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Suppressive effects of exercise-conditioned serum on cancer cells:A narrative review of the influence of exercise mode,volume,and intensity

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Journal of Sport and Health Science 2024年第4期13卷 484-498,F0003页

作者： Francesco Bettariga Dennis R.Taaffe Daniel A.Galvao Chris Bishop Jin-Soo Kim Robert u.Newton Exercise Medicine Research Institute Edith Cowan UniversityJoondalupWA 6027Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia London Sport Institute School of Science and TechnologyMiddlesex UniversityLondonNW44BTUK School of Human Movement and Nutrition Sciences University of QueenslandSt.LuciaQLD 4072Australia

Cancer is a major cause of morbidity and mortality worldwide,and the incidence is increasing,highlighting the need for effective strategies to treat this *** has emerged as fundamental therapeutic medicine in the management of cancer,associated with a lower risk of recur-rence and increased *** avenues of research demonstrate reduction in growth,proliferation,and increased apoptosis of cancer cells,including breast,prostate,colorectal,and lung cancer,when cultured by serum collected after exercise in vitro(i.e.,the cultivation of cancer cell lines in an experimental setting,which simpliﬁes the biological system and provides mechanistic insight into cell responses).The underlying mechanisms of exercise-induced cancer suppressive effects may be attributed to the alteration in circulating factors,such as skeletal muscle-induced cytokines(i.e.,myokines)and ***,exercise-induced tumor suppressive effects and detailed information about training interventions are not well investigated,constraining more precise application of exercise medicine within clinical *** date,it remains unclear what role different training modes(i.e.,resistance and aerobic training)as well as volume and intensity have on exercise-condi-tioned serum and its effects on cancer ***,the available evidence is that a single bout of aerobic training at moderate to vigorous intensity has cancer suppressive effects,while for chronic training interventions,exercise volume appears to be an inﬂuential candidate driving cancer inhibitory effects regardless of training *** for future research investigating training modes,volume and intensity are provided to further our understanding of the effects of exercise-conditioned serum on cancer cells.

关键词： Cancer cells High intensity interval training Moderate intensity continuous training Resistance training Myokines

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Endoscopic ultrasound-guided tissue acquisition for the diagnosis of focal liver lesion

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World Journal of Radiology 2024年第4期16卷 72-81页

作者： Alina Tantău Cosmina Sutac Anamaria Pop Marcel Tantău Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and PharmacyThe 4th Medical Clinic CF HospitalCluj-Napoca 400012ClujRomania Department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania Department of Gastroenterology and Hepatology Gastroenterology and Hepatology Medical CenterDigenio HospitalCluj-Napoca 400058ClujRomania Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and Pharmacy“Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania

In patients with liver tumors,the histopathology examination can assist in diagnosis,staging,prognosis,and therapeutic management *** ultrasound(EuS)-guided tissue acquisition using fine needle aspiration(FNA)or more newly fine needle biopsy(FNB)is a well-developed technique in order to evaluate and differentiate the liver *** goal of the EuS-FNA or EuS-FNB is to provide an accurate sample for a histopathology ***,malignant tumors such as hepatocarcinoma,cholangiocarcinoma and liver metastasis or benign tumors such as liver adenoma,focal hyperplastic nodular tumors and cystic lesions can be accurately diagnosed using EuS-guided tissue ***-FNB using 19 or 22 Ga needle provide longer samples and a higher diagnostic accuracy in patients with liver masses when compared with *** data are available on the diagnostic accuracy of EuS-FNB when compared with percutaneously,ultrasound,computer tomography or transjugulary-guided liver *** review will discuss the EuS-guided tissue acquisition options in patients with liver tumors and its efficacy and safety in providing accurate *** results of the last studies comparing EuS-guided liver biopsy with other conventional techniques are *** EuS-guided tissue acquisition using FNB can be a suitable technique in suspected liver lesions in order to provide an accurate histopathology diagnosis,especially for those who require endoscopy.

