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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

there is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： tonia s.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

the year 2024 marks the 60^(th)anniversary of title IX and 25 years since the New York times revealed bias against female faculty members at the massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included Pubmed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual times

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. the compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. these approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen Robert j.thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. the amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). the recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Acute phase reaction and acute phase proteins

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journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2005年第11期6卷 1045-1056页

作者： GRUYs E. tOUssAINt m.j.m. NIEWOLD t.A. KOOPmANs s.j. Department of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the NetherlandsDepartment of Pathobiology Faculty of Veterinary Medicine Utrecht University Utrecht the NetherlandsAnimal Sciences Group Wageningen University Research Lelystad the NetherlandsAnimal Sciences Group Wageningen University Research Lelystad the Netherlands

A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.

关键词： Acute phase protein Acute phase reaction Animal health Assessment Cytokine Index Nutrition

Effect of Pressure on Intermediate Valence states in Cerium Kondo Compounds

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journal of Rare Earths 2004年第1期22卷 7-12页

作者： Oomi G Kagayama t smith j L Lacerda A H Kaji s Ohashi m Department of Physics Kyushu University Ropponmatsu Fukuoka 810-8560 Japan Department of mechanical Engineering and materials sciences Kumamoto University Kumamoto 860-8555 Japan materials science and technology Los Alamos National Laboratory Los Alamos NM 87545 USA

Electrical resistance, thermal expansion, lattice constants of the intermediate valence materials, α-Ce and CeBe 13, were measured at high pressure. It is found that the Grüneisen parameters of Kondo temperature t K are 13 and 42 for α-Ce and CeBe 13, respectively, and it decreases with increasing pressure. the magnetoresistance of α-Ce shows H2 dependence and its coefficient increases with pressure below 1 GPa, but becomes nearly constant above 1 GPa. the results indicate that the intermediate valence states are enhanced at high pressure indicating the enhancement of hybridization between the 4f electron and conduction band.

关键词： condensel physics intermediate valence materials cerium rare earths

structural and mechanical properties of Al–C–N films deposited at room temperature by plasma focus device

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Chinese Physics B 2016年第7期25卷 299-304页

作者： Z A Umar R Ahmad R s Rawat m A Baig j siddiqui t Hussain National Centre for Physics Quaid-i-Azam University Campus Department of Physics GC University NssE National Institute of Education Nanyang Technological University Centre for Advanced studies in Physics GC University

the Al–C–N films are deposited on si substrates by using a dense plasma focus（DPF） device with aluminum fitted central electrode（anode） and by operating the device with CH_4/N_2 gas admixture ratio of 1：1. XRD results verify the crystalline Al N（111） and Al_3CON（110） phase formation of the films deposited using multiple shots. the elemental compositions as well as chemical states of the deposited Al–C–N films are studied using XPs analysis, which affirm Al–N, C–C, and C–N bonding. the FEsEm analysis reveals that the deposited films are composed of nanoparticles and nanoparticle agglomerates. the size of the agglomerates increases at a higher number of focus deposition shots for multiple shot depositions. Nanoindentation results reveal the variation in mechanical properties（nanohardness and elastic modulus）of Al–C–N films deposited with multiple shots. the highest values of nanohardness and elastic modulus are found to be about 11 and 185 GPa, respectively, for the film deposited with 30 focus deposition shots. the mechanical properties of the films deposited using multiple shots are related to the Al content and C–N bonding.

关键词： dense plasma focus XPs field emission scanning electron microscope elastic modulus

EFFECt OF CARBON mIGRAtION ON CREEP PROPERtIEs OF Cr5mo DIssImILAR WELDED jOINts WItH Ni-BAsED AND AUstENItIC WELD mEtAL

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Acta metallurgica sinica(English Letters) 2004年第4期17卷 560-568页

作者： j.m.Gong Y.jiang s.t.tu Nanjing University of technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 ChinaNanjing University of Technology Nanjing 210009 China East China University of Science and Technology Shanghai 200237 China

In this paper, the effect of carbon migration on creep properties of Cr5mo dissimilar welded joints with Ni-based (Inconel 182) and Cr23Nil3 (A302) austenitic weld metal was investigated. Carbon migration near the weld metal/ferritic steel interface of Cr5mo dissimilar welded joints was analyzed by aging method. Local creep deformations of the dissimilar welded joints were measured by a long-term local creep deformation measuring technique. the creep rupture testing was performed for Cr5mo dissimilar welded joints with Inconel 182 and A302 weld metal. the research results show that the maximum creep strain rate occurs in the decarburized zone located on heat affect zone (HAZ) of Cr5mo ferritic steel. the creep rupture life of Cr5mo dissimilar welded joints with A 302 weld metal decreases due to carbon migration and is about 50% of that welded with Inconel 182 weld metal.

关键词： dissimilar welded joint carbon migration creep rupture localized deformation