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Strategies for translating proteomics discoveries into drug discovery for dementia

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Neural Regeneration Research 2024年第1期19卷 132-139页

作者： Aditi halder Eleanor Drummond School of Medical Sciences and Brain&Mind Center University of SydneyNSWSydneyAustralia Department of Aged Care Prince of Wales HospitalSydneyNSWAustralia

Tauopathies,diseases characterized by neuropathological aggregates of tau including Alzheimer's disease and subtypes of fro ntotemporal dementia,make up the vast majority of dementia *** there have been recent developments in tauopathy biomarkers and disease-modifying treatments,ongoing progress is required to ensure these are effective,economical,and accessible for the globally ageing *** such,continued identification of new potential drug targets and biomarkers is critical."Big data"studies,such as proteomics,can generate information on thousands of possible new targets for dementia diagnostics and therapeutics,but currently remain underutilized due to the lack of a clear process by which targets are selected for future drug *** this review,we discuss current tauopathy biomarkers and therapeutics,and highlight areas in need of improvement,particularly when addressing the needs of frail,comorbid and cognitively impaired *** highlight biomarkers which have been developed from proteomic data,and outline possible future directions in this *** propose new criteria by which potential targets in proteomics studies can be objectively ranked as favorable for drug development,and demonstrate its application to our group's recent tau interactome dataset as an example.

关键词： Alzheimer's disease biomarkers drug development drug discovery druggability frontotemporal dementia interactome proteomics tau tauopathies therapeutics

Mode-locked 2 μm fiber laser with a multi-walled carbon nanotube as a saturable absorber

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Chinese Optics Letters 2015年第3期13卷 10-13页

作者： S.M.Azooz F.Ahmad H.Ahmad S.W.Harun B.A.Hamida S.Khan a.halder M.C.Paul M.Pal S.K.Bhadra Department of Electrical Engineering Faculty of Engineering University of Malaya Photonics Research Center University of Malaya Department of Electrical and Computer Engineering International Islamic University MalaysiaJalan Gombak Fiber Optics and Photonics Division Central Glass & Ceramic Research InstituteCSIR

We propose and demonstrate a passively mode-locked fiber laser operating at 1951.8 nm using a commercial thulium-doped fiber （TDF） laser, a homemade double-clad thulium-ytterbium co-doped fiber （TYDF） as the gain media, and a multi-walled carbon nanotube （MWCNT） based saturable absorber （SA）. We prepare the MWCNT composite by mixing a homogeneous solution of MWCNTs with a diluted polyvinyl alcohol （PVA） polymer solution and then drying it at room temperature to form a film. The film is placed between two fiber connectors as a SA before it is integrated into a laser ring cavity. The cavity consists of a 2 m long TDF pumped by a 800 nm laser diode and a 15 m long homemade TYDF pumped by a 905 nm multimode laser diode. A stable mode-locking pulse with a repetition rate of 34.6 MHz and a pulse width of 10.79 ps is obtained when the 905 nm multimode pump power reaches 1.8-2.2 W, while the single-mode 800 nm pump power is fixed at 141.5 mW at all times. To the best of our knowledge, this is the first reported mode-locked fiber laser using a MWCNT-based SA.

关键词： MWCNTs mode Mode-locked 2 m fiber laser with a multi-walled carbon nanotube as a saturable absorber

Self-starting harmonic mode-locked Tm-Bi co-doped germanate f iber laser with carbon nanotube-based saturable absorber

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Chinese Optics Letters 2013年第6期11卷 81-83页

作者： N.Saidin D.I.M.Zen S.S.A.Damanhuri S.W.Harun H.Ahmad F.Ahmad K.Dimyati a.halder M.C.Paul M.Pal S.K.Bhadra Photonics Research Centre University of Malaya50603 Kuala LumpurMalaysia Department of Electrical Engineering Faculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Department of Electrical and Electronic Engineering National Defense University of MalaysiaKem Sungai Besi57000 Kuala LumpurMalaysia Fiber Optics and Photonics Division Central Glass and Ceramic Research InstituteCSIRKolkataIndia

We report a ring cavity passively harmonic mode-locked fiber laser using a newly developed thulium- bismuth co-doped fiber （TBF） as a gain medium in conjunction with a carbon nanotube （CNT）-based saturable absorber. The TBF laser generates a third harmonic mode-locked soliton pulse train with a high repetition rate of 50 MHz and a pulse duration of 1.86 ps. The laser operates at 1 901.6 nm with an average power of 6.6 mW, corresponding to a pulse energy of 0.132 nJ, at a 1 552 nm pump power of 723.3 roW.

