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Environmental and Climate Justice in Palestine

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American Journal of Climate Change 2024年第2期13卷 251-280页

作者： jad Isaac Jane Hilal Applied Research Institute-Jerusalem (ARIJ) Society Bethlehem Palestine Water and Enviromenat Department Applied Research Institute-Jerusalem Society (ARIJ) Society Bethlehem Palestine

To have a clean, safe, and functional environment is not only essential for the purpose of preservation, but also imperative for safeguarding the most fundamental of human rights. Resolution 45/94 of the United Nations (UN) General Assembly also stresses and acknowledges that: “all individuals are entitled to live in an environment adequate for their health and wellbeing” (United Nations Digital Library System, 1991). Environmental and climate justice, which: “emerged in the context of the local environmental struggles of directly oppressed groups”, is a global movement dedicated to ensuring equal protection of people’s human rights (i.e., water, health, life, etc.) in the face of the climate crisis. Moreover, health, environment and human rights are part of the 2030 agenda (in particular, SDG 1, SDG 5, SDG 6, SDG 7, SDG 13, SDG 16, SDG 17). Individually, both environmental and climate justice are rooted in an intersectional outlook, by which they highlight the common threads between communities and the people’s inclusion, irrespective of race, class, or gender, in the pursuit of justice. On the other hand, they recognise and acknowledge the role and consequences of climate change in economic, social, and political dimensions;thus, drawing emphasis on the rights of people under the emerging inequities. In the case of Palestine, the Palestinian community is increasingly becoming vulnerable to these effects and the resulting inequalities of climate change. This vulnerability stems from: 1) The right to life;clean WASH;equitable work opportunities;access to resources;and free movement;are all examples of human rights that the Israeli colonial regime infringes upon;2) Infrastructure is essential for climate adaptation: 61% of the West Bank is ultimately barred from building infrastructure (B’Tselem, 2019) and Gaza Strip has major gaps in infrastructure due to intentional destruction by Israel;3) Palestinian deprivation of the sovereign right to natural resources by Isra

关键词： Environmental Degradation Climate Change Environmental and Climate Justice Human Rights Causes and Solution

Stem cell transplantation in cerebrovascular accidents:A global bibliometric analysis(2000-2023)

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World Journal of Stem Cells 2024年第9期16卷 832-841页

作者： jad El Masri Ahmad Afyouni Maya Ghazi Karim Hamideh Israe Moubayed Abdo Jurjus Hanine Haidar Ruzanna Petrosyan Pascale Salameh Hassan Hosseini École Doctorale Sciences de la Vie et de la Santé UniversitéParis-Est CréteilCréteil 94010France INSERM U955-E01 Institut Mondor de Recherche BiomédicaleUniversitéParis-Est CréteilCréteil 94000France Faculty of Medical Sciences Lebanese UniversityBeirut 1533Lebanon Department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107Lebanon Department of Neurology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Department of Pathology Faculty of MedicineLebanese American UniversityBeirut 1102Lebanon Faculty of Pharmacy Lebanese UniversityBeirut 1102Lebanon Faculty of Medicine Lebanese American UniversityBeirut 1102Lebanon Department of Primary Care and Population Health University of Nicosia Medical SchoolNicosia 2408Cyprus Institut National de SantéPublique d'Épidémiologie Clinique et de Toxicologie-Liban Beirut 1103Lebanon Department of Neurology Henri Mondor HospitalAP-HPCréteil 94000France

BACKGROUND Cerebrovascular accident(CVA)is a major global contributor to death and *** part of its medical management,researchers have recognized the importance of promising neuroprotective strategies,where stem cell transplantation(SCT)is thought to confer advantages via trophic and neuroprotective *** To evaluate the current state of research on SCT in patients with CVA,assess key trends and highlight literature *** PubMed was screened for SCT in CVA-related articles in October 2023,for each country during the period between 2000 and *** the World Bank data,total population and gross domestic product were collected for ***_1.6.19 was used to create the VOS figure using the results of the same *** and tables were obtained using Microsoft Office *** A total of 6923 studies were identified on SCT in CVA,making 0.03%of all published studies ***,68%were conducted in high-income countries,with a significant focus on mesenchymal stem *** journal“Stroke”featured the largest share of these articles,with mesenchymal SCT having the highest rate of inclusion,followed by hematopoietic *** time,there has been a noticeable shift from in vitro studies,which assess stem cell proliferation and neurogenesis,to in vivo studies aimed at evaluating efficacy and ***,the number of reviews increased along this *** This bibliometric analysis provides a comprehensive guide for physicians and researchers in the field through an objective overview of research activity,and highlights both current trends and *** a potential therapeutic role in CVA,more research is needed in the future to focus on different aspects of SCT,aiming to reach a better treatment strategy and improve life quality in patients.

