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Terrain based co-operative UAV mapping of complex obstacles using 2-D splinegon

International Journal of Intelligent Computing and Cybernetics 2012年第3期5卷 248-292页

作者： Samuel B.Lazarus Antonios Tsourdos Brian a.white Peter Silson Al Savvaris Camille-Alain Rabbath Nicolas Lèchevin School of Engineering Cranfield UniversityCranfieldUK Autonomous Systems Group Defence Academy of the United KingdomCranfield UniversityShrivenhamUK Defence Research and Development Canada-Valcartier Quebec CityCanada Numerica Technologies Inc.ValcartierQuebec CityCanada

Purpose-This paper aims to describe a recently proposed algorithm in terrain-based cooperative UAV mapping of the unknown complex obstacle in a stationary environment where the complex obstacles are represented as curved in *** also aims to use an extended Kalman filter(EKF)to estimate the fused position of the UAVs and to apply the 2-D splinegon technique to build the map of the complex shaped *** path of the UAVs are dictated by the Dubins path planning *** focus is to achieve a guaranteed performance of sensor based mapping of the uncertain environments using multiple ***/methodology/approach–An extended Kalman filter is used to estimate the position of the UAVs,and the 2-D splinegon technique is used to build the map of the complex obstacle where the path of the UAVs are dictated by the Dubins path planning ***-The guaranteed performance is quantified by explicit bounds of the position estimate of the multiple UAVs for mapping of the complex obstacles using 2-D splinegon *** is a newly proposed algorithm,the most efficient and a robust way in terrain based mapping of the complex *** proposed method can provide mathematically provable and performance guarantees that are achievable in ***/value-The paper describes the main contribution in mapping the complex shaped curvilinear objects using the 2-D splinegon *** is a new approach where the fused EKF estimated positions are used with the limited number of sensors’measurements in building the map of the complex obstacles.

关键词： Multiple sensor fusion Data fusion EKF based navigation Multiple UAVs 2-D splinegon Robust UAV localization Complex obstacle mapping Sensor fusion Navigation

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Aspirin-exacerbated respiratory disease:Update on medical management

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 241-247页

作者： Andrew a.white Katharine Woessner Ronald Simon Scripps Clinic Division of AllergyAsthm a and ImmunologyScripps Green HospitalSon DiegoCAUSA

Aspirin-exacerbated respiratory disease(AERD)is frequently diagnosed in patients with severe type 2 airway inflammation presenting with nasal polyps and severe *** has been associated with a recalcitrant course with high medical and surgical *** advent of recent biological and other targeted treatments show promise in the medical management of patient with *** goal of complete disease control where patients no longer require recurrent surgical procedures,systemic corticosteroid exposure and may live with a stable and relatively normal quality of life is now within *** work is necessary to identify biomarkers predictive of treatment response.

关键词： Aspirin-exacerbated respiratory disease Samter syndrome Aspirin intolerant asthma Nasal polyposis Severe asthma

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SDN在IP网络演进中的作用

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电信科学 2014年第5期30卷 1-13页

作者： Mark M.Clougherty Christopher a.white Harish Viswanathan Colin L.Kahn 阿尔卡特朗讯首席技术官办公室美国新泽西州莫雷山079740636 阿尔卡特朗讯贝尔实验室美国新泽西州莫雷山079740636

Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适... 详细信息

Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适应新的变化。软件定义网络(SDN)和网络功能虚拟化(NFV)就是其中两个能灵活地使能上述需求的技术。本文描述了SDN在IP网络领域中所起的作用(包括在实现NFV方面的关键作用),并介绍了关于网络如何引入SDN和NFV的场景和多个使用案例,用于说明SDN和NFV如何使得网络更加敏捷、可编程、优化地支持业务和用户的特殊需求。

关键词： SDN NFV IP网络网络演进

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精密相位发生器

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中国检验检测 1982年第4期 51-53页

作者： a.white 陈森元

一、引言在0～200kHz 频率范围,随着以测量相位差为其基础的系统和电路的性能的提高使得有必要建立高分辨率和准确度的标准。对标准的技术指标要求如下:频率范围为0～100kHz;相位差范围为0～360°;相位差分辨率为0.1°(<5kHz);准确度优... 详细信息

一、引言在0～200kHz 频率范围,随着以测量相位差为其基础的系统和电路的性能的提高使得有必要建立高分辨率和准确度的标准。对标准的技术指标要求如下:频率范围为0～100kHz;相位差范围为0～360°;相位差分辨率为0.1°(<5kHz);准确度优于0.04°;谐波分量低于基波功率电平60dB。上面对正弦波形的谐

