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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

Morphological variation in the short-tailed fruit bat(Carollia)in Ecuador,with comments on the practical and philosophical aspects of boundaries among species

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Integrative Zoology 2010年第3期5卷 226-240页

作者： Pablo JARRíN-v. Cristina.flores Janeth SALCEDO Yasuni Research Station School of Biological SciencesPontifical Catholic University of EcuadorQuitoEcuador Center for Ecology and Conservation Biology Department of BiologyBoston UniversityMassachusettsUSA Central University of Ecuador School of Biology and ChemistryQuitoEcuador

The mechanisms for the morphological delimitation of species in Carollia remain poorly *** is the first study to assess variation in size and shape from strictly geometric *** factors are assessed by statistical perspectives of distribution,overlap and relative *** its overlap,the size of the skull seems to be the most influential character for the discrimination of species,with shape playing a much smaller *** smallest species seems to be the most distinct in shape,not only in terms of distance among centroids in morphometric space,but also in the overall trend and direction of *** to previous studies,sexual dimorphism is not given by size but by distinct shapes of the *** such as the shape of the maxilla,previously described qualitatively as discrete with sharp boundaries,appear to be truly continuous with fuzzy borders among *** morphometric space is a gamut of continuous variation and overlap,the taxonomic error rate for size characters seems to be substantial for the medium-sized species(Carollia brevicauda Schinz,1821),with approximately 30–40%of individuals erroneously assigned to a different species after a jackknifed discriminant *** taxonomic error is higher for shape ***,systematic and ecological consequences of the observed patterns of shape and size variation are commented within the context of previously proposed arguments and hypotheses.

关键词： boundaries Carollia character state discriminant morphometrics

Resveratrol effects on neural connectivity during aging

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Neural Regeneration Research 2016年第7期11卷 1067-1068页

作者： Gonzalo flores Rubén Antonio vázquez-Roque Alfonso Diaz Instituto de fisiología Benemerita Universidad autónoma de Puebla.14 Sur 6301PueblaMexico Departamento de Farmacia Facultad de Ciencias químicasbenemérita Universidad autónoma de PueblaPueblaMexico

Aging has been considered a natural process of any living *** rate of aging depends on many factors,including genetic and environmental *** this reason,many researchers in this field suggest that aging is an epigeneti... 详细信息

关键词： resveratrol connectivity older hippocampus neuronal metabolism cortical Aging cortex PPAR

road to stemness in hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第37期23卷 6750-6776页

作者： Teresita NJ flores-Téllez Saúl villa-Trevino Carolina Pina-vázquez Departam ento de Biología Celular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN) Av.IPN No.2508 Col

Carcinogenic process has been proposed to relay on the capacity to induce local tissue damage and proliferative repair. Liver has a great regeneration capacity and currently, most studies point towards the dominant role of hepatocytes in regeneration at all levels of liver damage. The most frequent liver cancer is hepatocellular carcinoma(HCC). Historical findings originally led to the idea that the cell of origin of HCC might be a progenitor cell. However, current linage tracing studies put the progenitor hypothesis of HCC origin into question. In agreement with their dominant role in liver regeneration, mature hepatocytes are emerging as the cell of origin of HCC, although, the specific hepatocyte subpopulation of origin is yet to be determined. The relationship between the cancer cell of origin(CCO) and cancer-propagating cells, known as hepatic cancer stem cell(HCSC) is unknown. It has been challenging to identify the definitive phenotypic marker of HCSC, probably due to the existence of different cancer stem cells(CSC) subpopulations with different functions within HCC. There is a dynamic interconversion among different CSCs, and between CSC and non-CSCs. Because of that, CSC-state is currently defined as a description of a highly adaptable and dynamic intrinsic property of tumor cells, instead of a static subpopulation of a tumor. Altered conditions could trigger the gain of stemness, some of them include: EMT-MET, epigenetics, microenvironment and selective stimulus such as chemotherapy. This CSC heterogeneity and dynamism makes them out reach from therapeutic protocols directed to a single target. A further avenue of research in this line will be to uncover mechanisms that trigger this interconversion of cell populations within tumors and target it.

