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World Journal of Gastroenterology 2009年第29期15卷 3691-3693页

作者： Isamu Makino Takahiro yamaguchi Nariatsu Sato Toshiaki Yasui Ichiro Kita Department of Surgery Kanazawa Social Insurance Hospital Kanazawa Ishikawa 920-8610 Japan

Recently, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings resulted in a false-positive for the diagnosis of gallbladder ***, several reports have demonstrated that fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is useful in differentiating between benign and malignant lesions in the gallbladder. However, there is a limitation in the ability of FDG-PET to differentiate between inflammatory and malignant lesions. We herein present a case of xanthogranulomatous cholecystitis misdiagnosed as gallbladder carcinoma by ultrasonography and computed tomography. FDG-PET also showed increased activity. In this case, FDG-PET findings resulted in a false-positive for the diagnosis of gallbladder carcinoma.

关键词：胆囊炎肉芽肿阳性 FDG PET 断层扫描黄色癌

Safety and efficacy of self-expandable metallic stents in malignant small bowel obstructions

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World Journal of Gastroenterology 2016年第40期22卷 9022-9027页

作者： Akiyoshi Tsuboi Toshio Kuwai Tomoyuki Nishimura Sumio Iio Takeshi Mori Hiroki Imagawa Toshiki yamaguchi Atsushi yamaguchi Hirotaka Kouno Hiroshi Kohno Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer Center

In this report, we present 3 cases of malignant small bowel obstruction, treated with palliative care using endoscopic self-expandable metallic stent(SEMS) placement, with the aim to identify the safety and efficacy of this procedure. Baseline patient characteristics, procedure methods, procedure time, technical and clinical success rates, complications, and patient outcomes were obtained. All 3 patients had pancreatic cancer with small bowel strictures. One patient received the SEMS using colonoscopy, while the other 2 patients received SEMS placement via double balloon endoscopy using the through-the-overtube technique. The median procedure time was 104 min. The technical and clinical success rates were 100%. Post-treatment, obstructive symptoms in all patients improved, and a low-residue diet could be tolerated. All stents remained within the patients until their deaths. The median overall survival time(stent patency time) was 76 d. SEMS placement is safe and effective as a palliative treatment for malignant small bowel obstruction.

关键词：自我可扩充的金属性的 stents 恶意的小肠阻塞内视镜检查法案例报告胰腺的癌症

Family empowerment and quality of life of parents raising children with Developmental Disabilities in 78 Japanese families

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International Journal of Nursing Sciences 2017年第1期4卷 38-45页

作者： Rie Wakimizu Keiko yamaguchi Hiroshi Fujioka Department of Child Health Care Nursing Division of Health Innovation and NursingFaculty of MedicineUniversity of Tsukuba1-1-1 TennodaiTsukuba CityIbaraki 305-8575Japan Department of Nursing Science Doctor's Program Graduate School of Comprehensive Human SciencesUniversity of Tsukuba1-1-1 TennodaiTsukuba CityIbaraki 305-8575Japan Department of Nursing Tsukuba International University6-8-33 ManabeTsuchiura CityIbaraki 300-0051Japan

Objectives: The families of these children experience distress both at the time of diagnosis and afterward.A top priority is to understand family empowerment,family function,and family members' quality of life (QoL) and to effectively support these families in *** objective of this study was to assess the actual conditions of families living with children having DDs and to explore the factors associated with family empowerment and parents' ***: We surveyed ninety-three parents (78 mothers,15 fathers) from 78 families which lived with children with DDs in the capital region of *** assessed two main outcomes using the Japanese versions of the following instruments: Family Empowerment Scale (FES),World Health Organization Quality of Life 26 (WHOQOL26),and other six *** and multiple regression analyses were ***: No medication,cooperation with child rearing,assistance from a developmental support center,solved problems related to child rearing,and higher scores in Problem Solving contributed to higher FES *** WHOQOL26 scores were related to being a full-time housewife,higher self-esteem,no developmental support,a broad emotional support network,higher scores in Problem Solving and Role Function,and lower scores in Affective Reaction and General ***: We revealed that family empowerment and QoL of parents rearing children with DDs in Japan were affected by various subscales of family function and other family *** interventions for improving family empowerment and QoL should be researched in the future.

