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国际医学放射学杂志 2024年第3期 377-377页

作者： S.Zafar K.Y.Elbanna a.w.m.todd L.Guimaraes C.O'Brien A.Goel 余翔玲

摘要目的确定在CT上对不确定性结节进行相对（R）和绝对（A）动脉期过度增强（APHE）和廓清（wO）的定量评估，能否提高肝细胞癌（HCC）检测的总体敏感性。方法回顾

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molecular Docking Studies on Streptomycin Antileishmanial Activity

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Open Journal of Physical Chemistry 2024年第2期14卷 36-48页

作者： todd A. Young matthew George Jr. Ayele Gugssa william m. Southerland Yayin Fang Clarence m. Lee Department of Biology Howard University Washington DC United States Department of Biochemistry and molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if Streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using mOE (molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and H. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis Streptomycin Amphotericin B molecular Docking Aminoglycosides Antileishmanial

2023年美国麻醉医师学会神经肌肉阻滞监测与拮抗实践指南:美国麻醉医师学会工作组关于神经肌肉阻滞的报告

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中华麻醉学杂志 2024年第5期44卷 518-542页

作者： Stephan R.Thilen wade A.weigel michael m.todd Richard P.Dutton Cynthia A.Lien Stuart A.Grant Joseph w.Szokol Lars I.Eriksson myron Yaster mark D.Grant madhulika Agarkar Anne m.marbella Jaime F.Blanck Karen B.Domino 西雅图华盛顿州明尼阿波里斯明尼苏达州达拉斯得克萨斯州密尔沃基威斯康星州教堂山北卡罗来纳州洛杉矶加利福尼亚州斯德哥尔摩瑞典丹佛科罗拉多州绍姆堡伊利诺斯州巴尔的摩马里兰州

本实践指南基于证据提供了全身麻醉期间及术后神经肌肉功能监测与阻滞拮抗的管理推荐。主要关注神经肌肉功能监测的类型与部位及阻滞拮抗的过程,以减少肌肉松弛药残留阻滞。

关键词：神经肌肉阻滞肌肉松弛药神经肌肉功能监测舒更葡糖钠新斯的明

始新世中期安宁河断裂冲断变形特征及其构造意义:来自断层泥自生伊利石K-Ar定年的证据

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地学前缘 2024年第4期31卷 297-313页

作者：童馗李智武刘树根 I.Tonguç UYSAL 施泽进李金玺 Andrew todd 武文慧王自剑刘升武李轲华天成都理工大学油气藏地质及开发工程全国重点实验室四川成都610059 成都理工大学地质资源与地质工程博士后流动站四川成都610059 CSIRO Energy 26 Dick Perry AvenueKensingtonWA 6151Australia 西华大学四川成都610039 School of the Environment The University of QueenslandBrisbaneQLD 4072Australia 西南油气田分公司勘探开发研究院四川成都610051

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随... 详细信息

青藏高原及其周缘褶皱-冲断带变形方式和时限是验证高原形成众多大陆岩石圈变形动力学端员模型的关键。近年发展起来的断层泥自生伊利石K-Ar定年技术为精确限定褶皱-冲断带变形时限提供了有效手段。鲜水河—安宁河—小江断裂系作为伴随印度-欧亚板块碰撞造山和高原物质侧向挤出过程形成的大型左旋走滑断裂系,其变形过程可为解译印度-欧亚板块碰撞远程应力向东传递方式提供关键证据。本文选取安宁河断裂冕宁—西昌段作为研究对象,在详细构造解析以明确其构造运动学特征的基础上,开展了断层泥自生伊利石K-Ar定年研究,以期精确限定安宁河断裂脆性变形的时间。构造解析表明安宁河断裂在近Ew向挤压作用下经历了冲断变形,断层带发育碎斑岩和断层泥,指示为脆性变形。安宁河断裂不同粒级断层泥样品的黏土矿物学和伊利石K-Ar定年分析揭示,随着样品粒级减小,高温2m1型伊利石含量相对低温1m/1md型伊利石含量逐渐减少,其K-Ar年龄总体呈变年轻趋势,表明不同粒级伊利石K-Ar年龄是由碎屑2m1型和自生1m/1md型两个多型端员组成的混合年龄。伊利石年龄分析获得自生1m/1md型伊利石的年龄为(42.6±9.4)ma,表明安宁河断裂经历了始新世中期的冲断变形。结合前人构造变形、沉积学、低温热年代学和古地磁等研究,我们认为始新世中期青藏高原腹地及其周缘褶皱-冲断带发生准同期的构造挤压变形,其动力学机制可能与印度-欧亚板块硬碰撞以及青藏高原地块的陆内俯冲所导致的先存构造带活化有关。始新世中期安宁河断裂发生冲断变形直接证明印度-欧亚板块碰撞初期的远程应力已传递至青藏高原东南缘地区。

