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硫酸钡凝胶球诊断咽食管疾病的价值

放射学实践 1991年第2期6卷 47-50页

作者： Chr.hannig a.wuttge-hannig H.Daschner St.Baum St.Gütner 王天才 Institut fr Rntgendiagnostik des Klinikums rechts der Isar der Technischen Universitt Mnchen Apotheke des Klinikums rechts der Isar der Technischen Universitt Mnchen 同济医科大学附属同济医院

对固体物咽下困难的诊断,若各种原因所致食管狭窄很不明显时,会遇到较大困难。采用以下所述凝胶球检查可明显改善本病的诊断。

关键词：硫酸钡凝胶球食管痉挛

A fiducial approach to the nonparametric deconvolution problem:The discrete case

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Science China Mathematics 2024年

作者： Yifan Cui Jan hannig Center for Data Science Zhejiang University Department of Statistics and Operations Research University of North Carolina at Chapel Hill

Fiducial inference is applied to nonparametric g-modeling in the discrete case. We propose a computationally efficient algorithm to sample from the fiducial distribution and use the generated samples to construct point estimates and confidence intervals. We study the theoretical properties of the fiducial distribution and perform extensive simulations in various scenarios. The proposed approach gives rise to good statistical performance in terms of the mean squared error of point estimators and coverage of confidence intervals. Furthermore, we apply the proposed fiducial method to estimate the probability of each satellite site being malignant using gastric adenocarcinoma data with 844 patients.

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Human dental enamel： A masterpiece investigated natural nanotechnology by TEM and t-EBSD

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Nano Research 2018年第7期11卷 3911-3921页

作者： Anjela Koblischka-Veneva Michael R. Koblischka Jorg Schmauch Matthias hannig Experimental Physics Saafland University P. O. Box 151150 66041 Saarbrucken Germany Clinic of Operative dentistry Periodontology and Preventive Dentistry Saarland University Building 73 66421 Homburg/Saar Germany

The micro- and nanostructures of human dental enamel were investigated by transmission electron microscopy （TEM） and electron backscatter diffraction （EBSD）. For this purpose, TEM slices were prepared from teeth by focused ion-beam milling. These slices enabled TEM and transmission-EBSD （t-EBSD） investigations to be performed, while standard EBSD on bulk tooth samples resulted only in Kikuchi patterns. On the TEM slices, t-EBSD enabled automated mapping. The TEM images and the EBSD data dearly elucidated the arrangement of the hydroxyapatite crystals on the nanometer scale. Information regarding the crystallographic orientation of the apatite grains enabled the deduction of novel nanotechnological building principles of the enamel structure based on a chain-like arrangement of the crystallites.

关键词： enamel microstructure transmission electron microscopy (TEM) electron backscatter diffraction (EBSD) transmission-EBSD(t-EBSD)

Systematic Cross-biospecimen Evaluation of DNA Extraction Kits for Long-and Short-read Multi-metagenomic Sequencing Studies

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 405-417页

作者： Jacqueline Rehner Georges Pierre Schmartz Laura Groeger Jan Dastbaz Nicole Ludwig Matthias hannig Stefan Rupf Berthold Seitz Elias Flockerzi Tim Berger Matthias Christian Reichert Marcin Krawczyk Eckart Meese Christian Herr Robert Bals Soren L.Becker Andreas Keller Rolf Muller The IMAGINE Consortium Institute of Medical Microbiology and Hygiene Saarland UniversityD-66421 HomburgGermany Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Helmholtz Institute for Pharmaceutical Research Saarland D-66123 SaarbruckenGermany Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland UniversityD-66421 HomburgGermany Department of Ophthalmology Saarland University Medical CenterD-66421 HomburgGermany Department of Medicine Ⅱ Saarland University Medical CenterD-66421 HomburgGermany Department of Internal Medicine V–Pulmonology AllergologyIntensive Care MedicineSaarland UniversityD-66421 HomburgGermany

High-quality DNA extraction is a crucial step in metagenomic *** by different isolation kits impairs the comparison across datasets.A trending topic is,however,the analysis of multiple metagenomes from the same patients to draw a holistic picture of microbiota associated with *** thus collected bile,stool,saliva,plaque,sputum,and conjunctival swab samples and performed DNA extraction with three commercial *** each combination of the specimen type and DNA extraction kit,20-gigabase(Gb)metagenomic data were generated using short-read *** profiles of the specimen types showed close proximity to each other,we observed notable differences in the alpha diversity and composition of the microbiota depending on the DNA extraction *** kit outperformed all selected kits on every *** reached consistently good results using the Qiagen QiAamp DNA Microbiome *** on the specimen,our data indicate that over 10 Gb of sequencing data are required to achieve sufficient resolution,but DNA-based identification is superior to identification by mass ***,longread nanopore sequencing confirmed the results(correlation coefficient>0.98).Our results thus suggest using a strategy with only one kit for studies aiming for a direct comparison of multiple microbiotas from the same patients.

