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Lack of correlation between Treg quantification assays in inflammatory bowel disease patients

World Journal of Gastroenterology 2015年第11期21卷 3325-3329页

作者： Gunnar Brandhorst Darinka Todorova Petrova Sebastian Weigand Christoph Eberle Nicolas von Ahsen Jessica.schmitz Frank Christian Schultze Dirk Raddatz Michael Karaus Michael Oellerich Philip D Walson Department of Clinical Chemistry University Medical Center Department of Clinical Pharmacology University Medical Center Chronix Biomedical Clinics of Gastroen-terology and Endocrinology University Medical Center Department of Internal Medicine Evangelisches Krankenhaus G?ttingen--Weende

AIM:To compare the number of regulatory T-cells( Tregs) measured by flow cytometry with those obtained using a real-time quantitative PCR(q PCR) method in patients suffering from inflammatory bowel disease(IBD).METHODS:Tregs percentages obtained by both flow cytometry and q PCR methods in 35 adult IBD patients,18 out of them with Crohn′s disease(CD)and 17 with ulcerative colitis(UC)were compared to each other as well as to scores on two IBD activity questionnaires using the Harvey Bradshaw Index(HBI)for CD patients and the Simple Colitis Clinical Activity Index(SCCAI)for UC *** Treg percentages by flow cytometry were defined as CD4+CD25highCD127lowFOXP3+cells in peripheral blood mononuclear cells,whereas the Treg percentages by q PCR method were determined as FOXP3 promoter demethylation in genomic ***:We found an average of 1.56%±0.78%Tregs by using flow cytometry,compared to 1.07%±0.53%Tregs by using q PCR in adult IBD *** were no significant correlations between either the percentages of Tregs measured by flow cytometry or q PCR and the HBI or SCCAI questionnaire scores in CD or UC patients,*** addition,there was no correlation between Treg percentages measured by q PCR and those measured by flow cytometry(r=-0.06,P=0.73;Spearman Rho).These data suggest that,either Treg-related immune function or the clinical scores in these IBD patients did not accurately reflect actual disease *** the cause(s)for these differences are more clearly defined,the resultssuggest caution in interpreting studies of Tregs in various inflammatory ***:The two methods did not produce equivalent measures of the percentage of total Tregs in the IBD patients studied which is consistent with the conclusion that Tregs subtypes are not equally detected by these two assays.

关键词： Regulatory T-cells Inflammatory bowel disease Croh

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Argon-seeded plasma exposure and oxidation performance of tungsten-chromium-yttrium smart alloys

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Tungsten 2019年第2期1卷 159-168页

作者： Janina.schmitz Andrey M.Litnovsky Felix Klein Xiaoyue Tan Uwe Breuer Marcin Rasinski Stephan Ertmer Arkadi Kreter Jesus Gonzalez-Julian Martin Bram Jan Willem Coenen Christian Linsmeier Forschungszentrum Juelich GmbH Institut fuer Energie-und Klimaforschung52425 JuelichGermany Department of Applied Physics Ghent University9000 GhentBelgium School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Forschungszentrum Juelich GmbH Institut fuer Engineering und Analytik52425 JuelichGermany

Tungsten-chromium-yttrium(WCrY)smart alloys are foreseen as the first wall material for future fusion devices such as Demonstration Power Plant(DEMO).While suppressing W oxidation during accidental conditions,they should behave like pure W during plasma operation due to preferential sputtering of the lighter alloying elements Cr,Y,and W enrichment of the *** this paper,the erosion performance of WCrY and W samples simultaneously exposed to deuterium(D)plasma with the addition of 1%of the projectile ions being argon(Ar)ions at an ion energy of 120 eV is *** reference to the previous experiments at 120 eV in pure D plasma,the erosion for both WCrY and W is enhanced by a factor of~*** Ar to the D plasma suppresses significant W enrichment previously found for pure D *** investigate the impact of the plasma exposure onto the oxidation performance,plasma-exposed and non-exposed reference samples were oxidised in a dry *** show,on the one hand,that the oxida-tion suppression of WCrY in comparison to pure W is preserved during the plasma *** the other hand,it becomes evident that edge effects imposed by the geometry of the samples used in plasma experiments play a significant role for the oxidation behaviour.

