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Open Journal of Endocrine and Metabolic Diseases 2017年第1期7卷 22-34页

作者： Ana Raisa Jatahy Santos Sabrina Pinto Ferreira Moacir Benazzi Mara capra Helen Paula Apparicio Medeiros Ana Luísa de Jesus Mirella hansen de Almeida Larissa Bianca Paiva cunha de Sá Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Rio de Janeiro Brazil Porto Velho Garrison Hospital—HGuPV Porto Velho Brazil Division of Endocrinology Central Air Force Hospital Rio de Janeiro Brazil Diabetology Department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Dunnigan-type partial lipodystrophy, which is characterized by a number of metabolic alterations, change in body fat distribution, and autosomal dominant inheritance pattern, is rare in the general population. Objective: To report the case of an adolescent with clinical and laboratory findings suggestive of Dunnigan-type partial lipodystrophy. Methods: case report and literature review. Results: A 15-year-old adolescent presented at the clinic complaining of darkening of skin folds on her trunk and back. During physical examination, the presence of serious acanthosis nigricans in her cervical region, axillae, and intergluteal space was noted. Hirsutism in androgen-dependent areas was also observed, as well as relevant reduction of subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk and fat accumulation in the face and chin. Discussion. Dunnigan-type familial partial lipodystrophy is a rare dominant autosomal disease resulting from a heterozygous missense mutation in the LMNA gene, known as LPF type 2 (Dunnigan variant), which encodes the nuclear protein A/c-type lamin. It is characterized by the progressive disappearance of the subcutaneous adipose tissue in the limbs, gluteal region, abdomen, and trunk, with onset in puberty, followed by fat accumulation in other areas such as the face, chin, labia majora, and intra-abdominal region, leading to hypertrophy that may mimic the cushing’s syndrome phenotype. Affected patients display marked insulin resistance and may consequently develop diabetes mellitus, acanthosis nigricans, hirsutism, and polycystic ovary syndrome. conclusion: This case report highlights the importance of suspecting Dunnigan-type familial partial lipodystrophy in clinical practice. Early clinical diagnosis allows for measures that minimize the severe metabolic disorders associated with this disease and, consequently, these adolescents’ self-esteem issues.

关键词： Dunnigan-Type Familial Partial Lipodystrophy Insulin Resistance Heterozygous Mutation

心电图预激表现与心血管病和死亡风险的关系:哥本哈根心电图研究结果

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中华高血压杂志 2017年第10期25卷 989-989页

作者：刘莉叶鹏 Skov MW Rasmussen PV Ghouse J hansen SM Graff c Olesen MS Pietersen A Torp-Pedersen c HaunsS Kφber L Svendsen JH Holst AG Nielsen JB

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患... 详细信息

大部分心室预激患者临床发病过程中的心电图资料来源于三级医疗中心。为了调查患有心电图预激的初级保健人群的长期预后，来自丹麦哥本哈根Rigshospitalet心脏中心分子心脏病学实验室的研究人员在2001—2011年收集了328638例初级保健患者的电子心电图数据，确定了310例心电图显示预激（年龄8～85岁）的个体。并从丹麦全国注册管理机构获取关于患者药物、合并症和临床结局的资料。随访中位数为7．4（四分位间距4．6～10．3）年。

关键词：心电图数据心室预激哥本哈根死亡风险心血管病三级医疗中心临床发病过程初级保健

3-羟基-4-苯基-5-苯甲酰基-N-甲基-γ-内酰胺的合成

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华西药学杂志 1999年第4期14卷 260-260,262页

作者：林汉森广东药学院药学系广州510224

采用Ｎ（ＣＨ３）４ＯＨ／Ｃ２Ｈ２Ｃｌ２ Ｈ２Ｏ作为相转移系统，合成了３羟基４苯基５苯甲酰基 Ｎ甲基γ内酰胺。得到两个顺反异构体（２）和（３），其比例由文献的１∶１提到１∶３８～４... 详细信息

采用Ｎ（ＣＨ３）４ＯＨ／Ｃ２Ｈ２Ｃｌ２ Ｈ２Ｏ作为相转移系统，合成了３羟基４苯基５苯甲酰基 Ｎ甲基γ内酰胺。得到两个顺反异构体（２）和（３），其比例由文献的１∶１提到１∶３８～４９，环合总收率为８０％。

关键词：羟基苯基甲酰基甲基内酰胺中间体合成

Epidemiological Pattern of closed Femoral Shaft Fractures in a Regional Tertiary Hospital in Enugu, Nigeria

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Journal of Biosciences and Medicines 2019年第5期7卷 180-188页