关键词： Whole-genome analysis Comparative genomics Short-read sequencing Long-read sequencing DNA extraction Metagenomics

Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi Murad Sarah-Lilly Hassan Youssef Haikel Mossaad Megahed Matthias hannig Mohamed Hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental Medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la RecherchéMédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus(HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients' sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor(GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1(TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词：丙肝病毒瘙痒 Cholestasis 自体毒素 Lysophosphatidic 酸 PI3 kinase

Covariance estimation via fiducial inference

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Statistical Theory and Related Fields 2021年第4期5卷 316-331页

作者： W.Jenny Shi Jan hannig Randy C.S.Lai Thomas C.M.Lee Financial Planning&Analysis MassMutualBostonMAUSA Department of Statistics&Operations Research University of North CarolinaChapel HillNCUSA Department of Statistics University of CaliforniaDavisCAUSA

As a classical problem,covariance estimation has drawn much attention from the statistical com-munity for *** work has been done under the frequentist and Bayesian *** to quantify the uncertainty of the estimators without having to choose a prior,we have developed a fiducial approach to the estimation of covariance *** upon the Fiducial Berstein-von Mises Theorem,we show that the fiducial distribution of the covariate matrix is consistent under our ***,the samples generated from this fiducial distri-bution are good estimators to the true covariance matrix,which enable us to define a meaningful confidence region for the covariance ***,we also show that the fiducial approach can be a powerful tool for identifying clique structures in covariance matrices.

关键词： covariance estimation sparsity fiducial inference cliques

壁处与龈壁处的微渗漏的比较——湿润粘接技术修复V类洞洞型

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口腔医学 1999年第2期19卷 65-66页

作者：傅柏平 hannig,M 浙江医科大学附属第一医院口腔科

目的：实验研究湿润粘接技术修复Ｖ类洞洞型时，壁处与龈壁处的微渗漏的比较．方法：４８颗人离体磨牙根据颊、近中和远中面分别分成Ａ、Ｂ、Ｃ三组，每组又随机分成４小组（ｎ＝１２），洞型位于釉牙本质交界处．Ａ１和Ａ２组常规制... 详细信息

目的：实验研究湿润粘接技术修复Ｖ类洞洞型时，壁处与龈壁处的微渗漏的比较．方法：４８颗人离体磨牙根据颊、近中和远中面分别分成Ａ、Ｂ、Ｃ三组，每组又随机分成４小组（ｎ＝１２），洞型位于釉牙本质交界处．Ａ１和Ａ２组常规制备Ｖ类洞洞型；但Ａ２制备洞缘斜面；Ａ３、Ａ４用空气喷磨技术制备Ｖ类洞洞型，但分别使用方法５０μｍ和２７μｍ氧化铝微粒．Ｂ、Ｃ各小组处理与相应Ａ组相同．所有牙齿用０．５％亚甲基蓝着色．结果：所有标本在龈壁处存在严重的微渗漏（ｐ＜０．００１）．

关键词： V类洞湿润粘接剂微渗漏 He壁

Effect of anti-biofilm glass–ionomer cement on Streptococcus mutans biofilms

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International Journal of Oral Science 2016年第2期8卷 76-83页

作者： Su-Ping Wang Yang Ge Xue-Dong Zhou Hockin HK Xu Michael D Weir Ke-Ke Zhang Hao-Hao Wang Matthias hannig Stefan Rupf Qian Li Lei Cheng State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Department of Operative Dentistry and Endodontics West China Hospital of Stomatology Sichuan University Biomaterials and Tissue Engineering Division Department of Endodontics Prosthodontics and Operative Dentistry University of Maryland Dental School Clinic of Operative Dentistry Periodontology and Preventive Dentistry Saarland University

Dental restorative materials with antimicrobial properties can inhibit bacterial colonization, which may result in a reduction of caries at tooth-filling interaction zones. This study aimed to develop antibacterial glass-ionomer cements （GIC） containing a quaternary ammonium monomer （dimethylaminododecyl methacrylate, DMADDM）, and to investigate their effect on material performance and antibacterial properties. Different mass fractions （0, 1.1% and 2.2%） of DMADDM were incorporated into the GIC. The flexure strength, surface charge density, surface roughness and fluoride release were tested. A Streptococcus mutans biofilm model was used. Exopolysaccharides （EPS） staining was used to analyze the inhibitory effect of DMADDM on the biofilm matrix. In addition, biofilm metabolic activity, lactic acid metabolism and the expression of glucosyltransferase genes g/fB, gtfC and gtfD were measured. GIC containing 1.1% and 2.2% DMADDM had flexural strengths matching those of the commercial control （P〉0.1）. DMADDM was able to increase the surface charge density but reduced surface roughness （P〈0.05）. The incorporation of 1.1% and 2.2% DMADDM elevated the release of fluoride by the GIC in the first 2 days （P〈0.05）. The novel DMADDM-modified GIC significantly reduced biofilm metabolic activity （P〈 0.05） and decreased lactic acid production （P〈 0.05）. The quantitative polymerase chain reaction （qPCR） results showed that the expression of gtfB, g/fC and gtfD decreased when mass fractions of DMADDM increased （P〈0.05）. EPS staining showed that both the bacteria and EPS in biofilm decreased in the DMADDM groups. The incorporation of DMADDM could modify the properties of GIC to influence the development of S. mutans biofilms. In this study, we investigated the interface properties of antibacterial materials for the first time. GIC containing DMADDM can improve material performance and antibacterial properties and may contribute to the better management of secondary caries.

关键词： antibacterial properties dimethylaminododecyl methacrylate glass-ionomer cement material performance Streptococcusmutans biofilms

纳米颗粒漱口水对原位菌斑短期抑制作用的研究

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纳米颗粒漱口水对原位菌斑短期抑制作用的研究