关键词： Bibliometric analysis PubMed Stem cell transplantation Cerebrovascular accidents Stroke

Impact of the economic crisis and drug shortage on Lebanese cancer patients’care

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World Journal of Clinical Oncology 2024年第5期15卷 644-652页

作者： Dollen Eid jad Jabbour Elissar Moujaes Hampig Raphael Kourie Maissa Safieddine Joseph Kattan Department of Hematology and Oncology Saint Joseph UniversityFaculty of MedicineMar MikhaëlBeirut 0000Lebanon Department of Hematology and Oncology Institut Gustave RoussyVillejuif 94800France Department of Hematology and Oncology Hôtel-Dieu de France University HospitalBeirut 0000Lebanon Clinical Research Center Saint Joseph UniversityBeirut 0000Lebanon

BACKGROUND As a consequence of the economic crisis,the sociopolitical instability and the advent of the coronavirus disease-19 pandemic,nested challenges faced the Lebanese healthcare *** have resulted in critical shortages of essential resources,including medications vital for oncologic *** To assess the ramifications of the ongoing economic crisis on oncology patient care focusing on our outpatient oncology *** A questionnaire was distributed during the month of February 2022 to oncology patients in Hôtel Dieu de France University Hospital in Beirut during their outpatient *** primary objective was to assess the far-reaching impact of the economic crisis on patient care and the resulting psychological *** Among 182 interviewed patients,31.87%experienced treatment interruption mainly due to acute drug *** 87.91%of the patients benefiting from third-party coverage,69.60%had to self-pay for their medications leading to 69.78%of patients perceiving that healthcare was more difficult to access after ***,one-third of the patients exhibited symptoms of anxiety and/or depression,with 7 patients reporting suicidal ***,37.93%of patients who interrupted cancer treatment reported a history of comorbidities,and 89.66%who altered their treatment cited financial *** Lebanese cancer patients face complex challenges spanning economic,healthcare,and psychological *** inequalities exacerbated by the economic crisis hindered healthcare access.

关键词： Cancer care Drug shortage Economic crisis Cancer psychology Healthcare access

Colorectal cancer:Recent advances in management and treatment

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World Journal of Clinical Oncology 2024年第9期15卷 1136-1156页

作者： Hiba Fadlallah jad El Masri Hiam Fakhereddine Joe Youssef Chrystelle Chemaly Samer Doughan Wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1107-2020Lebanon

Colorectal cancer(CRC)is the third most common cancer worldwide,and the second most common cause of cancer-related *** 2020,the estimated number of deaths due to CRC was approximately 930000,accounting for 10%of all cancer deaths ***,there is a vast amount of ongoing research aiming to find new and improved treatment modalities for CRC that can potentially increase survival and decrease overall morbidity and *** management strategies for CRC include surgical procedures for resectable cases,and radiotherapy,chemotherapy,and immunotherapy,in addition to their combination,for non-resectable *** these options,CRC remains incurable in 50%of ***,significant improvements in research techniques have allowed for treatment approaches for CRC to be frequently updated,leading to the availability of new drugs and therapeutic *** review summarizes the most recent therapeutic approaches for CRC,with special emphasis on new strategies that are currently being studied and have great potential to improve the prognosis and lifespan of patients with CRC.

关键词： Colorectal cancer Treatment Surgery Chemotherapy Targeted therapy Immunotherapy

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 1-12页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy Ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha Nguyen Lan Huu Shedrawy jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

Background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;P<0.001). This resulted in no significant difference in catastrophic costs between the two cohorts (Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;P<0.001) and experiencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Acute Morphine Administration Reduces Cell-Mediated Immunity and Induces Reactivation of Latent Herpes Simplex Virus Type 1 in BALB/c Mice

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Cellular & Molecular Immunology 2009年第2期6卷 111-116页

作者： Shafi Mojadadi Abbas Jamali Behzad Khansarine jad Hoorieh Soleimanjahi Taravat Bamdad Neuroscience research center Kerman University of Medical Sciences Department of Virology Faculty of medical science Tarbiat Modares University Dept of virology School of medicalsciences Tarbiat Modares University Dept of Microbiology Arak University of Medical Sciences

Acute morphine administration is known to alter the course of herpes simplex virus infection. In this study, the effect of acute morphine administration on the reactivation of latent herpes was investigated in a mouse model. Because of the important role of cytolytic T lymphocyte （CTL） activity in the inhibition of herpes simplex virus type 1 （HSV-1） reactivation, the effect of acute morphine administration on CTL responses was also evaluated. Furthermore, lymphocyte proliferation and IFN-γ production were evaluated for their roles in the induction of the CTL response. The findings showed that acute morphine administration significantly reduced CTL responses, lymphocyte proliferation, and IFN-γ production. Furthermore, acute morphine administration has been shown to reactivate latent HSV-γ. Previous studies have shown that cellular immune responses have important roles in the inhibition of HSV reactivation. These findings suggest that suppression of a portion of the cellular immune response after acute morphine administration may constitute one part of the mechanism that induces HSV reactivation.

