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国际医学放射学杂志 2024年第4期 501-501页

作者： s.Y.Yang H.Bae N.seo K.han Y.d.han m.s.Cho 徐文睿

摘要目的研究旨在评估治疗前mRI检测壁外血管侵犯（pmr EmVI）对于接受新辅助放化疗（n CRT）的局部进展期直肠癌（LARC）病人生存的预测作用。方法回顾性分析2011

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mitochondrial diseases and mtdNA editing

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Genes & diseases 2024年第3期11卷 303-310页

作者： min song Lingqun Ye Yongjin Yan Xuechun Li Xinglong han shijun Hu miao Yu department of Cardiovascular surgery of the First Affiliated Hospital&Institute for Cardiovascular science Collaborative Innovation Center of HematologyState Key Laboratory of Radiation Medicine and ProtectionSuzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215000China Hai'an people's Hospital NantongJiangsu 226600China

mitochondrial diseases are a heterogeneous group of inherited disorders character-ized by mitochondrial dysfunction,and these diseases are often severe or even ***-chondrial diseases are often caused by mitochondrial dNA ***,there is no curative treatment for patients with pathogenic mitochondrial dNA *** the rapid development of traditional gene editing technologies,such as zinc finger nucleases and tran-scription activator-like effector nucleases methods,there has been a search for a mitochon-drial gene editing technology that can edit mutated mitochondrial dNA;however,there are still some problems hindering the application of these *** discovery of the dddA-derived cytosine base editor has provided hope for mitochondrial gene *** this paper,we will review the progress in the research on several mitochondrial gene editing technologies with the hope that this review will be useful for further research on mitochondrial gene editing technologies to optimize the treatment of mitochondrial diseases in the future.

关键词： Gene editing mitochondrialdisease mitochondrialdNA mutation Transcription activator-like effectornucleases Zinc finger nucleases

parallelogram 3d-4f-5d heterometallic clusters based on trilacunary tungstoantimonates with excellent proton conductivity

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Chinese Chemical Letters 2024年第3期35卷 528-531页

作者： Haiying Wang han Xu Chaolong Chen Yingjie Zhu Yikang Zhang dongdi Zhang Jingyang Niu Henan Key Laboratory of polyoxometalate Chemistry College of Chemistry and Molecular SciencesHenan UniversityKaifeng 475004China school of pharmaceutical science&Yunnan Key Laboratory of pharmacology for Natural products Kunming Medical UniversityKunming 650500China Collaborative Innovation Center of Chemistry for Energy materials State Key Laboratory of Physical Chemistry of Solid Surface and Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Two 3d-4f-5d heterometallic cluster-containing polyoxometalates,formulated as Na_(22){(sbW_(9)O_(33))_(4)[La_(3)W_(6)mO_(18)(H_(2)O)_(8)(CH_(3)COO)_(4)]_(2)}·nH_(2)O(abbreviated as La_(6)m_(2),m=Co/mn)were synthesized and structurally ***-crystal X-ray diffraction analyses reveal that the polyanions of La_(6)Co_(2)and La_(6)mn_(2)consist of the uncommon 3d-4f-5d clusters{La_(6)W_(12)Co_(2)}and{La_(6)W_(12)mn_(2)},which are encapsulated by four trilacunary Keggin tungstoantimonates to form the parallelogram-shaped title ***,the polyanions can be extended into a two-dimensional(2d)frame by the linkage of peripheral Na+*** inner space of the 2d layer was filled with water molecules and thus an H-bonded network was formed,which is expected to exhibit a fascinating proton *** study of water-assisted proton conduction demonstrated that La_(6)Co_(2)and La_(6)mn_(2)were temperature-and humiditydependent proton conductors,respectively,and the proton conductivities could reach 1.3×10^(-2)and 2.3×10^(-2)s/cm at 65℃and 90%RH conditions.

