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Journal of Forensic Science and Medicine 2023年第3期9卷 228-235页

作者： M.Sai Geethika N.Purnachandra Rao Naik a.ravi kiran Y.Samatha B.Naveen Kumar P.Shruthi Sethu Manjusha Saranu K.Pavani Sanjana Marpuri Department of Oral Medicine and Radiology Sibar Institute of Dental SciencesGunturAndhra PradeshIndia

Background:To evaluate morphologic,radiographic,and stereomicroscopic changes of teeth when subjected to specific high temperatures in both direct heat and gradual heat and to compare the changes among two heat groups and also among different types of *** and Methods:An in vitro study was conducted on 90 healthy extracted human teeth,in which the teeth were divided into two *** 1(45)was subjected to direct heat and Group 2(45)was subjected to gradual *** 1 and Group 2 were further subdivided into three subgroups(A)anteriors,(B)premolars,and(C)molars each consisting of 15 *** were subjected to temperatures of 200°C,400°C,600°C,800°C,and 1000°C in a muffle electric *** color changes were noted using the Revised Munsell soil color chart and the radiographic and stereomicroscopic changes were *** results obtained were subjected to statistical ***:Teeth in direct heat showed more destructive changes at lower temperatures,i.e.,400°C and 600°C when compared to gradual heat where changes are observed at 600°C and 800°*** different types of teeth,anteriors and premolars showed more changes when compared to *** and Conclusion:It can be concluded that dental evidence may provide clues to solve the mystery in fire investigations as dental structures are the last to be destroyed under extreme conditions,whether temperature,acid,or putrefaction.

关键词： Color changes in teeth forensic odontology high temperatures incinerated teeth radiographs stereomicroscope

A Two-stage Kalman Filter for Cyber-attack Detection in Automatic Generation Control System

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 50-59页

作者： Ayyarao S.L.V.Tummala.ravi kiran Inapakurthi GMR Institute of Technology RajamSrikakulamAndhra PradeshIndia Raghu Engineering College DakamarriVisakhapatnamAndhra PradeshIndia

Communication plays a vital role in incorporating smartness into the interconnected power ***,historical records prove that the data transfer has always been vulnerable to *** these cyber-attacks are identified and cordoned off,they may lead to black-out and result in national security *** paper proposes an optimal two-stage Kalman filter(OTS-KF)for simultaneous state and cyber-attack estimation in automatic generation control(AGC)***/cyber-attacks are modeled as unknown inputs in the AGC *** types of cyber-attacks,i.e.,false data injection(FDI),data replay attack,denial of service(DoS),scaling,and ramp attacks,are injected into the measurements and estimated using *** the load variations of each area are seldom available,OTS-KF is reformulated to estimate the states and outliers along with the load variations of the *** proposed technique is validated on the benchmark two-area,three-area,and five-area power system *** simulation results under various test conditions demonstrate the efficacy of the proposed filter.

关键词： Cyber-security automatic generation control(AGC) load frequency control false data injection cyber-attack detection

Surgery for Crohn’s disease:upfront or last resort?

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Gastroenterology Report 2022年第1期10卷 188-194页

作者： U.Ahmed Ali ravi P.kiran Division of Colorectal Surgery New York–Presbyterian/Columbia University Medical CenterNew YorkUSA

Crohn’s disease(CD)can involve the entire gastrointestinal tract from the mouth to the anus and can lead to a constellation of *** the advancement of effective medical treatments for CD,a tendency has emerged to consider surgical treatment as a last *** potentially has the disadvantage of delaying surgery and if it fails might leave patients sicker,less well nourished,and with more severe *** with most non-malignant diseases,the choice of surgery vs medical treatment is a patient’s personal preference under the guidance of the treating physician,except in extreme situations where surgery might be the only *** this article,we will discuss the available evidence regarding the optimal timing of surgery in CD,focusing on whether early surgery can bring benefits in terms of disease control,symptom relief,and quality of life.