作者： E. c. Iyidobi R. T. Ekwunife U. M. Enweani c. U. Nwadinigwe I. c. Okwesili H. c. Ekwedigwe National Orthopedic Hospital Enugu Nigeria city Specialist Hospital Enugu Nigeria college of Medicine University of Nigeria Eungu Campus Enugu State University Teaching Hospital Parklane Enugu Nigeria

Background: The femur is the longest and strongest tubular bone in the human body. The femoral shaft is the portion of the bone between 5 cm distal to the lesser trochanter and 6 cm proximal to the most distal point of the medial femoral condyle. Femoral shaft fractures often result from high energy forces. These fractures occur mostly among young adults. Objective: This was to determine the epidemiological pattern of closed femoral shaft fractures in a regional tertiary hospital in Enugu, Nigeria. Method: The study was a prospective study over a 12 month period (June 2015-May 2016) at National Orthopaedic Hospital, Enugu. Following ethical approval and written informed consent, patients were consecutively recruited. The patients were clinically and radiographically evaluated at presentation. The diagnosis of closed femoral shaft fractures were made from the physical examination finding of absent open wound communicating with the fracture hematoma in the thigh and anteroposterior (AP) and lateral x-rays of the affected thigh confirming the fracture pattern. The data collected included patients’ demographics, the cause of injury, the side of injury and anatomic site of the injury among other parameters. The data were collected using well designed and structured proforma. Results: A total of 52 femoral shaft fractures in 50 patients were included and analyzed using SPSS version 20.0. The age range of the patients is 18 - 85 years with a median age of 39.1 ± 14.9 years. The most commonly affected age group is 21 - 30 years. There was male preponderance with a male to female ratio of 2.3:1. Majority of the fractures (76.9%) resulted from road traffic crashes most commonly following motor vehicular accident (36.5%). Majority of the fractures (92.3%) are unilateral with right side to left side ratio of 1.2:1. Majority of the patients (51.9%) had Winquist hansen grade III type of fracture. The most common associated injury is fractures of tibia/fibula followed by fracture

关键词： Epidemiology closed Femoral Shaft Fracture

Synthetic,Zwitterionic Sp1 Oligosaccharides Adopt a Helical Structure crucial for Antibody Interaction

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Synthetic,Zwitterionic Sp1 Oligosaccharides Adopt a Helical ...

异丙托溴铵气雾剂中有关物质的HPLc法测定

中国化学会第三届全国糖化学会议

作者： Qingju Zhang Ana Gimeno Darielys Santana Zhen Wang Yury Valdes-Balbin Laura M.Rodríguez-Noda Thomas hansen Li Kong Mengjie Shen Herman S.Overkleeft Vicente Verez-Bencomo Gijsbert A.van der Marel Jesús Jiménez-Barbero Fabrizio chiodo Jeroen D.c.codée The National Research centre for carbohydrate Synthesis Jiangxi Normal University

The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide（Sp1） is an important anchor point for our immune system to act against streptococcal *** can recognize Sp1 saccharides,and it has been postulated that Sp1 can elicit a T-cell-dependent immune reaction as it can be presented by MHc-II *** unravel the molecular mode of action of this unique polysaccharide we here describe the chemical synthesis of a set of Sp1 fragments,ranging from 3 to 12 monosaccharides in *** outline a unique synthetic approach to overcome the major synthetic challenges associated with the complex Sp1 structure and provide a stereoselective route of synthesis for the oligosaccharide backbone as well as a strategy to introduce the carboxylic acid *** dynamics（MD） simulations together with NMR spectroscopy studies reveal that the oligosaccharides take up helical structures with the nona-and dodecasaccharide completing a full helical *** 3 D structure of the oligosaccharides coincides with the topology required for good interaction with anti-Sp1 antibodies,which has been mapped in detail using *** study has revealed the Sp1 nona-and dodecasaccharides as promising synthetic antigens,displaying all（3 D） structural elements required to mimic the natural polysaccharide and required to unravel the molecular mode of action of these unique zwitterionic polysaccharides.

关键词：

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中国医药工业杂志 2017年第8期48卷 1182-1187页

作者：王志军李慧义栾瀚森王浩杨莉国家药典委员会北京100061 药物制剂国家工程研究中心上海201203

建立了高效液相色谱法测定异丙托溴铵气雾剂中的有关物质。采用SunFire c_(18)色谱柱,流动相为乙腈∶0.25%庚烷磺酸钠溶液∶三乙胺(24∶76∶0.5,用磷酸调至pH 3.2),检测波长210 nm。结果异丙托溴铵与其有关物质分离完全。异丙托溴铵在0.... 详细信息