关键词： polyoxometalate parallelogram Heterometallic 3d-4f-5d cluster proton conductivity

Noncovalent cross-linked engineering hydrogel with low hysteresis and high sensitivity for flexible self-powered electronics

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Journal of Energy Chemistry 2024年第7期94卷 136-147页

作者： hang Yuan shaowei han Jia Wei songwei Li peipei Yang Hao-Yang mi Chuntai Liu Changyu shen National Engineering Research Center for Advanced polymer processing Technology Key Laboratory of Materials Processing and Mold(Ministry of Education)Zhengzhou UniversityZhengzhou450002HenanChina Yunnan TobaccoQuality Inspection&supervision station Kunming 650106YunnanChina

In this study,the hydrogel network was reinforced by covalent-like hydrogen bonding,and the strong binding ability of boron-nitrogen coordination served as the main driving *** them,acrylamide(Am)and 3-acrylamidophenylboronic acid(AApBA)were the main body,and the numerous hydroxyl groups in the trehalose(Treh)molecule and other polymer groups formed strong hydrogen bonding interactions to improve the mechanical properties of the pAm/pAApBA/Treh(pAAT)hydrogel and ensured the simplicity of the synthesis *** hydrogel possessed high strain at break(1239%),stress(64.7 kpa),low hysteresis(100%to 500%strain,corresponding to dissipation energy from 1.37 to 7.80 kJ/m^(3)),and outstanding cycling stability(retained more than 90%of maximum stress after 200 ten-sile cycles).By integrating carbon nanotubes(CNTs)into pAAT hydrogel(pAATC),the pAATC hydrogel with excellent strain response performance was successfully *** pAATC conductive hydro-gel exhibited high sensitivity(gauge factor(GF)=10.58 and sensitivity(s)=0.304 kpa^(-1)),wide strain response range(0.5%-1000%),fast response time(450 ms),and short recovery time(350 ms),excellent fatigue resistance,and strain response ***,the pAATC-based triboelectric nanogener-ator(TENG)displayed outstanding energy harvesting performance,which shows its potential for appli-cation in self-powered electronic devices.

关键词： Low hysteresis Covalent-like hydrogen bonding Boron-nitrogen coordination Hydrogel sensor Triboelectric nanogenerator

Optimizing 2d-metal contact in layered Tin-selenide via native oxide modulation

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Nano Research 2024年第4期17卷 3014-3020页

作者： Yue Zheng Qi You Zhentian Yin Jian Tang Ke Jiang Zihao Xie Henan Li Cheng han Yumeng shi International Collaborative Laboratory of 2d materials for Optoelectronics science and Technology of ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China

The discovery of two-dimensional(2d)semiconductor has opened up new avenues for the development of short-channel field-effect transistors(FETs)with desired electrical *** them,orthorhombic tin-selenide(snse)has garnered increasing attention due to its potential applications in a variety of electronic,optoelectronic,and thermoelectric ***,the realization of high-performance snse FETs with low contact resistance(Rc)remains a ***,we systematically investigate the contact of few-layer snse FETs through the modulation of native oxide on snse by using different *** is found that chromium(Cr)-contacted devices possess the best FET performance,such as electron mobility up to 606 cm^(2)/(V·s)at 78 K,current on/off ratio exceeding 1010,and saturation current of~550μA/μm,where a negligible schottky barrier(sB)of~30 meV and a low contact resistance of~425Ωμm are achieved.X-ray photoelectron spectroscopy(Xps)and cross-sectional electron dispersive X-ray spectroscopy(EdX)results further reveal that the improved contact arises from the Cr-induced reduction of native oxide(snOx)to sn,which thins the tunneling barrier for efficient electron *** findings provide a deep insight into the 2d-metal contact of snse and pave the way for its applications in future nanoelectronics.

关键词： few-layer snse field-effect transistors(FETs) Cr contact native oxide contact resistance(Rc) schottky barrier(sB)

High density 3d Carbon Tube Nanoarray Electrode Boosting the Capacitance of Filter Capacitor

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Nano-micro Letters 2024年第11期16卷 242-254页

作者： Gan Chen Fangming han Huachun ma pei Li Ziyan Zhou pengxiang Wang Xiaoyan Li Guowen meng Bingqing Wei Key Laboratory of materials physics and Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031People’s Republic of China department of materials science and Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China department of mechanical Engineering University of DelawareNewarkDE 19716USA mechano‑X Institute Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