关键词：只读存储器取字模变换器数一字长二进制唯读存储器进位计数制相位差奇次谐波

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Cancer Communications 2022年第8期42卷 716-749页

作者： Jang Hee Han Yong Keon Kim Hakhyun Kim Jooyoung Lee Myung Joon Oh Sang Bum Kim Minjee Kim Kook Hwan Kim Hyun Ju Yoon Myung-Shik Lee John D.Minna Michael a.white Hyun Seok Kim Severance Biomedical Science Institute Yonsei University College of MedicineSeoul 03722Korea Department of Medical Science Yonsei University Graduate SchoolSeoul 03722Korea Department of Urology Seoul National University HospitalSeoul 03722Korea Checkmate Therapeutics Inc. Seoul 07207Korea Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexas 75390USA Department of Cell Biology University of Texas Southwestern Medical CenterDallasTexas 75390USA Graduate School of Medical Science Brain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Korea

Background: Autophagy is elevated in metastatic tumors and is often associatedwith active epithelial-to-mesenchymal transition (EMT). However, the extent towhich EMT is dependent on autophagy is largely unknown. This study aimed toidentify the mechanisms by which autophagy facilitates ***: We employed a liquid chromatography-based metabolomic approachwith kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1)gene co-mutated (KL) cells that represent an autophagy/EMT-coactivatedinvasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation. Molecular mechanisms of autophagy-drivenEMT activation were further investigated by quantitative real-time polymerasechain reaction (qRT-PCR), Western blotting analysis, immunoprecipitation,immunofluorescence staining, and metabolite assays. The effects of chemicaland genetic perturbations on autophagic flux were assessed by two orthogonalapproaches: microtubule-associated protein 1A/1B-light chain 3 (LC3) turnoveranalysis by Western blotting and monomeric red fluorescent protein-greenfluorescent protein (mRFP-GFP)-LC3 tandem fluorescent protein quenchingassay. Transcription factor EB (TFEB) activity was measured by coordinatedlysosomal expression and regulation (CLEAR) motif-driven luciferase reporterassay. Experimental metastasis (tail vein injection) mouse models were used toevaluate the impact of calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVISluciferase imaging ***: We found that autophagy in KL cancer cells increased acetyl-coenzymeA (acetyl-CoA), which facilitated the acetylation and stabilization of theEMT-inducing transcription factor Snail. The autophagy/acetyl-CoA/acetylSnail axis was further validated in tumor tissues and in autophagy-activatedpancreatic cancer cells. TFEB acetylation in KL cancer cells sustained prometastatic autophagy in a mammalian target o

关键词： snail autophagy acetyl-coenzyme A epithelial-to-mesenchymal transition non-small-cell lung cancer CAMKK2 acetyl-snail pancreatic cancer KRAS inhibitor metastasis ACLY

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Meiotic recombination differences in human male and female

Meiotic recombination differences in human male and female

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中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Shunxin Wang Terry Hassold Patricia Hunt Martin a.white Denise Zickler Nancy Kleckner Liangran Zhang Center for Reproductive Medicine Shandong University Department of Molecular and Cellular Biology Harvard University School of Molecular Biosciences and Center for Reproductive Biology Washington State University Institute for Integrative Biology of the Cell(I2BC) CEACNRSUniversite' Paris-SudUniversite' Paris-Saclay State Key Laboratory of Microbial Technology School of Life SciencesShandong University

Meiosis is a process for gamete formation in sexually-reproducing *** this process,proper crossover recombination between homologous chromosomes is essential for regular chromosome *** number and distribution of crossovers are tightly *** placed crossovers including number and positions would cause infertility,sterility,birth defects and many kinds of genetic *** seems that meiotic recombination is different between human male and *** recently,we have identified specific "crossover maturation inefficiency" in human female meiosis,which causes 5%of the intermediates that should mature into crossover products actually fail to do *** "female-specific crossover maturation inefficiency" is the major contributor to the high level of chromosome missegregation and resultant aneuploidy for human female oocytes(e.g.,giving Down syndrome).We will discuss the possible cause and consequence of "crossover maturation inefficiency".