建立了高效液相色谱法测定异丙托溴铵气雾剂中的有关物质。采用SunFire c_(18)色谱柱,流动相为乙腈∶0.25%庚烷磺酸钠溶液∶三乙胺(24∶76∶0.5,用磷酸调至pH 3.2),检测波长210 nm。结果异丙托溴铵与其有关物质分离完全。异丙托溴铵在0.20~10.21μg/ml范围内线性关系良好,回收率为100.68%,RSD为1.26%。

关键词：异丙托溴铵气雾剂有关物质高效液相色谱含量测定

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激光-电弧复合焊接及其标准在邮轮中的应用

船舶标准化工程师 2022年第3期55卷 26-30页

作者：施佳慧周瀚森中国船级社上海规范研究所上海200135

为有效控制薄板焊接变形、提高焊接效率与质量,对邮轮薄板焊接的现状进行介绍,并分析不同焊接工艺的特点及存在的问题。重点对激光-电弧复合焊接在薄板焊接中的优势,以及该技术在邮轮制造中的应用进行阐述,并对比分析激光-电弧复合焊接... 详细信息

为有效控制薄板焊接变形、提高焊接效率与质量,对邮轮薄板焊接的现状进行介绍,并分析不同焊接工艺的特点及存在的问题。重点对激光-电弧复合焊接在薄板焊接中的优势,以及该技术在邮轮制造中的应用进行阐述,并对比分析激光-电弧复合焊接标准和常规电弧焊标准在工艺评定方法、适用范围及无损检测要求上的差异。研究成果可为激光-电弧复合焊接技术在邮轮制造中的应用提供一定参考。

关键词：激光-电弧复合焊接邮轮制造标准

不同器官MR抑制敏感技术是否已能用于临床工作？

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国际医学放射学杂志 2020年第2期 245-245页

作者： B.M.A.Delattre S.Boudabbous c.hansen A.Neroladaki A.Hachullal M.I.Vargas 胡现宁 Division of Radiology Geneva University Hospitals

目的评估从脑到膝不同临床应用中,采用抑制敏感(cS)加速技术3D或屏气序列的影像质量及其伪影敏感性。方法对107例病人10种不同临床应用进行了30%~

关键词：不同器官影像质量临床工作敏感技术

不同终板准备方法对ProDisc-c颈椎人工椎间盘假体稳定性的影响

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中国脊柱脊髓杂志 2007年第9期17卷 689-692,I0009页

作者：谭荣邹德威 hansen Yuan Amir H．Fayyazi Nathaniel R．Ordway Matthew J．Allen 北京解放军306医院骨科北京市100101 美国纽约上州医科大学医院骨科

目的:探讨不同颈椎终板准备方法对颈椎人工椎间盘置换术后金属-骨界面刚度的影响,了解终板准备方法与人工椎间盘假体稳定性的关系。方法:取6具新鲜成人尸体颈椎标本,分离出c3～T1共35个椎体(1例c6～c7融合),剔除每个椎体上下面的椎间盘... 详细信息

目的:探讨不同颈椎终板准备方法对颈椎人工椎间盘置换术后金属-骨界面刚度的影响,了解终板准备方法与人工椎间盘假体稳定性的关系。方法:取6具新鲜成人尸体颈椎标本,分离出c3～T1共35个椎体(1例c6～c7融合),剔除每个椎体上下面的椎间盘组织,显露出骨性终板,分为:去终板组17个,完全去除骨性终板;保留终板组18个,完整保留骨性终板。在所有椎体的上面安放相应大小的颈椎人工椎间盘(ProDisc-c)后用MTS-858生物力学实验机进行疲劳测试和屈服测试,得到金属-骨界面的刚度、位移和最大屈服压力,从其中1具颈椎标本取出4个椎体(每组各2个)切片行HE染色后用光镜观察金属-骨性界面。结果:疲劳前测试金属-骨界面刚度去终板组为1470±180N/mm,高于保留终板组的1260±170N/mm(P<0.0001);疲劳后测试两组刚度均有上升,去终板组刚度为1990±110N/mm,仍高于保留终板组的1680±140N/mm(P<0.0001)。疲劳前测试两组的终板位移分别为0.45±0.09mm和0.41±0.10mm,无显著性差异(P=0.15),疲劳后测试去终板组位移0.53±0.12mm小于保留终板组的0.66±0.14mm(P=0.005)。去终板组最大屈服压力为1110±350N,略小于保留终板组的1250±230N,但无显著性差异(P=0.27)。组织切片显示去终板组金属-骨界面贴合良好,而保留终板组金属-骨界面有明显的缝隙。结论:不同的终板准备方法会影响到假体金属-骨界面的刚度和稳定性。去终板组金属-骨界面的刚度和稳定性优于保留终板组,良好的金属-骨界面接触是颈椎人工椎间盘假体稳定的关键因素之一。

关键词：颈椎人工椎间盘生物力学终板刚度