关键词： Developmental disabilities Family empowerment Japan Multiple regression analysis Quality of life Social support

Configuration of Shock Waves in Two-Dimensional Overexpanded Jets

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Journal of Thermal Science 2003年第4期12卷 294-298页

作者： Masashi Kashitani Yutaka.yamaguchi Yoshiaki Miyazato Mitsuharu Masuda Kazuyasu Matsuo Department of Aerospace Engineering National Defense Academy 1-10-20 Hashirimizu Yokosuka Kanagawa 239-8686 JapanDepartment of Aerospace Engineering National Defense Academy 1-10-20 Hashirimizu Yokosuka Kanagawa 239-8686 JapanDepartment of Energy and Environmental Engineering Kyushu University 6-1 Kasuga-Kouen Kasuga Fukuoka 816-8580 JapanDepartment of Energy and Environmental Engineering Kyushu University 6-1 Kasuga-Kouen Kasuga Fukuoka 816-8580 JapanDepartment of Mechanical Systems and Environmental Engineering The University of Kitakyushu 1-1 Hibikino Wakamatsu-ku Kitakyushu Fukuoka 808-0315 Japan

An experimental and analytical study has been carried out to obtain the clear understanding of a shock wave transition associated with a steady two-dimensional overexpanded flow. Two-dimensional inviscid theory with respect to a shock wave reflection is used in the present study on the characteristic of shock waves. The results obtained from the flow analysis are compared with those obtained from flow visualizations. It is shown that in the region of regular reflection, the angle of an incident shock wave becomes lower than that calculated by two shock theory with an increment in the ratio PJPb of the nozzle exit pressure Pc to the back pressure Pb. It is indicated that the configuration of shock waves in overexpanded jets is influenced by the divergent angle at the nozzle exit. Also it is shown from the flow visualization that a series of shock waves move into the nozzle inside with a decrease in pressure ratio Pc/Pb, even if the Pc/Pb is under overexpanded conditions.

关键词：振动波超声喷管可压缩流体膨胀喷射空气动力学

Solid-State Interfacial Reaction between Eutectic Au-Ge Solder and Cu/Ni(P)/Au Metalized Ceramic Substrate and Its Suppression

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Journal of Materials Science & Technology 2015年第5期31卷 445-452页

作者： F.Q.Lang H.yamaguchi H.Nakagawa H.Sato Advanced Power Electronics Research Center(ADPERC) National Institute of Advanced Industrial Science and Technology(AIST).Central 21-1-1UmezonoTsukubaIbaraki 305-8568.Japan

Eutectic Au-12 Ge solder was employed to bond the SiC power devices to a Si3N4/Cu/Ni（P）/Au multilayered *** high-temperature reliability of the bond was investigated in detail at 200,250,300 and 330 ℃,*** and Ni5Ge3intermetallic compounds（IMCs） were identified at the Au-12Ge/Ni（P） interface by micro X-ray diffraction（μXRD） and scanning electron microscopy（SEM）equipped with energy dispersive X-ray analysis（EDX）.The growth of the Ni-Ge IMCs was dominated by Ni5Ge3layer,which formed at the Ni5Ge3/NiGe interface by outward diffusion of Ni from the Ni（P） *** activation energy of the total Ni-Ge IMCs growth was 66 kJ/*** shear strength of the bond was tested at both 25 ℃ and the aging temperatures,*** shear strength decreased slightly after aging at 200 and 250 ℃.The shear strength tested at 250 ℃ was 46 MPa after aging at 250 ℃ for 3000 *** shear strength aged at 300 and 330 ℃ rapidly decreased with aging time due to the rapid growth of the *** slow down the interfacial reaction between the high temperature solder and the Ni（P）layer,an approximately 200 nm-thick Ta/TaN/Ta new diffusion barrier（DB） was deposited on the *** by transmission electron microscopy（TEM） equipped with EDX,reveals that the Ta/TaN/Ta DB was bonded well to the Ni（P） layer and the *** temperature storage test at 330 ℃ for1500 h reveals that the bond of the SiC devices maintained its high shear strength of approximately56 MPa without *** new DB effectively suppressed the interfacial reaction between the Au-12 Ge solder and the Ni（P） layer of the substrate.

