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Ultrastructural Alterations in Testes from Rats Treated with Cysteine

Biomedical and Environmental sciences 1993年第2期6卷 172-178页

作者： a.s.bernacchi E.C.DEFERREYRA C.R.DECAsTRO J.A.CAsTRO Centro CentroCentroCentro de Investigaciones Toxicologicas(CEITOX)CITEFA/CONICETZufriategui4380(1603)Villa MartelliPcia.de Buenos AiresArgentina

Cysteinc administration in relatively large doses has been repetitively employed as preventive agent against chemically induced cell injury or as *** this work we report that administration of a dose standard for those purposes(1.9gr/kg,po in water)causes significant ultrastructurally evident alterations in testcs at *** involves scrtoli cells and *** found in the former include dilatation of nuclear membrane and of the smooth(sER)and rough endoplasmic reliculum(RER)and detachment of ribosomes from *** appeared more sparse and electron lucent than in controls and contained more lipid droplets and *** exhibited alterations in shape and *** in spermatids consisted of the appearance of irregular shape of the nucleus and alterations in their acrosomal *** was no histochemical evidence for either calcium accumulation or lipid peroxidation occurrence in testes of cysteine-trcated *** indicate that the large doses of cysteine employed in prevention of radiation or chemical effects is able to cause injury to sertoli cells of the *** observed does not reach irreversible stages but may be sufficient to lead to production of abnormal spermatids.

关键词：抗辐射药半胱氨酸处理大鼠睾丸组织生精能力超微结构变化

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Late Protective Effects of the Anticalmodulin Drug Fluphenazine on Carbon Tetrachloride-induced Liver Necrosis

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Biomedical and Environmental sciences 1995年第3期8卷 218-225页

作者： E. C. DE FERREYRA A. s. bernacchi M. F. sAN MARTIN G. D. CAsTRO AND J. A. CAsTRO (Centro de Investigaciones Toxicologicas (CEITOX)-CITEFA/CONICET,Zufriategui 4380, (1603) Villa Martelli, Buenos Aires, Angentina) Centro de Investigaciones Toxicológicas (CEITOX)-CITEFA/CONICET Zufriategui Buenos Aires Argentina.

Fluphenazine (FP) treatment (50mg/kg bw, ip in saline) 30 min before or 6 or 10 h after CCl4 administration (1 ml/kg ip in olive oil) significantly prevented the liver necrosis produced by the hepatotoxin at 24 h. FP had enhancing effects on the covalent binding of CCl4 reactive metabolites to cellular constituents and on CCl4 induced lipid *** lowered bOdy temperature of the CCl4-poisoned animals during the 24 h observation period. The obtained results are compatible but do not prove the hypothesis that calmodulin (CaM) had participation in late occurring events preceding necrosis. FP lowering action on body temperature, however, might also play a role in the effects of this drug on the onset of CCl4 induced liver necrosis. FP levels in liver tissue as determined by gas chromatography-mass spectrometry evidenced the presence of the drug in amounts suffi cient to inhibit CaM and that suggests that not all preventive effects of FP are due to its indirect actions on the central nervous system via decreased body temperature

关键词： ab Late Protective Effects of the Anticalmodulin Drug Fluphenazine on Carbon Tetrachloride-induced Liver Necrosis

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A Proof-of-Concept Assessment of the safety and Efficacy of Intralesional Diclofenac in the Treatment of Cutaneous Neurofibromas

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International Journal of Clinical Medicine 2015年第12期6卷 975-983页

作者： Mauro Geller Aguinaldo Bonalumi Filho Lisa Oliveira Allan ERubenstein Luiz Guilherme Darrigo Jr David Azulay Allan bernacchi Marcia Goncalves Ribeiro Karin soares Goncalves Cunha Immunology Department Fundacao Educacional Serra dos Orgaos(UNIFESO)TeresopolisBrazil Clinical Immunology Instituto de Pos-Graduacao Medica Carlos Chagas(IPGMCC)Rio de JaneiroBrazil Medical Genetics service IPPMG-Universidade Federal Rio de JaneiroRio de JaneiroBrazil Hospital Naval Marcilio Dias Rio de JaneiroBrazil sociedade Evangelica Beneficiente de Curitiba Outpatient Unit CuritibaBrazil NYU Langone Medical Center New YorkNYUSA Bone Marrow Transplant Unit Hospital das Clinicas da Faculdade de Medicina de Ribeirao PretoUniversidade de Sao Paulo(USP)Ribeirao PretoBrazil Pontifica Universidade Catolica do Rio de Janeiro(PUC-RJ) Rio de JaneiroRJBrazil Plastic surgery Post-Graduation PUC-RJRio de JaneiroBrazil 1 Universidade Federal Fluminense(UFF) Rio de JaneiroBrazil

The objectives of this study were to assess the safety and efficacy of intralesionally administered diclofenac in the treatment of cutaneous neurofibromas in patients with NF1. This was a proof-of-concept, prospective, safety and efficacy study of the effect of intralesionally administered diclofenac 25 mg/ml given once a week to 3 target cutaneous neurofibromas for 4 consecutive weeks. Overall, there was no significant change in neurofibroma size. During the study, some treated lesions developed signs of necrosis and fell off after a few weeks, but none of the control neurofibromas fell off. There were no significant changes in patient’s vital signs. A few adverse events occurred, mostly at the injection sites. During the study, some neurofibromas developed necrosis after the diclofenac injections and eventually detached from the patient. Overall, diclofenac was well tolerated, suggesting minimal systemic exposure, which required confirmation and further studies, including bioavailability analysis.

关键词： Neurofibromatosis Type 1 Cutaneous Neurofibromas Diclofenac sodium

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