关键词： surgery timing Crohn’s disease outcome

Swarm Optimization and Machine Learning for Android Malware Detection

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Computers, Materials & Continua 2022年第12期73卷 6327-6345页

作者： K.Santosh Jhansi P.ravi kiran Varma Sujata Chakravarty Centurion University of Technology and Management ParalakhemundiOdishaIndia Maharaj Vijayaram Gajapathi Raj College of Engineering VizianagaramIndia Centurion University of Technology and Management BhubaneswarOdishaIndia

Malware Security Intelligence constitutes the analysis of applications and their associated metadata for possible security *** Programming Interfaces(API)calls contain valuable information that can help with malware *** malware analysis with reduced feature space helps for the efficient identification of *** goal of this research is to find the most informative features of API calls to improve the android malware detection *** swarm optimization methods,viz.,Ant Lion Optimization(ALO),Cuckoo Search Optimization(CSO),and Firefly Optimization(FO)are applied to API calls using auto-encoders for identification of most influential *** nature-inspired wrapperbased algorithms are evaluated using well-known Machine Learning(ML)classifiers such as Linear Regression(LR),Decision Tree(DT),Random Forest(RF),K-Nearest Neighbor(KNN)&SupportVector Machine(SVM).A hybrid Artificial Neuronal Classifier(ANC)is proposed for improving the classification of android *** experimental results yielded an accuracy of 98.87%with just seven features out of hundred API call features,i.e.,a massive 93%of data optimization.

关键词： Android malware API calls auto-encoders ant lion optimization cuckoo search optimization firefly optimization artificial neural networks artificial neuronal classifier

Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohn’s colitis

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Gastroenterology Report 2016年第3期4卷 226-231,I0002页

作者： Udayakumar Navaneethan Tarun Rai Preethi GK Venkatesh ravi P kiran Department of Gastroenterology Digestive disease InstituteThe Cleveland ClinicClevelandOHUSA Department of Colorectal Surgery Digestive disease InstituteThe Cleveland ClinicClevelandOHUSA

Background and aim:Crohn’s colitis(CC)is associated with primary sclerosing cholangitis(PSC).However the risk of colon cancer or dysplasia in CC and PSC is *** aim was to study the risk of colon neoplasia in CC in patients with and without ***:This is a nested,case-control cohort study of all patients diagnosed with concurrent CC and PSC,seen at the Cleveland Clinic between 1985 and ***-three patients with both CC and PSC were compared with a random sample of 159 CC controls without PSC during the same ***:Seven(16.3%)of 43 CC patients with PSC developed colon cancer or dysplasia,compared with 22(13.8%)of 159 controls(P=0.98).Of seven colon neoplasia cases in the PSC group,100%occurred proximal to the splenic flexure,compared with 50%(11/22)cases of colon neoplasia in controls occurring in the proximal colon(P=0.001).Based on Cox regression analysis,male gender independently increased the risk of neoplasia[hazard ratio(HR)=2.68;95%confidence interval(CI)1.30-5.54;P=0.008],as did age at CC diagnosis(HR=1.29;95%CI 1.14-1.47;P<0.001),while the use of azathioprine/6-mercaptopurine was protective(HR=0.30;95%CI 0.13-0.70;P=0.005).The presence of PSC did not increase the risk for colon neoplasia(HR=0.45;95%CI 0.18-1.13;P=0.09).Conclusions:CC patients with PSC appear not to be at increased risk of developing colon *** patients in our cohort with colon neoplasia and concurrent PSC,the neoplasia occurred in the proximal colon in all cases.

关键词： Crohn’s colitis primary sclerosing cholangitis colon neoplasia

Colorectal cancer resection rates in patients with inflammatory bowel disease:a population-based study

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Gastroenterology Report 2018年第4期6卷 263-269,I0001页

作者： Udayakumar Navaneethan Xiang Zhu Dennisdhilak Lourdusamy Vennisvasanth Lourdusamy Bo Shen ravi kiran Center for Interventional Endoscopy Florida HospitalOrlandoFL 32803USA Center for Inflammatory Bowel Diseases The Cleveland ClinicClevelandOH 44195USA Division of Colorectal Surgery Columbia University Medical Center/New York Presbyterian HospitalNew YorkNY 10032USA

