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Hydrogen production at intermediate temperatures with proton conducting ceramic cells:Electrocatalytic activity,durability and energy efficiency

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Journal of Energy Chemistry 2023年第11期86卷 437-446,I0010页

作者： Haoyu Zheng Feng Han Noriko Sata Rémi costa Institute of Engineering Thermodynamics German Aerospace Center (DLR) Institute for Building Energetics Thermotechnology and Energy Storage (IGTE) University of Stuttgart

Proton conducting ceramic cells(PCCs)are an attractive emerging technology operating in the intermediate temperature range of 500 to 700℃.In this work,we evaluate the production of hydrogen at intermediate temperatures by proton conducting ceramic cell electrolysis(PCCEL).We demonstrate a highperformance steam electrolysis owing to a composite positrode based on BaGd_(0.8)La_(0.2)Co_(2)O_(6-δ)(BGLC1082)and BaZr0.5Ce0.4Y0.1O3-δ(BZCY541).The high reliability of PCCEL is demonstrated for 1680 h at a current density as high as-0.8 A cm^(-2)close to the thermoneutral cell voltage at 600℃.The electrolysis cell showed a specific energy consumption ranging from 54 to 66 kW h kg^(-1)that is comparable to state-of-the-art low temperature electrolysis technologies,while showing hydrogen production rates systematically higher than commercial solid oxide ceramic cells(SOCs).Compared to SOCs,the results verified the higher performances of PCCs at the relevant operating temperatures,due to the lower activation energy for proton transfer comparing with oxygen ion ***,because of the p-type electronic conduction in protonic ceramics,the energy conversion rate of PCCs is relatively lower in steam *** faradaic efficiency of the PCC in electrolysis mode can be increased at lower operating temperatures and in endothermic conditions,making PCCEL a technology of choice to valorize high temperature waste heat from industrial processes into *** increase the faradaic efficiency by optimizing the materials,the cell design,or the operating strategy is a key challenge to address for future developments of PCCEL in order to achieve even more superior techno-economic merits.

关键词： Steam electrolysis Hydrogen production Proton conducting ceramics Intermediate temperature Energy efficiency

Oxidative stress in N88S seipinopathy:novel insights into the mechanisms of neurodegeneration and therapeutic avenues

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中国神经再生研究：英文版 2023年第8期18卷 1719-1720页

作者： Vítor costa Vitor Teixeira i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoPortoPortugal Yeast Signalling Networks IBMC-Instituto de Biologia Molecular e CelularUniversidade do PortoPortoPortugal ICBAS Instituto de Ciências Biomédicas Abel SalazarUniversidade do PortoPortoPortugal

Lipid droplets (LDs) are ubiquitous cellular orga nelles that perform functions mostly dedicated to energy homeostasis and lipid *** neutral lipid depots (triacylglycerol,sterol esters),they can be rapidly mobilized through lipase-mediated hydrolysis (lipolysis) or via lipophagy,a specific form of autophagy devoted to consumption of LDs inside the lysosome.

关键词： hydrolysis insight devoted

Dynamic response of precast segmental bridge columns under heavy truck impact

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Frontiers of Structural and Civil Engineering 2023年第3期17卷 327-349页

作者： Yuye ZHANG Mingli HU Wei FAN Daniel DIAS-Da.costa Department of Civil Engineering Nanjing University of Science and TechnologyNanjing 210094China Research Institute of Hunan University in Chongqing Chongqing 401120China Key Laboratory for Wind and Bridge Engineering of Hunan Province Hunan UniversityChangsha 410082China School of Civil Engineering The University of SydneySydneyNSW 2006Australia

Considering the wide application of precast segmental bridge columns(PSBCs)in engineering practice,impact-resistant performance has gained significant ***,few studies have focused on PSBCs subjected to high-energy impacts caused by heavy truck ***,the behavior of PSBCs under a heavy truck impact was investigated in this study using high-fidelity finite element(FE)*** detailed FE modeling methods of the PSBCs and heavy trucks were validated against experimental *** validated modeling methods were employed to simulate collisions between PSBCs and heavy *** simulation results demonstrated that the engine and cargo caused two major peak impact forces during ***,the impact force,failure mode,displacement,and internal force of the PSBCs under heavy truck impacts were *** extensive study was performed to assess the influence of the section size,truck weight,impact velocity,and number of precast segments on the impact *** truck weight was found to have a minor effect on the engine impact *** was found to be localized at the bottom of the three segments,with the top remaining primarily *** parametric study demonstrated that larger cross-sections may be a preferred option to protect PSBCs against the impact of heavy trucks.