关键词： acute morphine herpes simplex virus-1 reactivation cell-mediated immunity

Hepatic portal venous gas: Physiopathology, etiology, prognosis and treatment

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World Journal of Gastroenterology 2009年第29期15卷 3585-3590页

作者： Bassam Abboud jad El Hachem Thierry Yazbeck Corinne Doumit Department of General Surgery Hotel-Dieu de France Hospital Boulevard Alfred Naccache Beirut 16-6830 Lebanon

Hepatic portal venous gas (HPVG), an ominous radiologic sign, is associated in some cases with a severe underlying abdominal disease requiring urgent operative intervention. HPVG has been reported with increasing frequency in medical literature and usually accompanies severe or lethal conditions. The diagnosis of HPVG is usually made by plain abdominal radiography, sonography, color Doppler flow imaging or computed tomography (CT) scan. Currently, the increased use of CT scan and ultrasound in the inpatient setting allows early and highly sensitive detection of such severe illnesses and also the recognition of an increasing number of benign and non-life threatening causes of HPVG. HPVG is not by itself a surgical indication and the treatment depends mainly on the underlying disease. The prognosis is related to the pathology itself and is not influenced by the presence of HPVG. Based on a review of the literature, we discuss in this paper the pathophysiology, risk factors, radiographic findings, management, and prognosis of pathologies associated with HPVG.

关键词： Hepatic portal venous gas Bowel ischemia/necrosis Diverticulitis Gastric pathologies Ulcerativecolitis Abdominal computed tomography scan Crohn'sdisease Liver transplantation Chemotherapy

Penile cancer:Updates in systemic therapy

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Asian Journal of Urology 2022年第4期9卷 374-388页

作者： Vidhu B.Joshi Juskaran Chadha jad Chahoud Department of Biochemistry and Molecular Biology Mayo ClinicRochesterMNUSA Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFLUSA

Penile cancer is a rare genitourinary malignancy with a greater incidence in parts of Asia,South America,and *** are very poor in patients with advanced disease and in those who do not respond to frstine mutimodal *** systemic therapy options,platinum-based chemotherapy is used in the frst line;however,approximately half of patients do not *** rates to systeric therapy as subsequent line treatment are historically *** is also a paucity of prognostic and predictive tools within the context of penile *** such,there remains an urgent need to expand systemic treatment options for patients with advanced penile *** purpose of this review is to summarize the existing evidence for standard-of-care lines of systemic treatment,examine the potential of novel lines of systemic therapy,and provide an update as to the status of these new therapies within the context of penile cancer.

关键词： Penile cancer Chemotherapy Immunotherapy Human papilloma virus Human papilloma virus-vaccine Adoptive cell therapy

Relationships Between Vertical Jump Metrics and Sprint Performance,and Qualities that Distinguish Between Faster and Slower Sprinters

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Journal of Science in Sport and Exercise 2022年第2期4卷 135-144页

作者： jad Adrian Washif Lian-Yee Kok High-Performance Branch Sports Performance DivisionNational Sports Institute of MalaysiaNational Sports ComplexBukit Jalil57000 Kuala LumpurMalaysia Department of Sport Science Tunku Abdul Rahman University CollegeKuala LumpurMalaysia

Purpose This study aimed to investigate the relationships between vertical jump metrics and phases during a 60 m *** variances in strength qualities between sprinters of different ability levels were also *** Eighteen young male elite sprinters(age:18.1±1.3 years;stature:1.72±0.07 m;body mass:66.3±6.2 kg)were assessed for squat(SJ),countermovement(CMJ),drop(DJ),and standing long jumps,a maximal load back-squat,and a 60-m sprint from a *** relationships between sprint performances with all variables were analysed using correlation and multiple regression while discriminative parameters between fast(100 m time:~10.50 s)and slow(~11.00 s)sprint groups were assessed using independent *** Higher associations existed between vertical jumps and longer sprint distances,especially between SJ height and relative peak power with 10 m(r=−0.47 and−0.47,respectively),30 m(−0.71 and−0.74),60 m(−0.76 and−0.81),10-30 m(−0.80 and−0.86),and 30-60 m(−0.78 and−0.84)sprint ***,variables such as relative maximal-strength,relative SJ parameters(height,peak force,and peak power),relative CMJ peak power,and reactive strength index(DJ from 35 cm height)had significant discriminative ability and correlations(P<0.05)with sprint distances involving maximal velocity and ***,a combination of SJ height and relative maximal-strength during back-squat accounted for 75%of the variance in 60 m sprint *** Relative measures of multiple strength metrics may provide better insight regarding factors that enhance sprint *** maximal-strength,high explosive power,and reactive strength seem necessary to improve sprint performance in young male elite sprinters.

关键词： Acceleration Mechanical power Maximum strength Neuromuscular abilities Reactive strength Track and field