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Therapy of Multiple Myeloma

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The Chinese-German Journal of Clinical Oncology 2002年第3期1卷 141-144页

作者： H.Goldschmidt F.W.Crmer Th.Möhler A.Krämer M.Görner G.Egerer a.d.ho department of Internal Medicine V University of Heidelberg Hospitalstr.3 D-68115Germany

Summary Multiple Myeloma(MM)is characterised by the accumulation of malignant plasma cells in the bone marrow producing a monoclonal *** standard conventional therapy is the combination of melphalan and prednisone resulting in a response rate of 40%-60%and in a median survival time of approximately 3 *** order to improve the therapeutic efficacy various combination regimens have been *** randomized trials have frailed to show a significant improvement in survival time when combination chemotherapy is used instead of melphalan with or without *** benefit of maintenance therapy with interferon-alpha has been *** toxicity of interferon-alpha,which may reduce the quality of life,should be ***,myeloma-treatment has been ***-dose chemotherapy accompanied by hematopoietic stem-cell support via autologous transplant is recommended up to the age of 65-70 *** results from a French study comparing single versus double autologous transplantation have shown a benefit in terms of event-free survival for the sequential *** as an adoptive immuntherapy to treat minimal residual disease are under *** mortality rale of allogeneic transplantation of hematopoietic stem cells has been reduced in the last 5 *** use of reduced conditioning regimens or the partial depletion of T cells in peripheral blood stem cell transplants in an effort to decrease transplant related mortality are promising ***-omide and its derivates are a new class of agents with independent anti-tumour activity in *** results with this antian-giogenic therapy in phase II trials have been *** therapies,such as the treatment of anaemia with erythropoietin,the management of renal failure and the use of bisphosphonates,improve the life quality of MM patients.

关键词： multiple myeloma treatment transplantation angiogenesis

Tacrolimus (FK506) for Graft-versus-host disease after Allogeneic Blood Stem Cell Transplantation for Hematologic Malignancies

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The Chinese-German Journal of Clinical Oncology 2004年第1期3卷 2-4,64页

作者： S.Gerull T.Luft M.Scheuer M.Kornacker H.J.Gebest S.Schonland J.Perz a.d.ho 德国海德堡大学内科学院 69115

This report is a retrospective analysis of 27 patients who received Tacrolimus because of intol- erance or for refractoriness to Cyclosporin A (CyA) as prophylaxis against acute and chronic GvHd at a single institution. 9 patients were treated with Tacrolimus as acute GvHd developed despite optimal concentrations of CyA and 8 developed chronic GvHd despite continuation of CyA. 10 patients developed World Health Organisation Score (Who) grade 2–3 toxicity to CyA. Overall 21 of 27 patients responded to Tacrolimus. Patients who underwent reduced conditioning responded as well as those patients who un- derwent conventional conditioning regimens. Tacrolimus is well tolerated and e?ective and might be an alternative primary agent for prevention of GvHd. Its role in reduced conditioning regimens needs to be further explored.

关键词：血液恶性肿瘤异源血干细胞移植术他克莫司移植物抗宿主反应环胞霉素A 耐受性

direct 4d printing of functionally graded hydrogel networks for biodegradable,untethered,and multimorphic soft robots

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International Journal of Extreme Manufacturing 2024年第2期6卷 407-416页

作者： Soo Young Cho dong Hae ho Sae Byeok Jo Jeong ho Cho department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea department of Mechanical Engineering Virginia TechBlacksburgVA 24061United States of America School of Chemical Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon 16419Republic of Korea

Recent advances in functionally graded additive manufacturing(FGAM)technology have enabled the seamless hybridization of multiple functionalities in a single *** robotics can become one of the largest beneficiaries of these advances,through the design of a facile four-dimensional(4d)FGAM process that can grant an intelligent stimuli-responsive mechanical functionality to the printed ***,we present a simple binder jetting approach for the 4d printing of functionally graded porous multi-materials(FGMM)by introducing rationally designed graded multiphase feeder *** graded cross-linking agents gradually form stable porous network structures within aqueous polymer particles,enabling programmable hygroscopic deformation without complex mechanical ***,a systematic bed design incorporating additional functional agents enables a multi-stimuli-responsive and untethered soft robot with stark stimulus *** biodegradability of the proposed 4d-printed soft robot further ensures the sustainability of our approach,with immediate degradation rates of 96.6%within 72 *** proposed 4d printing concept for FGMMs can create new opportunities for intelligent and sustainable additive manufacturing in soft robotics.