关键词： High-temperature solder Interfacial reaction Activ

PARP inhibitors as precision medicine for cancer treatment

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National Science Review 2017年第4期4卷 576-592页

作者： Yi Du Hirohito yamaguchi Jennifer L.Hsu Mien-Chie Hung Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer Center Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical University Department of Biotechnology Asia University Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Personalized or precision medicine is an emerging treatment approach tailored to individuals or certain groups of patients based on their unique characteristics. These types of therapies guided by biomarkers tend to be more effective than traditional approaches, especially in cancer. The inhibitor against poly(ADP-ribose) polymerase(PARP), olaparib(Lynparza, Astra Zeneca), which was approved by the US Food and Drug Administration(FDA) in 2014, demonstrated efficacy specifically for ovarian cancer patients harboring mutations in BRCA genes, which encode proteins in DNA double-strand break ***, the response to PARP inhibitors has been less encouraging in other cancer types that also carry defects in the BRCA genes. Thus, furthering our understanding of the underlying mechanism of PARP inhibitors and resistance is critical to improve their efficacy. In this review, we summarize the results of preclinical studies and the clinical application of PARP inhibitors, and discuss the future direction of PARP inhibitors as a potential marker-guided personalized medicine for cancer treatment.

关键词： PARP inhibitor kinase DNA damage precision medicine combination therapy

Gene Body CG and CHG Methylation and Suppression of Centromeric CHH Methylation are Mediated by DECREASE IN DNA METHYLATION1 in Rice

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Molecular Plant 2015年第10期8卷 1560-1562页

作者： Hisataka Numa Katsushi yamaguchi Shuji Shigenobu Yoshiki Habu Agrogenomics Research Center National Institute of Agrobiological Sciences Tsukuba Ibaraki 305-8602 Japan Functional Genomics Facility NIBB Core Research Facilities National Institute for Basic Biology Qkazaki Aichi 444-0867 Japan CREST JST Kawaguchi Saitama 332-0012 Japan

Dear Editor,DECREASE IN DNA METHYLATION1 （DDM1） is a chromatin remodeling protein required for maintenance of cytosine and histone H3K9 methylation in heterochromatin regions in the genome of Arabidopsis thaliana （Gendrel et al., 2002）. A ddm 1 mutant also increases the rate of meiotic recombination in euchromatic but not heterochromatic regions of A. thaliana （Melamed-Bessudo and Levy, 2012）, and changes the state of cytosine methylation of a gene flanked by a LINE element located in a region of euchromatin （Saze and Kakutani, 2007）. These studies indicate that the function of DDM1 is not limited to heterochromatin regions and show that it also acts on euchromatic regions in the genome, although the mechanism determining its target specificity remains obscure. Toward understanding the function of DDM1 in the maintenance of global epigenetic state of the genome in higher plants, we performed a genome-wide analysis of cytosine methylation in an antisense-mediated DDMl-knockdown rice line （asDDM1） that exhibits similar characteristics to that of ddml in A. thaliana （Higo et al., 2012; Habu et al., 2015）. Some intrinsic properties of rice genome differ greatly from those of A. thaliana, for example, the content of repeated sequences and their distribution, and therefore rice provides an opportunity to examine the effect of DDM1 deficiency on genomes with a higher content and broader distribution of repeats.

关键词： genomes broader distribution

Removal of competitive native species combined with tree planting can accelerate the initial afforestation process: an experiment in an old field in Japan invaded by dwarf bamboo and kudzu

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Journal of Forestry Research 2015年第3期26卷 581-588页

作者： Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi yamaguchi Takahiro Ara Nobukazu Nakagoshi Biodiversity Division National Institute for Agro-Environmental Sciences 3-1-3 Kannondai TsukubaIbaraki 305-8604 Japan Ecosystem Informatics Division National Institute for Agro-Environmental Sciences 3-1-3 Kannondai TsukubaIbaraki 305-8604 Japan Experimental Farm Management Division National Institute for Agro-Environmental Sciences 3-1-3 KannondaiTsukuba Ibaraki 305-8604 Japan Graduate School for International Development and Cooperation Hiroshima University 1-5-1 KagamiyamaHigashi-Hiroshima 739-8529 Japan

