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国际医学放射学杂志 2015年第5期 501-502页

作者： B.Bignotti a.signori M.P.Sormani L.Molfetta C.Martinoli A.Tagliafico 马艳 Institute of Anatomy Department of Experimental MedicineUniversity of Genoa

摘要目的比较US和MRI在莫顿神经瘤中的诊断价值。方法评估US和MRI对莫顿神经瘤诊断准确性的研究是由2人进行回顾分析,检索文献截止至2014年4月1日。采用预定义的纳入和排除标准。结果检索出227项研究,并对14项研究进行了meta分析。在5... 详细信息

摘要目的比较US和MRI在莫顿神经瘤中的诊断价值。方法评估US和MRI对莫顿神经瘤诊断准确性的研究是由2人进行回顾分析,检索文献截止至2014年4月1日。采用预定义的纳入和排除标准。结果检索出227项研究,并对14项研究进行了meta分析。在5项研究中对US的敏感性进行研究,在3项研究中对MRI的敏感性进行了研究,在6项研究中对两者均进行了研究。所有研究均以手术结果为参

关键词：神经瘤 MRI US 神经组织肿瘤 MR 莫顿

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一项临床可行的7 T方案用于多发性硬化皮质病变的识别

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国际医学放射学杂志 2020年第5期 629-629页

作者： S.Cocozza M.Cosottini a.signori L.Fleysher M.M.El Mendili F.Lublin 白晓燕 Department of Neuroscience Rehabilitation OphthalmologyGenetics Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research (CEBR) University of Genoa

摘要目的旨在评估在适合临床研究的时间和解剖覆盖范围内,7 T MRI扫描序列用于识别多发性硬化(MS)病人皮质病变(CL)的能力。此外,通过研究确认CL的临床意义,检

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Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma-a translational model

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Cancer Drug Resistance 2022年第3期5卷 595-611页

作者： Matias Tellado Sebastian Michinski Joseph Impellizeri Guillermo Marshall Emanuela.signori Felipe Maglietti VetOncologia Vet Cancer ClinicCiudad de Buenos Aires C1408Argentina Instituto de Fisica del Plasma Departamento de FisicaFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires-CONICETCiudad de Buenos Aires C1428Argentina Veterinary Oncology Services PLLC New YorkNY 10065USA Laboratory of Molecular Pathology and Experimental Oncology Institute of Translational PharmacologyCNRRome 00133Italy Instituto Universitario del Hospital Italiano-CONICET Ciudad de Buenos Aires C1199Argentina.

Aim:Cutaneous squamous cell carcinoma(cSCC)is a common disease in patients exposed to UV-light and human ***,a well-established treatment modality with minimum side effects in human and veterinary medicine,circumvents chemoresistance to bleomycin by the use of electric ***,patients are sensitive to the trauma produced by the insertion of the needles that lengthen recovery times,particularly cats with nasal planum *** address this matter,we developed thin-needles ***:Thin-needles electrodes developed using computer simulations and plant tissue models were compared to standard electrodes.A prospective non-randomized study recruiting 52 feline patients with nasal planum cSCC was *** response,anorexia,and overall survival were ***:Computer simulations and plant model experiments showed satisfactory results with both *** patients treated with the thin-needle electrode obtained similar local response rates compared to the standard group,OR 97.3%vs.80%,respectively(P<0.067).Most patients in the thin-needle group resumed eating in less than 48 h,as the anorexia was significantly lower(P<0.0001).Using the standard electrode,most patients took 3 to 5 days to resume normal *** electric current circulating in the standard electrode was 44% higher,contributing to a longer duration of anorexia due to tissue *** overall survival in both groups was ***:Electrochemotherapy using thin-needle electrodes provides equivalent local response rates and overall survival compared with standard electrodes but significantly reduced return to appetite after the *** results may be useful in the development of new electrodes for human patients.

关键词： Cancer SCC nose cat electroporation ECT tumor cSCC

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DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor

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World Journal of Gastroenterology 2005年第42期11卷 6694-6700页

作者： Paola Mazzarelli Paola Parrella Davide Seripa Emanuela.signori Giuseppe Perrone Carla Rabitti Domenico Borzomati Armando Gabbrielli Maria Giovanna Matera Carolina Gravina Marco Caricato Maria Luana Poeta Monica Rinaldi Sergio Valeri Roberto Coppola Vito Michele Fazio Laboratory of Molecular Medicine and Biotechnology Interdisciplinary Center for Biomedical Research Università Campus Bio-Medico Rome 00155 Italy Laboratory of Gene Therapy and Oncology IRCCS "Casa Sollievo della Sofferenza" Hospital San Giovanni Rotondo (FG) 71013 Italy Service of Histopathology Università Campus Bio-Medico Rome 00155 Italy Department of General Surgery Università Campus Bio-Medico Rome 00155 Italy Department of Digestive Disease Università Campus Bio-Medico Rome 00155 Italy CNR Gene-Medicine Division Section of Molecular Medicine Institute of Neurobiology and Molecular Medicine Rome 00133 Italy Laboratory of Gene Therapy and Oncology IRCCS "Casa Sollievo della Sofferenza" Hospital San Giovanni Rotondo (FG) 71013 Italy CNR Gene-Medicine Division Section of Molecular Medicine Institute of Neurobiology and Molecular Medicine Rome 00133 Italy

AIM: To determine the DNA binding activity and protein levels of the Ku70/80 heterodimer, the functional mediator of the NHEJ activity, in human colorectal ***: The Ku70/80 DNA-binding activity was determined by electrophoretic mobility shift assays in 20 colon adenoma and 15 colorectal cancer samples as well as matched normal colonic tissues. Nuclear and cytoplasmic protein expression was determined by immunohistochemistry and Western blot ***: A statistically significant difference was found in both adenomas and carcinomas as compared to matched normal colonic mucosa (P＜0.00). However,changes in binding activity were not homogenous with approximately 50% of the tumors showing a clear increase in the binding activity, 30% displaying a modest increase and 15% showing a decrease of the ***, with increased DNA-binding activity, also showed a statistically significant increase in Ku70 and Ku86nuclear expression, as determined by Western blot and immunohistochemical analyses (P＜0.001). Cytoplasmic protein expression was found in pathological samples,but not in normal tissues either from tumor patients or from healthy ***: Overall, our DNA-binding activity and protein level are consistent with a substantial activation of the NHEJ pathway in colorectal tumors. Since the NHEJ is an error prone mechanism, its abnormal activation can result in chromosomal instability and ultimately lead to tumorigenesis.

关键词： DNA Ku70/80 异质二聚体基因表达结肠癌直肠癌

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