关键词： intelligent and sustainable additive manufacturing multi-material four-dimensional printing untethered soft robot multi-stimuli-responsive soft robot biodegradable soft robotics

大剂量化疗联合外周血干细胞移植治疗复发性或难治性霍奇金病:远期疗效及预后因子

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德国医学 2001年第4期18卷 207-209页

作者： K.Neben S.hohaus H.Goldschmidt G.Egerer M.T.Voso a.d.ho R.Haas 孙岚 departmentof internal Medicine V University of Heidelberg 华中科技大学同济医学院附属同济医院

大剂量化疗联合外周血干细胞移植为血癌患者和具有危险因素者提供了增强剂量的巩固治疗.尽管晚期霍奇金病患者对传统的细胞毒化疗的有效率和EFS有了很大提高,但有20%～30%的霍奇金病患者对化疗无反应或在最初有效后复发.目前对这些患者... 详细信息

大剂量化疗联合外周血干细胞移植为血癌患者和具有危险因素者提供了增强剂量的巩固治疗.尽管晚期霍奇金病患者对传统的细胞毒化疗的有效率和EFS有了很大提高,但有20%～30%的霍奇金病患者对化疗无反应或在最初有效后复发.目前对这些患者的抢救治疗包括多药联合方案,如dexaBEAM,其由地塞米松、卡氮芥、鬼臼乙甙、阿糖胞苷和美法伦组成.此方案对复发性霍奇金病有效.尽管最初的有效率为60%,这些患者的临床转归相对较差.

关键词：化疗外周血干细胞移植霍奇金病血癌预后因子疗效研究

血液恶性肿瘤异源血干细胞移植术后他克莫司治疗GvHd的疗效(英文)

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Oncology and Translational Medicine 2004年第1期3卷 6-8+68页

作者： S.Gerull,T.Luft,M.Scheuer,M.Kornacker,H.J.Gebest,S.Schonland,J.Perz,a.d.ho 德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院德国海德堡大学内科学院 69115 69115 69115 69115 69115 69115 69115 69115

该研究回顾性分析了某院27例由于对环胞霉素A不能耐受或无效而使用他克莫司预防急性和慢性移植物抗宿主反应(GvHd)的患者。9例患者即使血中环胞霉素A达到理想浓度仍出现急性GvHd,8例在连续使用环胞霉素A后仍出现慢性GvHd。10例患者出现2... 详细信息

该研究回顾性分析了某院27例由于对环胞霉素A不能耐受或无效而使用他克莫司预防急性和慢性移植物抗宿主反应(GvHd)的患者。9例患者即使血中环胞霉素A达到理想浓度仍出现急性GvHd,8例在连续使用环胞霉素A后仍出现慢性GvHd。10例患者出现2～3级(Who评分)的环胞霉素A毒性反应。27例中超过21例他克莫司有效。接受减低调理剂量的患者与接受常规预处理方案的患者疗效相同。他克莫司具有较好的耐受性和疗效,可能成为防止GvHd的另外一种主要药物。其减少预处理剂量的原理有待进一步研究。

关键词：他克莫司患者 GvHd 疗效

Optimization of the Use of Spherical Targets for Point Cloud Registration Using Monte Carlo Simulation

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Journal of Geodesy and Geoinformation Science 2024年第2期7卷 18-36页

作者： CHAN Ting On XIAO Hang XIA Linyuan LICHTI derek d LI Ming ho dU Guoming School of Geography and Planning Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Urbanization and Geo-Simulation Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Engineering Research Center for Public Security and disasters Sun Yat-sen UniversityGuangzhou 510275China department of Geomatics Engineering Schulich School of EngineeringUniversity of CalgaryCalgary AB T2N 1N4Canada