关键词： Cancer stem cell Liver progenitor cell Liver stem progenitor cell Stemness Plasticity Cancer cell of origin Cancer stem cells subpopulations

Continued circulation of a single genotype of dengue virus serotype 2 in the Philippines

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Asian Pacific Journal of Tropical Medicine 2014年第1期7卷 30-33页

作者： Joy Ann G Petronio Ricky B vinarao Kristine Marie G flores Raul v Destura Institute of Molecular Biology and Biotechnology National Institutes of Health-University of the PhilippinesManila Section of Molecular Diagnostics The Medical CityPhilippines

Objective:To obtain descriptive information of behavioral pattern in Chinese school-aged children with cleft lip and ***:A total of 93 cleft lip and palate patients between the age of 6-11 year-old and treated at West China Stomatology Hospital were *** another100 unaffected controls,matched for age and gender,were recruited randomly from a common primary school in *** review of medical records was used to obtain psychosocial *** were compared with published norms and controls to evaluate the risk of problems,separately for three diagnostic ***:The patients group had lower scores of social and academic competencies,especially those with facial deformity or speech *** difference was found in the aspect of activity *** patients showed elevations in behavior *** the type of behavior problems varied in different ***:Chinese school-aged children with cleft lip and palate are at raised risk for social and academic *** pattern of behavior problems displays differently depending on gender of the patient.

关键词： Cleft lip and palate CBCL Psychosocial adjustment Behavior problems

Recent Advances in Synthesis and Properties of Hybrid Halide Perovskites for Photovoltaics

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Nano-Micro Letters 2018年第4期10卷 167-200页

作者： C.C.vidyasagar Blanca M.Muoz flores víctor M.Jimnez Prez Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Ciudad Universitaria School of Basic Sciences and Research in Chemistry Rani Channamma University

The progress made by the scientific community in emerging photovoltaic technologies over the past two decades has been outstanding. Numerous methods have been developed for the preparation of hybrid organic–inorganic perovskite solar cells. The power conversion efficiency has been up to 14% by a one-step vacuum deposition technique. A serious concern is the toxicity of the materials. In this review, several methods aimed at resolving these problems to some extent have been compiled, including eco-friendly synthesis. Further efficiency enhancements are expected following optimization, and a better fundamental understanding of the internal electron charge transfer, electron–hole diffusion to the corresponding layers, flexibility, and stability-dependent bandgaps is reported. This paper explores the green synthesis of organic–inorganic perovskites for industrialization. Concerning the above facts, a simple low-cost model called‘‘dispersed photovoltaic cells' ' is presented.

关键词： Perovskites Solar cells Organic–inorganic perovskites Synthetic routes Fluorescence

KCl:Eu^(2+) as a solar Uv-C radiation dosimeter. Optically stimulated luminescence and thermoluminescence analyses

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Journal of Rare Earths 2009年第4期27卷 579-583页

作者： I.Aguirre de Cárcer H.L.D'Antoni M.Barboza.flores v.Correcher F.Jaque Departamento Física de Materiales Universidad Autónoma Madrid Spain NASA Ames Research Center Moffett Field California USA Centro de Investig ción en Física Universidad de Sonora México Centro Investigaciones Energía y Medioambientales (CIEMAT) Madrid Spain

The KCI：Eu2＋ system response to Uv-C was investigated by analyzing the optically stimulated luminescence （OSL） and ther- mo-luminescence （TL） signal produced by ultraviolet light exposure at room temperature. It was found that after Uv-C ***, OSL was produced on a wide band of visible wavelengths with decay time that varied by several orders of magnitude depending on the Eu2＋ aggregation state. In spite of the low intensity of solar Uv-C reaching the Earth＇s surface in Madrid （40° N, 700 m a.s.1.）, it was possible to measure the Uv-C radiation dose at 6：48 solar time by using the TL response of the KCI：Eu2＋ system and differentiate it from the ambient beta radiation dose.

