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Diverse Chromatic Acclimation Processes Regulating Phycoerythrocyanin and Rod-Shaped Phycobilisome in Cyanobacteria

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Molecular Plant 2019年第8期12卷 715-725页

作者： Yuu Hirose Song Ghihong Mai Watanabe Chinatsu yonekawa Kazuyoshi Murata Masahiko Ikeuchi Toshihiko Eki Department of Environmental and Life Sciences Toyohashi University of Technology1-1 HibarigaokaTempakuToyohashiAichi 441-8580Japan National Institute for Physiological Sciences(NIPS) 38 NishigonakaMyodaijiOkazakiAichi 444-8585Japan Department of Life Sciences(Biology) The University of Tokyo3-8-1 KomabaMeguroTokyo 153-8902Japan

Cyanobacteria have evolved various photoacclimation processes to perform oxygenic photosynthesis under different light *** acclimation(CA)is a widely recognized and ecologically important type of photoacclimation,whereby cyanobacteria alter the absorbing light colors of a supermolecular antenna complex called the *** date,several CA variants that regulate the green-absorbing phycoerythrin(PE)and/or the red-absorbing phycocyanin(PC)within the hemi-discoidal form of phycobilisome have been *** this study,we identified a unique CA regulatory gene cluster encoding yellow-green-absorbing phycoerythrocyanin(PEC)and a rod-membrane linker protein(CpcL)for the rod-shaped form of *** the cyanobacterium Leptolyngbya *** 6406,we revealed novel CA variants regulating PEC(CA7)and the rod-shaped phycobilisome(CAO),which maximize yellowgreen light-harvesting capacity and balance the excitation of photosystems,respective!*** of the distribution of CA gene clusters in 445 cyanobacteria genomes revealed eight CA variants responding to green and red light,which are classified based on the presence of PEC,PE,cpcL,and CA photosensor *** analysis further suggested that the emergence of CA7 was a single event and preceded that of heterocystous strains,whereas the acquisition of CAO occurred multiple *** together,these results offer novel insights into the diversity and evolution of the complex cyanobacterial photoacclimation mechanisms.

关键词： cyanobacteria chromatic acclimation cyanobacteriochrome phycobilisome phycoerythrocyanin

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Nasolabial Cyst in an Elderly Patient: Report of a Case and Literature Review

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Open Journal of Stomatology 2017年第10期7卷 455-461页

作者： Takaki Iwagami Yoshihiro Morita Atsuko Niki-yonekawa Yukiko Kusuyama Nobuo Morita Department of Oral and Maxillofacial Surgery Seichokai Hannan Municipal Hospital Hannan City Japan Departments of Oral and Maxillofacial Surgery II Osaka University Graduate School of Dentistry Osaka City Japan Stephenson Cancer Center University of Oklahoma Health Science Center Oklahoma USA Department of Oral-Maxillofacial Surgery NS Medical & Healthcare Service General Incorporation Foundation Wakayama City Japan

Nasolabial cysts are uncommonly diagnosed non-odontogenic soft tissue lesions occurring close to the nasal alar region of the face. Patients usually present with a slowly enlarging asymptomatic swelling. Diagnosis is usually made in the early stages because of the esthetic effects. Histologically, the lesion is lined with non-keratinized squamous epithelium or, more frequently, pseudostratified columnar epithelium with goblet cells. These cysts are most often diagnosed in the fourth decade of life. However, we report a case of nasolabial cyst in an 80-year-old woman, and discuss the diagnosis, differential diagnosis, and treatment with reference to the literature.

关键词： Nasolabial Cyst Klestadt Cyst Pseudostratified Columnar Epithelium Goblet Cell

Effect of Difference in Form of Driving Support Agent to Driver’s Acceptability<br/>—Driver Agent for Encouraging Safe Driving Behavior (2)

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Journal of Transportation Technologies 2018年第3期8卷 194-208页

作者： Takahiro Tanaka Kazuhiro Fujikake Takashi yonekawa Makoto Inagami Fumiya Kinoshita Hirofumi Aoki Hitoshi Kanamori Institutes of Innovation for Future Society Nagoya University Nagoya Japan

In recent years, the number of traffic accidents caused by elderly drivers has increased in Japan. However, a car is an important mode of transportation for the elderly. Therefore, to ensure safe driving, a system that can assist elderly drivers is required. In this study, we propose a driver-agent system that provides support to elderly drivers during and after driving and encourages them to improve their driving. This paper describes the prototype system based on the analysis of the teaching records of a human instructor, and the subjective evaluation of driving support to elderly and non-elderly driver from three different agent forms, a voice, visual, and robot. The result revealed that the robot form is more noticeable, familiar, and acceptable to the elderly and non-elderly than other forms.

关键词： Driving support Agent Elderly

Thrombotic microangiopathy-like disorder after living-donor liver transplantation:A single-center experience in Japan

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World Journal of Gastroenterology 2011年第14期17卷 1848-1857页

作者： Tomohide Hori Toshimi Kaido Fumitaka Oike Yasuhiro Ogura Kohei Ogawa Yukihide yonekawa Koichiro Hata Yoshiya Kawaguchi Mikiko Ueda Akira Mori Yasutsugu Takada Hiroto Egawa Atsushi Yoshizawa Shinji Uemoto Hajime Segawa Kimiko Yurugi Takuma Kato Kanako Saito Linan Wan Mie Torii Feng Chen Ann-Marie T Baine Lindsay B Gardner Departments of Hepato-pancreato-biliary Transplant and Pediatric Surgery Kyoto University Hospital Kyoto 606-8507 Japan Department of Critical Care Medicine Kyoto University Hospital Kyoto 606-8507 Japan Department of Transfusion Medicine and Cell Therapy Kyoto University Hospital Kyoto 606-8507 Japan Department of Cellular and Molecular Immunology Mie University Hospital Graduate School of Medicine Mie 514-8507 Japan Department of Neuroscience Mayo Clinic Florida FL 32224 United States