关键词： Tungsten-based alloys Plasma-facing material Smart alloys DEMO

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2D NMR对Sarcophine所有~1H NMR和^(13)C NMR归属的指定

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有机化学 1997年第6期17卷 542-546页

作者：孟艳辉苏镜娱曾陇梅阎素君 FRANCIS schmitz 中山学院应化系中山大学化学系 Department of Chemistry and Biochemistry University of OklahomaNormanOK 73019-0370

从中国南海软珊瑚Sarcophyton molle中分离得到大环二萜内酯Sarcophine(1)。本文利用~1H-~1HCOSY,HMQC,HMBC等二维谱手段首次对Sarcophine所有~1H NMR、^(13)C NMR的信号归属进行了完全的指定。并第一次报道了其^(13)C NMR数据。

关键词：软珊瑚二萜 Sarcophine 毒素南海

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球墨外围奥氏体壳的形成过程与对石墨畸变的影响

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金属学报 1989年第1期25卷 B037-B041页

作者：周继扬 W.schmitz S.ENGLER 大连理工大学铸工教研室联邦德国亚琛工业大学

本文用彩色金相法研究了球墨外围奥氏体壳的生长过程及奥氏体对石墨畸变的影响。结果表明,球墨外围的奥氏体壳不是连续的奥氏体层,而是由若干个楔形晶体组成。由于球墨外围奥氏体成核的有利条件不同;故在不同位置先后成核并生长。之后,... 详细信息

本文用彩色金相法研究了球墨外围奥氏体壳的生长过程及奥氏体对石墨畸变的影响。结果表明,球墨外围的奥氏体壳不是连续的奥氏体层,而是由若干个楔形晶体组成。由于球墨外围奥氏体成核的有利条件不同;故在不同位置先后成核并生长。之后,互相接触形成一个壳。经电子探针分析,沟槽中正偏析元素及低熔点金属含量高,因而沟槽液体的熔点低、凝固慢。根据沟槽的凝固速度,奥氏体壳可分成快封闭、慢封闭及不封闭三种类型,与石墨球的畸变有密切关系。

关键词：球墨奥氏体彩色金相法石墨畸变

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Negotiating a new chair package:context and considerations

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Family Medicine and Community Health 2023年第1期11卷 26-32页

作者： Amanda Weidner Samantha Elwood Richelle Koopman Julie Phillips David schmitz Li Li A Peter Catinella Jehni Robinson Nahid Rianon C J Peek Irfan Asif Family Medicine University of WashingtonSeattleWashingtonUSA Association of Departments of Family Medicine LeawoodKansasUSA Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Family and Community Medicine University of Missouri School of MedicineColumbiaMissouriUSA Family Medicine Michigan State UniversityEast LansingMichiganUSA Family and Community Medicine University of North Dakota School of Medicine and Health SciencesGrand ForksNorth DakotaUSA Family Medicine University of Virginia School of MedicineCharlottesvilleVirginiaUSA Family Medicine Texas Tech University TransmountainEl PasoTexasUSA Family&Community Medicine Texas Tech University Health Sciences Center El PasoPaul L.Foster School of MedicineEl PasoTexasUSA Family Medicine University of Southern California Keck School of MedicineLos AngelesCaliforniaUSA Family and Community Medicine The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical SchoolHoustonTexasUSA Family Medicine and Community Health University of Minnesota Medical SchoolMinneapolisMinnesotaUSA Family and Community Medicine The University of Alabama at Birmingham Heersink School of MedicineBirminghamAlabamaUSA