关键词： Endoscopic ultrasound-guided liver biopsy Liver tissue acquisition Fine-needle aspiration Fine-needle biopsy Liver tumors Focal liver lesions

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Protein-activated atomic layer deposition for robust crude-oil-repellent hierarchical nano-armored membranes

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Science Bulletin 2024年第2期69卷 218-226页

作者： Xiaobin Yang Pan Sun Yajie Wen Anil u.Mane Jeffrey W.Elam Jun Ma Shaomin Liu Seth B.Darling Lu Shao MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont IL 60439USA Applied Materials Division Argonne National LaboratoryLemont IL 60439USA Advanced Materials for Energy-Water Systems Energy Frontier Research Center Argonne National LaboratoryLemont IL 60439USA Pritzker School of Molecular Engineering University of ChicagoChicago IL 60637USA Department of Physics University of Ilinois at ChicagoChicago IL 60607USA School of Environment Harbin Institute of TechnologyHarbin 150090China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA 6845Australia

Atomic layer deposition(ALD)offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water ***,current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation ***,we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/*** a proof of concept,TiO2 ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity,ultralow underwater crude oil adhesion,and robust tolerance to rigorous environments including acid,alkali,saline,and *** importantly,excellent cyclable crude oil-in-water emulsion separation performance can be *** mechanism for activation/sensitization is rooted in reactivity for a particular set of amino ***,the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering,environmental remediation,lowcarbon manufacturing,catalysis,and beyond.

关键词： Membrane separation Atomic layer deposition Water treatment Antifouling

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Towards a New Model of Teacher Training in Europe

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Journalism and Mass Communication 2024年第4期14卷 260-266页

作者： Teodor Pătrăuță “Vasile Goldiș”Western university of Arad AradRoumania

The current situation of European educational systems leads to the lack of historical precedents,considering that it implies the end of educational systems based on exclusion,configuring a new conception of educational systems that we are still not able to appreciate at their true value,because we were educated by and in the previous educational *** other references,we inevitably tend to compare current problems with previous situations,without understanding that the generalization of education to 100%of the population implies a qualitative change that modifies the objectives,forms of work,and the very essence of the educational *** stage change,marked by the acceleration of social changes,including the pandemic situation,explains why,despite the best educational system so far,teachers with the best levels of training and a financial and material endowment unimaginable until recently,try a sense of crisis and a general feeling of confusion is manifested among the teachers and parents of the children,seeing that education is no longer what it used to be(Esteve,1998).The key to defuse this apparent paradox is in the tendency to judge the new education system by the mentality and standards of the former selective education,in which most of the adults present were ***,although we continue to apply to the new general education situation the parameters of the previous situation,in which the selective system excluded every year the students who had behavior problems in the class or had difficulties regarding the mastery of certain educational subjects(Esteve,1998).In this way,we are currently criticizing the school failure of a percentage of our students,without realizing that their schooling itself is a success,because,although their level is low,they had no level *** speaks of a low educational level,when,in reality,the educational level is increasing—the general level of the people and the individual level of the best students(Baudelo

关键词： education model teacher education exclusion selection schooling

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Symmetries,optimal system,exact and soliton solutions of(3+1)-dimensional Gardner-KP equation

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Journal of Ocean Engineering and Science 2024年第2期9卷 178-190页

作者： Amjad Hussain Ashreen Anjum M.Junaid-u-Rehman Ilyas Khan Mariam A.Sameh Amnah S.Al-Johani Department of Mathematics Quaid-I-Azam University 45320Islamabad 44000Pakistan Department of Mathematics College of Science Al-ZulfiMajmaah UniversityAl-MajmaahP.O Box 66Majmaah 11952Saudi Arabia Electrical Engineering Department Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo 11845Egypt Mathematics Department Faculty of ScienceUniversity of TabukTabukSaudi Arabia

In this research article,the(3+1)-dimensional nonlinear Gardner-Kadomtsov-Petviashvili(Gardner-KP)equation which depicts the nonlinear modulation of periodic waves,is analyzed through the Lie group-theoretic *** the Lie invariance condition,we find the symmetry *** pro-posed model yields eight-dimensional Lie ***,an optimal system of sub-algebras is com-puted,and similarity reductions are *** considered nonlinear partial differential equation is re-duced into ordinary differential equations(ODEs)by utilizing the similarity transformation method(STM),which has the benefit of yielding a large number of accurate traveling wave *** ODEs are further solved to get closed-form solutions of the Gardner-KP equation in some cases,while in other cases,we use the new auxiliary equation method to get its soliton *** evolution profiles of the obtained solutions are examined graphically under the appropriate selection of arbitrary parameters.