AIM:To investigate thrombotic microangiopathy (TMA)in liver transplantion,because TMA is an infrequent but life-threatening complication in the transplantation field. METHODS:A total of 206 patients who underwent living-donor liver transplantation (LDLT) were evaluated,and the TMA-like disorder (TMALD) occurred in seven recipients. RESULTS:These TMALD recipients showed poor outcomes in comparison with other 199 recipients. Although two TMALD recipients successfully recovered,the other five recipients finally died despite intensive treatments including repeated plasma exchange (PE) and re-transplantation. Histopathological analysis of liver biopsies after LDLT revealed obvious differences according to the outcomes. Qualitative analysis of antibodies against a disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs (ADAMTS-13) were negative in all patients. The fragmentation of red cells,the microhemorrhagic macules and the platelet counts were early markers for the suspicion of TMALD after LDLT. Although the absolute values of von Willebrand factor (vWF) and ADAMTS-13 did not necessarily reflect TMALD,the vWF/ADAMTS-13 ratio had a clear diagnostic value in all cases. The establishment of adequate treatments for TMALD,such as PE for ADAMTS-13 replenishment or treatments against inhibitory antibodies,must be decided according to each case. CONCLUSION:The optimal induction of adequate therapies based on early recognition of TMALD by the reliable markers may confer a large advantage for TMALD after LDLT.

关键词： Thrombotic microangiopathy Liver transplan-tation von Willebrand factor A disintegrin-like domain and metalloproteinase with thrombospondin type 1 motifs Complication

Relationship between Senior Drivers’ Cognitive and Physical Functions and Urban Driving Behaviors during Behind-the-Wheel Driving Education Sessions with Driving Instructors

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Journal of Transportation Technologies 2017年第2期7卷 148-166页

作者： Takashi yonekawa Takahiro Tanaka Hirofumi Aoki Misako Yamagishi Yuki Yoshihara Eijiro Takeuchi Issey Takahashi Yoshiki Ninomiya Hitoshi Kanamori Tatsuya Suzuki Makoto Inagami Institute of Innovation for Future Society Nagoya University Nagoya Japan

Recently, traffic accidents caused by elderly drivers have been increasing. It is thought that the reasons of accidents are functions such as decline of eyesight, cognition and physical strength caused by aging. In order to assist safe driving for elderly drivers, it is necessary to sufficiently understand any possible relationship of various senior drivers’ cognition, physical strength and driving behavior. In this paper relationship of elderly driver’s cognition, physical strength and driving behaviors were analyzed using the result of driving instructions on urban road by driving school instructors.

关键词： Human Engineering Elderly Person Driver Characteristics Driving Instruction

Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide

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World Journal of Gastroenterology 2010年第25期16卷 3120-3132页

作者： Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto Department of Neuroscience Mayo Clinic Jacksonville Florida FL 32224 United States Division of Hepato-Pancreato-Biliary Transplant and Pediatric Surgery Department of Surgery Kyoto University HospitalSakyo-ku Kyoto 606-8507 Japan Division of Transplant Surgery Department of Transplantation Mayo Clinic Jackson-ville Florida FL 32224 United States Institute for Laboratory Animal Science and Ex-perimental Surgery RWTH-Aachen University D-52074 AachenGermany Department of Cellular and Molecular Immu-nology Mie University Graduate School of Medicine Tsu Mie514-8507 Japan New Zealand Liver Transplant Unit Auckland City Hospital Auckland 92024 New Zealand

AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful ***: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model.

关键词： Animal model Liver transplantation Microsurgery Rat Reperfusion injury Ultra-microsurgery

Present Status of the KSTAR Superconducting Magnet System Development

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Plasma Science and Technology 2004年第5期6卷 2445-2450页

作者： Keeman Kim H.K.Park K.R.Park B.S.Lim S.I.Lee M.K.Kim Y.Chu W.H.Chung S.H.Baek J.Y.Cho H.yonekawa A.Chertovskikh Y.B.Chang J.S.Kim C.S.Kim D.J.Kim N.H.Song K.P.Kim Y.J.Song I.S.Woo W.S.Han D.K.Lee Y.K.Oh K.W.Cho J.S.Park G.S.Lee H.J.Lee T.K.Ko S.J.Lee National NationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalNationalKorea Atomic Energy Research InstituteDaejeonRepublic of KoreaYonsei UniversitySeoulRepublic of KoreaYonsei UniversitySeoulRepublic of Korea Fusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science InstituteDaejeonRepublic of KoreaFusion R&D CenterKorea Basic Science

The mission of Korea Superconducting Tokamak Advanced Research (KSTAR)project is to develop an advanced steady-state superconducting tokamak for establishing a scientificand technological basis for an attractive fusion reactor. Because one of the KSTAR mission is toachieve a steady-state operation, the use of superconducting coils is an obvious choice for themagnet system. The KSTAR superconducting magnet system consists of 16 Toroidal Field (TF) coils and14 Poloidal Field (PF) coils. Internally-cooled Cable-In-Conduit Conductors (CICC) are put into usein both the TF and PF coil systems. The TF coil system provides a field of 3.5 T at the plasmacenter and the PF coil system is able to provide a flux swing of 17 V-sec. The major achievement inKSTAR magnet-system development includes the development of CICC, the development of a full-size TFmodel coil, the development of a coil system for background magnetic-field generation , theconstruction of a large-scale superconducting magnet and CICC test facility. TF and PF coils are inthe stage of fabrication to pave the way for the scheduled completion of KSTAR by the end of 2006.

关键词： superconducting magnet KSTAR CICC