Negotiating a resource package as a potential new department chair is common practice in academic *** foundations for this negotiation include the historical presence of the department in relation to the broader institution,projections for future growth,accounting for mission/vision,resource needs(space,personnel,finances,etc),faculty and staff development,and external partnerships within and outside the *** similarities in this process across departments,many nuances influence the development of a specific new chair package,such as,department size;desires,perspectives and talents of the incoming chair,the department faculty,the medical school and dean;prevailing agendas and mission imperatives;and the overall priorities of the *** strategy and forethought,a new chair package can promote a successful chair tenure and departmental *** through the Association of Departments of Family Medicine with input from several dozen department chairs and senior leaders,this is intended to serve as a practical guide to new chair packages for chair candidates.

关键词： finance prevailing outside

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短期高脂饮食对中国汉族男性2型糖尿病患者糖脂代谢的影响

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中国医学科学院学报 2008年第4期30卷 509-515页

作者：李文慧肖新华于康孙琦杨国华王姮 Ole schmitz 中国医学科学院北京协和医学院北京协和医院内分泌科北京100730 中国医学科学院北京协和医学院北京协和医院临床营养科北京100730 Department of Medicine M(Endocrinology & Diabetes) University Hosptial of AarhusDenmark

目的研究短期高脂饮食对中国汉族男性2型糖尿病(T2DM)患者糖脂代谢的影响。方法9例单纯饮食控制或仅用二甲双胍治疗的男性2型糖尿病患者先后分别服用高碳水化合物餐(HCD)和高脂肪餐(HFD)3 d,进食第3天多点抽血,测定血浆葡萄糖及胰岛素变... 详细信息

目的研究短期高脂饮食对中国汉族男性2型糖尿病(T2DM)患者糖脂代谢的影响。方法9例单纯饮食控制或仅用二甲双胍治疗的男性2型糖尿病患者先后分别服用高碳水化合物餐(HCD)和高脂肪餐(HFD)3 d,进食第3天多点抽血,测定血浆葡萄糖及胰岛素变化,并于第4天行静脉葡萄糖耐量试验(IVGTT)。结果进食HFD患者的非酯化脂肪酸(NEFA)24 h曲线下面积(AUC)显著高于进食HCD患者(P<0.001),且其24 h血浆葡萄糖AUC显著低于HCD患者(P<0.05);而24 h胰岛素AUC两种饮食患者差异无显著性;进食HFD患者72 h后空腹血浆葡萄糖接近显著意义地升高(P=0.056),低密度脂蛋白胆固醇水平升高(P<0.05)。IVGTT进食HFD患者葡萄糖刺激的胰岛素快速反应接近显著意义地升高(P=0.06),血浆空腹和早餐段餐后胰升血糖素亦显著升高。结论短期进食HFD使NEFA暴露水平显著升高,葡萄糖暴露水平显著降低,空腹血浆葡萄糖升高但不伴胰岛素水平的显著变化可能是肝糖输出增加、胰岛素抵抗形成的早期表现,提示胰升血糖素在胰岛素抵抗的形成中起了重要作用,而显著的β细胞功能失调(脂毒性)可能需要更长时间。

关键词：高脂饮食 2型糖尿病糖脂代谢胰岛素抵抗

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Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia

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World Journal of Gastroenterology 2006年第37期12卷 6002-6007页

作者： Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm schmitz Wolfram Domschke Jan W Konturek Joachim Neumann Medizinische Klinik und Poliklinik B Universittsklinikum Mnster 48129 Mnster Germany Institut fr Pharmakologie und Toxikologie Universittsklinikum Mnster 48149 Mnster Germany Institut fr Pharmakologie und Toxikologie Martin-Luther-Universitt Halle-Wittenberg 06112 Halle (Saale) Germany Klinik fr Innere Medizin/Gastroenterologie Elbe Klinikum Stade 21682 Stade Germany

AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+.