Restoring natural forests after field abandon- ment is a land management objective that fosters the re- covery of forest biodiversity. We performed seeding and transplanting of native tree species 40 years after the abandonment of an arable field that became dominated by a dwarf bamboo （Pleioblastus chino （Franch. et Sav.） Makino） and by kudzu （Pueraria lobata （Willd.） Ohwi）. By permutation tests, the removal of competing vegetation （gap creation） significantly increased the survival of three seeded species of Fagaceae and of eight transplanted spe- cies. In contrast, intact vegetation prevented most indi- viduals of all species from surviving for 1 year after planting. The lack of natural recruitment of Fagaceae in the nonseeded subplots indicated that seed limitation was a cause of the slow afforestation. Although litter accumula- tion in gaps at the time of seeding slightly increased sur- vival for late-germinating Quercus myrsinifolia Blume andCastanopsis sieboldii （Makino） Hatus. ex T. Yamaz. et Mashiba, the effect was not consistent among plots and was not statistically significant. Our results suggest that for successful afforestation using native trees in abandoned fields, it will be necessary to remove competitive native species to avoid severe limitations on microsite availability and that simultaneous tree establishment by seeding or transplanting should be implemented to accelerate the establishment of native tree species.

关键词： Farmland abandonment - Micrositelimitation Pleioblastus chino Pueraria lobata Treeseedling

A model to estimate available timber and forest biomass and reforestation expenses in a mountainous region in Japan

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Journal of Forestry Research 2013年第2期24卷 345-356页

作者： Kazuhiro Aruga Ayami Murakami Chikara Nakahata Reiko yamaguchi Masashi Saito Kanae Kanetsuki Department of Forest Science Faculty of Agriculture Utsunomiya University Frontier Agriscience and Technology Center Faculty of Agriculture Shinshu University Nasunogahara Land Improvement Districts

We developed a model to estimate supply potentials and available amounts of timber and forest biomass resources from profitable sub-compartments of thinning and final felling operations. Economic balances were estimated while considering not only harvesting expenses but also reforestation expenses after final felling, which should be considered for sustainable forest management. Harvesting expenses were estimated based on two types of timber harvesting systems and three types of forest biomass harvesting systems in each sub-compartment. Then, the model was applied to Nasushiobara city of Tochigi prefecture, Japan. Reforestation expenses had large negative impacts on the financial balances of final felling operations. Few sub-compartments were profitable after considering reforestation expenses. Most profitable sub-compartments were those with mechanized operation systems and landing sales. These accounted for 17.19% of all sub-compartments, while only 5.75% of the sub-compartments were profitable based on their current operation systems and landing sales. Although the overall supply potentials of timber and forest biomass resources were 380,000 m3 and 210,000 Mg, respectively, and 15 times the planned harvest of coniferous tree volume of 25,000 m3year-1 and 50 times the annual demand for the woody gasification power generation of 4,000 Mg year-1 in Nasushiobara, available amounts of timber and forest biomass resources were only49,429 m3 and 33,333 Mg, which were 13.0% and 15.7% of supply potentials for landing sales with mechanized operation systems.

关键词： forest biomass resources supply potentials available amounts economic balance GIS

A dwarf bamboo(Pleioblastus chino) and winter browsing by Japanese hare(Lepus brachyurus) combine to limit establishment of transplanted native tree seedlings in an abandoned agricultural field

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Journal of Forestry Research 2016年第6期27卷 1287-1294页

作者： Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi yamaguchi Takahiro Ara Nobukazu Nakagoshi Biodiversity Division National Institute for Agro-Environmental Sciences (NIAES) Ecosystem Informatics Division NIAES Experimental Farm Management Division NIAES Graduate School for International Development and Cooperation Hiroshima University

Natural forest recovery on abandoned farmland is hindered by a variety of factors and active restoration plays an important role when quick afforestation is desired. We investigated seedling survival of four transplanted native tree species （Quercus myrsinifolia, Quercus serrata, Aphananthe aspera, and Rhus sylvestris） by experimentally manipulating the vegetation cover, which was mainly dominated by dwarf bamboo （Pleioblastus chino）, and herbivore access to the planting sites on farmland that had been abandoned for 15 years at the start of the study. Few transplanted seedlings of any species survived under intact vegetation cover, irrespective of herbivore presence. In gaps in the vegetation cover, winter browsing by Japanese hare （Lepus brachyurus） damaged all species. However, lower browsing frequency and higher resprouting ability after grazing of the seedlings enabled both Quercus species to survive better than the other species. These results indicate that dwarf bamboo and the hare jointly limit the establishment of native trees in old fields. If active afforestation by transplanting seedlings at sites dominated by dwarf bamboo is planned, a combination of vegetation removal, selection of suitable species, and temporary seedling protection will be most effective.

关键词： Farmland abandonment Microsite limitation Monodominant dwarf bamboo Resprouting Seedling herbivory