关键词：安宁河断裂断层泥自生伊利石 K-Ar定年始新世中期

New methodological Approach to Investigation of Kinetics of REE Extraction in Nonstationary Conditions

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Journal of Rare Earths 2007年第4期25卷 385-391页

作者： Kopyrin A A Fomichev A A Afonin m A todd T A Saint-Petersburg Institute of Technology Idaho National Laboratory

The influence of periodical oscillations of the temperature on extraction and stripping processes in the extraction systems was studied. Two extraction systems were investigated：（1） 6 mol · L^-1 NaNO3-Nd（NO3）3-Pr（NO3）3-TBP kerosene and （2） [Nd（NO3）3 · 3TBP] -[ Pr（NO3）3 · 3TBP] -kerosene - 0.1 mol · L^-1 HNO3. mathematical modeling of the nonstationary membrane extraction has been enhanced by including the dependence of the extraction rate constants on temperature. The values of activation energy for direct and reverse extraction and stripping reactions of Pr and Nd were calculated from experimental temporal dependencies of metal concentration and temperature by solving the reverse kinetics problem using the proposed mathematical model, A series of experiments with periodical oscillations of the temperature on the extraction system for the separation of rare earth elements （REE） using bulk liquid membrane between two extractors were performed. The mathematical model adequately describes the experimental data. The optimization of the extraction process for separation of REE by liquid membrane, under the influence of periodical oscillation of the temperature, was made based on the extraction rate constants and activation energies. The optimal conditions of separation by liquid membrane were found： frequency and amplitude of thermal oscillations, liquid membrane flow rate, and optimal ratio between organic and aqueous phase in extractors.

关键词： kinetics extraction non-stationary rare earths

Effect of longwall-induced subsurface deformations on shale gas well casing stability under deep covers

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International Journal of mining Science and Technology 2019年第1期29卷 3-8页

作者： Daniel w.H.Su Peter Zhang mark Van Dyke todd minoski Center for Disease Control and Prevention(CDC) National Institute for Occupational Safety and Health(NIOSH)Pittsburgh Mining Research Division(PMRD)

This paper presents the results of a 2017 study conducted by the National Institute for Occupational Safety and Health(NIOSH), Pittsburgh mining Research Division(PmRD), to evaluate the effects of longwall-induced subsurface deformations within a longwall abutment pillar under deep cover. The 2017 study was conducted in a southwestern Pennsylvania coal mine, which extracts 457 m-wide longwall panels under 361 m of cover. One 198 m-deep, in-place inclinometer monitoring well was drilled and installed over a 45 m by 84 m center abutment pillar. In addition to the monitoring well, surface subsidence measurements and underground coal pillar pressure measurements were conducted as the 457 m-wide longwall panel on the south side of the abutment pillar was being mined. Prior to the first longwall excavation, a number of simulations using FLAC3D^(Tm) were conducted to estimate surface subsidence, increases in underground coal pillar pressure, and subsurface horizontal displacements in the monitoring well. Comparisons of the pre-mining FLAC3D simulation results and the surface, subsurface,and underground instrumentation results show that the measured in-place inclinometer casing deformations are in reasonable agreement with those predicted by the 3D finite difference models. The measured surface subsidence and pillar pressure are in excellent agreement with those predicted by the 3D *** from this 2017 research clearly indicate that, under deep cover, the measured horizontal displacements within the abutment pillar are approximately one order of magnitude smaller than those measured in a 2014 study under medium cover.

关键词： Longwall Deformations Shale gas wells Casing Safety and health

Dietary mitigation of enteric methane emissions from ruminants:A review of plant tannin mitigation options

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Animal Nutrition 2020年第3期6卷 231-246页