Electric double-layer capacitors(EdLCs)with fast frequency response are regarded as small-scale alternatives to the commercial bulky aluminum electrolytic *** carbon-based nanoarray electrodes with precise alignment and smooth ion channels is crucial for enhancing EdLCs’***,controlling the density of macropore-dominated nanoarray electrodes poses challenges in boosting the capacitance of line-filtering ***,a simple technique to finely adjust the vertical-pore diameter and inter-spacing in three-dimensional nanoporous anodic aluminum oxide(3d-AAO)template is achieved,and 3d compactly arranged carbon tube(3d-CACT)nanoarrays are created as electrodes for symmetrical EdLCs using nanoporous 3d-AAO template-assisted chemical vapor deposition of *** 3d-CACT electrodes demonstrate a high surface area of 253.0 m^(2) g^(−1),a d/G band intensity ratio of 0.94,and a C/O atomic ratio of *** a result,the high-density 3d-CT nanoarray-based sandwich-type EdLCs demonstrate a record high specific areal capacitance of 3.23 mF cm^(-2) at 120 Hz and exceptional fast frequency response due to the vertically aligned and highly ordered nanoarray of closely packed CT *** 3d-CT nanoarray electrode-based EdLCs could serve as line filters in integrated circuits,aiding power system miniaturization.

关键词： Compactly arranged Three-dimensional carbon tube nanoarray dimensional carbon tube nanoarray Fast frequency response Electric double-layer capacitors Layer capacitors AC line-filtering Filtering

The RFI Fast mitigation Algorithm Based on Block Lms Filter

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Research in Astronomy and Astrophysics 2024年第1期24卷 265-272页

作者： han Wu Hai-Long Zhang Ya-Zhou Zhang Jie Wang Xu du Ting Zhang Xin-Chen Ye Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical data Center Beijing 100101China

The radio telescope possesses high sensitivity and strong signal collection *** receiving celestial radiation signals,it also captures Radio Frequency Interferences(RFIs)introduced by human ***,as signals originating from sources other than the astronomical targets,significantly impacts the quality of astronomical *** paper presents an RFI fast mitigation algorithm based on block Least mean square(Lms)*** enhances the traditional adaptive Lms filter by grouping L adjacent time-sampled points into one block and applying the same filter coefficients for filtering within each *** transformation reduces multiplication calculations and enhances algorithm efficiency by leveraging the time-domain convolution *** algorithm is tested using baseband data from the parkes 64 m radio telescope's pulsar observations and simulated *** results confirm the algorithm's effectiveness,as the pulsar profile after RFI mitigation closely matches the original pulsar profile.

关键词： methods:data analysis techniques:interferometric (stars:)pulsars:individual(J0437-4715)

Cancer-educated neutrophils promote lung cancer progression via pARp-1-ALOX5-mediated mmp-9 expression

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Cancer Biology & medicine 2024年第2期21卷 175-192页

作者： Lulu han Yuxin Chen Nan Huang Xiaowan Zhou Yanfang Lv Huizhong Li dafei Chai Junnian Zheng Gang Wang Cancer Institute Xuzhou Medical University209 Tongshan RoadXuzhou 221004China Center of Clinical Oncology The Affiliated Hospital of Xuzhou Medical University99 West Huaihai RoadXuzhou 221002China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Xuzhou Medical University209 Tongshan RoadXuzhou 221004China department of Oncology Suzhou Xiangcheng People’s HospitalSuzhou 215131China

