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基于生成对抗网络加速超分辨率超声定位显微成像方法研究

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物理学报 2022年

作者：隋怡晖郭星奕郁钧瑾 Alexander a.solovev 他得安许凯亮复旦大学材料科学系复旦大学信息科学与工程学院生物医学工程中心复旦大学工程与应用技术研究院

超快超分辨率超声定位显微成像（uULM），突破了制约传统超声的衍射极限的约束，可实现分辨率远小于发射波长的在体深层微血管精准成像。通过对微血管中数以万计的运动微泡进行中心点定位和轨迹追踪，uULM技术可重建微血管图像。通常一...

超快超分辨率超声定位显微成像（uULM），突破了制约传统超声的衍射极限的约束，可实现分辨率远小于发射波长的在体深层微血管精准成像。通过对微血管中数以万计的运动微泡进行中心点定位和轨迹追踪，uULM技术可重建微血管图像。通常一张uULM图像需要数十秒甚至数百秒的连续长程图像采集，这在一定程度上限制了其更广泛的临床应用。针对这一挑战，本研究在阐明了超声衍射极限、超分辨率定位理论方法的基础上，给出了基于傅里叶环相关的分辨率测定原理和实现方法，并结合传统uULM重建技术，发展了一种基于生成对抗网络的深度学习超分辨超声成像方法，以缩减uULM对图像采集时长的依赖，提高成像速度和成像分辨率。针对大鼠脑的在体数据分析结果表明，基于生成对抗网络的超声定位显微技术可以分辨小于10 μm的微血管，在保持较高超声成像空间分辨率和图像饱和度的同时，数据采集时间缩减一半，从而显著降低了uULM对图像数据采集时长的依赖。相关深度学习模型连接轨迹的计算复杂度较小，且避免了人工调参以及轨迹筛选，为加速超分辨率uULM微血流成像和提升uULM成像分辨率提供了一种有效的工具。相关思路与方法对促进超分辨率uULM成像技术发展具有一定的借鉴意义。

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TiO2 nanosheets synthesized by atomic layer deposition for photocatalysis

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Progress in Natural Science:Materials International 2016年第5期26卷 493-497页

作者： Riyanto Edy Yuting Zhao Gaoshan S.Huang Jianjun J.Shi Jing Zhang Alexander a.solovev Yongfeng Mei State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and Engineering Donghua University Department of Materials Science Fudan University College of Science Donghua University

Two-dimensional TiOnanosheets were synthesized by atomic layer deposition(ALD) on dissolvable sacrificial polymer layer. The photocatalytic performance of free-standing TiOnanosheets prepared with different numbers of ALD cycles(100, 300, 500, and 1000) were investigated by evaluating the degradation rates of methyl orange solutions. It is shown that the photocatalytic activity increases due to Tidefect and the locally ordered structures in amorphous TiOnanosheets. The difference in the surface areas of nanosheets may also play a crucial role in the photocatalytic activity. The results obtained in this work can have potential applications in fields like water splitting and dye-sensitized solar cells.

关键词： TiO2 Atomic layer deposition Nanosheet Photocatalysis

Gas-Solution Interface Technique as a simple method to produce inorganic microtubes with scroll morphology

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Progress in Natural Science:Materials International 2020年第3期30卷 279-288页

作者： Larisa B.Gulina Valeri P.Tolstoy Alexander a.solovev Vladislav E.Gurenko Gaoshan Huang Yongfeng Mei Department of Solid State Chemistry Saint-Petersburg State University Department of Materials Science Fudan University

Over the past decade, numerous studies have dealt with new properties of inorganic nanomaterials with improved characteristics due to a particular morphology, and new facile methods to produce such materials have been reported. Inorganic microtubes can be designed for multifunctional materials with highly specific surface area. These microtubes can act as individual on-chip components of miniature devices or off-chip micromachines. The paper first discusses the main regularities of the reactions at the gas-solution interface and then goes on to present the basic principles of the Gas-Solution Interface Technique(GSIT), thus demonstrating a new way of facile synthesis of inorganic rolled-up microtubes. A distinctive feature of the technique is the formation of a gradient solid layer on the surface of the aqueous solution as a result of the gaseous and liquid reagents interaction. When dried in the air, this thin layer is capable of self-folding into microtubes with specific morphology. The paper considers the specific features of microtubes obtained by GSIT from numerous classes of inorganic compounds, including oxides, hydroxides, sulfides, fluorides. Further areas of possible practical applications of GSIT microtubes are discussed. The prospects of future development of the GSIT are outlined.

