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Advancements in medical treatment for pancreatic neuroendocrine tumors:A beacon of hope

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World Journal of Gastroenterology 2024年第12期30卷 1670-1675页

作者： Somdatta.giri Jayaprakash Sahoo Department of Endocrinology and Metabolism Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry605006India

This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific *** surgery and somatostatin analogs(SSAs)play pivotal roles in managing tumors,while palliative options such as molecular targeted therapy,peptide receptor radionuclide therapy,and chemotherapy are reserved for SSA-refractory ***,insul-inomas,glucagonomas,carcinoid tumors and VIPomas necessitate distinct thera-peutic *** the genetic basis of pan-NETs and exploring immunotherapies could lead to promising avenues for future *** review underscores the evolving landscape of pan-NET treatment,offering renewed hope and improved outcomes for patients facing this complex disease.

关键词： Pancreatic neuroendocrine tumor Medical management Somatostatin analog Immunotherapy Everolimus

Tuning the crystallinity of titanium nitride on copper-embedded carbon nanofiber interlayers for accelerated electrochemical kinetics in lithium-sulfur batteries

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Carbon Energy 2024年第6期6卷 40-55页

作者： Yinyu Xiang Liqiang Lu Feng Yan Debarun Sengupta Petra Rudolf Ajay giri Prakash Kottapalli Yutao Pei Advanced Production Engineering Engineering and Technology Institute GroningenUniversity of GroningenGroningenThe Netherlands Zernike Institute for Advanced Materials University of GroningenGroningenThe Netherlands

The development of lithium-sulfur(Li-S)batteries is hindered by the disadvantages of shuttling of polysulfides and the sluggish redox kinetics of the conversion of sulfur species during discharge and ***,the crystallinities of a titanium nitride(TiN)film on copper-embedded carbon nanofibers(Cu-CNFs)are regulated and the nanofibers are used as interlayers to resolve the aforementioned crucial issues.A low-crystalline TiN-coated Cu-CNF(L-TiN-Cu-CNF)interlayer is compared with its highly crystalline counterpart(H-TiN-Cu-CNFs).It is demonstrated that the L-TiN coating not only strengthens the chemical adsorption toward polysulfides but also greatly accelerates the electrochemical conversion of *** to robust carbon frameworks and enhanced kinetics,impressive highrate performance at 2 C(913 mAh g^(-1)based on sulfur)as well as remarkable cyclic stability up to 300 cycles(626 mAh g^(-1))with capacity retention of 46.5%is realized for L-TiN-Cu-CNF interlayer-configured Li-S *** under high loading(3.8 mg cm^(-2))of sulfur and relatively lean electrolyte(10μL electrolyte per milligram sulfur)conditions,the Li-S battery equipped with L-TiN-Cu-CNF interlayers delivers a high capacity of 1144 mAh g^(-1)with cathodic capacity of 4.25 mAh cm^(-2)at 0.1 C,providing a potential pathway toward the design of multifunctional interlayers for highly efficient Li-S batteries.

关键词： crystallinity electrochemical kinetics interlayer lithium-sulfur batteries titanium nitride

Cracking the silent gallstone code:Wait or operate?

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World Journal of Clinical Cases 2024年第16期12卷 2692-2697页

作者： Aakansha.giri Goswami Somprakas Basu Department of General Surgery All India Institute of Medical SciencesRishikesh 249203UttarakhandIndia

The widespread availability of abdominal ultrasound has revealed the common occurrence of asymptomatic *** the treatment for symptomatic gallstones is clear,the benefits of minimally invasive laparoscopic cholecystectomy have sparked debate about the best approach to managing silent *** potential for asymptomatic gallstones to become symptomatic or lead to complications complicates the decision-making process regarding surgical intervention,as it's uncertain when or which patients might develop ***,risk stratification appears to play a critical role in guiding decisions about silent ***,there is no definitive evidence to direct management,and a consensus-based on high-quality evidence is yet to be established.

