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Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

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Food Science and Human Wellness 2024年

作者： Mirco Vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco Maria.calabrese Marco Gobbetti Maria de Angelis Faculty of Science and Technology Free University of Bozen Evonik Operations GmbH Department of Soil Plant and Food Sciences University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

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Challenges and advancing strategies of endoscopic submucosal dissection for early gastric cancer:The puzzle of eCura C1

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 439-444页

作者： Giulio calabrese Guido Manfredi Marcello F Maida Francesco V Mandarino Endrit Shahini Francesco Pugliese Paolo Cecinato Liboria Laterza Emanuele Sinagra Sandro Sferrazza Department of Gastroenterology and Endoscopy ARNAS Civico–Di Cristina–BenfratelliPalermo 90127SiciliaItaly Department of Gastroenterology and Digestive Endoscopy Ospedale MaggioreCrema 26013Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100SiciliaItaly Department of Gastroenterology and Digestive Endoscopy IRCCS Ospedale San RaffaeleMilan 20132LombardyItaly Department of Gastroenterology National Institute of Gastroenterology-IRCCS“Saverio de Bellis”Castellana GrotteBari 70013Italy Department of Digestive and Interventional Endoscopy Niguarda HospitalASST NiguardaMilan 20162LombardyItaly Department of Medical and Surgical Sciences IRCCS Azienda Ospedaliero-Universitaria di BolognaPoliclinico Sant’OrsolaBologna 40138Emilia-RomagnaItaly Department of Gastroenterology and Endoscopy Fondazione Instituto San Raffaele GiglioCefalù90015PalermoItaly

In this editorial,we explore the challenges of managing noncurative resections in early gastric cancer after endoscopic submucosal dissection(ESD),starting from the consideration recently made by Zhu et ***,we evaluate the management of eCura C1 lesions,where decisions regarding further interventions are pivotal yet *** among endoscopists,surgeons,and pathologists is underscored to refine risk assessment and personalize therapeutic *** advancements in ESD techniques and interdisciplinary collaboration offer opportunities for outcome optimization in managing eCura C1 ***,despite needing further clinical validation,molecular biomarkers have emerged as promising tools for enhancing *** manuscript highlights the ongoing research attempts to define treatment paradigms effectively and evaluates the potential of emerging options,ultimately aiming to improve patient care and outcomes in this complex clinical scenario.

关键词： Early gastric cancer Endoscopic submucosal dissection eCura Non-curative resection Multidisciplinary approach

The intricate debate on neurodegeneration and neuroinflammation in Parkinson’s disease:which came first?

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Neural Regeneration Research 2023年第1期18卷 125-126页

作者： Antonella Cardinale Valeria.calabrese Experimental Neurophysiology Laboratory IRCCS San Raffaele RomaRomeItaly Department of Medicine Universitàdegli Studi di PerugiaPerugiaItaly

Parkinson’s disease(PD)is a heterogeneous multifactorial disorder and,during the last years,new scientific evidence has supported this *** principal hallmarks of PD are the loss of dopaminergic neurons in the substan... 详细信息

关键词： inflammation aggregation debate

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The relationship between controllability, optimal testing resource allocation, and incubation-latent period mismatch as revealed by COVID-19

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Infectious Disease Modelling 2023年第2期8卷 514-538页

作者： Jeffery Demers William F.Fagan Sriya Potluri Justin M.calabrese Center for Advanced Systems Understanding(CASUS) Helmholtz-Zentrum Dresden-Rosendorf(HZDR)G€orlitzGermany Dept.of Biology University of MarylandCollege ParkMDUSA Dept.of Ecological Modelling Helmholtz Centre for Environmental Research-UFZLeipzigGermany

The severe shortfall in testing supplies during the initial COVID-19 outbreak and ensuing struggle to manage the pandemic have affirmed the critical importance of optimal supplyconstrained resource allocation strategies for controlling novel disease *** address the challenge of constrained resource optimization for managing diseases with complications like pre-and asymptomatic transmission,we develop an integro partial differential equation compartmental disease model which incorporates realistic latent,incubation,and infectious period distributions along with limited testing supplies for identifying and quarantining infected *** model overcomes the limitations of typical ordinary differential equation compartmental models by decoupling symptom status from model compartments to allow a more realistic representation of symptom onset and presymptomatic *** analyze the influence of these realistic features on disease controllability,we find optimal strategies for reducing total infection sizes that allocate limited testing resources between‘clinical’testing,which targets symptomatic individuals,and‘non-clinical’testing,which targets non-symptomatic *** apply our model not only to the original,delta,and omicron COVID-19 variants,but also to generically parameterized disease systems with varying mismatches between latent and incubation period distributions,which permit varying degrees of presymptomatic transmission or symptom onset before *** find that factors that decrease controllability generally call for reduced levels of non-clinical testing in optimal strategies,while the relationship between incubation-latent mismatch,controllability,and optimal strategies is *** particular,though greater degrees of presymptomatic transmission reduce disease controllability,they may increase or decrease the role of nonclinical testing in optimal strategies depending on other disease factors like transmissibility