关键词： Interface Rolled-up microtubes 2D nanocrystals Inorganic machines Nanomaterials

生成对抗网络加速超分辨率超声定位显微成像方法研究

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物理学报 2022年第22期71卷 143-154页

作者：隋怡晖郭星奕郁钧瑾 Alexander Asolovev 他得安许凯亮复旦大学工程与应用技术研究院上海200433 复旦大学信息科学与工程学院生物医学工程中心上海200438 复旦大学材料科学系上海200438

超快超声定位显微成像(uULM),突破了传统超声衍射极限,可实现分辨率远小于发射波长的在体深层微血管精准成像.通过对微血管中数以万计的运动微泡进行中心点定位和轨迹追踪, uULM技术可重建微血管图像.通常一张uULM图像需要数十秒甚至数... 详细信息

超快超声定位显微成像(uULM),突破了传统超声衍射极限,可实现分辨率远小于发射波长的在体深层微血管精准成像.通过对微血管中数以万计的运动微泡进行中心点定位和轨迹追踪, uULM技术可重建微血管图像.通常一张uULM图像需要数十秒甚至数百秒的连续长程图像采集,这在一定程度上限制了其更广泛的临床应用.针对这一挑战,本研究在阐明了超声衍射极限、超分辨率定位理论方法的基础上,给出了基于傅里叶环相关的分辨率测定原理和实现方法,并结合传统uULM重建技术,发展了一种基于生成对抗网络的深度学习超分辨超声成像方法,以缩减uULM对图像采集时长的依赖,提高成像速度和成像分辨率.针对大鼠脑的在体数据分析结果表明,基于生成对抗网络的超声定位显微技术微血管分辨达到10μm,在保持较高超声成像空间分辨率和图像饱和度的同时,数据采集时间缩减一半,从而显著降低了uULM对图像数据采集时长的依赖.相关深度学习模型连接轨迹的计算复杂度较小,且避免了人工调参以及轨迹筛选,为加速超分辨率uULM微血流成像和提升uULM成像分辨率提供了一种有效的工具.相关思路与方法对促进超分辨率uULM成像技术发展具有一定的借鉴意义.

关键词：超分辨率超声定位显微卷积神经网络生成对抗网络

微流控合成铃铛状水凝胶壳-光催化剂核可自驱动微胶囊及其水净化应用

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微流控合成铃铛状水凝胶壳-光催化剂核可自驱动微胶囊及其水净化...

Ion heat transport in electron cyclotron resonance heated L-mode plasma on the T-10 tokamak

中国化学会第十七届全国胶体与界面化学学术会议

作者：刘锦润 Alexander a.solovev 梅永丰复旦大学材料科学系

近年来,有机-无机结合的新型结构材料引起了研究人员的兴趣,将有机与无机材料的优势相结合1,可以扩展二者的应用。本文在微流控装置的帮助下,将无机光催化剂包封到有机聚（酸）水凝胶微胶囊中,制备了一种铃铛状水凝胶壳-光催化剂核微胶... 详细信息

近年来,有机-无机结合的新型结构材料引起了研究人员的兴趣,将有机与无机材料的优势相结合1,可以扩展二者的应用。本文在微流控装置的帮助下,将无机光催化剂包封到有机聚（酸）水凝胶微胶囊中,制备了一种铃铛状水凝胶壳-光催化剂核微胶囊,并用显微镜、场发射电子显微镜和傅里叶变换红外光谱对其形貌和化学结构进行了表征。水凝胶壳层可以让小分子扩散或吸收进入胶囊内部,并且为催化剂提供一个保护环境;此外,光生自由基在胶囊内产生,可与吸附和扩散在内的染料进行更长时间的反应,有利于有机染料更好的去除。以氧化锌和二氧化钛为包封的模型光催化剂,通过对光催化亚甲基蓝的去除,研究了它们的吸附活性和光催化性能。利用铃铛状水凝胶壳-光催化核微胶囊的光催化稳定性和无需离心回收的优势,将铃铛状水凝胶壳-光催化核微胶囊填充入闪式层析柱中,制成了流动反应器。它可以在97秒内吸附溶液中近100%的亚甲蓝,并可简单地通过紫外线照射再生。此外,利用电子束蒸发镀膜技术赋予了水凝胶壳-光催化核微胶囊以自驱动能力、自搅拌能力以及可回收的能力,有利于混合、吸附和光催化降解过程2。这项工作可为有机材料和无机材料的结合提供一种新型通用策略,以一种创新的方式扩展这两种材料的应用。

关键词：微流控合成水凝胶光催化水处理流动反应器

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Plasma Science and Technology 2024年第4期26卷 52-60页

作者： V.A.KRUPIN M.R.NURGALIEV A.R.NEMETS I.A.ZEMTSOV S.D.SUNTSOV T.B.MYALTON D.S.SERGEEV N.a.solovev D.V.SARYCHEV D.V.RYJAKOV S.N.TUGARINOV N.N.NAUMENKO National Research Centre“Kurchatov Institute” Moscow 123182Russia Bauman Moscow State Technical University Moscow 105005Russia Institution“Project Center ITER” Moscow 123098Russia JSC“SOLAR” Minsk 220034Belarus