Registrations based on the manual placement of spherical targets are still being employed by many professionals in the ***,the placement of those targets usually relies solely on personal experience without scientific evidence supported by numerical *** paper presents a comprehensive investigation,based on Monte Carlo simulation,into determining the optimal number and positions for efficient target placement in typical scenes consisting of a pair of *** demonstrates new check-up statistical rules and geometrical constraints that can effectively extract and analyze massive simulations of unregistered point clouds and their corresponding *** than 6×10^(7) sets of the registrations were simulated,whereas more than IOO registrations with real data were used to verify the results of *** results indicated that using five spherical targets is the best choice for the registration of a large typical registration site consisting of two vertical facades and a ground,when there is only a box set of spherical targets *** a result,the users can avoid placing extra targets to achieve insignificant improvements in registration *** results also suggest that the higher registration accuracy can be obtained when the ratio between the facade-to-target distance and target-to-scanner distance is approximately 3:***,the targets should be placed closer to the scanner rather than in the middle between the facades and the scanner,contradicting to the traditional thought. Besides,the results reveal that the accuracy can be increased by setting the largest projected triangular area of the targets to be large.

关键词： point cloud registration Monte Carlo simulation optimalization spherical target

Changes in structural plasticity of hippocampal neurons in an animal model of multiple sclerosis

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Zoological Research 2024年第2期45卷 398-414页

作者： Poornima d.E.Weerasinghe-Mudiyanselage Sohi Kang Joong-Sun Kim Sung-ho Kim hongbing Wang Taekyun Shin Changjong Moon department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 FOUR ProgramChonnam National UniversityGwangju 61186Republic of Korea department of Anatomy and Convergence Medical Science Institute of Health SciencesCollege of MedicineGyeongsang National UniversityJinju 52727Republic of Korea department of Physiology and Neuroscience Program Michigan State UniversityEast LansingMI 48824USA department of Veterinary Anatomy College of Veterinary Medicine and Veterinary Medical Research InstituteJeju National UniversityJeju 63243Republic of Korea

Structural plasticity is critical for the functional diversity of neurons in the *** autoimmune encephalomyelitis(EAE)is the most commonly used model for multiple sclerosis(MS),successfully mimicking its key pathological features(inflammation,demyelination,axonal loss,and gliosis)and clinical symptoms(motor and non-motordysfunctions).Recentstudieshave demonstrated the importance of synaptic plasticity in EAE *** the present study,we investigated the features of behavioral alteration and hippocampal structural plasticity in EAE-affected mice in the early phase(11 days post-immunization,dPI)and chronic phase(28dPI).EAE-affected mice exhibited hippocampus-related behavioral dysfunction in the open field test during both early and chronic *** complexity was largely affected in the cornu ammonis 1(CA1)and CA3 apical and dentate gyrus(dG)subregions of the hippocampus during the chronic phase,while this effect was only noted in the CA1 apical subregion in the early ***,dendritic spine density was reduced in the hippocampal CA1 and CA3 apical/basal and dG subregions in the early phase of EAE,but only reduced in the dG subregion during the chronic ***,mRNA levels of proinflammatory cytokines(Il1β,Tnfα,and Ifnγ)and glial cell markers(Gfap and Cd68)were significantly increased,whereas the expression of activity-regulated cytoskeletonassociated protein(ARC)was reduced during the chronic ***,exposure to the aforementioned cytokines in primary cultures of hippocampal neurons reduced dendritic complexity and ARC *** cultures of hippocampal neurons also showed significantly reduced extracellular signal-regulated kinase(ERK)phosphorylation upon treatment with proinflammatory ***,these results suggest that autoimmune neuroinflammation alters structural plasticity in the hippocampus,possibly through the ERK-ARC pathway,indicating that this alteration may be associated with hi

关键词： Activity-regulated cytoskeleton-associated protein Anxiety-like behavior Experimental autoimmune encephalomyelitis Hippocampal dysfunction Neuroinflammation

