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A Systematic Review of cannabidiol Effects in coronary Syndromes: challenges to clinical Translation

Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala Alejandra Meaney-Martínez Alejandro Alcocer-chauvet vidal Gonzalez-coronado Nestor Rubio-Infante Gerardo Garcia-Rivas Department of cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. cannabidiol (cBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of cBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Review of Animal Data from Experimental Studies (cAMARADES) guidelines, in the electronic database from PubMed, Web of Science and Scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: currently there are no good-quality clinical trials with the use of cBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with cBD. Mechanisms of cBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. conclusion: No clinical recommendation can be issued with the current evidence, on the use of cBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include cBD in the management of coronary syndromes.

关键词： cannabis cannabidiol Acute coronary Syndromes Myocardial Infarction Myocardial Ischemia and Oxidative Stress

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Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria

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中国化学快报：英文版 2023年第2期34卷 214-218页

作者： Zhiping Liu Fanny Demontrond Anne Imberty Andrew c.-H.Sue Sébastien vidal Hongxia Zhao Tianjin Key Lab for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Institut de chimie et Biochimie Moléculaires et Supramoléculaires Laboratoire de Chimie Organique 2-GlycochimieUMR 5246CNRSUniversitéClaude Bernard Lyon 1Universitéde LyonVilleurbanne 69622France cNRS Univ.Grenoble AlpesCERMAVGrenoble 38000France college of chemistry and chemical Engineering Xiamen UniversityXiamen 361005China cNRS Institut de Chimie des Substances NaturellesUniversitéParis-SaclayUPR 2301Gif-sur-Yvette 91198France

Macrocycle-based glycoclusters, on account of their promising anti-adhesive properties against bacteria,are potential therapeutic alternatives to classic antibiotics through the much less explored anti-adhesive strategy. In this study, a series of constitutionally-pure pentavalent glycoclusters was prepared by conjugating assorted azido-carbohydrates onto a penta-propargyl rim-differentiated pillar[5]arene(RD-P[5])scaffold through cu(I)-catalyzed azide–alkyne cycloaddition “click” reactions. Their binding towards therapeutically relevant bacterial lectins, such as Lec A and Lec B from Pseudomonas aeruginosa and concanavalin A(con A), were evaluated subsequently by isothermal titration calorimetric studies. Most of these isomerfree RD-P[5] pentavalent glycoclusters, except the fucosylated ones, display good affinities to lectins.Nonetheless, the dissociation constants observed are similar to those displayed by an analogous pentavalent glycocluster consisting of four P[5] constitutional isomers, in which the RD-P[5] component merely accounts for 7% in the mixture. Our results revealed that high constitutional purity is not essential for achieving effective multivalent interactions between P[5]-based glycoclusters and lectins, presumably as a result of the conformationally labile nature of the P[5] scaffold. This information provides valuable design principles for low-cost and facile syntheses of glycosylated P[5]s for biomedical applications.

关键词： Glycocluster Lectin Pillararene Multivalency constitutional purity

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Evolutionary importance of the relationship between cytogeography and climate:New insights on creosote bushes from North and South America

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Plant Diversity 2022年第5期44卷 492-498页

作者： Romina vidal-Russell Mariana Tadey Romana Urfusova Tomás Urfus cintia Paola Souto Laboratorio Ecotono-INIBIOMA(cONIcET-UNcomahue) Quintral1250BarilocheRío NegroArgentina Department of Botany Faculty of ScienceCharles UniversityBenátská212800PragueCzech Republic

Relationships between genome size and environmental variables suggest that DNA content might be adaptive and of evolutionary importance in plants.The genus Larrea provides an interesting system to test this hypothesis,since it shows both intra-and interspecific variation in genome size.Larrea has an amphitropical distribution in North and South American deserts,where it is most speciose.Larrea tridentata in North America shows a gradient of increasing autopolyploidy;while three of the four studied South American species are diploids,Larrea divaricata,Larrea nitida,Larrea ameghinoi,and the fourth is an allopolyploid,Larrea cuneifolia.We downloaded available focal species’georeferenced records from seven data reservoirs.We used these records to extract biologically relevant environmental variables from Worldclim at 30 arc seconds scale,to have a broad characterization of the variable climatic conditions of both regions,and a climatic envelope for each species.We estimated relative DNA content index and relative monoploid genome values,by flow cytometry,of four most abundant Larrea species throughout their respective ranges.Then we winnow the bioclimatic dataset down to uncorrelated variables and sampled locales,to analyse the degree of association between both intra-and interspecific relative DNA content and climatic variables that are functionally relevant in arid environments using Pearson correlations,general linear and mixed effects models.Within the genus Larrea,relative DNA content increases with rising temperature and decreases with rising precipitation.At the intraspecific level,all four species show relative DNA content variation across climatic conditions.Larrea is a genus that shows genome size variation correlated with climate.Our results are also consistent with the hypothesis that extreme environmental pressures may have facilitated repeated whole genome duplication events in North America,while in South America,reticulate evolution,as allopolyploidization,and speciation might have been climate-depend