关键词： thermo-luminescence rare-earth-doped alkali halides solar ultraviolet dosimeter environmental radiation

Petiveria alliacea Suppresses Airway Inflammation and Allergen-Specific Th2 Responses in Ovalbumin-Sensitized Murine Model of Asthma

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Chinese Journal of Integrative Medicine 2018年第12期24卷 912-919页

作者： Rosa Martha Perez Gutierrez Jose Maria Mota.flores Natural Products Research Laboratory Higher School of Chemical Engineering and Extractive IndustriesInstituto Politecnico Nacional (IPN) Professional Unit Adolfo Lopez Mateos Av. Instituto Politécnico NacionalS/N

Objective： To examine the effect of metanol extract of Petiveria alliacea （PM） on airway inflammation in a murine model of chronic asthma. Methods： Two-month-old male BALB/c mice （n=6-8/group） were sensitized on days 0 and 14 by intraperitoneal injection of 20μg ovalbumin （OvA）. On day 25, the mice received an airway challenge with OvA （3%, w/v, in phosphate buffered saline）. PM was administered orally by oral gavage to mice at doses of 100, 200 and 400 mg/kg body weight once daily from days 18 to 23. Control mice were orally administered phosphate buffered saline （PBS） to induce a model of asthma. At the end of the test, respiratory reactivity was assayed, the total cell number, interleukin-4 （IL-4）, IL-5, IL-13, tumor necrosis factor-alpha （TNF-α） and reactive oxygen species （ROS） in the bronchoalveolar lavage fluid （BALF） were determined and the levels of serum IgE, intercellular cell adhesion molecule 1 （ICAM-1） and eotoxin were measured. In addition, lung tissue was used to qualify the IL-4, IL-5, IL-13, TNF-α and transforming growth factor beta 1 （TGF-β1）. Histologic examination was performed to observe inflammatory cellular infiltration. Results： The administration of PM in comparison with the OvA-only treated group significantly attenuated the infiltration of eosinophUs and other inflammatory cells （P〈0.01）. Airway resistance （RI） in the OvA-only induced group was significantly higher than that of the PBS control group （P〈0.01） when methacholine was added. TNF-α, IgE, TGF-β1 and cytokine levels IL-4, IL-5, IL-β in the BALF decreased compared to control mice （P〈0.01 or P〈0.05）. PM treatment also inhibited the production of chemokines, eotaxin and ICAM-1 in BALF （P〈0.01）, which improved lung function. Histopathological examination revealed that the sensitized treated PM groups had significant lower in inflammatory scores similar to dexamethasone treatments and the untreated group. Conclusion： Administration of PM could inhibit airway inflammation, regulate cyt

关键词： Petiveria alliacea allergy antiinflammation asthma

Dipole and generalized oscillator strength derived electronic properties of an endohedral hydrogen atom embedded in a Debye-Huckel plasma

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Matter and Radiation at Extremes 2018年第5期3卷 227-242页

作者： C.Martínez-flores R.Cabrera-Trujillo Instituto de Ciencias Físicas Universidad Nacional Autonoma de MexicoAp.Postal 43-8CuernavacaMorelos62251Mexico

We report electronic properties of a hydrogen atom encaged by an endohedral cavity under the influence of a weak plasma interaction. Weimplement a finite-difference approach to solve the Schrodinger equation for a hydrogen atom embedded in an endohedral cavity modeled by theWoods-Saxon potential with well depth v0, inner radius R0, thickness D, and smooth parameter g. The plasma interaction is described by aDebye-Hu¨ckel screening potential that characterizes the plasma in terms of a Debye screening length lD. The electronic properties of theendohedral hydrogen atom are reported for selected endohedral cavity well depths, v0, and screening lengths, lD, that emulate differentconfinement and plasma conditions. We find that for low screening lengths, the endohedral cavity potential dominates over the plasma interaction by confining the electron within the cavity. For large screening lengths, a competition between both interactions is observed. We assessand report the photo-ionization cross section, dipole polarizability, mean excitation energy, and electronic stopping cross section as function of lD and v0. We find a decrease of the Generalized Oscillator Strength (GOS) when the final excitation is to an s state as the plasma screeninglength decreases. For a final excitation into a p state, we find an increase in the GOS as the endohedral cavity well-depth increases. For the caseof the electronic stopping cross section, we find that the plasma screening and endohedral cavity effects are larger in the low-to-intermediateprojectile energies for all potential well depths considered. Our results agree well to available theoretical and experimental data and are afirst step towards the understanding of dipole and generalized oscillator strength dependent properties of an atom in extreme conditions encagedby an endohedral cavity immersed in a plasma medium.

关键词： Oscillator strengths Debye-Huckel plasma Cavities Endohedral Energy loss Stopping power