关键词： Asymptomatic gallstones Silent gallstones Cholecystectomy Gallbladder cancer Risk stratification

Database Search Behaviors: Insight from a Survey of Information Retrieval Practices

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Intelligent Information Management 2024年第5期16卷 195-218页

作者： Babita Trivedi Brijender Dahiya Anjali Maan Rajesh giri Vinod Prasad Department of Physics Swami Shraddhanand College University of Delhi Delhi India Department of Physics Pt.N.R.S.G.C. Rohtak Maharshi Dayanand University Rohtak India Department of Physics Rajdhani College University of Delhi Delhi India

This study examines the database search behaviors of individuals, focusing on gender differences and the impact of planning habits on information retrieval. Data were collected from a survey of 198 respondents, categorized by their discipline, schooling background, internet usage, and information retrieval preferences. Key findings indicate that females are more likely to plan their searches in advance and prefer structured methods of information retrieval, such as using library portals and leading university websites. Males, however, tend to use web search engines and self-archiving methods more frequently. This analysis provides valuable insights for educational institutions and libraries to optimize their resources and services based on user behavior patterns.

关键词： Information Retrieval Database Search User Behavior Patterns

Probabilistic Analysis of Slope Using Finite Element Approach and Limit Equilibrium Approach around Amalpata Landslide of West Central, Nepal

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International Journal of Geosciences 2024年第5期15卷 416-432页

作者： Mahendra Acharya Khomendra Bhandari Sandesh Dhakal Aasish giri Prabin Kafle Central Department of Geology Tribhuvan University Kathmandu Nepal Department of Geology Tri-Chandra Multiple Campus Tribhuvan University Kathmandu Nepal Sri Revana Siddeshwara Institute of Technology Visvesvaraya Technological University Bengaluru India

The stability study of the ongoing and recurring Amalpata landslide in Baglung in Nepal’s Gandaki Province is presented in this research. The impacted slope is around 200 meters high, with two terraces that have different slope inclinations. The lower bench, located above the basement, consistently fails and sets others up for failure. The fluctuating water level of the slope, which travels down the slope masses, exacerbates the slide problem. The majority of these rocks are Amalpata landslide area experiences several structural disruptions. The area’s stability must be evaluated in order to prevent and control more harm from occurring to the nearby agricultural land and people living along the slope. The slopes’ failures increase the damages of house existing in nearby area and the erosion of the slope. Two modeling techniques the finite element approach and the limit equilibrium method were used to simulate the slope. The findings show that, in every case, the terrace above the basement is where the majority of the stress is concentrated, with a safety factor of near unity. Using probabilistic slope stability analysis, the failure probability was predicted to be between 98.90% and 100%.

关键词： Finite Element Approach Limit Equilibrium Method Slope Factor of Safety

Prevalence and outcome of sarcopenia in non-alcoholic fatty liver disease

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 44-54页

作者： Suprabhat giri Prajna Anirvan Sumaswi Angadi Ankita Singh Anurag Lavekar Department of Gastroenterology and Hepatology Kalinga Institute of Medical SciencesBhubaneswar 751024OdishaIndia Department of Gastroenterology Kalinga Gastroenterology FoundationCuttack753001OdishaIndia Department of Gastroenterology Nizam’s Institute of Medical SciencesHyderabad 500082TelanganaIndia Department of Gastroenterology Seth GS Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sagar HospitalBengaluru 560041KarnatakaIndia

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced ***,characterized by decreased muscle strength and mass,shares common pathophysiological traits with *** association exists between sarcopenia and increased NAFLD ***,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain *** To analyze the prevalence and outcomes of sarcopenia in patients with *** We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June *** included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse *** also used the Newcastle-Ottawa scale for quality *** Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for *** was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such *** in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and *** This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD *** variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent *** review demonstrates the multidimension

关键词： Non-alcoholic fatty liver disease Sarcopenia Hepatic fibrosis Low muscle mass Hand grip strength Bioelectric impedance analysis Dual X-ray absorptiometry

Fixed-time Distributed Voltage and Reactive Power Compensation of Islanded Microgrids Using Sliding-mode and Multi-agent Consensus Design

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 232-240页

作者： Mohamed Ghazzali Mohamed Haloua Fouad giri Electrical Engineering Department Mohammadia School of EngineersUniversity Mohammed VRabatMorocco Caen Automation Laboratory(LAC) Caen Normandie University(UNICAEN)CaenFrance

This paper investigates a fixed-time distributed voltage and reactive power compensation of islanded microgrids using sliding-mode and multi-agent consensus design.A distributed sliding-mode control protocol is proposed to ensure voltage regulation and reference tracking before the desired preset fixed-time despite the unknown *** reactive power sharings among distributed generators are *** secondary controller is synthesized without the knowledge of any parameter of the *** is implemented using a sparse one-way communication network modeled as a directed graph.A comparative simulation study is conducted to highlight the performance of the proposed control strategy in comparison with finite-time and asymptotic control systems with load power variations.

