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氯化锂除湿转轮的性能预测

同济大学学报（自然科学版） 2002年第7期30卷 807-810页

作者：秦朝葵 Gerhard schmitz 同济大学热能工程系上海200092 汉堡技术大学技术热物理所德国汉堡21073

对氯化锂除湿转轮的吸附过程进行了分析 ,建立了传热传质模型并得到了数值解 .计算结果与实验数据吻合 ,说明该模型可较好地定量预测氯化锂转轮的除湿效果 .结果有助于推动这一设备在空调系统设计中的应用 .

关键词：氯化锂除湿转轮数值模型性能预测空调系统热质交换设备传热传质模型

How Sugars Might Coordinate Chloroplast and Nuclear Gene Expression during Acclimation to High Light Intensities

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Molecular Plant 2014年第7期7卷 1121-1137页

作者： Rainer E. Haiusler Luisa Heinrichs Jessica.schmitz Ulf-Ingo Flugge Department of Botany II Cologne Biocenter University of Cologne ZuIpicherstr. 47b 50674 Cologne Germany Present address: Plant Molecular Physiology and Biotechnology Heinrich-Heine-University Universitatsstrasse 1 40225 D~sseldorfGermany

The concept of retrograde control of nuclear gene expression assumes the generation of signals inside the chloroplasts, which are either released from or sensed inside of the organelle. In both cases, downstream signaling path- ways lead eventually to a differential regulation of nuclear gene expression and the production of proteins required in the chloroplast. This concept appears reasonable as the majority of the over 3000 predicted plastidial proteins are encoded by nuclear genes. Hence, the nucleus needs information on the status of the chloroplasts, such as during acclimation responses, which trigger massive changes in the protein composition of the thylakoid membrane and in the stroma. Here, we propose an additional control mechanism of nuclear- and plastome-encoded photosynthesis genes, taking advantage of pathways involved in sugar- or hormonal signaling. Sugars are major end products of photosynthesis and their con- tents respond very sensitively to changes in light intensities. Based on recent findings, we ask the question as to whether the carbohydrate status outside the chloroplast can be directly sensed within the chloroplast stroma. Sugars might syn- chronize the responsiveness of both genomes and thereby help to coordinate the expression of piastome- and nuclear- encoded photosynthesis genes in concert with other, more specific retrograde signals.

关键词： acclimation--physiological assimilate allocation/partitioning carbohydrate metabolism molecular physiology membrane proteins Arabidopsis.

Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function

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World Journal of Gastroenterology 2007年第39期13卷 5217-5225页

作者： Jürgen Bock Gerhard Liebisch Joachim Schweimer Gerd schmitz Gerhard Rogler Department of Internal Medicine I University of RegensburgGermany Institute for Clinical Chemistry University of Regensburg Germany

AIM: To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium. METHODS: Monolayers of Caco-2 cells were used as an in vitro model for the intestinal barrier. Permeability was determined by quantifi cation of transepithelialflux and transepithelial resistance. Sphingolipid-rich membrane microdomains were isolated by a discontinuous sucrose gradient and characterized by Western-blot. Lipid content of microdomains was analysed by tandem mass spectrometry. Ceramide was subcellularly localized by immunofluorescent ***: Exogenous sphingomyelinase increased transepithelial permeability and decreased transepithelial resistance at concentrations as low as 0.01 U/mL. Lipid analysis showed rapid accumulation of ceramide in the membrane fractions containing occludin and claudin-4, representing TJs. In these fractions we observed a concomitant decrease of sphingomyelin and cholesterol with increasing concentrations of ceramide. Immunofluorescent staining confirmed clustering of ceramide at the sites of cell-cell contacts. Neutralization of surface ceramide prevented the permeability-increase induced by platelet activating factor. CONCLUSION: Our findings indicate that changes in lipid composition of TJs impair epithelial barrier functions. Generation of ceramide by sphingomyelinases might contribute to disturbed barrier function seen in diseases such as inflammatory, infectious, toxic or radiogenic bowel disease.

关键词： Ceramide Cholesterol Tight-junction Caco-2 cells Permeability Inflammatory bowel disease

Magnetically controlled growing instrumentation for early onset scoliosis: Caution needed when interpreting the literature

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World Journal of Orthopedics 2019年第11期10卷 394-403页

作者： Kenneth Aaron Shaw Justin M Hire Scott Kim Dennis P Devito Michael L schmitz Joshua S Murphy Department of Orthopaedic Surgery Dwight D.Eisenhower Army Medical CenterFort GordonGA 30905United States Department of Orthopaedic Surgery General Leonard Wood Army Community HospitalFort Leonard WoodMO 65473United States University of Tennessee Health Science Center MemphisTN 38163United States Department of Pediatric Orthopaedic Surgery Children’s Healthcare of AtlantaScottish Rite CampusAtlantaGA 30342United States

