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嘌呤信号:中医药研究新靶点

成都中医药大学学报 2024年第3期47卷 1-7页

作者：尹海燕 Patrizia.rubini Peter Illes 唐勇成都中医药大学针灸推拿学院四川成都611137 嘌呤信号国际联合研究中心四川成都611137 莱比锡大学医学院德国莱比锡04107 成都中医药大学养生康复学院四川成都611137

嘌呤信号主要包括三磷酸腺苷(Adenosine Triphosphate,ATP)、二磷酸腺苷(Adenosine Diphosphate,ADP)、一磷酸腺苷(Adenosine Monophosphate,AMP)和腺苷(Adenosine,ADO)4类物质、CD39和CD73两种酶以及19种嘌呤受体(P1、P2X、P2Y),与机... 详细信息

关键词：嘌呤信号中医药靶点

l_(1)-based calibration of POD-Galerkin models of two-dimensional unsteady flows

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Chinese Journal of Aeronautics 2021年第1期34卷 226-236页

作者： Riccardo rubini Davide LASAGNA Andrea DA RONCH Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171BJUnited Kingdom

This paper discusses a physics-informed methodology aimed at reconstructing efficiently the fluid state of a ***,the generation of an accurate reduced order model of twodimensional unsteady flows from data leverages on sparsity-promoting statistical learning *** cornerstone of the approach is l_(1) regularised regression,resulting in sparselyconnected models where only the important quadratic interactions between modes are *** original dynamical behaviour is reproduced at low computational costs,as few quadratic interactions need to be *** approach has two key ***,interactions are selected systematically as a solution of a convex optimisation problem and no a priori assumptions on the physics of the flow are ***,the presence of a regularisation term improves the predictive performance of the original model,generally affected by noise and poor data *** cases are for two-dimensional lid-driven cavity flows,at three values of the Reynolds number for which the motion is chaotic and energy interactions are scattered across the *** is found that:(A)the sparsification generates models maintaining the original accuracy level but with a lower number of active coefficients;this becomes more pronounced for increasing Reynolds numbers suggesting that extension of these techniques to real-life flow configurations is possible;(B)sparse models maintain a good temporal stability for *** methodology is ready for more complex applications without modifications of the underlying theory,and the integration into a cyberphysical model is feasible.

关键词： Computational methods Dynamical systems Lid-driven cavity L_(1)-based regression Reduced order models Sparsification Stabilization of ROMs

Regulation of neural stem/progenitor cell functions by P2X and P2Y receptors

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Neural Regeneration Research 2017年第3期12卷 395-396页

作者： Peter Illes Patrizia.rubini Rudolf-Boehm-Institut fur Pharmakologie und Toxikologie Universitat LeipzigLeipzigGermany

Neural stem/progenitor cells：Radial glial cells constitute multipotent cells in the ventricular zone,lining the wall of the lateral ventricle of the embryonic *** have the capacity to give rise to cells belonging to ... 详细信息

关键词： NSCs cell Regulation of neural stem/progenitor cell functions by P2X and P2Y receptors stem

Astrocyte-derived ATP:A New Etiological Factor for Autism Spectrum Disorder

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Neuroscience Bulletin 2022年第1期38卷 104-106页

作者： Jie Li Patrizia.rubini Yong Tang Peter Illes School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu610075China International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengdu610075China Rudolf Boehm Institute for Pharmacology and Toxicology University of Leipzig04109LeipzigGermany

In the central nervous system,purinergic signaling plays an important role in maintaining the functions of neurons,astrocytes,and microglia,thereby regulating brain homeostasis,with consequences for higher-order cognitive processes[1].ATP released from astrocytes in conjunction with several additional signaling molecules modulates neuronal circuits.

关键词： thereby consequences purine

Impaired ATP Release from Brain Astrocytes May be a Cause of Major Depression

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Neuroscience Bulletin 2020年第11期36卷 1281-1284页

作者： Peter Illes Patrizia.rubini Haiyan Yin Yong Tang Rudolf Boehm Institute for Pharmacology and Toxicology University of Leipzig04107 LeipzigGermany School of Acupuncture and Tuina Chengdu University of Traditional Chinese MedicineChengdu 610075China

Major depressive disease(MDD)is one of the most common mental disorders and a leading cause of disability[1].Core symptoms include depressed mood,increased apathy,and a general loss of *** consequence,it represents not only a personal hardship for the patients themselves,but also a major socio-economic burden for society as a whole.

关键词： cytes depressed Release

Identification of BRAF V600E mutation in odontogenic tumors by high-performance MALDI-TOF analysis

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International Journal of Oral Science 2022年第2期14卷 212-219页

作者： Lucrezia Togni Antonio Zizzi Roberta Mazzucchelli Andrea Santarelli Corrado rubini Marco Mascitti Department of Clinical Specialistic and Dental Sciences Marche Polytechnic Universityvia Tronto 10AnconaItaly Department of Biomedical Sciences and Public Health Marche Polytechnic Universityvia Tronto 10AnconaItaly Dentistry Clinic National Institute of Health and Science of AgingIRCCS INRCAvia Tronto 10AnconaItaly