关键词： Esophageal and gastric motility Esophagus Calsequestrin Calreticulin

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《不同社会网站使用与大学生抑郁的关系：链式中介模型》翻译实践报告

《不同社会网站使用与大学生抑郁的关系：链式中介模型》翻译实践...

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作者：马文（schmitz, Marvin Bernhard）北京外国语大学

学位级别：硕士

本文是在翻译一个示范性源文本的基础上对科学文章的翻译实践进行的报告和分析。作为一种理论方法,根据Gerzymisch-Arbogast提出的方面清表(Aspektliste)的概念,以及它对观察点在微观(Mikroebene)和宏观层面(Makroebene)的划分为论文理... 详细信息

本文是在翻译一个示范性源文本的基础上对科学文章的翻译实践进行的报告和分析。作为一种理论方法,根据Gerzymisch-Arbogast提出的方面清表(Aspektliste)的概念,以及它对观察点在微观(Mikroebene)和宏观层面(Makroebene)的划分为论文理论框架,最后对方面清表能够具体应用于科学文章的程度进行了评估。开始翻译过程之前,笔者探索了于中文为术语,科学翻译和方面清表使用相关的研究情况,发现研究不多。因此,想回答的问题是:1)中文作为一种专用语言的翻译有什么特点和困难?为了回答这个问题,笔者来比较原文和译文的一些例子,代表不同关于中文作为专用语言的特点,例如说,长句,被句和句子里的信息结构。2)中文专用语言于德语术语有哪些不同?关于德语术语,已经有较多专家和研究员讨论基本规定。例如说,禁用“我”、比喻和叙述。关于中文术语也有,但是比较少。3)Gerzymisch-Arbogast的方面清表如何帮助翻译家解决翻译术语的问题?笔者想测试方面清表如何在科学文章的翻译过程中实施。实施方面清表首先需要决定哪些方面最适当。因此要查原文和平行文章,选择方面,然后翻译家需要进行层次化,决定哪个方面最重要。论文结果和上述三个问题的回答包含:1)对于中文作为专用语言的研究还有较少,但是一些研究员制定了基本规定:可以分为两种。中文专用语言独特的方面跟德语专用语言一样的方面。中文专用语言独特的特点包括古典汉语的文字,创造术语词的不同方法等等。汉德两个专用语言都避免人称代词,用被句子和复句,倾向于名词化等等。2)论文的例子和比较表明:因为科学文章和专用语言的目标是传递信息,强调的不是意味,而是含义,所以中性词发非常重要。句子结构不可以太复杂或者特别长,混淆信息迷惑读者。为了整理句子结构和信息格局,方面清表提出的主题/述题结构有关。3)方面清表的优点之一是,它可以根据源文本和手头的翻译任务进行定制。它允许译者进行分层,从而使其方法优先化和具体化。通过这种方式,它可以起到指导作用,帮助译者忠实于特定的翻译路线,从而创造出更清晰、更易读的译文。在分析中,它为从不同角度或在不同方面考察个别段落提供了差异化和多层次的可能性。然而,这种大量的多样化观察的可能性使得它对于分析长篇文章甚至整本书来说相当不切实际。它也拂去了许多不同的其他理论和概念,但这通常只是表面上的,因为对每个方面的每个理论框架进行深入研究是很难做到的。总体上说本论文发现,文章的具体部分上使用方面清表能够提供大量的支持,提醒翻译家注意具体的房面,也提供从不同角度来分析原文和译文的机会。用方面清表也强调层次化,让翻译家始终保持风格。尽管中国欧洲之间的交流近年逐渐上涨了,但科学汉德翻译工作经常不超越理科研究领域。在此,心理学能当理科和文科之间的桥梁作用。中文作为专用语言不仅是理科研究的一个主题,而是语言学和翻译学的一个巨大论题。这样还需要更多的研究以中文当专用语言为探索题目。

关键词：翻译专用语言方面清表翻译实践

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