关键词： DNA content Drylands Genome size Jarilla Larrea Zygophyllaceae

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Fear of cOVID-19 and emotional dysfunction problems:Intrusive,avoidance and hyperarousal stress as key mediators

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World Journal of Psychiatry 2022年第8期12卷 1088-1101页

作者： Raquel Falcó Verónica vidal-Arenas Jordi Ortet-Walker Juan c Marzo JoséA Piqueras PSIcO-REcURSOS cOVID-19 Study Group Department of Health Psychology and center for Applied Psychology Universidad Miguel HernándezElche 03202AlicanteSpain Department of Basic and clinical Psychology and Psychobiology Universitat Jaume ICastellóde la Plana 12071CastellónSpain

BAcKGROUND There is mounting empirical evidence of the detrimental effects of the coronavirus disease 2019(cOVID-19)outbreak on mental health.Previous research has underscored the effects of similar destabilizing situations such as war,natural disasters or other pandemics on acute stress levels which have been shown to exacerbate current and future psychopathological symptoms.AIM To explore the role of acute stress responses(intrusive,avoidance and hyperarousal)as mediators in the association between fear of cOVID-19 and emotional dysfunction-related problems:Depression,agoraphobia,panic,obsessivecompulsive,generalized anxiety,social anxiety and health anxiety symptoms.METHODS A sample of 439 participants from a university community in Spain(age:mean±SD:36.64±13.37;73.1%females)completed several measures assessing their fear of cOVID-19,acute stress responses and emotional dysfunction syndromes through an online survey.Data collection was carried out from the start of home confinement in Spain until May 4,2020,coinciding with initial de-escalation measures.Processing of the dataset included descriptive and frequency analyses,Mann-Whitney U Test of intergroup comparisons and path analysis for direct and indirect effects.This is an observational,descriptive-correlational and crosssectional study.RESULTS The prevalence of clinical symptoms in our sample,reported since the beginning of the pandemic,reached 31.44%.The female group presented higher scores although the effect size was small.Overall,the participants who exceeded the clinical cut-off points in emotional problems showed higher levels of fear of cOVID-19 and of cognitive,motor and psychophysiological responses of acute stress,unlike the group with normative scores.In addition,the results show significant mediated effects of hyperarousal stress among fear of cOVID-19 and emotional dysfunction psychopathology.However,the clinical syndromes most related to the consequences of the pandemic(e.g.,social contact avoidance or frequent hand washing),such as agorapho

关键词： Fear of cOVID-19 Acute stress Emotional dysfunction Psychophysiological activation Mediated effects

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Twenty-four hours intraocular pressure in keratoconic eyes assessed by applanation tonometry and Tono-Pen AVIA

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International Journal of Ophthalmology(English edition) 2022年第1期15卷 52-58页

作者： Rafael vidal Merola Sebastião cronemberger Artur William Veloso Alberto Diniz-Filho Nassim calixto Glaucoma Service of São Geraldo Eye Hospital Clinic HospitalFederal University of Minas GeraisBelo HorizonteBelo Horizonte 30130-100State of Minas GeraisBrazil

AIM:To assess intraocular pressure(IOP)during the daily curve of intraocular pressure(DcPo)in keratoconic eyes and compare Goldmann applanation tonometer(GAT),without and with astigmatism correction(n GAT and c GAT)and Tono-Pen AVIA(TPA)assessment methods.METHODS:Thirty-nine keratoconic eyes of 24 patients were assessed.DcPo was evaluated with five IOP measurements;four were performed with a GAT(n GAT and c GAT),and a Tono-Pen AVIA(TPA)at various times throughout the day.RESULTS:Mean IOP DcPo values(mm Hg)were:n GAT,9.9±2.6;c GAT,11.3±2.6;TPA 12.3±3.1.Mean IOP DcPo differences(mm Hg)and Spearman’s correlation coefficients were as follows:c GATc-n GAT,1.32±1.31,r_(s)=0.879(Pc GAT-TPA,-1.02±2.08,r_(s)=0.723(Pc GAT-TPA and n GAT-TPA mean IOP DcPo measurements revealed a mean difference of 1.02(95%cI,0.35-1.70)and 2.35(95%cI,1.62-3.07)mm Hg,respectively.Regression analysis yielded the following equation:TPA IOP=5.49+0.775×c GAT-0.015×AcD-0.299×corneal astig matism,which allowed us to infer TPA IOP values from other parameters.cONcLUSION:In keratoconic eyes,IOP peaks of DcPo measurements are identified at 6 a.m.,independent of the tonometer.The mean DcPo values are:TPA>c GAT>n GAT.IOP TPA measures are predictive of c GAT values,adjusted according to anterior chamber depth and corneal astigmatism.