Objective:Neutrophils are one of the most predominant infiltrating leukocytes in lung cancer tissues and are associated with lung cancer *** neutrophils promote lung cancer progression,however,has not been ***:Kaplan–meier plotter online analysis and tissue immunohistochemistry were used to determine the relationship between neutrophils and overall survival in lung cancer *** effect of neutrophils on lung cancer was determined using the Transwell migration assay,a proliferation assay,and a murine tumor *** knockdown was used to determine poly Adpribose polymerase(pARp)-1 function in lung cancer-educated *** blot analysis and gelatin zymography were used to demonstrate the correlation between pARp-1 and matrix metallopeptidase 9(mmp-9).Immunoprecipitation coupled to mass spectrometry(Ip/ms)was used to identify the proteins interacting with ***-immunoprecipitation(Co-Ip)was used to confirm that pARp-1 interacts with arachidonate 5-lipooxygenase(ALOX5).Neutrophil pARp-1 blockage by AG14361 rescued neutrophil-promoted lung cancer ***:An increased number of infiltrating neutrophils was negatively associated with overall survival in lung cancer patients(pphil activation promoted lung cancer cell invasion,migration,and proliferation in vitro,and murine lung cancer growth in ***,pARp-1 was shown to be involved in lung cancer cell-induced neutrophil activation to increase mmp-9 expression through interacting and stabilizing ALOX5 by post-translational protein modification(pARylation).Blocking pARp-1 by gene knockdown or AG14361 significantly decreased ALOX5 expression and mmp-9 production,and eliminated neutrophil-mediated lung cancer cell invasion and in vivo tumor ***:We identified a novel mechanism by which pARp-1 mediates lung cancer cell-induced neutrophil activation and pARylates ALOX5 to regulate mmp-9 expression,which exacerbates lung cancer

关键词： Lung cancer neutrophils pARp-1 ALOX5 mmp-9

Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

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Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling Wu Xiangchuan meng Qingyang Zhang Xiaowan han Feiya Yang Qinghua Wang Hai-Yu Hu Nianzeng Xing department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China state Key Laboratory of Bioactive substances and Function of Natural medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

photoacoustic agents combining photodynamic therapy(pdT) and photothermal therapy(pTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(pAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2), X = O, s, se) to significantly increase photothermal conversion efficiency for pTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2),X = O, s, se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-se-NO_(2)-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic pTT/pdT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect phototherapy photoacoustic imaging Hypoxia-responsive prostate cancer

primordial black hole mass functions as a probe of cosmic origin

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science China(physics,mechanics & Astronomy) 2024年第5期67卷 164-171页

作者： Yi-Fu Cai Chengfeng Tang Geyu mo sheng-Feng Yan Chao Chen Xiao-han ma Bo Wang Wentao Luo damien A.Easson Antonino marcianò deep space Exploration Laboratory/school of physical sciences University of Science and Technology of ChinaHefei 230026China CAs Key Laboratory for Researches in Galaxies and Cosmology/department of Astronomy School of Astronomy and Space ScienceUniversity of Science and Technology of ChinaHefei 230026China Istituto Nazionale di Fisica Nucleare(INFN) Sezione di MilanoMilano 20146Italy disAT Universitàdegli Studi dell'InsubriaComo 22100Italy Jockey Club Institute for Advanced study The Hong Kong University of Science and TechnologyHong KongChina department of physics Arizona State UniversityTempe 85287-1504USA department of physics&Center for Field Theory and particle physics Fudan UniversityShanghai 200433China Laboratori Nazionali di Frascati INFN Via Enrico Fermi 541 Frascati(Roma)00044Italy INFN sezione Roma Tor Vergata Rome I-00133Italy school of physics University of Electronic Science and Technology of ChinaChengdu11731China

We discuss a novel window to probe the origin of our universe via the mass functions of primordial black holes(pBHs).The mass functions of pBHs are simply estimated using the conventional press-schechter formalism for two paradigms of cosmic origin,including inflationaryΛCdm and bounce *** standard inflationaryΛCdm model cannot generate an appreciable number of massive pBHs;however,non-trivial inflation models with blue-tilted power spectra at small scales and matter bounce cosmology provide formation mechanisms for heavy pBHs,which in turn,may seed the observed supermassive black holes(smBHs).By fitting the smBH mass functions at high redshift(z~6)derived from sloan digital sky survey(sdss)and Canada-France High-z Quasar survey(CFHQs)quasars,for two paradigms of cosmic origin,we derive constraints on the pBH density fraction fpBHat z~6 and the characteristic mass m_(★),with the prior assumption that all smBHs stem from *** demonstrate that this newly proposed procedure,relying on astronomical measurements that utilize deep-field surveys of smBHs at high redshift,can be used to constrain models of cosmic ***,although not the main focus of this paper,we evolve the mass function from z~6 to z~0 through an assumption of 3×10^(8)-year Eddington’s accretion,and give a rough estimation of fpBHat z~0.

关键词： origin cosmic massive