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国际结核病与肺部疾病杂志 2000年第1期3卷 4-9页

作者： J.R.Glynn J.Bauer a.s.deboer M.W.Borgdorff P.E.M.Fine P.Godfrey-Faussett E.Vynnycky 丁北川 Department of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine Keppel St LondonUK Department of Mycobacteriology Statens Serum Institut Copenhagen Denmark National Institute of Public Health and the Environment Bilthoven Royal Netherlands Tuberculosis Association The Hague The Netherlands Department of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine Keppel St London UK European Concerted Actionon Molecular Epidemiology Control of Tuberculosis

许多研究已在其结核分枝杆菌分离株共享DNA指纹的基础上定义了患者簇。成簇相当于最近的传播,并且对伴随结核分枝杆菌正在高度传播人群亚组来说,与成簇有关的因素已作为指标被找出。在进行和解释这些研究中值得考虑的提醒应予以注意。例... 详细信息

许多研究已在其结核分枝杆菌分离株共享DNA指纹的基础上定义了患者簇。成簇相当于最近的传播,并且对伴随结核分枝杆菌正在高度传播人群亚组来说,与成簇有关的因素已作为指标被找出。在进行和解释这些研究中值得考虑的提醒应予以注意。例如,根据标志物的稳定性和长时间在人群中的菌株数量,某些并非近期传播的原因使菌株组可能完全相同。如果病例对特定人群是新移民或在研究中不是所有人群中的病例都被包括的话,确定由近期传播引发的病例可能不作为成簇被见到。所见的成簇数量将根据研究持续的时间。在研究的设计、所包括病例的比例、补充和所使用成簇的界定上,研究应给出精确的资料。成簇的数据应至少被年龄、性别和移民状况分开。为了最大的获得信息,研究应涉及一个人群中所有病例的高比例、与传统的流行病学接触调查结合进行(如果可能的话)、并且提供人群中结核病发病资料和患者的年龄、性别、人类免疫缺损病毒状况、耐药性及社会和种族组资料。关键词:结核病;分子流行病学;DNA指纹;RFLP;传播;

关键词：结核分枝杆菌 tuberculosis DNA指纹 Mycobacterium 成簇流行病学 Tropic 菌株结核病时间窗口

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Integrative and Comparative Genomic Analysis of HPV-Positive and HPV-Negative Head and Neck squamous Cell Carcinomas

Integrative and Comparative Genomic Analysis of HPV-Positive...

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中国生物工程学会第六次全国会员代表大会暨第九届学术年会

作者： Tanguy Y.seiwert Zhixiang Zuo Michaela K.Keck Arun Khattri Chandra s.Pedamallu Thomas stricker Christopher Brown Trevor J.Pugh Petar stojanov Juok Cho Michael s.Lawrence Gad Getz Johannes Br?gelmann Rebecca deboer Ralph R.Weichselbaum Alexander Langerman Louis Portugal Elizabeth Blair Kerstin stenson Mark W.Lingen Ezra E.W.Cohen Everett E.Vokes Kevin P.White Peter s.Hammerman section of Hematology/Oncology Department of MedicineThe University of Chicago The University of Chicago Comprehensive Cancer Center Institute for Genomics and systems Biology University of Chicago Broad Institute of Harvard and MIT Department of Medical Oncology Dana Farber Cancer Institute Department of Pathology Microbiologyand ImmunologyVanderbilt University Department of Genetics University of Pennsylvania Department of Radiation Oncology The University of Chicago Department of Otolaryngology/Head and Neck surgery The University of Chicago Department of Pathology University of Chicago

Purpose:The genetic differences between human papilloma virus(HPV)–positive and –negative head and neck squamous cell carcinomas(HNsCC) remain largely *** identify differential biology and novel therapeutic targets for both entities,we determined mutations and copy-number aberrations in a large cohort of locoregionally advanced *** Design:We performed massively parallel sequencing of 617 cancer-associated genes in 120 matched tumor/normal samples(42.5% HPV-positive).Mutations and copy-number aberrations were determined and results validated with a secondary ***:The overall mutational burden in HPV-negative and HPV-positive HNsCC was similar with an average of 15.2 versus14.4 somatic exonic mutations in the targeted cancer-associated ***-negative tumors showed a mutational spectrum concordant with published lung squamous cell carcinoma analyses with enrichment for mutations in TP53,CDKN2 A,MLL2,CUL3,NsD1,PIK3 CA,and NOTCH ***-positive tumors showed unique mutations in DDX3 X,FGFR2/3 and aberrations in PIK3 CA,KRAs,MLL2/3,and NOTCH1 were enriched in HPVpositive *** targetable genomic alterations were identified in FGFR1,DDR2,EGFR,FGFR2/3,EPHA2,and PIK3 ***,CCND1,and FGFR1 amplifications occurred in HPV-negative tumors,whereas 17.6% of HPV-positive tumors harbored mutations in fibroblast growth factor receptor genes(FGFR2/3),including six recurrent FGFR3 s249 C ***-positive tumors showed a 5.8% incidence of KRAs mutations,and DNArepair gene aberrations,including 7.8% BRCA1/2 mutations,were ***:The mutational makeup of HPV-positive and HPV-negative HNsCC differs significantly,including targetable *** harbors multiple therapeutically important genetic aberrations,including frequent aberrations in the FGFR and PI3K pathway genes.

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2-6 First Direct Measurement of 12C(12C, n)23Mg at stellar Energies

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IMP & HIRFL Annual Report 2015年第1期 56-58页

作者： Tang Xiaodong B. Bucher X. Fang A. Heger s. Almaraz-Calderon A. Alongi A.D. Ayangeakaa M. Beard A. Best J. Browne C. Cahillane M. Couder R.J. deboer A. Kontos L. Lamm Y.J. Li A. Long W. Lu s. Lyons M. Notani D. Patel N. Paul M. Pignatari A. Roberts D. Robertson K. smith E. stech R. Talwar W.P. Tan M. Wiescher s.E. Woosley Institute of Modern Physics Chinese Academy of Science Lanzhou 730000 China Institute for structure and Nuclear Astrophysics Joint Institute for Nuclear AstrophysicsUniversity of Notre Dame Notre Dame Indiana 46556 USA Lawrence Livermore National Laboratory Livermore California 94550 USA Monash Center for Astrophysics School of Physics and Astronomy Monash University Victoria 3800 Australia Department of Physics and Astronomy Shanghai Jiao-Tong University CNA Shanghai 200240 China school of Physics and Astronomy University of Minnesota Minneapolis Minnesota 55455 USA China Institute of Atomic Energy Beijing 102413 China Konkoly Observatory Research Centre for Astronomy and Earth Sciences Hungarian Academy of SciencesKonkoly Thege Mikl′os′ut 15-17 H-1121 Budapest Hungary Department of Physics University of Basel Basel CH-4056 Switzerland Department of Astronomy and Astrophysics University of California Santa Cruz California 95064 USA

The first stars in the early Universe were formed about 400 million years after the big bang. Verification of the existence of these stars is important for our understanding of the evolution of the Universe[1]. It has been predicted that for Population-III stellar production yields, the abundances of odd-Z elements are remarkably deficient compared to their adjacent even-Z elements[2]. Astronomers are searching for long-lived, low mass stars with the unique nucleosynthetic pattern matching the predicted yields[3].

关键词： First Direct Measurement

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