作者： Byeng R.min Sandra Solaiman Heidi m.waldrip David Parker Richard w.todd David Brauer United States Department of Agriculture(USDA) Agricultural Research Service(ARS)BushlandTX79012USA Tuskegee University TuskegeeAL36088USA

methane gas from livestock production activities is a significant source of greenhouse gas(GHG)emissions which have been shown to influence climate *** technologies offer a potential to manipulate the rumen biome through genetic selection reducing CH4 *** production may also be mitigated to varying degrees by various dietary intervention *** to reduce GHG emissions need to be developed which increase ruminant production efficiency whereas reducing production of CH4 from cattle,sheep,and *** emissions may be efficiently mitigated by manipulation of natural ruminal microbiota with various dietary interventions and animal production efficiency *** some CH4 abatement strategies have shown efficacy in vivo,more research is required to make any of these approaches pertinent to modern animal production *** objective of this review is to explain how anti-methanogenic compounds(e.g.,plant tannins)affect ruminal microbiota,reduce CH4 emission,and the effects on host ***,this review provides information relevant to understanding the impact of tannins on methanogenesis,which may provide a cost-effective means to reduce enteric CH4 production and the influence of ruminant animals on global GHG emissions.

关键词： Feed efficiency Greenhouse gas(GHG)emission methanogenesis Tannin Ruminant

ERCP for the treatment of bile leak after partial hepatectomy and fenestration for symptomatic polycystic liver disease

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world Journal of Gastroenterology 2012年第28期18卷 3705-3709页

作者： Nayantara Coelho-Prabhu David m Nagorney todd H Baron mayo Clinic College of medicine Rochester MN 55905 United States

AIm: To describe endoscopic treatment of bile leaks in these patients and to identify risk factors in these patients which can predict the development of bile leaks. mETHODS: Retrospective case-control study examining consecutive patients who underwent partial hepatectomy for polycystic liver disease (PLD) and developed a postoperative bile leak managed endoscopically over a ten year period. Each case was matched with two controls with PLD who did not develop a postoperative bile leak. RESULTS: Ten cases underwent partial hepatectomy with fenestration for symptoms including abdominal distention, pain and nausea. Endoscopic retrograde cholangiopancreatography (ERCP) showed anatomic abnormalities in 1 case. A biliary sphincterotomy was performed in 4 cases. A plastic biliary stent was placed with the proximal end at the site of the leak in 9 cases; in 1 case two stents were placed. The overall success rate of ERCP to manage the leak was 90%. There were no significant differences in age, gender, comorbidities, duration of symptoms, history of previous surgery or type of surgery performed between cases and controls. CONCLUSION: ERCP with stent placement is safe and effective for management of post-hepatectomy bile leak in patients with PLD.

关键词： Polycystic liver Hepatectomy Bile leak Endoscopic retrograde cholangiopancreatography

Accelerated partial breast irradiation: Past, present, and future

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world Journal of Clinical Oncology 2016年第5期7卷 370-379页

作者： Anne w Tann Sandra S Hatch melissa m Joyner Lee R wiederhold todd A Swanson Department of Radiation Oncology the University of Texas Medical Branch

Accelerated partial breast irradiation(APBI) focuses higher doses of radiation during a shorter interval to the lumpectomy cavity, in the setting of breast conserving therapy for early stage breast cancer. The utilization of APBI has increased in the past decade because of the shorter treatment schedule and a growing body of outcome data showing positive cosmetic outcomes and high local control rates in selected patients undergoing breast conserving therapy. Technological advances in various APBI modalities, including intracavitary and interstitial brachytherapy, intraoperative radiation therapy, and external beam radiation therapy, have made APBI more accessible in the community. Results of early APBI trials served as the basis for the current consensus guidelines, and multiple prospective randomized clinical trials are currently ongoing. The pending long term results of these trials will help us identify optimal candidates that can benefit from ABPI. Here we provide an overview of the clinical and cosmetic outcomes of various APBI techniques and review the current guidelines for selecting suitable breast cancer patients. we also discuss the impact of APBI on the economics of cancer care and patient reported quality of life.

关键词： Breast cancer Intracavitary brachytherapy Accelerated partial breast irradiation Interstitial brachytherapy

Upper bounds on a two-term exponential sum

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Science China mathematics 2001年第8期44卷 1003-1015页

作者： todd COCHRANE 郑志勇 Department of mathematics Kansas State University Manhattan KS 66506 USA Department of mathematics Tsinghua University Beijing 100084 China

we obtain upper bounds for mixed exponential sums of the type $S(\chi ,f,p^m ) = \sum\nolimits_{x = 1}^{p^n } {\chi (x)e} _{p^m } (ax^n + bx)$ where pm is a prime power with m? 2 and X is a multiplicative character (mod pm). If X is primitive or p?(a, b) then we obtain |S(χ,f,p m)| ?2np 2/3 m . If X is of conductor p and p?( a, b) then we get the stronger bound |S(χ,f,p m)|?np m/2.

关键词： exponential sums primitive character weil’sbound