关键词： intraocular pressure keratoconus tonometry

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Kinetic Slip Boundary condition for Isothermal Rarefied Gas Flows through Static Non-Planar Geometries Based on the Regularized Lattice-Boltzmann Method

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communications in computational Physics 2022年第3期31卷 816-868页

作者： Jean-Michel Tucny David vidal Sebastien Leclaire Francois Bertrand Mechanical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7 chemical Engineering Department Polytechnique MontralP.O.Box 6079Stn.CVMontrealQCCANADAH3C 3A7

The simulation of rarefied gasflows through complex porous media is chal-lenging due to the tortuousflow pathways inherent to such structures.The Lattice Boltzmann method(LBM)has been identified as a promising avenue to solveflows through complex geometries due to the simplicity of its scheme and its high parallel computational efficiency.It has been proposed to model the stress-strain relationship with the extended Navier-Stokes equations rather than attempting to directly solve the Boltzmann equation.However,a regularization technique is required tofilter out non-resolved higher-order components with a low-order velocity scheme.Although slip boundary conditions(Bcs)have been proposed for the non-regularized multiple relaxation time LBM(MRT-LBM)for planar geometries,previous slip Bcs have never been verified extensively with the regularization technique.In this work,following an extensive literature review on the imposition of slip Bcs for rarefiedflows with the LBM,it is proven that earlier values for kinetic parameters developed to impose slip Bcs are inaccurate for the regularized MRT-LBM and differ between the D2Q9 and D3Q15 schemes.The error was eliminated for planarflows and good agreement be-tween analytical solutions for arrays of cylinders and spheres was found with a wide range of Knudsen numbers.

关键词： Lattice Boltzmann method(LBM) boundary condition(Bc) rarefiedflow nonplanar geometry

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Depleted uranium oxide supported nickel catalyst for autothermal cO_(2)methanation in non-adiabatic reactor under induction heating

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Journal of Energy chemistry 2023年第10期85卷 310-323,I0010页

作者： Lai Truong-Phuoc Jean-Mario Nhut Loïc vidal cuong Duong-Viet Sécou Sall corinne Petit christophe Sutter Mehdi Arab Alex Jourdan cuong Pham-Huu Institute of chemistry and Processes for Energy Environment and Health(ICPEES)ECPMUMR 7515 CNRS-University of Strasbourg25 rue Becquerel67087 Strasbourg Cedex 02France BlackLeaf SAS 210 rue Geiler de Kaysersberg67400 IllkirchFrance Institute of Materials Science of Mulhouse IS2MUMR 7361Universitéde Haute-AlsaceCNRS15rue Jean Starcky-BP 248868057 MulhouseFrance ORANO Tricastin Direction de La Recherche&DéveloppementSite du TRICASTIN BP 1626701 Pierrelatte CedexFrance

Undoped nickel-based catalysts supported on depleted uranium oxide allow one to carry out cO_(2)methanation process under extremely low reaction temperature under atmospheric pressure and powered by a contactless induction heating.By adjusting the reaction conditions,the catalyst is able to perform cO_(2)methanation reaction under autothermal process operated inside a non-adiabatic reactor,without any external energy supply.Such autothermal process is possible thanks to the high apparent density of the UO_x which allows one to confine the reaction heat in a small catalyst volume in order to confine the exothermicity of the reaction inside the catalyst and to operate the reaction at equilibrium heat in-heat out.Such autothermal operation mode allows one to significantly reduce the complexity of the process compared to that operated using adiabatic reactor,where complete insulation is required to prevent heat disequilibrium,in order to reduce as much as possible,the heat exchange with the external medium.The catalyst displays an extremely high stability as a function of time on stream as no apparent deactivation.It is expected that such new catalyst with unprecedented catalytic performance could open new era in the field of heterogeneous catalysis where traditional supports show their limitations to operate catalytic processes under severe reaction conditions.