Background and objective:Inflammatory bowel disease(IBD)is associated with an increased risk of colorectal cancer(CRC).This study aimed to analyse the trends in rates of resection for IBD-related CRC in the ***:We used the Nationwide Inpatient Sample from 1995 to *** trends in age-adjusted rates of resection for CRC in the setting of IBD were analysed using multivariate Joinpoint regression *** primary outcome was surgical resection of CRC in the setting of ***:We included 3597168 IBD discharges in the present study,of which 275479 underwent CRC resection between 1995 and *** annual CRC resection rates among IBD population decreased significantly from 1995 to *** decrease was significant in all age groups with an annual decrease of 393(P75 years,*** annual IBD-CRC resection rate per 100000 IBD discharges for proximal CRC decreased by 149(P75 years,between 1995 and *** multivariate Poisson regression analysis,after adjustment for age and sex,CRC resections decreased by 3.9%each year from 1995 to ***:CRC resection rates among IBD patients have continued to decrease annually from 1995 to *** is a population-level decrease in resection of both proximal and distal CRC reflecting a decreasing incidence of IBD-related CRC incidence in the USA.

关键词： Colorectal cancer inflammatory bowel disease Crohn’s disease ulcerative colitis surgery

Assessment of phytochemicals and antioxidant activities of raw and germinating Ceiba pentandra (kapok) seeds

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The Journal of Biomedical Research 2015年第5期29卷 414-419页

作者： Chekuboyina.ravi kiran Dadi Bhaskara Rao Nagala Sirisha Tamanam Raghava Rao Department of Biochemistry College of Science and TechnologyAndhra University

To determine the significance of germination on phytochemical constituents and non-enzymatic antioxidant activ- ities of Ceiba pentandra seed extracts. Phytochemicals and antioxidant activities of raw and germinating seeds of Ceiba pentandra were estimated by different methods. The levels of phytochemical constituents were influenced by germination and increased except alkaloids and tannins, which were decreased significantly during germination. Among non-enzymatic antioxidants like DPPH, FRAP, reducing assay and hydroxyl radical scavenging activity all showed improved activity compared with non-germinating seeds. This may be due to various reactive oxygen species （ROS） that were generated as by-products of metabolism during germination. This group of ROS included superoxide radicals （O2）, hydrogen peroxide radicals （HzOz） and hydroxyl radicals （OH）. The formation of these oxygen radicals resulted in the accumulation of lipid hydroperoxides by radical chain oxidation via phospholipids peroxy radicals within membranes. Therefore, it was hypothesized that this could be related to the increase of anti- oxidant activity in large unilamellar vesicles observed in germinated seeds. The implication of this study is that the Ceiba pentandra seeds as natural antioxidant agents and put forward the possibility of employing for therapeutic potential.

关键词： antioxidants butylated hydroxy toluene phytochemicals rutin

Comparison of outcomes for patients with primary sclerosing cholangitis associated with ulcerative colitis and Crohn’s disease

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Gastroenterology Report 2016年第1期4卷 43-49,I0002页

作者： Udayakumar Navaneethan Preethi GK Venkatesh Ramprasad Jegadeesan Vennisvasanth Lourdusamy Jeffrey P Hammel ravi P kiran Bo Shen Department of Gastroenterology Digestive Disease InstituteThe Cleveland ClinicClevelandOHUSA Department of Colorectal Surgery Columbia University Medical CenterNew York Presbyterian HospitalNew YorkNYUSA.

Background:The comparative outcomes of ulcerative colitis(UC)and Crohn’s disease(CD)in patients with primary sclerosing cholangitis(PSC)are unclear;the aim of our study was to make an objective ***:A total of 273 patients with PSC and inflammatory bowel disease(223 with UC and 50 with CD)were *** and demographic variables were ***:The PSC risk score was similar for both *** median follow-up period in patients with PSC-UC was 12 years(range 0–38)and that for PSC-CD was 14 years(range 1–36).The median number of disease flares per year was higher in PSC-UC patients than in the PSC-CD group[1vs.0(ranges 0–20 and 0–9,respectively);P<0.001].More patients with UC developed colon neoplasia than CD(35.9%vs.18%;P=0.009).On proportional hazards analysis for the risk of colectomy,UC patients had a 12%higher risk for colectomy[hazard ratio(HR)=0.88;95%confidence interval(CI)0.51–1.51;P=0.64].Liver transplantation for PSC was associated with decreased risk(HR=0.57;95%CI 0.37–0.89;P=0.013),while colon neoplasia increased the risk(HR=3.83;95%CI 2.63–5.58;P<0.001)for *** proportional hazards analysis for the risk of colon neoplasia,UC patients had 56%higher risk of developing colon neoplasia than CD(HR=0.44;95%CI 0.16–1.25;P=0.12).Conclusions:PSC patients with CD appear to be associated with a lower risk of colon neoplasia and colectomy than PSC patients with UC.