关键词： mode Self-starting harmonic mode-locked Tm-Bi co-doped germanate f iber laser with carbon nanotube-based saturable absorber CNT Tm Bi

High Amounts of Halogenated Natural Products in Sperm Whales(Physeter macrocephalus)from Two Italian Regions in the Mediterranean Sea

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Environment & Health 2024年第4期2卷 233-242页

作者： Sina Schweizer Kristin halder Annika Schafer Jakob Hauns Letizia Marsili Sandro Mazzariol Maria Cristina Fossi Juan Muñoz-Arnanz Begoña Jiménez Walter Vetter Institute of Food Chemistry Department of Food Chemistry(170b)University of Hohenheim70599 StuttgartGermany European Union Reference Laboratory(EURL)for Halogenated POPs in Feed and Food 79114 FreiburgGermany Department of Environmental Earth and Physical SciencesUniversity of Siena53100 SienaItaly Department of Public Health Comparative Pathology and Veterinary HygieneUniversity of Padova35020 LegnaroItaly Department of Instrumental Analysis and Environmental Chemistry Institute of Organic Chemistry(IQOG-CSIC)28006 MadridSpain

Halogenated natural products(HNPs)are considered to be emerging contaminants whose environmental distribution and fate are only incompletely ***,several persistent and bioaccumulative HNP groups,together with manmade polychlorinated biphenyls(PCBs)and polybrominated diphenyl ethers(PBDEs),were quantified in the blubber of nine sperm whales(Physeter macrocephalus)stranded on the coast of the Mediterranean Sea in *** naturally occurring polybrominated hexahydroxanthene derivatives(PBHDs;sum of TetraBHD and TriBHD)were the most prominent substance class with up to 77,000 ng/g *** mean PBHD content(35,800 ng/g blubber)even exceeded the one of PCBs(28,400 ng/g blubber),although the region is known to be highly contaminated with manmade *** on mean values,Q1∼PBDEs>MeO-BDEs∼2,2′-diMeO-BB 80 and several other HNPs followed with decreasing *** blubber samples contained an abundant compound whose molecular formula(C_(16)H_(19)Br_(3)O_(2))was verified using high-resolution mass *** only plausible matching isomer was(2S,4′S,9R,9′S)-2,7-dibromo-4′-bromomethyl-1,1-dimethyl-2,3,4,4′,9,9′-9,9′-hexahydro-1H-xanthen-9-ol(OH-TriBHD),a hydroxylated secondary metabolite previously detected together with TriBHD and TetraBHD in a sponge known to be a natural producer of *** estimated mean amount of the presumed OH-TriBHD was 3000 ng/g blubber,which is unexpectedly high for hydroxylated compounds in the lipids of marine mammals.

关键词： Halogenated natural product naturally occurring polyhalogenated compound persistent organic pollutant sperm whale Italy polar metabolite

A Critical Review of Community Resilience Building Framework: Contexts of Climate Change and Disasters in Bangladesh

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Journal of Geoscience and Environment Protection 2024年第9期12卷 315-334页

作者： Abdul Alim Shaikh Mousumi halder Muhammad Ramzan Ali Ruhul Amin Md Saifur Rahman Md. Kamruzzaman Khulna University Khulna Bangladesh Climate Change Program Christian Commission for Development in Bangladesh (CCDB) Dhaka Bangladesh International Rescue Committee-UK Coxs Bazar Bangladesh Tropical and International Forestry Technical University Dresden Cotta Bau Pienner Strae 7 01737 Tharandt Germany Forestry and Wood Technology Discipline Khulna University Khulna Bangladesh

The concept of community resilience in the contexts of climate change and disasters draws increasing attention and interest from practitioners and researchers in recent development discourse. This paper provides a critical review of six selected frameworks of community resilience building operationalized in Bangladesh over the span of years. In other words, this study aims to contribute to the understanding of resilience through a systematic analysis of the dimensions and indicators of community resilience frameworks. The analysis shows that comprehensive and effective community resilience frameworks should incorporate the missing components linked to fundamental elements of good governance, economic growth, environmental sustainability, social transformation, and capacity development. The paper concludes by highlighting a few other areas of grave concern that need more appropriate attention, considering the severe threats posed by climate change and natural disasters in line with sustainable development goals. Finally, this study recommends further research regarding the effectiveness of these frameworks in different climatic and disaster contexts that can lead the concept into a new dimension of community resilience and sustainability.