关键词： meiosis crossover maturation inefficiency homologous chromosome

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用于油气勘探和评价的探区组合图

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海洋地质译丛 1989年第3期 48-54页

作者： David a.white 李培廉

油气探区组合(Play)概要图显示叠置边界有利于对油气产出——源岩、运移、储集层、■闭、■闭形成时间、盖层、保存等所有重要的地质控制以及对在成因上为一组的探区或油气田进行回采。这些图件对准确地划分最佳地区具有极大的价值,勘... 详细信息

油气探区组合(Play)概要图显示叠置边界有利于对油气产出——源岩、运移、储集层、■闭、■闭形成时间、盖层、保存等所有重要的地质控制以及对在成因上为一组的探区或油气田进行回采。这些图件对准确地划分最佳地区具有极大的价值,勘探风险可因此而减少。在对探区和探区组合带的评价中,可定量估算烃含量以及成功率。深区组合概要图以一套标准的勘探图为基础,而且要求对所有基本的地质控制因素进行系统解释,因为没有一项因素从可靠程度考虑可予以忽视。

关键词：石油开然气勘探探区组合图

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Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter

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Light(Science & Applications) 2021年第8期10卷 1494-1506页

作者： Linli Shi Ying Jiang Fernando R.Fernandez Guo Chen Lu Lan Heng-Ye Man John a.white Ji-Xin Cheng Chen Yang Department of Chemistry Boston University580 Commonwealth AvenueBostonMA 02215USA. Department of Biomedical Engineering Boston University44 Cummington MallBostonMA 02215USA. Center for Systems Neuroscience Boston University610 Commonwealth AveBostonMA 02215USA. Neurophotonics Center Photonics CenterBoston University8 St.Mary's StreetBostonMA 02215USA. Department of Electrical and Computer Engineering 8 St.Mary's StreetBostonMA 02215USA. Department of Biology Boston University5 Cummington MallBostonMA 02215USA

Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical ***,we developed a tapered fiber optoacoustic emitter(TFOE)generating an ultrasound field with a high spatial precision of 39.6 pm,enabling optoacoustic activation of single neurons or subcellular structures,such as axons and ***,a single acoustic pulse of sub-microsecond converted by the TFOE from a single laser pulse of 3 ns is shown as the shortest acoustic stimuli so far for successful neuron *** precise ultrasound generated by the TFOE enabled the integration of the optoacoustic stimulation with highly stable patch-clamp recording on single *** measurements of the electrical response of single neurons to acoustic stimulation,which is difficult for conventional ultrasound stimulation,have been *** coupling TFOE with ex vivo brain slice electrophysiology,we unveil cell-type-specific responses of excitatory and inhibitory neurons to acoustic *** results demonstrate that TFOE is a non-genetic single-cell and sub-cellular modulation technology,which could shed new insights into the mechanism of ultrasound neurostimulation.

关键词： emitter fiber stimulation

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如何平衡你的学业与社交生活?

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英语沙龙（高中） 2009年第10期 46-47页

作者： Zoe a.white 默然

编者按：许多刚步入大学校园的学生们可能会有一种困惑：学业固然很重要，但是社交生活也同样起着举足轻重的作用。但是，要想全心全意地投入到学习中去，就必然没有充裕的时间去跟自己的朋友相处，或者去看外面精彩的世界。读完本文，... 详细信息

编者按：许多刚步入大学校园的学生们可能会有一种困惑：学业固然很重要，但是社交生活也同样起着举足轻重的作用。但是，要想全心全意地投入到学习中去，就必然没有充裕的时间去跟自己的朋友相处，或者去看外面精彩的世界。读完本文，你可能会得到你想要的答案，因为只要你足够的用心，“鱼”和“熊掌”就可以兼得。

关键词：社交生活学业平衡大学校园编者按

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The use of faecal NIRS to monitor diet quality different grazing systems in tropical savannas

The use of faecal NIRS to monitor diet quality different gra...

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ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： a.white L.P.Hunt S.R.Petty D.P.Poppi Heytesbury Beef University of Queensland CSIRO Sustainable Ecosystems

＜正＞Introduction Nutrition is the major factor influencing animal production in grazing systems,however it is very difficult to monitor in extensive *** is especially so in northern Australia which has distinct wet and dry seasons,large paddocks with highly heterogeneous pastures and the likelihood for selective *** NIRS is one method to monitor diet quality in these extensive systems（Givens et al.,1997）.Here we present data that illustrates the considerable seasonal differences in nutrition across four different grazing systems and discuss this in relation to collection methods and inter-animal variation that occurs.

关键词： animal nutrition NIRS tropical savannas grazing systems

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