关键词： Gardner-KP equation Lie symmetry analysis Optimal system New auxiliary equation method Solitary wave solutions

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Abiotic and Biotic Factors Controlling Grain Aroma along Value Chain of Fragrant Rice:A Review

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Rice science 2024年第2期31卷 142-158页

作者： Ayut KONGPuN Tonapha PuSADEE Pennapa JAKSOMSAK Kawiporn CHINACHANTA Patcharin TuIWONG Phukjira CHAN-IN Sawika KONSAENG Wasu PATHOM-AREE Suchila uTASEE Benjamaporn WANGKAEW Chanakan PROM-u-THAI Faculty of Agricultural Technology Kalasin UniversityKalasin 46000Thailand Department of Plant and Soil Sciences Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Program in Agricultural Chemistry Faculty of Agricultural ProductionMaejo UniversityChiang Mai 50290Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Lanna Rice Research Center Chiang Mai UniversityChiang Mai 50200Thailand

The aroma of fragrant rice is one of the grain quality attributes that significantly influenceconsumer preferences and prices in world markets. The volatile compound 2-acetyl-1-pyrroline (2AP) isrecognized as a key component of the aroma in fragrant rice. The variation in grain 2AP content amongvarious fragrant rice varieties is associated with the expression of the badh2 gene, with 19 alleles havingbeen identified so far. The grain 2AP content is strongly influenced by environmental and managementfactors during cultivation as well as post-harvest conditions. This review pinpointed the major abiotic andbiotic factors that control grain 2AP content. Abiotic factors refer to water, temperature, light quality,fertilizer application (both macro- and micro-nutrients), and soil properties, including salinity, while bioticfactors include microorganisms that produce aromatic compounds, thus influencing the grain aroma infragrant rice. Post-harvest management, including storage and drying conditions, can significantly impactthe grain 2AP content, and proper post-harvest conditions can intensify the grain aroma. This reviewsuggests that there are rice varieties that can serve as potential sources of genetic material for breedingrice varieties with high grain aroma content. It offers an overview of recent research on the major factorsaffecting the aroma content in fragrant rice. This knowledge will facilitate further research on theproduction of high-quality rice to meet the demands of farmers and consumers.

关键词： aromatic rice 2-acetyl-1-pyrroline abiotic stress biotic stress post-harvest management

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Advancing public health preparedness:Establishment of Nipah virus molecular diagnostic test at the National Reference Laboratory,Sri Lanka

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 369-374页

作者： Hewa Babarandage Chathurika Harshani Denagama Vitharanage Rishan Geeth Ruwan udage Kankanamge Isuru udara Samaraweera Dedunu C u Dias Weligamage Janaki I Abeynayake Medical Research Institute Colombo-08Sri Lanka

Objective:To establish Nipah virus diagnostic capabilities at the National Reference Laboratory in Sri Lanka using the NIV Pune real-time PCR ***:Strict safety precautions were adhered during testing due to the high pathogenicity of the Nipah virus,with all diagnostics conducted in a BSL2+laboratory at the Medical Research Institute in Sri *** extraction was performed using the QIAamp Viral RNA Mini *** NIV Pune in-house real-time PCR kit was employed,following established primer/probe sequences and *** assay was validated using the Rotor-Gene Q Series Real-time PCR ***:The validation run of the Nipah virus real-time PCR test demonstrated robust performance,with positive controls consistently detecting Nipah RNA at a Ct value of 21.50±*** controls confirmed assay specificity with an external negative control which was also used as an extraction control and showed no *** internal control exhibited stable behavior,enhancing confidence in PCR *** qPCR analysis graph illustrated the successful detection of internal and positive controls,validating the reliability of the ***:Establishing Nipah virus diagnostic capabilities in Sri Lanka signifies a proactive and collaborative response to the persistent global health threat.

关键词： Nipah virus Real-time PCR Validation Molecular diagnostics

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Hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin H.K.Connor S.Hoilijoki M.Battarbee Y.Pfau-Kempf u.Ganse K.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

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Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong

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Virologica Sinica 2024年第2期39卷 343-346页

作者： Guoqian Gu Congnuan Liu Song Hao Lee Lewis Sze Chun Choi Michael T.Wilson Dirk u.Pfeiffer Yun Young Go Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina Center for Applied One Health Research and Policy Advice Jockey Club College of Veterinary Medicine and Life SciencesCity University of Hong KongHong Kong SARChina College of Veterinary Medicine Konkuk UniversitySeoul143-701Republic of Korea

Dear Editor,Influenza A viruses(IAVs)are responsible for significant respiratory illnesses in humans and a broad range of animal *** outbreaks and the rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for swine *** are susceptible to avian and human IAV infections and are considered“mixing vessels”where human,avian,and swine IAVs can recombine and generate novel reassortant influenza viruses with pandemic potential(Vincent et al.,2014).

关键词： swine influenza mixing

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Role of marine natural products in the development of antiviral agents against SARS‑CoV‑2:potential and prospects

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Marine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.M.Liyanage Thilina u.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Department of Marine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Department of Chemistry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada Marine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health ***,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic *** natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 Marine natural products Drug targets Inhibitors

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