关键词： Community Resilience Resilience Building Framework Resilience Indicators Climate Change Disaster Bangladesh

Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

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World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip Kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande Rana Rathor Roy Debopriyo Mondal Ashesh halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

Heat Transfer and Thermal Characteristics Effects on Moving Plate Impinging from Cu-Water Nanofluid Jet

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Journal of Thermal Science 2020年第1期29卷 182-193页

作者： DATTA Abanti KUMAR Sonal halder Pabitra Department of Aerospace Engineering and Applied Mechanics Indian Institute of Engineering Science and Technology

The present article is focused on modelling of flow and heat transfer behaviour of Cu-water nanofluid in a confined slot jet impingement on hot moving *** parameters such as various moving plate velocities,nanoparticles at various concentrations,variation in turbulent Reynolds number and jet nozzle to plate distance have been considered to study the flow field and convective heat transfer performance of the *** of distribution of local and average Nusselt number and skin friction coefficients at the plate surface are shown to elucidate the heat transfer and fluid flow *** analysis of both stream function and isotherm contours are carried out to perceive the flow pattern and heat transfer mechanism due to moving *** results revealed that average Nusselt number significantly rises with plate velocity in addition with jet inlet Reynolds *** of the average Nusselt numbers are presented.

关键词： Cu-water nanofluid,multiphase mixture model moving plate jet impingement CFD

Nonequilibrium Phase Transition in Spin-S Ising Ferromagnet Driven by Propagating and Standing Magnetic Field Wave

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Communications in Theoretical Physics 2017年第11期67卷 600-610页

作者： Ajay halder Muktish Acharyya Department of Physics Presidency University

The dynamical response of spin-S(S=1, 3/2, 2, 3) Ising ferromagnet to the plane propagating wave, standing magnetic field wave and uniformly oscillating field with constant frequency are studied separately in two dimensions by extensive Monte Carlo simulation. Depending upon the strength of the magnetic field and the value of the spin state of the Ising spin lattice two different dynamical phases are observed. For a fixed value of S and the amplitude of the propagating magnetic field wave the system undergoes a dynamical phase transition from propagating phase to pinned phase as the temperature of the system is cooled down. Similarly in case with standing magnetic wave the system undergoes dynamical phase transition from high temperature phase where spins oscillate coherently in alternate bands of half wavelength of the standing magnetic wave to the low temperature pinned or spin frozen phase. For a fixed value of the amplitude of magnetic field oscillation the transition temperature is observed to decrease to a limiting value as the value of spin S is increased. The time averaged magnetisation over a full cycle of the magnetic field oscillation plays the role of the dynamic order parameter. A comprehensive phase boundary is drawn in the plane of magnetic field amplitude and dynamic transition temperature. It is found that the phase boundary shrinks inwards for high value of spin state *** in the low temperature(and high field) region the phase boundaries are closely spaced.

关键词： Ising model dynamic phase transition Monte-Carlo algorithm propagating wave standing wave

Robust Nonlinear Analytic Redundancy for Fault Detection and Isolation in Mobile Robot

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International Journal of Automation and computing 2007年第2期4卷 177-182页

作者： Bibhrajit halder Nilanjan Sarkar Department of Mechanical Engineering Vanderbilt UniversityNashvilleTN-37212USA

A robust nonlinear analytical redundancy （RNLAR） technique is presented to detect and isolate actuator and sensor faults in a mobile robot. Both model-plant-mismatch （MPM） and process disturbance are considered during fault detection. The RNLAR is used to design primary residual vectors （PRV）, which are highly sensitive to the faults and less sensitive to MPM and process disturbance, for sensor and actuator fault detection. The PRVs are then transformed into a set of structured residual vectors （SRV） for fault isolation. Experimental results on a Pioneer 3-DX mobile robot are presented to justify the effectiveness of the RNLAR scheme.

关键词： Fault detection fault isolation nonlinear systems robustness uncertainty.