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全身性脑膜炎球菌菌血症儿童纤溶酶原激活物抑制剂1基因中的4G/5G启动因子多态现象

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 18-18页

作者： Geishofer G. binder A. Mller M. W. Zenz 贺莉 Department of General Paedi atrics Medical University of Graz Auenbruggerplatz 30 8036 Graz Austria

Meningococcal disease may present as sepsis, meningitis or a combination of bo th. Impaired fibrinolysis and massive elevation of the plasminogen activator inh ibitor-1 (PAI-1) is a characteristic feature of meningococcal sepsis. Previous ly, an association between mortality and the functional 4G/5G promoter polymorph ism of the PAI-1gene in a cohort of UK and Dutch children with meningococcal se psis was reported. We carried out a prospective, multicentre study to investigat e the association of the 4G/5G PAI-1 polymorphism, diagnosis, and outcome in me ningococcal disease in a Central European and UK population. Blood samples and c linical information of 347 previously healthy children with meningococcal infect ion were collected from 95 paediatric hospitals in Germany, Switzerland, Italy, the United Kingdom, and Austria from 2000 until 2002. Mortality was significantl y associated with the 4G/4G genotype (12 of 90 (13%) vs. 15 of 240 (6%), P =0. 037), resulting in an odds ratio of 2.31. The diagnosis of sepsis (independent o f symptoms of meningitis) was significantly more frequent in carriers of the 4G/ 4G genotype (P =0.01), resulting in an odds ratio of 2.21 to develop sepsis. Men ingitis was not associated with the PAI-1 4G/5G polymorphism, and allele freque ncies were similar in patient and control groups. Conclusion:Our data show a cor relation between the 4G/4G genotype in the plasminogen activator inhibitor-1 ge ne and poor outcome in children with meningococcal infection. In addition, 4G ho mozygous patients were prone to develop sepsis. We found no influence of the pla sminogen activator inhibitor-1 polymorphism on the susceptibility to invasive m eningococcal infection.

关键词：脑膜炎球菌菌血症多态现象启动因子感染性疾病脓毒症临床信息机能减退血液样本儿童医院

通过检测凝血酶的生成量可识别复发性静脉血栓栓塞低危患者

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世界核心医学期刊文摘（心脏病学分册） 2007年第2期3卷 4-4页

作者： Hron G. Kollars M. binder B.R. P.A. Kyrle 任付先 Department of Internal Medicine I Medical University of Vienna Whringer Gürtel 18-20 A-1090 Vienna Austria.Dr

背景:筛查静脉血栓栓塞症(VTE)患者的血栓形成倾向危险因素是常见的临床实践活动。由于危险因素众多,评估患者个体的复发风险较为复杂,因此需要一种可涵盖多种原因的血栓形成倾向预测方法。

关键词：静脉血栓栓塞低危患者血栓形成倾向临床实践复发风险预测方法抗凝血因子内一科复发率拮抗

脚趾的黑纵甲床炎在活检中Medlar体的表现

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世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 32-32页

作者： Ko C.J. Sarantopoulos G.P. binder S.W. 阎小宁 Dept.of Pathol. and Lab. Medicine UCLA Medical CenterDavid Geffen School of MedicineLos Angeles CAUnited States

A 9- year-old girl presented with a 2- year history of pigmented streaks on her second right toenail as well as on her fourth and fifth left toenails. The patient was otherwise asymptomatic with no other physical findings. Owing to parental concern, a biopsy was performed, which revealed numerous bacteria as well as Medlar bodies overlying the nail bed with no evidence of a nevomelanocytic lesion. To our knowledge, this is the first report of Medlar bodies causing pigmented streaks in the toenails.