BACKGROUND Magnetically controlled growing rods(MCGR) are a novel treatment option for early onset scoliosis(EOS). Although the complication profile with MCGR use has been reviewed, these reviews do not take into account important implants modifications, termed iterations, that were made due to early on postoperative complications is not well reported or *** To assess the effect of MCGR implant iterations on post-operative complications in *** A systematic review was performed to identify studies investigating MCGR specifically for the treatment of EOS, refined to those reporting the implant iteration, specifically the incorporation of the keeper plate to the implant *** with mixed implant iteration usage were excluded. Complications following surgery were recorded as well as potential risk factors and compared between implant *** Although 20 articles were identified for inclusion, 5 included mixed implant iteration leaving a total of 271 patients identified through 15 clinical studies thatmet inclusion criteria. The average follow-up was 25.4-mo. Pre-keeper plate implants were utilized in 3 studies with a total of 49 patients. Overall, 115(42.4%)post-operative complications were identified, with 87% defined as major. The addition of the keeper plate significantly decreased the rate of post-operative complications per study(35.7% vs 80.6%, P = 0.036), and the rate of distraction failure(8.1% vs 40.8%, P = 0.02). Unplanned reoperation occurred in 69(26.7%)patients but was not different between implant iteration cohorts(25.5% without keeper plate vs 27.1% with keeper plate, P = 0.92).CONCLUSION MCGR for EOS has a cumulative complication rate of 42.4% but this is significantly reduced to 35.7% when reviewing only keeper-plate enabled implants. However, 25% of published articles included mixed implant *** studies should discern between implants iterations when reporting on the usage of MCGR for EOS.

关键词： Complications Early onset scoliosis Magnetically controlled growing instrumentations Keeper plate Reoperation Systematic review

基于Modelica的生物质燃气内燃机性能模拟研究

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工程设计学报 2011年第1期18卷 28-33页

作者：郭甲生秦朝葵 GERHARD schmitz 同济大学机械工程学院上海201804 汉堡工业大学热流体动力学研究所德国汉堡21079

针对由沼气成分及其理化特性导致的内燃机燃用沼气时会发生燃烧速度慢、后燃严重、排气温度高等问题,将生物质燃气内燃机作为研究对象,基于可重用性及面向对象的Modelica语言建立内燃机模型库,将生物质燃气为燃料对四缸四冲程火花点火... 详细信息

针对由沼气成分及其理化特性导致的内燃机燃用沼气时会发生燃烧速度慢、后燃严重、排气温度高等问题,将生物质燃气内燃机作为研究对象,基于可重用性及面向对象的Modelica语言建立内燃机模型库,将生物质燃气为燃料对四缸四冲程火花点火内燃机性能进行分析.通过仿真研究不同比例天然气(体积分数分别为33%,67%及100%)和LPG(体积分数分别为5%,10%及15%)对内燃机性能的影响,并在一台原汽油机改装的生物质燃气内燃机进行实验验证.结果表明:随着天然气/LPG的加入,内燃机的热效率及功率有所提高,且随着生物质燃气中天然气/LPG体积分数的增加,内燃机的热效率及功率也将相应增加,天然气/LPG的加入有利于内燃机燃烧;基于可重用性及面向对象的建模语言Modelica,不仅大大提高内燃机建模及仿真效率,也将有效改进内燃机的设计及参数优化.

关键词：面向对象 Modelica 火花点火内燃机生物质燃气

用水模型模拟研究铝合金立式连续铸造时的浇铸过程

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轻合金加工技术 1991年第6期19卷 18-24页

作者： W.schmitz 张育钦

铝合金连续铸造时,液穴中强制热对流过程对铸造组织和几种典型铸造缺陷的形成有强烈的影响。除了铸造设备运行参数之外,浇铸系统的设计也起重要作用。本文以模拟水模型对这一问题进行了研究。

关键词：铝合金连续铸造水模型模拟

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

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Translational Neurodegeneration 2020年第1期9卷 39-54页

作者： Niccolo Candelise Matthias schmitz Katrin Thüne Maria Cramm Alberto Rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr Department of Neurology University Medicine Goettingen and the German Center for Neurodegenerative Diseases(DZNE)Robert-Koch-Stra?e 4037075 G?ttingenGermany Biomedical Engineering and Sciences Department School of Mechanical and Manufacturing Engineering(SMME)National University of Sciences and Technology(NUST)IslamabadPakistan Department of Experimental Diagnostic and Speciality MedicineUniversity of BolognaBolognaItaly Departamento de Neuropatología y Banco de Tejidos(BT-CIEN) Fundación CIENInstituto de Salud Carlos III Centro Alzheimer Fundación Reina SofíacValderrebollo n°528031 MadridSpain ADx NeuroSciences Technologiepark 4GhentBelgium CIBERNED(Network center for biomedical research of neurodegenerative diseases) Institute Carlos IIIMadridSpain Bellvitge Biomedical Research Institute(IDIBELL) Hospitalet de LlobregatBarcelonaSpain

Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly *** inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic *** on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,*** real-time quaking-induced conversion(RT-QuIC),had been *** diagnostics, α-synuclein RT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different *** addition,the α-synuclein RT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and ***:The variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies.

关键词： RT-QuIC α-Synucleinopathies Protein misfolding Protein strains

Methanol from CO2 and Solar Energy A Literature Review

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Journal of Energy and Power Engineering 2012年第3期6卷 361-368页

作者： Sven Kluczka Mark schmitz Martin Roeb Christiane VaeBen Solar Institute Julieh Julich 52428 Germany German Aerospace Centre Cologne 51147 Germany

The project ＂SolMethCO2＂ deals with the options of an effective methanol synthesis from atmospheric or industrial CO2 sources by implementing solar energy. First part of the projects is a wide-range survey of the many different processes and sub-processes that may be involved in methanol production and of the possibilities how to make these processes available for solarization. The different fields of research were CO2 capturing, Hg/syngas-synthesis, biotechnological techniques for methanol synthesis, photocatalytical approaches and solar reactor.

关键词： Methanol CO2 solar energy biomass CCS photocatalysis hydrogen.

SOME ASPECTS OF DICHLOROSILANE BASED CVD-WSix FOR POLYCIDE APPLICATIONS

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SOME ASPECTS OF DICHLOROSILANE BASED CVD-WSix FOR POLYCIDE A...