关键词： primary sclerosing cholangitis ulcerative colitis Crohn’s disease colon neoplasia colectomy liver transplantation

Avoiding second donor site and the second set of neck vessels in a case of absent peroneal skin perforators

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Plastic and Aesthetic Research 2022年第1期9卷 661-666页

作者： Aditya Narayan Choudhary Rajan Arora Kripa Shanker Mishra.ravi kiran Naalla Saket Srivastava Ajay Kumar Dewan Department of Reconstructive and Microvascular Surgery Rajiv Gandhi Cancer Institute and Research CentreRohiniNew Delhi 110085India Department of Surgical Oncology Rajiv Gandhi Cancer Institute and Research CentreRohiniNew Delhi 110085India

This report describes the procedure of a case in which the skin paddle of the free fibula flap derived its supply solely from a soleal musculocutaneous perforator originating from the posterior tibial *** contrast,the osteo-muscular component was supplied by the peroneal vascular *** harvested the skin paddle with its vascular supply from the posterior tibial artery separately,and the osteo-muscular fibula was harvested with its supply from peroneal *** this way,we avoided violation of the second donor site for the skin *** addition,we used the distal end of peroneal vessels to salvage our skin paddle instead of sacrificing another set of neck vessels for *** technique may also be utilised in cases where the neck vessels may not be available due to previous surgeries,radiation therapy,or decision by the surgery team to not sacrifice two sets of neck vessels for anastomosis.

关键词： Free fibula flap peroneal vessels posterior tibial vessels mandible reconstruction flaps in series

Effect of quality of bowel preparation on quality indicators of adenoma detection rates and colonoscopy completion rates

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Gastroenterology Report 2016年第2期4卷 148-153,I0003页

作者： Tarun Rai Udayakumar Navaneethan Tushar Gohel Amareshwar Podugu Prashanthi N.Thota.ravi P.kiran Rocio Lopez Madhusudhan R.Sanaka Digestive Disease Institute The Cleveland ClinicClevelandOHUSA

Background and aim:Adequate bowel preparation is important for safe and effective *** indicators(QI)for colonoscopy include achieving at least 95%completion rate and an adenoma detection rate(ADR)of at least 25%in average-risk men and 15%in average-risk women aged over *** aim was to investigate the impact of bowel preparation on ADR and colonoscopy completion ***:This retrospective cohort study included patients who underwent colonoscopy between January 2008 and December *** main outcome measurements were ADR and colonoscopy completion rates to the ***:A total of 2519 patients was included;1030(41.0%)had excellent preparation,1145(45.5%)good-,240(9.5%)fair-,and 104(4.1%)poor *** completion rates were significantly lower in patients with poor or fair preparation(72.1%and 75.4%,respectively)than in those with good and excellent preparation(99.7%and 99.9%,respectively;P<0.001),and significantly lower than the QI of 95%(P<0.001).ADR in men and women combined was similar in all four grades of preparation(excellent,good,fair and poor)at 24.2%vs.26.8%vs.32.1%vs.22.1%,respectively;P¼*** the groups had ADR above the QI(25%for men and 15%for women)with evidence of significantly higher ADR in the women with excellent or good preparation and in men with excellent,good or fair *** multivariate analysis,male gender was significantly associated with increased ADR(P<0.001),while the quality of bowel preparation did not influence ***:Patients with fair and poor standards of preparation have significantly lower colonoscopy completion rates than those with excellent and good ***,there was no difference in ADR between the different grades of preparation.

关键词： bowel preparation adenoma detection rate colonoscopy completion rate quality indicators