southern Part of the Siberian Craton ppm

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Targeting KRAS in pancreatic cancer

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Oncology Research 2024年第5期32卷 799-805页

作者： SANDRA STICKLER BARBARA RATH GERHARD hamilton Institute of Pharmacology Medical University of ViennaViennaA-1090Austria

Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient *** Kirsten rat sarcoma virus(KRAS)oncogene is mutated in up to 90%of all pancreatic ductal adenocarcinomas(PDACs)and constitutes an attractive target for ***,the most common KRAS mutations in PDAC are G12D(44%),G12V(34%)and G12R(20%)that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung *** G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is detected only in 2%–3%of ***,the KRAS G12D-directed MRTX1133 inhibitor has entered clinical trials and more of such inhibitors are in *** other KRAS mutations may be targeted indirectly via inhibition of the cognate guanosine exchange factor(GEF)Son of Sevenless 1 that drives *** agents seem to provide the means to target the most frequent KRAS mutations in PDAC and to improve patient outcomes.

关键词： Pancreatic cancer PDAC KRAS SOS1 PROTAC

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Development of PROTACS degrading KRAS and SOS1

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Oncology Research 2024年第8期32卷 1257-1264页

作者： GERHARD hamilton MARIE-THERESE EGGERSTORFER SANDRA STICKLER Institute of Pharmacology Medical University of ViennaVienna1090Austria

The Kirsten rat sarcoma virus—son of sevenless 1(KRAS-SOS1)axis drives tumor growth preferentially in pancreatic,colon,and lung ***,KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of ***,the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%,lasting for a mean period of 8 *** approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras(PROTACs),which degrade the proteins of interest and exhibit much higher antitumor activity through multiple cycles of ***,PROTACs have been developed based on KRAS-or SOS1-directed inhibitors coupled to either von Hippel-Lindau(VHL)or Cereblon(CRBN)ligands that invoke the proteasomal *** of these PROTACs show increased activity in vitro and in vivo compared to their cognate inhibitors but their toxicity in normal tissues is not *** CRBN PROTACs containing thalidomide derivatives cannot be tested in experimental *** to such PROTACS arises through downregulation or inactivation of CRBN or factors of the functional VHL E3 ubiquitin *** highly active KRAS and SOS1 PROTACs have been formulated their clinical application remains difficult.

关键词： Proteolysis-targeting chimeras(PROTACs) Kirsten rat sarcoma virus(KRAS) Son of sevenless 1(SOS1) Von Hippel-Lindau Cereblon

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