Odontogenic tumors are rare lesions with unknown *** of them are benign,but local aggressiveness,infiltrative potential,and high recurrence rate characterize some *** MAP-kinase pathway activation can represent a primary critical event in odontogenic ***,the BRAF V600E mutation has been involved in 80%–90%of ameloblastic lesions,offering a biological rationale for developing new targeted *** study aims to evaluate the BRAF V600E mutation in odontogenic lesions,comparing three different detection methods and focusing on the Sequenom MassARRAY System.81 surgical samples of odontogenic lesions were subjected to immunohistochemical analysis,Sanger Sequencing,and Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry(Sequenom).The BRAF V600E mutation was revealed only in ameloblastoma ***,the presence of BRAF V600E was significantly associated with the mandibular site(ρ=0.627;P value<0.001)and the unicystic histotype(ρ=0.299,P value<0.001).However,any significant difference of 10-years disease-free survival time was not ***,Sequenom showed to be a 100%sensitive and 98.1%specific,suggesting its high-performance diagnostic *** results suggest the MAP-kinase pathway could contribute to ameloblastic ***,they could indicate the anatomical specificity of the driving mutations of mandibular ameloblastomas,providing a biological rational for developing new targeted ***,the high diagnostic accuracy of Sequenom was confirmed.

关键词： V600E BRAF specificity

Contactless Monitoring of the Diameter-Dependent Conductivity of GaAs Nanowires

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Nano Research 2010年第10期3卷 706-713页

作者： Fauzia Jabeen Silvia.rubini Faustino Martelli Alfonso Franciosi Andrei Kolmakov Luca Gregoratti Matteo Amati Alexei Barinov Andrea Goldoni Maya Kiskinova Sincrotrone Trieste S.C.P.A. Elettra LaboratoryArea Science ParkS.S.14Km.163.5I-34149 TriesteItaly Laboratorio TASC IOM-CNR Area Science ParkS.S.14Km.163.5I-34149 TriesteItaly Department of Physics Southern Illinois University Carbondale1245 Lincoln Dr.Neckers 478CarbondaleIL 62901-4401USA

Contactless monitoring with photoelectron microspectroscopy of the surface potential along individual nano-structures,created by the X-ray nanoprobe,opens exciting possibilities to examine quantitatively size-and surface-chemistry-effects on the electrical transport of semiconductor nanowires(NWs).Implementing this novel approach-which combines surface chemical microanalysis with conductivity measurements-we explored the dependence of the electrical properties of undoped GaAs NWs on the NW width,temperature and surface *** following the evolution of the Ga 3d and As 3d core level spectra,we measured the position-dependent surface potential along the GaAs NWs as a function of NW diameter,decreasing from 120 to~20 nm,and correlated the observed decrease of the conductivity with the monotonic reduction in the NW diameter from 120 to~20 *** of the GaAs NWs to oxygen ambient leads to a decrease in their conductivity by up to a factor of 10,attributed to the significant decrease in the carrier density associated with the formation of an oxide shell.

关键词： Semiconductor nanowires charge transport surface oxidation photoelectron X-ray microscopy charging GaAs

Gastric metastasis from ovarian adenocarcinoma presenting as a subepithelial tumor and diagnosed by endoscopic ultrasound-guided tissue acquisition

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World Journal of Gastrointestinal Oncology 2017年第11期9卷 452-456页

作者： Filippo Antonini Liboria Laterza Lorenzo Fuccio Massimo Marcellini Lucia Angelelli Sonia Calcina Corrado rubini Giampiero Macarri Department of Gastroenterology A. Murri Hospital Polytechnic University of Marche Endoscopy Unit AUSL Department of Medical and Surgical Sciences S. Orsola-Malpighi Hospital University of Bologna Medical Oncology Principe di Piemonte Hospital Medical Oncology Mazzoni Hospital Department of Gastroenterology San Salvatore Hospital University of L’Aquila Department of Biomedical Sciences and Public Health Pathological Anatomy and Histopathology Polytechnic University of Marche

We describe an uncommon case of a patient with a metastatic adenocarcinoma of ovarian origin presented as a gastric subepithelial tumor(SET) and that was diagnosed by endoscopic ultrasound fine-needle biopsy(EUS-FNB). Malignant gastric lesions are rarely metastatic and the primary tumor is mainly breast, lung, esophageal cancer or cutaneous melanoma. Gastric metastasis from ovarian cancer is unusual, presenting synchronously with the primary tumor but also several years later than the initial diagnosis. From an endoscopic point of view, gastric metastasis does not present specific features. They may mimic both a primary gastric tumor or, less frequently, an *** case demonstrates the importance of EUS-FNB in distinguishing SETs and how this may alter treatment and prognosis.

关键词： Metastasis Subepithelial lesion Gastric cancer Ovarian Endoscopic ultrasonography

Non-Intrusive Context Aware Transactional Framework to Derive Business Insights on Big Data

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Journal of Signal and Information Processing 2015年第2期6卷 73-78页

作者： Siva Chidambaram P. E. rubini V. Sellam Department of Computer Science Engineering Sri Muthukumaran Institute of Technology Chennai India Department of Computer Science Engineering SRM University Chennai India

To convert invisible, unstructured and time-sensitive machine data into information for decision making is a challenge. Tools available today handle only structured data. All the transaction data are getting captured without understanding its future relevance and usage. It leads to other big data analytics related issue in storing, archiving, processing, not bringing in relevant business insights to the business user. In this paper, we are proposing a context aware pattern methodology to filter relevant transaction data based on the preference of business.

关键词： Context Aware Pattern Recognizer Big Data