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Fungal Microbes Associated with Agarwood Formation

American Journal of Plant Sciences 2016年第10期7卷 1445-1452页

作者： Muthuraj Sangareswari@Nagajothi Kalappan Thangamuthu Parthiban Subramani Umesh Kanna Loganathan Karthiba Duraisamy saravanakumar Forest College and Research Institute Tamil Nadu Agricultural University Mettupalayam India Department of Food Production Faculty of Food and Agriculture The University of the West Indies St. Augustine Trinidad and Tobago

Agarwood is studied as the resinous secondary metabolites produced by the natural microbial infection. The current study investigated the range of microbial infection in agarwood trees collected from various parts of India. A total of 17 isolates were collected and identified based on the morphological and molecular studies. The study revealed that the agarwood was naturally infected with Aspergillus, Lasiodiploidia, Chaetomium, Fusarium and Penicillium species. Further studies on enzyme activities involved in the pathogenesis process showed the higher cellulase, ligninolytic and laccase activities in Aspergillus isolate AR13 when compared to other isolates. The current study has offered a potential opportunity to further strengthen the research on possible development of microbial strains for artificial inoculation in agar trees to induce agarwood formation.

关键词： Agarwood Aspergillus Cellulase Laccase Fungi

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Cluster Based Hierarchical Routing Algorithm for Network on Chip

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Circuits and Systems 2013年第5期4卷 401-406页

作者： U. saravanakumar R. Rangarajan R. Haripriya R. Nithya K. Rajasekar Department of Electronics and Communication Engineering Indus College of Engineering Coimbatore India Department of Electronics and Communication Engineering PSG College of Technology Coimbatore India

This paper presents a new logical mechanism called as Cluster Based Hierarchical Routing (CBHR) to improve the efficiency of NoC. This algorithm comprises the following steps: 1) the network is segmented logically into clusters with same size or different sizes;2) algorithms are assigned for internal and global routing;3) routers working functions are modified logically to support local and global communication. The experiments have conducted for CBHR algorithm for two dimensional mesh and torus architectures. The performance of this mechanism is analyzed and compared with other deterministic and adaptive routing algorithms in terms of energy, throughput with different packet injection ratios.

关键词： System on Chip Network on Chip Deterministic and Adaptive Routing Algorithms Mesh Torus

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Acetylation of ezrin regulates membrane–cytoskeleton interaction underlying CCL18-elicited cell migration

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Journal of Molecular Cell Biology 2020年第6期12卷 424-437页

作者： Xiaoyu Song Wanjuan Wang Haowei Wang Xiao Yuan Fengrui Yang Lingli Zhao McKay Mullen Shihao Du Najdat Zohbi saravanakumar Muthusamy Yalei Cao Jiying Jiang Peng Xia Ping He Mingrui Ding Nerimah Emmett Mingming Ma Quan Wu Hadiyah-Nicole Green Xia Ding Dongmei Wang Fengsong Wang Xing Liu School of Traditional Medicine Beijing University of Chinese MedicineBeijingChina MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics Hefei National Center for Physical Sciences at the MicroscaleHefeiChina Morehouse School of Medicine Keck Center for Organoids PlasticityAtlantaGAUSA Optics and Optical Engineering University of Science and Technology of ChinaHefeiChina School of Life Science Anhui Medical UniversityHefeiChina

Ezrin,a membrane–cytoskeleton linker protein,plays an essential role in cell polarity establishment,cell migration,and *** studies show that ezrin phosphorylation regulates breast cancer metastasis by promoting cancer cell survivor and promotes intrahepatic metastasis via cell ***,it was less characterized whether there are additional post-translational modifications and/or post-translational crosstalks on ezrin underlying context-dependent breast cancer cell migration and *** we show that ezrin is acetylated by p300/CBP-associated factor(PCAF)in breast cancer cells in response to CCL18 *** physically interacts with PCAF and is a cognate substrate of *** acetylation site of ezrin was mapped by mass spectrometric analyses,and dynamic acetylation of ezrin is essential for CCL18-induced breast cancer cell migration and ***,the acetylation reduced the lipid-binding activity of ezrin to ensure a robust and dynamic cycling between the plasma membrane and cytosol in response to CCL18 *** analyses show that ezrin acetylation prevents the phosphorylation of *** atomic force microscopic measurements,our study revealed that acetylation of ezrin induced its unfolding into a dominant structure,which prevents ezrin phosphorylation at ***,these results present a previously undefined mechanism by which CCL18-elicited crosstalks between the acetylation and phosphorylation on ezrin control breast cancer cell migration and *** suggests that targeting PCAF signaling could be a potential therapeutic strategy for combating hyperactive ezrin-driven cancer progression.

关键词： ezrin acetylation phosphorylation actin cell migration

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