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国际医学放射学杂志 2016年第5期 577-577页

作者： H.Chandarana A.M.Doshi a.shanbhogue J.S.Babb M.T.Bruno T.J.Zhao 刘萍 Department of Radiology New York University School of Medicine

摘要目的研发一种新的MR胆胰管成像(MRCP)扫描方法:基于5%k空间预采样数据稀疏迭代重建屏气(BH)多翻转角三维快速自旋回波(BH SPARSE-SPACE),并将其与常规呼吸触发(RT SPACE)结果进行比较。材料与方法这项符合HIPAA的前瞻性研究获得伦... 详细信息

摘要目的研发一种新的MR胆胰管成像(MRCP)扫描方法:基于5%k空间预采样数据稀疏迭代重建屏气(BH)多翻转角三维快速自旋回波(BH SPARSE-SPACE),并将其与常规呼吸触发(RT SPACE)结果进行比较。材料与方法这项符合HIPAA的前瞻性研究获得伦理委员会批准。应用3 T设备对29例病人进行了常规RT SPACE及BH加速5%k空间数据采样SPACE扫描。两者空间分辨率和其他参数尽可

关键词：胆胰管成像 MR 稀疏重建

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Evaluation of a locked nucleic acid form of antisense oligo targeting HIF-1α in advanced hepatocellular carcinoma

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World Journal of Clinical Oncology 2019年第3期10卷 149-160页

作者： Jennifer Wu Merly Contratto Krishna P shanbhogue Gulam A Manji Bert H O'Neil Anne Noonan Robert Tudor Ray Lee Division of Hematology and Oncology Perlmutter Cancer CenterNew York University School of Medicine Department of Radiology at New York University School of Medicine Division of Hematology and Oncology Columbia University Medical Center Division of Hematology and Oncology Indiana University Division of Hematology and Oncology Ohio State University Medical Center Roche Pharmaceutical Company Roche and Teclison Pharmaceutical Company

BACKGROUND Hypoxia-inducible factor 1α(HIF-1α) is a gene that regulates tumor survival,neovascularization and invasion. Overexpression of HIF-1α correlates with poor prognosis in hepatocellular carcinoma(HCC). RO7070179 is a HIF-1α inhibitor that decreases HIF-1α mRNA and its downstream targets, it could be a potential treatment in *** To evaluate safety and preliminary activity of RO7070179 in patients with previously treated HCC, with focus on a patient with prolonged response to *** In the preclinical study of RO7070179 in a HCC xenograft model, the mice wereseparated into 4 groups with each group received doses of 0, 3, 10 and 30 mg/kg for total 10 doses. HCC patients who failed at least one line of systemic treatment,received RO7070179 as a weekly infusion, each cycle is 6 wk. We evaluated the safety and HIF-1α mRNA levels of *** Preclinical evaluation of RO7070179 in orthotopic HCC xenograft model showed no significant differences in HCC tumor weight between the 3 and 10 mg/kg groups. However, dose of 10 mg/kg of RO7070179, has shown 76% reduction of the amount of HIF-1α mRNA in HCC tissue. In the phase 1 b study of RO7070179 in previously treated HCC patients, 8 out of 9 were evaluable: 1 achieved PR and1 SD. The patient with PR responded after 2 cycles treatments, which has been maintained for 12 cycles. This patient also showed reduction in perfusion of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) after 1 cycle of treatment. After 1 cycle of treatment, both patients with PR and SD showed decrease in HIF-1α mRNA at the root of biopsies(each biopsy was divided into 2 specimens, the tip and the root).CONCLUSION RO7070179 can reduce HIF-1α mRNA level in HCC patients with SD or PR. It is well tolerated at 10 mg/kg, with transaminitis as the dose of increased *** study indicates that RO7070179 might benefit HCC patients, and an early signal for clinical benefit can potentially be predicted through changes

关键词： Hepatocellular carcinoma Hypoxia-inducible factor 1α RO7070179,Superresponder Dynamic contrast-enhanced-magnetic resonance imaging

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