关键词： Testing quarantine control Optimal resource allocation Presymptomatic transmission Latent period Incubation period Age of infection

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博洛尼亚Bonfiglioli总部大楼

现代装饰 2024年第3期 24-31页

作者： Peter Pichler(设计) Silvana Ordinas(设计) Niklas Knap(设计) Simona Alu(设计) Ugo Licciardi(设计) Cem Ozbasaran(设计) Filippo Ogliani(设计) Giovanni Paterlini(设计) Domenico calabrese(设计) Nathalia Rotelli(设计) Angela Ferrari(设计) Alessandro Cardellini(设计) Simone Valbusa(设计) Gustav Willeit(摄影) 范嘉苑(编译) 不详

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历... 详细信息

Peter Pichler Architecture近期落成的Bonfiglioli总部大楼现已揭幕,该项目位于意大利博洛尼亚的Calderara di Reno地区。新总部设计旨在打造一座高效且功能齐全的办公建筑,以此展现出这家意大利企业的专业性、创新性以及引以为傲的历史。创立于1956年,Bonfiglioli公司是一家拥有领先地位的制造商以及供应商,产品门类涵盖齿轮电动机、驱动系统、减速齿轮箱和变频器等。Bonfiglioli的产品解决方案在全球范围内的自动化、移动机械和可再生能源领域都具有强有力的推动作用。

关键词：产品门类减速齿轮箱移动机械可再生能源博洛尼亚总部大楼办公建筑产品解决方案

Decarboxylative Cyclization of Allylic Cyclic Carbamates: Mechanism Studies and Applications to the Synthesis of Natural Products

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有机化学 1993年第2期13卷 175-177页

作者： Joseph C. calabrese Du Pont Co. CR&DD Experimental Station

The mechanism of decarboxylative cyclization of allylic cyclic carbamates 1 leading to 2-substituted △~3-piperidines and-pyrrolidines, as well as its applications to the total synthesis of (--)codonopsine, are descri... 详细信息

关键词： mechanism allylic cyclic carbamates codonopsine

Albumin-bilirubin score in non-malignant liver diseases should be properly validated

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World Journal of Gastroenterology 2023年第46期29卷 6089-6091页

作者： Andrea Pasta Francesco calabrese Maria Corina Plaz Torres Giorgia Bodini Manuele Furnari EdoardoVincenzo Savarino Vincenzo Savarino Edoardo Giovanni Giannini Elisa Marabotto Gastroenterology Unit Department of Internal MedicineUniversity of GenoaIRCCS‐Ospedale Policlinico San MartinoGenoa 16132Italy Department of Surgery Oncology and GastroenterologyUniversity Hospital of PaduaPadua 35128Italy

The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic *** letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year *** score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s *** concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk *** reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation *** letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive ***,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this *** suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease.

关键词： Albumin-bilirubin score Decompensated cirrhosis Liver disease Nonmalignant liver disease Portal hypertension

Temperature-induced hormesis in plants

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Journal of Forestry Research 2019年第1期30卷 13-20页

作者： Evgenios Agathokleous Mitsutoshi Kitao Hisanori Harayama Edward J.calabrese Hokkaido Research Center Forestry and Forest Products Research Institute (FFPRI) Forest Research and Management Organization Research Faculty of Agriculture Hokkaido University Department of Environmental Health Sciences Morrill IN344 University of Massachusetts

Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress. To investigate these, dose–response relationships should be clarified. It was previously assumed that the fundamental nature of biological dose–responses follows a linear model, either with no threshold or with a threshold below which no effects are expected to occur in biological endpoints. However, substantial literature, including widespread documentation in plants, has revealed that hormesis commonly occurs. Hormesis is highly generalized and can be utilized as a quantitative measure of biological plasticity. Conditioning induced by adaptive responses also occurs in the framework of hormesis and is of particular importance to environmental change biology with regards to evolutionary *** paper presents additional evidence for hormetic dose responses induced by temperature in plants. The current understanding on hormesis provides a perspective for next generation environmental change research. Hormesis should have a central role in environmental change biology of vegetation.

关键词： Adaptive response Biological plasticity Dose response Hormesis Stress biology

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Information security intelligence : cryptographic principles and applications /

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