关键词： Secondary controller microgrids reactive power control voltage control

Application of subfossil cladocerans(water fleas) in assessing ecological resilience of shallow Yangtze River floodplain lake systems(China)

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Science China Earth Sciences 2018年第9期61卷 1157-1168页

作者： giri KATTEL Ke ZHANG Xiangdong YANG State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences Environmental Hydrology and Water Resources Group Department of Infrastructure EngineeringThe University of Melbourne

Majority of shallow floodplain lake ecosystems of the middle and lower reaches of the Yangtze River(China) have gone through serious eutrophication problems over the recent past. The severe environmental deterioration accompanied by cyanobacterial blooms have become major water resource management challenges in the region. An advanced research method is urgently needed to tackle these challenges. The concept of ecological resilience address pressing questions of non-linear dynamics, threshold effects and regime shifts in shallow floodplain lakes, and help manage the ecosystem effectively. Palaeolimnological techniques are important for assessing long term resilience and associated thresholds effects of shallow lake ecosystems. However, the lack of reliable proxy methods available, the assessment of long term ecological resilience of shallow Yangtze River lake systems has become increasingly difficult. Cladocerans(water fleas) play a central role in lacustrine food webs by responding to external drivers and internal ecosystem processes in lakes. Their subfossils are well preserved and becoming one of potential proxy indicators of lake ecosystems change for a longer time scale. This study explores the potential application of subfossil cladocerans and their ephippia in assessing a long term ecological resilience and help better management strategies of lake ecosystems and water resources of the middle and lower reaches of the Yangtze River in China.

关键词： Subfossil cladoceran Yangtze River lake system Food web Ecological resilience Regime shift Threshold

Ciprofloxacin degradation in photo-Fenton and photo-catalytic processes: Degradation mechanisms and iron chelation

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Journal of Environmental Sciences 2019年第6期31卷 82-92页

作者： Ardhendu Sekhar giri Animes Kumar Golder Department of Chemical Engineering Indian Institute of Science Education and Research Bhopal Department of Chemical Engineering Indian Institute of Technology Guwahati

Ciprofloxacin(CIP)is a broad spectrum synthetic antibiotic drug of fluoroquinolones *** can act as a bidentate ligand forming iron complexes during its degradation in the photoFenton process(PFP).This work investigates on PFP for the degradation of CIP to understand the formation mechanism and stability of iron complexes under ultraviolet(UV)-light illumination.A comparison was made with the UV-photocatalysis(UV/TiO_2)process where CIP doesn't form a *** PFP,the optimal dose of Fe^(2+)and H_2O_2were found to be 1.25 and10 mmol/L with pH of *** optimal TiO_2dose of 1.25 g/L was determined in the UV/TiO_*** CIP removal and mineralization efficiency of 93.1%and 47.3%were obtained in PFP against 69.7%and 27.6%in the UV/TiO_*** mass spectra could identify seventeen intermediate products including iron-CIP complexes in PFP,and only seven intermediate products were found in the UV/TiO_2process with a majority of common products in both the *** proposed mechanism supported by the mass spectra bridged the routes of CIP cleavage in the PFP and UV/TiO_2process,and the decomposition pathway of Fe^(3+)-CIP chelate complexes in PFP was also *** in PFP and UV/TiO_2processes,the target site of HO~·radical attack was the secondary-N atom present in the piperazine ring of the CIP *** death of Escherichia coli bacteria was 55.7%and 66.8%in comparison to the control media after 45 min of treatment in PFP and UV/TiO_2process,respectively.

关键词： Advanced oxidation processes Antibiotic decomposition Iron chelation Antimicrobial activity