关键词： precast segmental bridge columns heavy truck collision dynamic response

Ground-borne vibrations induced by impact pile driving: experimental assessment and mitigation measures

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 105-115页

作者： A.Colaço A.M.Abouelmaty P.Alves costa CONSTRUCT-FEUP University of PortoRua Dr.Roberto FriasPorto 4200-465Portugal Arab Academy for Science Technology&Maritime TransportCollege of Engineering and TechnologyAlexandriaEgypt

Impact pile driving is an interesting technique for the construction of deep foundations from a practical and economical point of ***,the generalization of this technique can be restricted due to the excessive vibration levels that can be generated,which can be especially problematic in residential ***,different mitigation measures can be applied to prevent excessive vibration levels inside buildings located near construction *** compare its efficiency through a numerical prediction tool,two experimental test sites are first presented and *** the results obtained,it was found that the construction of an open trench near the impact source can be used as an efficient mitigation measure to reduce the maximum vibration levels evaluated in this study.

关键词： impact pile driving ground-borne vibrations experimental and numerical analysis mitigation measures

Weighted individual-resource networks in prey–predator systems: the role of prey availability on the emergence of modular structures

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Integrative Zoology 2022年第1期17卷 115-127页

作者： Andrea.costa Antonio ROMANO Giacomo ROSA Sebastiano SALVIDIO Department of Earth Environment and Life Sciences(DISTAV)University of GenovaGenovaItaly Italian National Research Council(CNR) Agriculture and Food Sciences Department(IBE)Institute of Bioeconomy–BiologyRomaRMItaly

Ecological networks,usually depicting interactions among species,have been recently down-scaled to the individual level,permitting description of patterns of inter-individual resource variation that are usually hindered at the species *** diet theory(ODT)models,applied to prey–predator systems,predict different patterns of nestedness and modularity in the network,depending on the available resources and intra-specific *** effect of resource availability on the emergence of networks structures,and ODT framework,has not yet fully been ***,we analyzed the structural patterns of individual-resource networks in 3 species of Mediterranean salamanders,in relation to changes in prey *** used weighted individual-resource network metrics to interpret the observed patterns,according to 3 ODT *** found significant nestedness recurring in our study system,indicating that both selective and opportunistic individuals occur in the same *** diversity,rather than abundance,was apparently related to inter-individual resource variation and promoted the emergence of significant modularity within all *** observed patterns of nestedness and modularity,together with the variation in resource diversity and intra-specific competition,are in agreement with the distinct preferences model of *** findings suggest that in the focal prey–predator systems,individuals were able to perceive changes in prey diversity and to exploit in different ways the variations in composition of available resources,shifting their diet assembly rules *** findings also confirm that the use of weighted individual-resource networks,in prey–predator systems,allows to disclose dynamics that are masked at the species or population level.

关键词： inter-individual resource variation network-analysis optimal diet theory prey availability salamanders

Heme as an inducer of cerebral damage in hemorrhagic stroke:potential therapeutic implications

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Neural Regeneration Research 2022年第9期17卷 1961-1962页

作者： Luiz Ricardo da.costa Vasconcellos Pedro Moreno Pimentel-Coelho Cellular Signalling and Cytoskeletal Function Laboratory The Francis Crick InstituteLondonUK Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroInstituto Nacional de Ciência e Tecnologia em Medicina RegenerativaRio de JaneiroRJBrazil

Intracerebral hemorrhage(ICH)consists of the rupture of a cerebral artery leading to bleeding into the surrounding *** event has a primary phase of brain injury consisting of mechanical tissue damage due to the mass effect,followed by a secondary phase of brain injury triggered by the presence of blood components released at the site of bleeding(Bulters et al.,2018).Despite the high rates of mortality and morbidity from ICH,no effective treatment is available so far.