关键词： cO_(2)methanation Auto-methanation Induction heating Depleted uranium oxide Electrification process Operando DRIFTS

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The importance of the bite angle of metal(Ⅲ) salen catalysts in the sequestration of cO_(2) with epoxides in mild conditions

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Green chemical Engineering 2022年第2期3卷 180-187页

作者： Anna vidal-Lopez Sergio Posada-Perez Miquel Sola Valerio D'Elia Albert Poater Institut de Quimica computacional i catalisi and Departament de Quimica Universitat de GironaC/Maria Aurelia Capmany6917003GironaCataloniaSpain Department of chemistry Universitat Autonoma de BarcelonaCerdanyola del VallesCatalonia08193Spain Department of Materials Science and Engineering School of Molecular Science and EngineeringVidyasirimedhi Institute of Science and Technology(VISTEC)21210PayupnaiWang ChanThailand

Located in the middle of the fever to solve the problem of cO_(2)emissions in the environment,cO_(2)sequestration by reaction with epoxides is one of the key tools,as it not only fixes cO_(2),but also makes it functional by leading to cyclic carbonates.Herein,the results are focused specifically on the formation of cyclic organic carbonates catalyzed by metal-salen complexes,previously achieved with yttrium and scandium,that are compared with those of analogous complexes containing metals from the first transition series,such as cobalt or chromium.Density functional theory(DFT)calculations allow to determine whether this switch of metals will be feasible and provide the basis for instigating future experimental efforts in this regard.The calculations analyzing the structure and electronics of the catalysts allow us to give not only a clear picture of whether these catalysts will be efficient,but also allow us to assess which metal center is the most convenient and/or whether the catalytic reaction will occur under mild conditions.Advanced buried volume calculations with the SambVca packages shed light on the different catalytic pockets of monometallic first row transition metals vs.group III salen complexes.Our predictive catalysis results show that the bite O-M-O angle plays an essential role in the catalysis.

关键词： cO_(2)fixation Salen catalyst cO_(2)functionalization cyclic carbonate DFT calculations Predictive catalysis

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Intimate partner violence against women. Does violence decrease after the entry of the alleged offender into the criminal justice system?

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Forensic Sciences Research 2022年第1期7卷 53-60页

作者： Paulo Vieira-Pinto JoséIgnacio Muñoz-Barús Tiago Taveira-Gomes Maria João vidal-Alves Teresa Magalhães Department of Forensic Sciences PathologyGynaecology and ObstetricsPaediatricsInstitute of Forensic SciencesUniversity of Santiago de CompostelaSantiago de CompostelaSpain IINFAc TS-Institute of Research and Advanced Training in Health Sciences Department of SciencesCESPUUniversity Institute of Health Sciences(IUCS)GandraPortugal cFaculty of Medicine University of PortoPortoPortugal cINTESIS-centre of Health Technology and Service Research University of PortoPortoPortugal Fernando Pessoa University PortoPortugal

Intimate partner violence(IPV)is simultaneously assumed as a serious crime and a major public health issue,having recurrences as one of its main characteristics and,consequently,re-entries of some alleged offenders in the criminal justice system(cJS).The main goal of this study is to assess if in cases of female victims of IPV,violence decreases after the first entry of the alleged offender in the cJS.A retrospective study was performed based on the analysis of police reports of alleged cases of IPV during a 4-year period.The final sample(n=1488)was divided into two groups according to the number of entries in the cJS(single or multiple)followed by a comparative approach.Results suggest that violence decreases after the first entry of alleged offenders in the cJS.Re-entries were found in only 15.5%of the cases but they were accountable for 3.3 times more crimes on average.Besides,victims of recidivism presented more injuries and required more medical care.Thus,a small group of alleged offenders seems to be more violent and accountable for most of the IPV crimes registered in the cJS suggesting that regardless of legal sanctions aiming to deter violence,these measures may not be enough for a certain group of offenders.This study sustains the need for a predictive model to quantify the risk of repeated IPV cases within the Portuguese population.

关键词： Forensic sciences intimate partner violence women re-entry recidivism criminal justice system

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根据2021年世界卫生组织对中枢神经系统肿瘤的新分类，质子MR波谱在区分高级别星形细胞瘤亚组方面的能力有所提高

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国际医学放射学杂志 2024年第3期 376-376页

作者： c.Majós A.Pons-Escoda P.Naval A.Güell A.Lucas N.vidal 吴小佳

摘要目的 2021年世界卫生组织（WHO）对中枢神经系统（cNS）肿瘤的分类优先考虑异柠檬酸脱氢酶（IDH）突变，以确定弥漫性胶质瘤的肿瘤类型；而2016年的分类则优先

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