Revealing the influence of in-situ formed LiCl on garnet/Li interface for dendrite-free solid-state batteries

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Journal of Energy Chemistry 2024年第5期92卷 394-403页

作者： Seoyoon Shin Jinuk Lee Tae ho Shin Seokhee Lee Hydrogen Energy Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju-siGyeongsangnam-do 52851Republic of Korea department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea

Inadequate interfacial contact between lithium and solid-state electrolytes(SSEs)leads to elevated impedance and the growth of lithium dendrites,presenting significant obstacles to the practical viability of solid-state batteries(SSBs).To ameliorate interfacial contact,optimizing the surface treatment of SSEs has been widely ***,the formation of LiCl through acid treatment,an equally crucial factor impacting SSB performance,has received limited attention,leaving its underlying mechanism *** study aims to shed light on SSE characteristics following LiCl formation and the removal of Li_(2)CO_(3) through acid *** seek to establish quantifiable links between SSE surface structure and SSB performance,focusing on interfacial resistance,current distribution,critical current density(CCd),and lithium *** formation of LiCl,occurring as Li_(2)CO_(3) is removed through acid treatment,effectively mitigates lithium dendrite formation on SSE *** action inhibits electron injection and reduces the diffusion rate of Li ***,acid treatment transforms the SSE surface into a lithiophilic state by eliminating surface Li_(2)CO_(3).Consequently,the interfacial resistance between lithium and SSEs substantially decreases from 487.67 to 35.99Ωcm^(2) at 25°*** leads to a notably high CCd of 1.3 mA cm^(-2) and a significantly extended cycle life of 1,000 ***,in full SSBs incorporating LiCoO_(2)cathodes and acid-treated garnet SSEs,we observe exceptional cyclability and rate *** findings highlight that acid treatment not only establishes a fundamental relationship between SSE surfaces and battery performance but also offers an effective strategy for addressing interfacial challenges in SSBs.

关键词： Solid-statebatteries Acidtreatment Interfacial stability LiCl Surface modification

development of vehicle-recognition method on water surfaces using LidAR data:SPd^(2)(spherically stratified point projection with diameter and distance)

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defence Technology（防务技术） 2024年第6期36卷 95-104页

作者： Eon-ho Lee Hyeon Jun Jeon Jinwoo Choi Hyun-Taek Choi Sejin Lee The department of Mechanical Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea Ocean System Engineering Research division Korea Research Institute of Ships and Ocean Engineering(KRISO)Daejeon 34103Republic of Korea The division of Mechanical&Automotive Engineering Kongju National University1223-24 Cheonan-daeroCheonan 31080Republic of Korea

Swarm robot systems are an important application of autonomous unmanned surface vehicles on water *** monitoring natural environments and conducting security activities within a certain range using a surface vehicle,the swarm robot system is more efficient than the operation of a single object as the former can reduce cost and save *** is necessary to detect adjacent surface obstacles robustly to operate a cluster of unmanned surface *** this purpose,a LidAR(light detection and ranging)sensor is used as it can simultaneously obtain 3d information for all directions,relatively robustly and accurately,irrespective of the surrounding environmental *** the GPS(global-positioning-system)error range exists,obtaining measurements of the surface-vessel position can still ensure stability during platoon *** this study,a three-layer convolutional neural network is applied to classify types of surface *** aim of this approach is to redefine the sparse 3d point cloud data as 2d image data with a connotative meaning and subsequently utilize this transformed data for object classification ***,we have proposed a descriptor that converts the 3d point cloud data into 2d image *** use this descriptor effectively,it is necessary to perform a clustering operation that separates the point clouds for each *** developed voxel-based clustering for the point cloud ***,using the descriptor,3d point cloud data can be converted into a 2d feature image,and the converted 2d image is provided as an input value to the *** intend to verify the validity of the proposed 3d point cloud feature descriptor by using experimental data in the ***,we explore the feasibility of real-time object classification within this framework.

关键词： Object classification Clustering 3d point cloud data LidAR(light detection and ranging) Surface vehicle