关键词： cerebral damage rupture

Structural optimization of patient-specific temporomandibular joint replacement implants for additive manufacturing:novel metrics for safety evaluation and biomechanical performance

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Bio-Design and Manufacturing 2022年第2期5卷 333-347页

作者： Manuel Pinheiro Anouar Krairi Robin Willaert Maria C.costa Wim Van Paepegem Mechanics of Materials and Structures(MMS) Ghent UniversityGhentBelgium Materials Innovation Institute(M2i) DelftThe Netherlands Department of Oral and Maxillofacial Surgery University Hospitals Leuven LeuvenBelgium 4 Department of Head and Neck SurgeryGhent University HospitalGhentBelgium

Total temporomandibular joint(TMJ)replacement is recommended only when there is irreversible damage to the joint and no conservative treatment can provide functional *** stock and custom-made TMJ implants have been made available;however,retrospective and comparative studies were unable to find significant differences between the two types of *** introduction of additive manufacturing(AM)techniques in medical practice allows for a greater freedom of design and a higher degree of device *** combination of AM with structural optimisation may streamline development and provide the key for fabricating biomechanic ally enhanced TMJ *** this study,structural optimis ation techniques were applied to develop and numerically validate a patient-specific TMJ *** biomechanical behaviour of each intermediate TMJ design was assessed under four different nominal and maximum biting tasks using finite element *** addition,a new set of metrics were proposed to compare each design regarding biomechanical performance and implant *** results suggest that 55-82%of the natural/intact strain patterns can be recovered with the finally selected TMJ *** represents an increase of 15%in biomechanical performance for incisor biting,15%for right molar biting,17%for left molar biting and a decrease of 2%for left group biting compared with the initial *** results also suggest that load transfer at the proximal ramus reduces the implant’s impact on the mandible’s strain ***,structural optimisation allows for a volume reduction of up to 44%with a minimum loss of implant safety and biomechanical performance.

关键词： Temporomandibular joint Additive manufacturing Implant safety Biomechanical performance Finite element analysis

Parkinson's Disease:A Multisystem Disorder

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Neuroscience Bulletin 2023年第1期39卷 113-124页

作者： Helena Nunes costa Ana Raquel Esteves Nuno Empadinhas Sandra Morais Cardoso CNC–Center for Neuroscience and Cell Biology and CIBB–Center for Innovative Biomedicine and Biotechnology University of Coimbra3004-504CoimbraPortugal IIIUC–Institute for Interdisciplinary Research University of Coimbra3004-504CoimbraPortugal Faculty of Medicine University of Coimbra3004-504CoimbraPortugal

The way sporadic Parkinson's disease(PD)is perceived has undergone drastic changes in recent *** a long time,PD was considered a brain disease characterized by motor disturbances;however,the identification of several risk factors and the hypothesis that PD has a gastrointestinal onset have shed additional ***,after recognition of prodromal non-motor symptoms and the pathological processes driving their evolution,there is a greater understanding of the involvement of other organ *** this reason,PD is increasingly seen as a multiorgan and multisystemic pathology that arises from the interaction of susceptible genetic factors with a challenging environment during aging-related decline.

关键词： Parkinson's disease Gut microbiome Intestinal barrier α-Synuclein Blood-brain barrier

The brain as a source and a target of prolactin in mammals

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Neural Regeneration Research 2022年第8期17卷 1695-1702页

作者： Ana R.costa-Brito Isabel Gonçalves Cecília R.A.Santos CICS-UBI-Health Sciences Research Centre Universidade da Beira InteriorCovilhãPortugal C4-UBI-Cloud Computing Competence Centre Universidade da Beira InteriorCovilhãPortugal

Prolactin is a polypeptide hormone associated with an extensive variety of biological *** the roles of prolactin in vertebrates,some were preserved throughout *** is the case of its function in the brain,where prolactin receptors,are expressed in different structures of the central nervous *** the brain,prolactin actions are principally associated with reproduction and parental behavior,and involves the modulation of adult neurogenesis,neuroprotection,and neuroplasticity,especially during pregnancy,thereby preparing the brain to *** is mainly produced by specialized cells in the anterior pituitary ***,during vertebrate evolution many other extrapituitary tissues do also produce prolactin,like the immune system,endothelial cells,reproductive structures and in several regions of the *** review summarizes the relevance of prolactin for brain function,the sources of prolactin in the central nervous system,as well as its local production and secretion.A highlight on the impact of prolactin in human neurological diseases is also provided.

关键词： brain brain disease choroid plexus neurogenesis neuroplasticity neuroprotection prolactin prolactin receptor