Anomalous ion heat transport is analyzed in the T-10 tokamak plasma heated with electron cyclotron resonance heating(ECRH) in second-harmonic extra-ordinary mode. Predictive modeling with empirical scaling for Ohmical heat conductivity shows that in ECRH plasmas the calculated ion temperature could be overestimated, so an increase of anomalous ion heat transport is required. To study this effect two scans are presented: over the EC resonance position and over the ECRH power. The EC resonance position varies from the high-field side to the low-field side by variation of the toroidal magnetic field. The scan over the heating power is presented with on-axis and mixed ECRH regimes. Discharges with high anomalous ion heat transport are obtained in all considered regimes. In these discharges the power balance ion heat conductivity exceeds the neoclassical level by up to 10 times. The high ion heat transport regimes are distinguished by three parameters: the ratio Te/Ti, the normalized electron density gradient R/■, and the ion–ion collisionality νii~*. The combination of high Te/Ti, high νii~*, and R/■=6-10 results in values of normalized anomalous ion heat fluxes up to 10 times higher than in the low transport scenario.

关键词： tokamak L-mode electron cyclotron resonance heating ion heat transport

Requirement and Development of Hydrogel Micromotors towards Biomedical Applications

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Research 2020年第1期2020卷 1357-1371页

作者： Xinyi Lin Borui Xu Hong Zhu Jinrun Liu Alexander solovev Yongfeng Mei Department of Materials Science State Key Laboratory of ASIC and SystemsFudan UniversityShanghai 200433China

With controllable size,biocompatibility,porosity,injectability,responsivity,diffusion time,reaction,separation,permeation,and release of molecular species,hydrogel microparticles achieve multiple advantages over bulk hydrogels for specific biomedical procedures.Moreover,so far studies mostly concentrate on local responses of hydrogels to chemical and/or external stimuli,which significantly limit the scope of their applications.Tetherless micromotors are autonomous microdevices capable of converting local chemical energy or the energy of external fields into motive forces for self-propelled or externally powered/controlled motion.If hydrogels can be integrated with micromotors,their applicability can be significantly extended and can lead to fully controllable responsive chemomechanical biomicromachines.However,to achieve these challenging goals,biocompatibility,biodegradability,and motive mechanisms of hydrogel micromotors need to be simultaneously integrated.This review summarizes recent achievements in the field of micromotors and hydrogels and proposes next steps required for the development of hydrogel micromotors,which become increasingly important for in vivo and in vitro bioapplications.

关键词： steps autonomous separation

Computer Modelling Average Annual Temperature in the Ground Layer of Air for the South of Western Siberia (Russia)

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Journal of Geoscience and Environment Protection 2014年第5期2卷 8-12页

作者： N. A. Shergunova S. V. solovev K. S. Baikov Yu. V. Chernenko Ya. G. Poshivailo Institute of Soil Science and Agrochemisry Novosibirsk Russia

Computer modelling the map of average annual temperature in the ground layer of air is performed for the southern part of Western Siberia (Russia). Four methods for data interpolation were used in ArcMap 9. Procedure of creation of digital model is described in detail. An original mathematic way for ranking of methods is proposed. According to results, Ordinary Kriging method gives the best approximation to the initial data.

关键词： Computer Modelling Temperature Interpolation Western Siberia

冻土地带钻石矿区含桩基础坑口的土壤温度状况预测(英文)

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黑龙江大学工程学报 2014年第3期5卷 117-122页

作者： Urii A.Khokholov Dmitrii E.solovev Alexander S.Kurilko Alexander V.Drozdov 俄罗斯科学院西伯利亚分院北极矿业研究所

构建了冻土区垂直井轴套环的环绕岩石部分与空气热交换的三维数学模型。模型充分考虑了冷却器的存在、冻结液体的温度、冻结孔的长度及其数量和位置、大气温度、矿内的空气不均匀度以及所包含岩石的盐分程度。模型可以计算并预测坑口桩... 详细信息

构建了冻土区垂直井轴套环的环绕岩石部分与空气热交换的三维数学模型。模型充分考虑了冷却器的存在、冻结液体的温度、冻结孔的长度及其数量和位置、大气温度、矿内的空气不均匀度以及所包含岩石的盐分程度。模型可以计算并预测坑口桩承载能力的变化,并将该变化作为影响冷冻系统工作的一个因素。通过使用这种三维数学模型,可确定出最合理的冷冻系统状态(针对于ALROSA证券公司矿山的条件)。这些系统状态数据包括坑口桩的承载能力和尺寸<0.5 m坑轴阻尼解冻环轮保护混凝土衬砌免受坑轴冻结和可能发生的变形侵害。

关键词：矿坑口桩基础冻土区冷冻系统