关键词： Medlar 黑素细胞首例报道纵纹

Influence of structural defects on charge density waves in 1T-TaS_(2)

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Nano Research 2023年第8期16卷 11528-11539页

作者： Iaroslav Lutsyk Karol Szalowski Pawel Krukowski Pawel Dabrowski Maciej Rogala Witold Kozlowski Maxime Le Ster Michal Piskorski Dorota A.Kowalczyk Wojciech Rys Rafal Dunal Aleksandra Nadolska Klaudia Toczek Przemyslaw Przybysz Ewa Lacinska Johannes binder Andrzej Wysmolek Natalia Olszowska Jacek J.Kolodziej Martin Gmitra Takuma Hattori Yuji Kuwahara Guang Bian Tai-Chang Chiang Pawel J.Kowalczyk Faculty of Physics and Applied Informatics University of LodzPomorska 149/15390-236 LodzPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Faculty of Physics Astronomyand Applied Computer ScienceJagiellonian UniversityLojasiewicza 1130-348 KrakowPoland National Synchrotron Radiation Centre SOLARIS Jagiellonian UniversityCzerwone Maki 9830-392 KrakówPoland Institute of Physics Faculty of SciencePavol JozefŠafárik University in KošicePark Angelinum 904001 KošiceSlovakia Institute of Experimental Physics Slovak Academy of SciencesWatsonova 4704001 KošiceSlovakia Department of Precision Engineering Graduate School of EngineeringOsaka University2-1 Yamada-okaSuita 565-0871Japan Department of Physics and Astronomy University of MissouriColumbiaMissouri 65211USA Department of Physics and Frederick Seitz Materials Research Laboratory University of Illinois at Urbana-ChampaignUrbanaIllinois 61801-3080USA

The influence of intrinsic defects of 1T-TaS_(2)on charge density waves(CDWs)is studied using scanning tunneling microscopy and spectroscopy(STM,STS),angle-resolved photoelectron spectroscopy(ARPES),and density functional theory(DFT).We identify several types of structural defects and find that most have a local character limited to a single CDW site,with a single exception which effectively behaves as a dopant,leading to band-bending and affecting multiple neighboring *** only one type of defect can be observed by STM topographic imaging,all defects are easily resolved in STS *** results indicate modulation of the Mott band gap commensurate with the CDW and breaking of the three-fold symmetry of electronic *** calculations(with included Coulomb interactions)are used to investigate the electronic structure,focusing on both sulfur vacancy and oxygen-sulfur *** sulfur vacancy system,characterized with a metallic behavior,is identified as the origin of one of the experimentally observed ***,the effect of oxidation of 1T-TaS_(2)depends on the substitution site,leading to the heterogeneity of electronic properties.

关键词： structural charge sulfur

应用空间谱激励快速脂肪选择性GRE成像评估肥胖青少年的脂肪肝:与光谱结果的定量数据对比研究

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国际医学放射学杂志 2011年第3期 304-304页

作者： F.Springer S.Ehehalt J.Sommer V.Ballweg J.Machann G.binder 郭丽君 Section on Experimental Radiology Department of Diagnostic and Interventional RadiologyUniversity Hospital Tübingen

目的测试空间谱激励快速脂肪选择性GRE成像这一技术在评估肥胖青少年肝内脂肪(IHL)含量的可行性。方法单次屏气内行脂肪选择性MR成像(1.5T),记录有代表

关键词： MRS MRI 肝脏脂肪含量定量脂肪选择性成像肥胖青少年

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急诊室CT:医生制定决策改变的实时研究

国际医学放射学杂志 2016年第3期 304-304页

作者： P.V.Pandharipande A.T.Reisner W.D.binder A.Zaheer M.L.Gunn K.F.Linnau 李志鹏 Department of Radiology Institute for Technology AssessmentMassachusetts General Hospital

摘要目的明确急诊室CT如何影响医生的诊断、诊断的不确定性以及收治决策。材料与方法本研究由伦理委员会批准,并符合HIPAA。数据收集时间为2012年7月12日—2014年1月13日,未征求病人的同意。在这项4个中心的前瞻性研究中,病人以腹痛、... 详细信息

摘要目的明确急诊室CT如何影响医生的诊断、诊断的不确定性以及收治决策。材料与方法本研究由伦理委员会批准,并符合HIPAA。数据收集时间为2012年7月12日—2014年1月13日,未征求病人的同意。在这项4个中心的前瞻性研究中,病人以腹痛、胸痛和/或呼吸困难、或头痛到急诊部就诊,并接受CT检查。分别于CT检查前后调查医生的主要诊断、诊断的信心(范围:0～100%)、可能的排除

关键词：急诊室呼吸困难胸痛主要诊断疼痛科学管理决策 CT